Paper - Re-framing the Theory of Autoimmunity in the Era of the microbiome: Persistent Pathogens, Autoantibodies, and Molecular Mimicry

Type: Paper
Authors: Amy D. Proal PhD, Trevor G Marshall PhD
Publication: Discovery Medicine
Citation: Proal AD, Marshall TG. Re-framing the theory of autoimmunity in the era of the microbiome: persistent pathogens, autoantibodies, and molecular mimicry. Discov Med. 2018 Jun;25(140):299-308.
[PMID: 30021103]

Full text see : Re-framing the Theory of Autoimmunity

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Abstract

An extensive microbiome comprised of bacteria, viruses, bacteriophages, and fungi is now understood to persist in nearly every human body site, including tissue and blood. The genomes of these microbes continually interact with the human genome in order to regulate host metabolism. Many components of this microbiome are capable of both commensal and pathogenic activity. They are additionally able to persist in both “acute” and chronic forms. Inflammatory conditions historically studied separately (autoimmuneA condition or disease thought to arise from an overactive immune response of the body against substances and tissues normally present in the body, neurological and malignant) are now repeatedly tied to a common trend: imbalance or dysbiosis of these microbial ecosystems. Population-based studies of the microbiome can shed light on this dysbiosis. However, it is the collective activity of the microbiome that drives inflammatory processes via complex microbe-microbe and host-microbe interactions. Many microbes survive as polymicrobial entities in order to evade the immune response. Pathogens in these communities alter their gene expression in ways that promote community-wide virulence. Other microbes persist inside the cells of the immune system, where they directly interfere with host transcription, translation, and DNA repair mechanisms. The numerous proteins and metabolites expressed by these pathogens further dysregulate human gene expression in a manner that promotes imbalance and immunosuppression. Molecular mimicry, or homology between host and microbial proteins, complicates the nature of this interference. When taken together, these microbe-microbe and host-microbe interactions are capable of driving the large-scale failure of human metabolism characteristic of many different inflammatory conditions.

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https://www.discoverymedicine.com/Amy-D-Proal/2018/06/autoimmunity-in-era-of-microbiome-persistent-pathogens-autoantibodies-molecular-mimicry/

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Published on June 26, 2018

Proal AD, Marshall TG. Re-framing the theory of autoimmunity in the era of the microbiome: persistent pathogens, autoantibodies, and molecular mimicry. Discov Med. 2018 Jun;25(140):299-308.
[PMID: 30021103]

Proal AD, Marshall TG.

Discov Med. 2018 Jun;25(140):299-308.