Marshall Protocol Knowledge Base

Hormone and pro-hormone therapy

Joyful — 2010-03-19T01:27:17-07:00

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-	<blockquote>When I started the MP, I was also taking DHEA, pregnenolone, progesterone and testosterone. When I tested them again in December, the DHEA and pregnenolone were back to normal and I had to reduce the progesterone! I was able to stop progesterone and testosterone a few months ago as well!	+	<blockquote>
		+	When I started the MP, I was also taking DHEA, pregnenolone, progesterone and testosterone. When I tested them again in December, the DHEA and pregnenolone were back to normal and I had to reduce the progesterone! I was able to stop progesterone and testosterone a few months ago as well!

	//Alayne//</blockquote>		//Alayne//</blockquote>
		+
		+	<blockquote>
		+	My wife gets HRT due to surgery to remove fibroid tumors. She's had to lower the dose to the smallest available while on the MP. HRT is simply sometimes necessary, and the MP can be done in combination with the HRT. However, you do need to be able to change the dose level of the HRT as the MP changes things.
		+
		+	//Chris//</blockquote>

Test: Alanine Aminotransferase (ALT)

Joyful — 2010-03-18T22:54:04-07:00

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	Alanine Aminotransferase test is [[http://www.labtestsonline.org/understanding/analytes/alt/test.html\|described here]].		Alanine Aminotransferase test is [[http://www.labtestsonline.org/understanding/analytes/alt/test.html\|described here]].
		+
		+	<blockquote>
		+	I also wanted to note that a couple of years ago independent of the MP I had a slightly elevated ALT reading. My doc wasn't too worried because he said typically it was a fairly high reading which caused medical concern but he had no clue why it was just slightly elevated. A couple of months later I decided to google it and found a newly released study from UNC-CH that Tylenol could raise ALT levels slightly even in healthy people. The weird thing was that it didn't take much and the elevation lasted several days after the Tylenol was stopped. I also found that environmental toxins and junk food could raise the values according to some sources.It just sounds like the ALT reading is very sensitive in some of us. Just think what a total bacterial dump would do to something this sensitive.
		+
		+	//Mindy, MarshallProtocol.com// </blockquote>

	{{tag>}}		{{tag>}}

Paper - Autoimmune disease in the era of the metagenome

Paul Albert — 2010-03-14T11:43:22-07:00

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	Notes: Paper based on [[home:publications:proal_congress_on_autoimmunity_2008\|presentation]] given at [[http://www.kenes.com/autoimmunity/\|6th International Congress on Autoimmunity]], Porto, Portugal, September 2008		Notes: Paper based on [[home:publications:proal_congress_on_autoimmunity_2008\|presentation]] given at [[http://www.kenes.com/autoimmunity/\|6th International Congress on Autoimmunity]], Porto, Portugal, September 2008

		+	<html><form>
		+	<a href="http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf"><input type="image" name="Submit" value="Download as PDF" src="http://mpkb.org/lib/exe/fetch.php/home:downloadpdf.gif"; class="buttoncalc hide" /></a>
		+	</form>
		+
		+
		+
		+	<style type="text/css">
		+	input.buttoncalc {background: #d2d2d2 !important; color: #000 !important; padding:2px !important; text-align: left !important; display: inline !important;}
		+	input:hover.buttoncalc {background: #fff !important;}
		+	a:hover .buttoncalc {background: #fff !important;}
		+	input:hover .buttoncalc {background: #fff !important;}</style>
		+	</html>

	===== Abstract =====		===== Abstract =====

Presentation - Vitamins D in chronic disease

Malinda Dry — 2010-03-12T21:57:59-07:00

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	is this little red oxygen. It’s actually an OH and this is added and it		is this little red oxygen. It’s actually an OH and this is added and it
	makes all the difference. And here we have a nice picture of a		makes all the difference. And here we have a nice picture of a
-	kidney. O.K. So we have the molecule is transformed by adding	+	kidney. O.K. So we have the molecule transformed by adding
	the hydroxyl group so it can now activate the vitamin D receptor.		the hydroxyl group so it can now activate the vitamin D receptor.
	Most doctors rely on the 25D precursor to decide how much		Most doctors rely on the 25D precursor to decide how much

Science behind Pathogenesis

Ron — 2010-03-08T13:51:25-07:00

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	<mainarticle> [[home:pathogenesis:kochs_postulates\|Koch's posutlates]] </article>		<mainarticle> [[home:pathogenesis:kochs_postulates\|Koch's posutlates]] </article>

-	</article>	+	{{section>:home:pathogenesis:kochs_postulates&amp;noheader&;firstseconly}}

Home

Paul Albert — 2010-03-08T07:55:19-07:00

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-	* //October 2009// – Proal //et al.// 2009 //Autoimmunity Reviews// [[home:publications:proal_autoimmunity_reviews_2009#appraisal_by_faculty_of_1000\|rated "must read"]] by prestigious literary awareness group "Faculty of 1000"	+	* //October 2009// – Proal //et al.// 2009 //Autoimmunity Reviews// [[home:publications:proal_autoimmunity_reviews_2009#appraisal_by_faculty_of_1000\|rated "must read"]] by prestigious literary awareness group "Faculty of 1000 Medicine"

Dosage and administration of olmesartan (Benicar)

Joyful — 2010-03-07T23:20:25-07:00

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	* missing information on time-release benicar from here [[http://www.marshallprotocol.com/forum32/1134.html]]		* missing information on time-release benicar from here [[http://www.marshallprotocol.com/forum32/1134.html]]

		+	"40mg q6h leaves me fatigued/stuck in bed and wishing for more benicar at exactly 5.25 hours. As a compromise, 20mg q4h allows me to function, not be fatigued so much, to get out and work. * 20mg q3h works great. * Starting to get beyond the constant fatigue -- waking up earlier and can get in 4-6 hours of work before needing a rest. I have missed the q3h/q4h in the middle of the night a few times, but so far have waked up at 6-7 hours and doubled up (the missed 20mg and the scheduled 20mg). Feel a little rotten for an hour, but the rest of the day goes fine -- this in contrast with taking 40mg at bedtime and sleeping 10-12 hours through all alarms and waking up feeling like roadkill, having lost the blockade, and am useless the next 24 hours. -Chef Bama"

Minocycline

Joyful — 2010-03-07T23:19:22-07:00

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	<blockquote>The easiest route is to either have the minocycline compounded at 25mg or to get 50mg tablets that can be cut in half with a pill cutter. Both of these options are more expensive than buying 50mg capsules and dividing the contents in half yourself.		<blockquote>The easiest route is to either have the minocycline compounded at 25mg or to get 50mg tablets that can be cut in half with a pill cutter. Both of these options are more expensive than buying 50mg capsules and dividing the contents in half yourself.
-
-	Minocycline is taken in doses of 25, 50, 75 or 100 milligrams every 48 hours (every 2 days) starting in phase 1 of the protocol. Do not take less than 25mg or more than 100mg.

	//Joyful// </blockquote>		//Joyful// </blockquote>
		+
		+	Minocycline is taken in doses of 25, 50, 75 or 100 milligrams every 48 hours (every 2 days) starting in phase 1 of the protocol. Do not take less than 25mg or more than 100mg.

	==== Contraindications ====		==== Contraindications ====

Tutorial - An overview of the Marshall Protocol: the science, the treatment, and the guidelines

Joyful — 2010-03-06T17:13:31-07:00

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	I feel honored to be part of such an exciting scientific movement that will lead to some of the greatest paradigm shifts ever made in medicine.		I feel honored to be part of such an exciting scientific movement that will lead to some of the greatest paradigm shifts ever made in medicine.

-	Everyone else at Autoimmunity Research Foundation is a volunteer for similar reasons. All services on the site are provided free of charge and Autoimmunity Research Foundation makes money only from donations. The nurse moderators, the patient advocates, and Dr. Marshall all work for free because, like me, they realize that the Marshall Protocol has the potential to affect the lives of millions and change the concept of chronic disease as we know it.	+	Everyone else at Autoimmunity Research Foundation is a volunteer for similar reasons. All services on the site are provided free of charge and Autoimmunity Research Foundation makes money only from donations. The moderators, the patient advocates, and Dr. Marshall all work for free because, like me, they realize that the Marshall Protocol has the potential to affect the lives of millions and change the concept of chronic disease as we know it.

	Change in the medical world is a slow process. As German philosopher Arthur Schopenhauer once stated, "All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."		Change in the medical world is a slow process. As German philosopher Arthur Schopenhauer once stated, "All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."

Dutch Translations

Ron — 2010-03-03T13:40:55-07:00

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	===== Informatie voor Eerste Hulp =====		===== Informatie voor Eerste Hulp =====

-	//This is the Dutch translation of the ER document. The content here is also available as a [[http://mpkb.org/lib/exe/fetch.php/home:basics:translations:eerstehulp.pdf?id=home%3Abasics%3Atranslations%3Adutch&cache=cache\|printable document]].//	+	//This is the Dutch translation of the ER document. The content here is also available as a [[http://mpkb.org/lib/exe/fetch.php/home:patients:translations:eerstehulp.pdf\|printable document]].//

	== Aan zorgverleners die deze patiënt behandelen in een noodsituatie: ==		== Aan zorgverleners die deze patiënt behandelen in een noodsituatie: ==

Cost of the Marshall Protocol

Dr Trevor Marshall — 2010-03-02T13:27:14-07:00

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-	Three to four times every day, MP patients take 40mg doses of olmesartan (Benicar), a medication for which there is no substitute. Patients can use the generic form (olmesartan) or the brand name (Benicar). For patients who must buy olmesartan out of pocket, [[home:mp:mpmeds:olmesartan:buying#sources_of_olmesartan\|online discount pharmacies]] sell a month's worth of generic olmesartan for around $80 or less.	+	Three to four times every day, MP patients take 40mg doses of olmesartan (Benicar), a medication for which there is no substitute. Patients can use the generic form (olmesartan medoxomil) or the brand name (Benicar). For patients who must buy olmesartan out of pocket, [[home:mp:mpmeds:olmesartan:buying#sources_of_olmesartan\|online discount pharmacies]] sell a month's worth of generic olmesartan for around $80 or less.

	Patients who have a medication benefit to their [[home:mp:insurance\|insurance coverage]], including Medicare and Medicaid, may have to file an appeal to obtain full coverage of the recommended dose of olmesartan. If any problems are encountered, patients //usually// win on appeal of their claims, unless their insurance policy specifically states that off-label use of medications is prohibited.		Patients who have a medication benefit to their [[home:mp:insurance\|insurance coverage]], including Medicare and Medicaid, may have to file an appeal to obtain full coverage of the recommended dose of olmesartan. If any problems are encountered, patients //usually// win on appeal of their claims, unless their insurance policy specifically states that off-label use of medications is prohibited.

Skin Protection

Joyce Waterhouse — 2010-02-28T16:45:25-07:00

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	//F.J. Moloney, et al.// (({{pubmed>long:11978139}})) </blockquote>		//F.J. Moloney, et al.// (({{pubmed>long:11978139}})) </blockquote>
-
-
-	Other researchers have shown that what effect sunscreen use does have on vitamin D production is not one which leads to certain conditions (erroneously) associated with vitamin deficiency.

	<blockquote>		<blockquote>

Alopecia

Paul Albert — 2010-02-28T07:19:52-07:00

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-	<note>Dear MPKB Reader: You have arrived at a page that has not yet been written, revised, and edited. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we just haven't gotten around to. Thanks for your patience.</note>	+	<note>Dear MPKB Reader: You have arrived at an article that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we just haven't gotten around to. Thanks for your patience.</note>

	====== Alopecia ======		====== Alopecia ======
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	Maryborough, in central Victoria has an approximate population of 8000 and census data is well matched for Australia overall. Australia has compulsory voting and registration on the electoral roll. To determine the age-related prevalence of balding among men and women in Maryborough we conducted a postal survey of 5000 men and women aged 20 or older, and 427 were invited to attend for examination. Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p<0.01). The prevalence of mid-frontal hair loss increases with age and affects 57% of women and 73.5% of men aged 80 and over.		Maryborough, in central Victoria has an approximate population of 8000 and census data is well matched for Australia overall. Australia has compulsory voting and registration on the electoral roll. To determine the age-related prevalence of balding among men and women in Maryborough we conducted a postal survey of 5000 men and women aged 20 or older, and 427 were invited to attend for examination. Additional data was collected on dandruff, presence of gray hair. Supplementary questionnaires were sent to 340 children aged 5-9, attending a coeducational primary school. 1456 adults (34.1%) responded to the questionnaire. 396 attended for examination. The prevalence of androgenetic alopecia (AGA) increased with advancing age. 98.6% of men had bitemporal recession and severity was significantly associated with vertex and mid-frontal hair loss (p <0.01) but not age (p = 0.06). In all, 64.4% of women had bitemporal hair loss, and similar to men there was a significant association with mid-frontal hair loss (p =0.042) but not age (p =0.467). One hundred and forty children with completed questionnaires were examined. All 72 females and 68 males were assessed as stage 1 on the mid-line part and with no bitemporal recession (frequency stage 1 = 100%, 95% CI (confidence interval) 97.4%-100%). A significant but weak positive association existed between presence of gray hair and history of dandruff (p<0.01). The prevalence of mid-frontal hair loss increases with age and affects 57% of women and 73.5% of men aged 80 and over.
	PMID: 16382660		PMID: 16382660
-
-
	===== Evidence of infectious cause =====		===== Evidence of infectious cause =====

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	PMID: 16402270 [PubMed - indexed for MEDLINE]		PMID: 16402270 [PubMed - indexed for MEDLINE]
		+
		+
		+	Dermatol Online J. 2010 Feb 15;16(2):3.
		+	Does D matter? The role of vitamin D in hair disorders and hair follicle cycling.
		+	Amor KT, Rashid RM, Mirmirani P.
		+
		+	Department of Dermatology, University of Texas and MD Anderson Cancer Center, Houston, Texas. rashidrashid.mdphd@yahoo.com.
		+	BACKGROUND: The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology. OBJECTIVE: We sought to evaluate the role that vitamin D and the vitamin D receptor play in the hair cycle and assess how this can be clinically applied to the treatment of hair disorders. METHODS: A MEDLINE search (1955-July 2009) was preformed to find relevant articles pertaining to vitamin D, the vitamin D receptor, and hair loss. RESULTS: The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood. LIMITATIONS: The review is broad and there are limited human studies available to date. CONCLUSION: Additional studies to evaluate the role of vitamin D in the hair cycle should be done. Treatments that up regulate the vitamin D receptor may be successful in treating hair disorders and are a potential area of further study.
		+
		+	PMID: 20178699
		+	http://www.ncbi.nlm.nih.gov/pubmed/20178699

	{{tag>diseases}}		{{tag>diseases}}

Laboratory tests

Joyful — 2010-02-25T21:37:40-07:00

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	Doctors find it helpful to track (every 2-3 months) the level of the D Metabolite, [[.:tests:25d\|25-D]], for patients on the protocol. This allows the doctor and the patient to be aware of when the 25-D level is starting to get low enough that the patient's innate immune response begins to return. This is a critical point to discern so that any strong increase in immunopathology (IP) can be quickly addressed with appropriate measures.		Doctors find it helpful to track (every 2-3 months) the level of the D Metabolite, [[.:tests:25d\|25-D]], for patients on the protocol. This allows the doctor and the patient to be aware of when the 25-D level is starting to get low enough that the patient's innate immune response begins to return. This is a critical point to discern so that any strong increase in immunopathology (IP) can be quickly addressed with appropriate measures.
		+
		+	<blockquote>
		+	[Frequency of 25-D testing] depends on the level. If your 25-D consistently tests below 8 ng/ml then every 3-6 months should be OK, but if you are hovering in the teens, I would think every month or two to track the changes you are making to your diet.
		+
		+	//Trevor Marshall, PhD// </blockquote>

	===== Retesting prior to the start of Phase 2 =====		===== Retesting prior to the start of Phase 2 =====

Vitamin D metabolite test instructions

Joyful — 2010-02-25T21:34:42-07:00

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	When the 1,25-D test is drawn at the same time, the same blood specimen is probably used for both tests and they can both be frozen. Freezing preserves the specimen and will not harm it even if it isn't necessary.		When the 1,25-D test is drawn at the same time, the same blood specimen is probably used for both tests and they can both be frozen. Freezing preserves the specimen and will not harm it even if it isn't necessary.

-	There is an [[homekit\|at-home 25-D test kit]] available for routine testing.	+	There is an [[home:tests:homekit\|at-home 25-D test kit]] available for routine testing.

	===== Special handling for the 1,25-D test =====		===== Special handling for the 1,25-D test =====

Home 25-D test kits - Page moved from home:test:25d:homekit to home:tests:homekit

Joyful — 2010-02-25T21:33:59-07:00

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Food and drink

Joyful — 2010-02-25T18:48:32-07:00

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	* cereal bars and nutrition bars		* cereal bars and nutrition bars

		+	<blockquote>
		+	For some people they will find that their 25D rises after a few months on the MP. This may be due to a hidden source of D in their food/supplements, combined with the fact that the 25D is no longer rapidly converting to 1,25D as it was before starting the Benicar.
		+
		+	You would be surprised where those hidden sources of D turn up. Some on the MP have found that they had to forgo grain beers, realized they were eating foods with mushrooms in them, taking a "harmless supplement" with D in it, or discovered their yogurt or ice cream was made with D fortified milk ... to name a few scenarios.
		+
		+	//Joyful, MarshallProtocol.com// </blockquote>

	==== Avoid foods containing supplemental folic acid ====		==== Avoid foods containing supplemental folic acid ====

The over-exuberant Stage-Five immune response

Joyce Waterhouse — 2010-02-23T20:38:15-07:00

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	The characteristics of patients suffering from an over-exuberant Stage Five are as follows:		The characteristics of patients suffering from an over-exuberant Stage Five are as follows:
	* usually (but not always) have been on the MP several years		* usually (but not always) have been on the MP several years
-	* no longer photosensitive	+	* may not be photosensitive in the same way as in the past
	* experienced symptom improvement as evidence of antibiotic effectiveness in Stages Three and Four		* experienced symptom improvement as evidence of antibiotic effectiveness in Stages Three and Four
-	* previously been successful in dampening immunopathology by adjusting antibiotics as evidence of antibiotic modulaton of the immune system in Stages Three and Four	+	* previously been successful in dampening immunopathology by adjusting antibiotics as evidenced by antibiotic modulation of the immune system in Stages Three and Four
	* extensive systemic inflammation (joints, lymphatic system, nerves) or inflammation in major organs (lungs, liver, heart, kidneys) with the potential for tissue remodeling to reveal a large amount of bacteria at once		* extensive systemic inflammation (joints, lymphatic system, nerves) or inflammation in major organs (lungs, liver, heart, kidneys) with the potential for tissue remodeling to reveal a large amount of bacteria at once
	* successful in using olmesartan to dampen symptoms as evidence that the effect of Benicar has become primarily palliative		* successful in using olmesartan to dampen symptoms as evidence that the effect of Benicar has become primarily palliative
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	//Trevor Marshall, PhD// </blockquote>		//Trevor Marshall, PhD// </blockquote>
		+
	===== Predicting an over-exuberant Stage Five response =====		===== Predicting an over-exuberant Stage Five response =====

Baking soda

Joyful — 2010-02-22T23:28:04-07:00

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	<blockquote>It is not dangerous, but it tastes appalling and can make you want to retch. It can make some people nauseous when it hits their stomach and a few suffer an upset stomach or diarrhoea when they take it.		<blockquote>It is not dangerous, but it tastes appalling and can make you want to retch. It can make some people nauseous when it hits their stomach and a few suffer an upset stomach or diarrhoea when they take it.

-	//Dr. Folland//(([[http://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece\|Times Online]])) </blockquote>	+	//Dr. Folland, [[http://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece\|Times Online]]// </blockquote>

	It is recommended that you not take it orally, except with the approval of your doctor. Occasional use of baking soda in a bath may be ok.		It is recommended that you not take it orally, except with the approval of your doctor. Occasional use of baking soda in a bath may be ok.

Non-MP treatments

Joyful — 2010-02-22T23:26:03-07:00

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	No reference to St. John's Wort. Common antidepressant. --- //Joyful 08.16.2009//		No reference to St. John's Wort. Common antidepressant. --- //Joyful 08.16.2009//
		+
		+	Resource for market drug information:
		+	* http://dailymed.nlm.nih.gov/dailymed/about.cfm

Test: total iron binding capacity (TIBC)

Joyful — 2010-02-22T23:23:53-07:00

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	* Legacy content		* Legacy content
	* [[http://www.marshallprotocol.com/forum32/3479.html]]		* [[http://www.marshallprotocol.com/forum32/3479.html]]
-	*	+
		+	* Research notes
		+	* http://www.labtestsonline.org/understanding/analytes/tibc/test.html
		+
	===== References =====		===== References =====

Weaning from corticosteroids

Joyful — 2010-02-21T18:24:08-07:00

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	====== Weaning from corticosteroids ======		====== Weaning from corticosteroids ======

-	Because they suppress the innate immune response and do significant long-term damage, all [[home:othertreatments::corticosteroids\|corticosteroids]] and hormonal steroids are contraindicated and must be discontinued before beginning the Marshall Protocol (MP). As damaging as they are, the abrupt discontinuation of corticosteroids can cause serious harm. MP patients currently taking corticosteroids should consult with their physicians to slowly wean off the drugs. The successful completion of this process can take months and sometimes a year or more. Members of the MP study site are advised //not// to begin steroid withdrawal without first discontinuing antibiotics and consulting with a nurse moderator.	+	Because they suppress the innate immune response and do significant long-term damage, all [[home:othertreatments::corticosteroids\|corticosteroids]] and hormonal steroids are contraindicated and must be discontinued before beginning the Marshall Protocol (MP). As damaging as they are, the abrupt discontinuation of corticosteroids can cause serious harm. MP patients currently taking corticosteroids should consult with their physicians to slowly wean off the drugs. The successful completion of this process can take months and sometimes a year or more. Members of the MP study site are advised //not// to begin steroid withdrawal without first discontinuing antibiotics and consulting with our support community.

Pain medications

Paul Albert — 2010-02-17T18:23:46-07:00

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	Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications.		Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications.

-	NSAIDS and COX-2 inhibitors can increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used. A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.	+	NSAIDS and COX-2 inhibitors can increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used. A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.(({{pubmed>long:20031832}}))

Managing immunopathology (IP)

Paul Albert — 2010-02-17T17:01:14-07:00

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	* Extend minocycline from every other day dosing out to three days or longer.		* Extend minocycline from every other day dosing out to three days or longer.

-	Please note: minocycline is not palliative for all people. From some, increased frequency of minocycline results in more immunopathology. This is more likely to be the case if one experiences less immunopathology toward the end of the 48 hours between doses.	+	Please note: minocycline is not palliative for all people. For some, increased frequency of minocycline results in more immunopathology. This is more likely to be the case if one experiences less immunopathology toward the end of the 48 hours between doses.

Bactrim DS (co-trimoxazole)

Paul Albert — 2010-02-16T20:37:14-07:00

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	Bactrim DS is the brand name. It is also known as Septra, Sulfatrim, Cotrim, Novo-Trimel, Nu-Cotrimox, Resprim, Roubac and Septrin. The generic name is co-trimoxazole.		Bactrim DS is the brand name. It is also known as Septra, Sulfatrim, Cotrim, Novo-Trimel, Nu-Cotrimox, Resprim, Roubac and Septrin. The generic name is co-trimoxazole.

-	Either generic or brand name is appropriate to use.	+	Bactrim DS has a reputation for targeting the bacteria in the gastrointestinal tract. Either generic or brand name is appropriate to use.

Children and the Marshall Protocol - add link to rickets article

Joyful — 2010-02-15T15:28:17-07:00

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-	It will be important to reduce 25-D in a child on the MP to a therapeutic 12ng/ml while ensuring an adequate intake of calcium for growing bones. Parents of a child on the MP must carefully supervise the child's diet to ensure compliance with MP dietary restrictions. Lack of dietary vitamin D does not cause rickets.	+	It will be important to reduce 25-D in a child on the MP to a therapeutic 12ng/ml while ensuring an adequate intake of calcium for growing bones. Parents of a child on the MP must carefully supervise the child's diet to ensure compliance with MP dietary restrictions. Lack of dietary vitamin D does not cause [[home:diseases:rickets\|rickets]].

Vitamin and mineral supplementation

Joyce Waterhouse — 2010-02-13T19:08:19-07:00

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	* [[home:food:folic_acid_and_folate\|folic acid and folate]] – folate is a water-soluble B-vitamin that occurs naturally in foods; folic acid is the synthetic form of folate; MP patients must avoid products containing supplemental folic acid as it contributes to bacterial growth		* [[home:food:folic_acid_and_folate\|folic acid and folate]] – folate is a water-soluble B-vitamin that occurs naturally in foods; folic acid is the synthetic form of folate; MP patients must avoid products containing supplemental folic acid as it contributes to bacterial growth
-	* vitamin B12 – readily available in meat and dairy products so, unless a person is a vegan, he or she is probably not deficient; the exception is people who cannot absorb B-12, a condition called pernicious anemia	+	* vitamin B12 – readily available in meat and dairy products so, unless a person is a vegan, he or she is probably not deficient; exceptions include certain malabsorption syndromes and pernicious anemia, conditions where people cannot absorb B-12
	* vitamin C – ascorbates promote the transcription of Th1 inflammatory mediators and, therefore, vitamin C (ascorbic acid) may prove to affect the immune system in a way that is counterproductive; as little as 10mg per day of vitamin C is needed to prevent scurvy		* vitamin C – ascorbates promote the transcription of Th1 inflammatory mediators and, therefore, vitamin C (ascorbic acid) may prove to affect the immune system in a way that is counterproductive; as little as 10mg per day of vitamin C is needed to prevent scurvy
	* vitamin E – supplementation has fallen out of favor with healthcare professionals		* vitamin E – supplementation has fallen out of favor with healthcare professionals

Baths

Joyful — 2010-02-09T22:20:30-07:00

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	However, if you have a lot of sensitivities, or have not responded well to Epsom salt baths in the past, you may do better with a smaller amount of Epsom salts (e.g., 1/4 cup) as a starting point. Only use as much as appears beneficial. The Epsom salts may be drying to the skin.		However, if you have a lot of sensitivities, or have not responded well to Epsom salt baths in the past, you may do better with a smaller amount of Epsom salts (e.g., 1/4 cup) as a starting point. Only use as much as appears beneficial. The Epsom salts may be drying to the skin.

-	Those with moderate to severe impairment of kidney function should consult one's doctor before using Epsom salts and exercise caution. Excessive serum magnesium can occasionally occur from the over use of Epsom salts and other magnesium-containing products in those with inadequate renal function.	+	Those with moderate to severe impairment of kidney function should exercise caution and consult one's doctor before using Epsom salts. Excessive serum magnesium can occasionally occur from the over use of Epsom salts and other magnesium-containing products in those with inadequate renal function.

	{{tag> }}		{{tag> }}

Assessing the published literature

Paul Albert — 2010-02-09T09:43:06-07:00

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	-Therapeutic interventions, for which there is a [[home:publications:albert_autoimmunity_reviews_2009\|short-term benefit but long-term harm]], are not accurately represented in studies over shorter time windows. [[home:pathogenesis:vitamind:longterm\|Insufficient follow-up]] is particularly problematic in studies looking at vitamin D and other immunosuppressants. Successful treatments must be [[home:patients:assessing_literature:palliative\|curative, not palliative]].		-Therapeutic interventions, for which there is a [[home:publications:albert_autoimmunity_reviews_2009\|short-term benefit but long-term harm]], are not accurately represented in studies over shorter time windows. [[home:pathogenesis:vitamind:longterm\|Insufficient follow-up]] is particularly problematic in studies looking at vitamin D and other immunosuppressants. Successful treatments must be [[home:patients:assessing_literature:palliative\|curative, not palliative]].
	-Many of the articles that appear in scientific journals, under the bylines of prominent academics, are actually written by ghostwriters, who are paid by drug companies.(({{pubmed>long:16506304}})) These seemingly objective articles, which doctors around the world use to guide their care of patients, are often part of a marketing campaign by companies to promote a product or play up the condition it treats. One recent and prominent example relates to the way studies supporting HRT were [[http://www.nytimes.com/2009/08/05/health/research/05ghost.html?_r=1&emc=eta1\|written by ghostwriters]].		-Many of the articles that appear in scientific journals, under the bylines of prominent academics, are actually written by ghostwriters, who are paid by drug companies.(({{pubmed>long:16506304}})) These seemingly objective articles, which doctors around the world use to guide their care of patients, are often part of a marketing campaign by companies to promote a product or play up the condition it treats. One recent and prominent example relates to the way studies supporting HRT were [[http://www.nytimes.com/2009/08/05/health/research/05ghost.html?_r=1&emc=eta1\|written by ghostwriters]].
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	===== Read more =====		===== Read more =====

	{{topic>Assessing_Medical_Literature}}		{{topic>Assessing_Medical_Literature}}

		+	Spielmans and Parry offer a robust critique of the series of assumptions upon which evidence-based medicine is based in their 2010 //Bioethical Inquiry// paper available [[http://i.bnet.com/blogs/spielmans-parry-ebm-to-mbm-jbioethicinqu-2010.pdf\|here]].

Introduction to the Marshall Protocol

Joyful — 2010-02-05T22:47:37-07:00

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	At its essence, the MP involves four key elements, each of which is supported by the [[home:protocol\|latest insights]] in molecular science:		At its essence, the MP involves four key elements, each of which is supported by the [[home:protocol\|latest insights]] in molecular science:
-	* take 3-4 doses of olmesartan (Benicar) per day	+	* take 4 doses of olmesartan (Benicar) per day
	* take varying combinations of pulsed, low doses of specific bacteriostatic antibiotics		* take varying combinations of pulsed, low doses of specific bacteriostatic antibiotics
	* wean off any immunosuppressive or potentially immunosuppressive [[home:othertreatments\|therapies]]		* wean off any immunosuppressive or potentially immunosuppressive [[home:othertreatments\|therapies]]