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Diseases associated with low levels of 25-D

Related articles: Mistaking correlation for causation in vitamin D studies, Incidence and prevalence of chronic disease

According to the Marshall PathogenesisA description for how chronic inflammatory diseases originate and develop., chronic inflammatory disease is caused by a microbiotaThe bacterial community which causes chronic diseases - one which almost certainly includes multiple species and bacterial forms. of pathogens which interfere with proper functioning of the innate immune system. Patients suffering from inflammatory diseases have been shown to have lower than normal levels of 25-hydroxyvitamin DThe vitamin D metabolite widely (and erroneously) considered best indicator of vitamin D "deficiency." Inactivates the Vitamin D Nuclear Receptor. Produced by hydroxylation of vitamin D3 in the liver. , and there are at least several reasons why bacterial pathogens generate this response.

A full understanding of vitamin D metabolism supports the conclusion that elevated 1,25-D and depressed 25-D are a result rather than a cause of the inflammatory process.

Lower than normal levels of 25-D have been independently associated both with all-cause mortality1 and a number of chronic inflammatory diseases. The following selection of diseases (and patient groups) have been observed to display the hallmarks of this kind of dysregulated vitamin D metabolism.

Anomalies

In a 2008 nested case-control study appearing in Journal of the National Cancer Institute, Ahn et al. found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.60

Notes and comments

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References

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