Doxycycline

Related article: High-dose antibiotics

A member of the tetracycline family of antibiotics, doxycycline is used against a variety of inflammatory conditions including Lyme disease, rheumatoid arthritis, multiple sclerosis, and cystic fibrosis. Although the MP antibiotic minocycline is also a tetracycline, doxycycline and minocycline are significantly different from each other – both in terms of structure and function.

Doxycycline's effectiveness over short periods of time is due in part to the relatively high doses at which it is typically administered: 200 mg per day.

Doxcycline is ineffective and makes patients worse

The rationale for using minocycline (or demeclocycline) as opposed to doxycycline is as follows:

Short-term use of doxycycline (a month or so) will do no harm, but in the long term the species which are resistant to it will continue to proliferate and exacerbate the chronic disease.

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Does anybody have a reference for the addictive effect or other references about how doxycycline works?