Marshall Protocol Knowledge Base

Marshall Protokollen (Norsk oversettelse) - removed - external edit (Unknown date)

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-	====== Marshall Protokollen (Norsk oversettelse) ======

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-	Dette dokumentet er en en-artikkel oppsummering av sentrale problemstillinger knyttet til Marshall-protokollen, særlig når det er relevant for leger. Mange av emnene som dekkes her er gjennomgått i større dybde i hele Knowledge Base.
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-	<note>This article is a summary of the Marshall Protocol in Norwegian.</note>
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-	=====Tilgjengelige oversettelser =====
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-	Oversettelser av dette dokumentet er tilgjengelig for [[home:patients:translations\|enkelte språk]].
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-	===== Ressurser for leger =====
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-	* [[http://bit.ly/dvmqKG\|Vitamin D-status og sykdom – forhastede konklusjoner?]] – 2009 paper in Tidsskr //Nor Legeforen nr// av Inge Lindseth
-	* MPKB.org – The Marshall Protokollen Knowledge Base inneholder lenker til de nyeste peer-reviewed forskning fra ARF samt artikler om hundrevis av temaer og skrevet for en rekke målgrupper.
-	* CureMyTh1.org – Forkortelse for "Cure My Th1 sykdom," CureMyTh1.org er åpent for alle. På CureMyTh1.org, kan pasienter stille spørsmål om MP, finne en lege, og dele symptom rapporter. CureMyTh1.org er moderert av pasienten talsmenn.
-	* MarshallProtocol.com – Dette nettstedet hjelper pasienter og leger bedre forstå Marshall Protokollen. MarshallProtocol.com er åpen for nye pasienter gjennom invitasjon og inneholder pasientenes symptomer rapporter og science-relaterte diskusjoner. Helsepersonell oppfordres til å delta i [[http://www.marshallprotocol.com/forum17/\|Private Seksjon for Health Professionals forum]] på MarshallProtocol.com studiested, som er åpen på e-post forespørsel. MarshallProtocol.com er moderert av professor Trevor Marshall, medlemmer av forskerteamet, og pasienten talsmenn.
-	* AutoimmunityResearch.org – På dette nettstedet kan man lære mer om stiftelsen som støtter Marshall-protokollen og utforske hele virkningene av en metagenomic patogenesen av kronisk sykdom.
-	* Bacteriality.com - Amy Proal sine intervjuer med MP pasienter, sammen med artikler om vitenskapen underliggende protokollen.
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-	Mens legen har ansvaret for pasientbehandling, kan pasientene gjøre minst noen av fotarbeid, henting av informasjon slik at legen kan ta fullt informerte avgjørelser. Faktisk, uten aktiv deltakelse av pasientene ved MarshallProtocol.com eller CureMyTh1.org, støtter vi ikke eller lisens offentlig bruk av denne behandlingen.
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-	===== Bakgrunn og vitenskapelig rasjonale for terapi =====
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-	<relatedarticlesno> [[home:protocol#science_behind_marshall_pathogenesis\|Science behind Marshall Pathogenesis]], [[home:protocol#science_behind_marshall_protocol\|Science behind Marshall Protocol]], [[home:mp:stages\|Stages of illness and recovery]] </article>
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-	The Marshall Protokollen (MP) er navnet gitt til en terapi utarbeidet av professor Trevor Marshall, og er basert på patogenesen han har foreslått for kronisk sykdom.
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-	Marshall (og kolleger) en hypotese om at kroniske inflammatoriske sykdommer, inkludert mange autoimmune sykdommer, er forårsaket av en metagenomic bakterieflora: samfunn av bakterier, hvorav mange vedvare intracellulært. En nylig peer-reviewed papir beskriver dette Patogenese nærmere.(({{pubmed>long:19393196}}))
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-	The Marshall Protocol, en medisinsk behandling som støttes av Autoimmunitet Research Foundation, har vært tilgjengelig siden 2002 og har vært brukt i en rekke kroniske inflammatoriske sykdommer.
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-	Et betydelig antall pasienter diagnostisert med sarkoidose, post-behandling kronisk Lyme syndrom, kronisk utmattelsessyndrom, uveitt, Hashimotos thyreoiditt, revmatoid artritt, fibromyalgi, diabetes, psoriasis, lupus (SLE), multippel sklerose, og en rekke andre diagnoser viser en lovende respons fra å være behandlet med protokollen.
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-	Ved avgjørelsen av om en pasient kan bli behandlet med MP, spesifikk kronisk sykdom diagnose er en ikke så viktig som den kliniske vurderingen av en kunnskapsrik helsepersonell, resultatene av en terapeutisk probe , og utfallet av D metabolitter vitamin blodprøve.(({{pubmed>long:19758177}}))
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-	Ifølge Marshall Patogenese, er kronisk inflammatorisk sykdom karakterisert ved feilregulering av kjernefysiske reseptoren baner som kontrollerer medfødte immunforsvaret. Den Vitamin D kjernefysiske reseptor (VDR) uttrykker mange av kroppens antimikrobielle peptider (sammen med TLR2). I tillegg til nedregulering av uttrykk av VDR seg selv ved mange vanlige patogener, antagonistisk bakterielle metabolitter trinnvis blokk ligander fra aktivere den. Inntatt vitamin D bremser aktiviteten til reseptoren på samme måte, hindrer kroppen fra å drepe patogener i hjertet av sykdommen staten. Det er derfor unngåelse av inntatt vitamin D (i mat og kosttilskudd) er avgjørende for det medfødte immunsystemet skal fungere korrekt mens pasientene er på MP.(({{pubmed>long:19393200}})) ((Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. [[home:publications:waterhouse_new_research_2006\|High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor — Implications of dysregulated vitamin D for diagnosis and treatment of Chronic Disease]]. In //Vitamin D: New Research//.
-	Volume 1. Edited by: Stoltz VD. New York: Nova Science Publishers; 2006. ISBN: 1-60021-000-7.))
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-	MP bruker fire-ganger daglig dosering av olmesartanmedoksomil (Benicar, Olmecip, Olmetec) for å re-aktivere Vitamin D Nuclear Receptor, løsner bakteriell ligander i prosessen. Dette stoffet ble utviklet som en angiotensin II-reseptorblokker (ARB), men det har flere handlinger i kroppen når de gis som definert av Marshall. I tillegg til immunostimulation via VDR, reduserer Olmesartan også inflammatorisk cytokin produksjonen ved å hemme NF Kappa-B transkripsjon veien. Dette hemmer, blant annet utgivelsen av TNF-alfa, bidrar til å beskytte organer fra virkningene av overdreven inflammasjon.
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-	I tillegg flere puls, lav dose, kan bakteriostatisk oral antibiotika brukes til å hjelpe en sterkt svekket immunforsvar gjenkjenner patogener i metagenomic bakterieflora. Fem bakteriostatisk antibiotika: minocycline, azitromycin (zithromax), klindamycin, har sulfametoksazol-trimetoprim (Bactrim DS), og demeclocycline (Declomycin) vist seg å hjelpe immunforsvaret svekkes og angriper deler av systemisk bakterieflora. Minocycline tillegg virker direkte på en immunsuppressiv måte på PXR kjernefysiske reseptoren, og dette biokjemisk handling kan være nyttig i pulserende immunopathology til (for eksempel) en 48 timers syklus.
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-	Alvorlig syke pasienter kan utvikle fotosensitivitet under healing prosessen, slik unngåelse av direkte og indirekte sollys kan være nødvendig. Pasienter kan ha behov for å beskytte øynene fra skarpt lys for å hindre ytterligere skade netthinnen og redusere nevrologiske symptomer skyldes blant annet effekten av okulære 1,25-D produksjon på hjernen. Noen pasienter opplever ikke noen betydelig fotosensitivitet under gjenoppretting, og de som ofte finner det mer håndterlig etter 12 til 18 måneder.
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-	==== Immunopathology ====
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-	<mainarticleno> [[home:protocol:immunopathology\|Science behind immunopathology]] </article>
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-	Når pasienter på MP dreper bakterier de opplever en reaksjon som kalles immunopathology. Immunopathology er en økning i ens nåværende symptomer på Th1 betennelse, eller en avkastning på tidligere Th1 inflammatoriske symptomer, som forårsakes hovedsakelig av cytokiner generert av immunforsvaret og endotoksiner frigjøres fra å dø bakterier. Av og til vil immunopathology bestå av et nytt symptom eller unormal lab verdi (for eksempel, forhøyet kreatinin, forhøyede leverenzymer, lavt antall hvite blod teller, etc.) på grunn av forekomsten av subklinisk bakteriell betennelse som har blitt avslørt av Olmesartan er aktivering av immunsystemet . Immunopathology synes å være en nødvendig del av utvinning. Mengden immunopathology en pasient opplever på Marshall Protokollen (MP) er korrelert med sykdommens alvorlighetsgrad og bakteriell belastning. Pasienter som er mindre syke vil ha relativt mindre sterke immunopathology.
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-	Immunopathology brukes noen ganger synonymt med "Jarisch-Herxheimer reaksjon" eller "herx."
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-	Mange MP pasienter som har opplevd lengre perioder med immunopathology har nådd trinn i betydelig bedring eller remisjon. Dette tjener til å bekrefte den konklusjon at immunopathology er en nødvendig følge av kronisk bakteriell død, og en forløper til sykdom reversering. MP er ikke unik i denne forbindelse. En rekke andre sykdommer og / eller behandling generere immunopathological eller immunopathological-lignende reaksjoner.(({{pubmed>long:11997718}})) (({{pubmed>long:18600241}})) (({{pubmed>long:12604286}}))
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-	Laboratoriearbeid og pasienten rapporter kan brukes til å spore kliniske tegn på immunopathology .
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-	===== Pasient valgbarhet og forutsetninger =====
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-	The Marshall-protokollen har blitt brukt i en rekke kroniske inflammatoriske sykdommer. Gullstandarden for å vurdere om MP er berettiget er terapeutisk probe, en kort prøveversjon av Marshall-protokollen for å se om olmesartanmedoksomil og minocycline vil generere en immunopathological respons. Resultatene fra en vitamin D metabolitter test, mens mindre definitiv, kan også foreslå tilstedeværelsen av behandle tilstanden. For en automatisert tolkning av vitamin D metabolitter, se [[home:tests:vitdinterpretation\|Vitamin D metabolitten kalkulator]].
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-	Andre pasientgrupper:
-	* [[home:special:pregnancy\|gravide/ammende kvinner]] – Både olmesartan og minocycline, de to bærebjelke medisiner av MP, er kontraindisert under graviditet og mens du ammer. Kvinner i fertil alder på MP bør ta tilstrekkelig prevensjon.
-	* [[home:special:children\|barn]] – Barn med en rekke sykdommer og tilstander kan behandles med MP. Det er mer enn et dusin i studien kohorten som gjør det bra. FDA har nylig godkjent bruk av olmesartan for hypertensive barn i alderen 6-16.
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-	Før du starter behandling, leger og pasienter bør gjøre seg kjent med [[home:starting:prempchecklist\|pre-MP sjekkliste]], som gjennomgår medisiner, øyebeskyttelse, og mulige livsstil modifikasjoner er nødvendig for behandling suksess og sikkerhet.
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-	===== Sikkerhetshensyn =====
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-	<mainarticleno> [[home:starting:safety_warnings\|Safety warnings for the Marshall Protocol]] </article>
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-	- Noen pasienter med alvorlige former for sykdom kan utvikle sterke immunopathology som er vanskelig å kontrollere - Mens de fleste pasientene kan justere antibiotika for å tolerere immunopathology vellykket på en dag-til-dag basis, med alvorlige former for sykdom kan pasientene utvikle sterke immunopathology som er vanskelig å kontrollere. Leger bør hjelpe sine pasienter internalisere strategier for håndtering immunopathology. Å vite hvordan du skal håndtere MP uavhengig av hverandre på en dag-til-dag basis vil tjene pasientene også bør en presserende situasjon oppstå. Pasientene bør oppfordres til å søke støtte fra stiftelsen nettsider.
-	- For sykere pasienter, kan immunopathology være fysisk og mentalt utfordrende - Støtte fra en kunnskapsrik lege og familie / venner blir av største betydning. Med mindre pasienten har en god innsikt i IP og andre ulemper av behandlingen, bør pasienten ikke starte behandlingen.
-	- Pasienter fysisk avhengig av flere palliativ medisiner vil generelt ha store problemer med avvenning fra disse stoffene, en nødvendig forutsetning for slik det medfødte immunsystemet til å fungere ordentlig, og induserer utvinning. Våre medlemmer har hatt suksess avvenning fra kortikosteroider, men psykotrope stoffer og enkelte smertestillende tabletter har vist seg svært vanskelig å avvenne
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-	==== Ikke-MP behandlinger ====
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-	<mainarticleno> [[home:othertreatments#medications\|Ikke-MP behandlinger]] </article>
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-	Mens det er unntak, bør Marshall Protokollen (MP) ikke kombineres med andre protokoller, behandlinger eller kosttilskudd, spesielt de som er immunsuppressiv eller immunmodulerende. Bruk av andre behandlinger, mens på MP kan hindre fremdriften på MP - eller være farlig for MP pasienter.
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-	For utålelige symptomer, visse palliativ medisiner som sovemedisin , smertestillende medikamenter, og antidepressiva er akseptable. Det anbefales generelt at MP pasienter bruke laveste dose av medisiner som er effektive.
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-	Det følgende er en oppsummering av vanlige medikamenter som har potensial til å forstyrre MP. En mer komplett liste over medisiner er tilgjengelig i Non-MP behandlinger artikkelen.
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-	* [[home:othertreatments:antibacterials\|antibakterielle midler]] - Sulfusalazene, Plaquenil og Methotrexate er antimetabolite antibiotika med tiltak som ligner Bactrim og kan gi uønskede eller ukontrollert immunopathology. De må være avviklet før du starter MP.
-	* antibiotika - Olmesartan potenserer sterkt handlingen av mange antibiotika. Følgelig, alvorlig eller livstruende immunopathological reaksjon kan følge hvis ikke-MP antibiotika er foreskrevet. Olmesartan beskytter vitale organer fra cytokin storm, og det må ikke trekkes tilbake. Hvis en [[home:othertreatments:antibacterials:takingnonmpantibiotics\|ikke-MP antibiotika]] er midlertidig behov for en akutt infeksjon, [[home:physicians:emergency\|Følg instruksjonene i Notice for akuttmedisinsk personell]].
-	* [[home:othertreatments:anticoagulants\|antikoagulanter]] - Olmesartan kan dypt påvirke antikoagulerende dosering kravet. Det er helt nødvendig å følge nøye med enhver pasient på antikoagulantia.
-	* [[home:othertreatments:antifungals\|soppdrepende midler]] - Legemidler som Diflucan og Lamisil er kjent for å forstyrre med vitamin D metabolismen og er generelt kontraindisert.
-	* [[home:othertreatments:antivirals\|antivirale midler]] - Antivirale midler kan ha dyptgripende virkninger på immunsystemet så vel som en rekke alvorlige bivirkninger. Rutinemessig bruk er generelt kontraindisert for MP pasienter.
-	* [[home:othertreatments:boneagents\|bisfosfonater]] - Kan føre til kalsium deponering inn i myke vev, redusert organfunksjon og mulige osteonekrose i kjeven.
-	* kalsiumtilskudd - Bør unngås i nærvær av hyperkalsuri eller hyperkalsemi. De uten disse forholdene bør generelt konsumere 1000-1500 mg kalsium daglig, fortrinnsvis fra hele matvarer , men hvis dette ikke er mulig, kalsiumtilskudd uten vitamin D er akseptable.
-	* [[home:othertreatments:corticosteroids\|kortikosteroider]] - Terapi ikke vil være effektive når kortikosteroider er undertrykke immunsystemet. Begynne eller fortsette gradvis avvenning prosessen ved hjelp av palliasjon fra olmesartan. ACTH og kortisol produksjonen kan overvåkes for å vurdere adrenal funksjon.
-	* [[home:othertreatments:diuretics\|diuretika]] - Noen diuretika inklusive tiazider er kontraindisert for MP pasienter. Hvis en vanndrivende er nødvendig, er Lasix foretrukket.
-	* [[home:food:folic\|folsyre (resept eller over skranke)]] - Folsyre gjør det lettere for okkulte bakterier å kopiere og lage nye DNA. Forbruker en balansert diett lav på supplerende folinsyre bør gi tilstrekkelig folinsyre.
-	* [[home:othertreatments:hormone_therapy\|hormonell substitusjonsbehandling]] (f.eks progesteron, østrogen og testosteron) - Fordi hormonelle tilskudd kan forstyrre aktiviteten til mange av de kjernefysiske reseptorene, kosttilskudd er hormonell kontraindisert. Men under visse omstendigheter, kan pasienter fortsette østrogenbehandling, til de er i stand til å avvenne fra det. Se artikkel om hormonell substitusjonsbehandling .
-	* [[home:othertreatments:interferon\|interferon]] - Interferon behandling er immunsuppressivt, reduserer i antall både cytokiner og immunceller.
-	* intravenøs immunglobulin (IVIG) - IVIG er avledet fra blodet av en pool av mer enn hundre tilsynelatende friske individer. Det er en betydelig sannsynlighet for at arter fra bakterieflora av disse menneskene kan spre seg til bakterieflora av en Th1 pasient.
-	* [[home:othertreatments:statins\|statiner]] - Statiner har en rekke dokumenterte negative bivirkninger og har vist seg å forverre visse former for kronisk sykdom. Noen konkurrerer for VDR bindende lommen. De er kontraindisert.
-	* [[home:othertreatments:thyroid_hormones\|thyroid kosttilskudd]] - Behov for slike tilskudd kan endres i løpet av en dag eller to for å være på olmesartan alene. Monitor funksjon i skjoldbruskkjertelen nøye og justere nivået på skjoldbruskkjertelen tilskudd nedover etter behov.
-	* TNF-alfablokkere - tumor nekrose faktor-alfa eller TNF-alfa er et cytokin avgjørende for effektiv immun overvåking. Anti-TNF legemidler, også kjent som TNF-alfa-blokkere, er medikamenter som påvirker kroppens produksjon av TNF-alfa. Mens olmesartan også reduserer nivået av TNF-alfa, gjør den det ved å blokkere den første generasjonen av stoffet snarere enn invalidiserende frittflytende TNF-alfa etter at cytokin er produsert.
-	===== Mat og drikke =====
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-	<mainarticleno> [[home:food\|Mat og drikke]] </article>
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-	Pasienter på MP må unngå all mat og drikke som inneholder [[home:food:vitamind\|ekstra vitamin D eller høye nivåer av naturlig forekommende vitamin D]]. MP pasienter må unngå mat og drikke høyt i klorogensyre særlig kaffe, konsentrert juice, og kosttilskudd og multivitaminer tilsatt [[home:food:folic\|folic syre]]. En [[home:food:carbohydrates#Low-carb,_insulin-resistant_diet\|lav-karbohydrat, insulin-resistente]] kosthold anbefales for MP pasienter, men er ikke nødvendig. Spesielle ernæringsmessige ubalanser bør i noen tilfeller være rettet, men dette krever god forståelse av både MP og de ernæringsmessige behovene til kroppen av helsepersonell.
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-	===== Fotosensibilitet =====
-	<mainarticleno> [[home:lifestyle:light:Photosensitivity\|Fotosensibilitet]] </article>
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-	Unormal lysømfintlighet og skarpt lys er kjent som fotosensitivitet og noen ganger referert til som "sol flare" eller lysskyhet. I sammenheng med MP, ultimate årsaken til fotosensitivitet er The Th1 betennelsessykdom prosessen - ikke selve behandlingen . Eksponering for naturlige eller sterkt kunstig lys i en lysfølsomme person kan føre til bluss av interne sykdomsaktivitet, inklusive forverring av eventuelle betennelsessykdom symptomer.
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-	Fotosensitivitet kan oppstå enten når huden blir eksponert for lys naturlig lys eller øynene er utsatt for enten naturlig eller kunstig lys. Noen ganger kan en reaksjon på lys kan være momentan. Fotosensitivitet symptomer kan oppstå umiddelbart etter eksponering eller begynner 1 til 3 dager senere, noen ganger vedvarende 5 dager eller mer. Mengden av akseptabel lyseksponering en MP pasienten kan få er basert på individuelle toleranse for symptomer.
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-	Personer som er lysfølsomme, før MP vil trolig bli mer lysfølsomme på MP. Personer som ikke har noen tegn til fotosensitivitet kan eller ikke kan bli lysfølsomme på MP. Personer med begrenset inflammatoriske symptomer (som tyder på tidlig sykdom) er den mest sannsynlige til å kunne tåle mer lys eksponering mens på MP. Det finnes ingen sikker måte å fortelle på forhånd nøyaktig hvordan lysfølsomme en person vil bli når du er på MP. Først etter et individ har begynt behandlingen kan fotosensitivitet vurderes.
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-	Pasienter på MP ofte nytte av å bruke spesielle briller som blokkerer et bredere spekter av lys og i mange tilfeller må dekke huden når du er i solen. Ytterligere retningslinjer er tilgjengelig på Knowledge Base-artikler om [[home:lifestyle:light:eye_protection\|Øyevern]] og [[home:lifestyle:light:skin_protection\|Skin beskyttelse]].
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-	[{{ :home:figure2.gif?450\|Eksempel på immunopathology – Pasienter på MP, slik som denne 50-år gammel mann med Bekhterevs sykdom, har en tendens til å oppleve midlertidig økning i markører for betennelse.
-	((Proal AD, Albert PJ, Blaney GP, Lindseth IA, Benediktsson C, Marshall TG. 2011. //Cell Mol Immunol//. [[http://www.ncbi.nlm.nih.gov/pubmed?term=21278764\|Immunostimulation in the era of the metagenome]].))}}]
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-	===== Laboratorieforsøk =====
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-	<mainarticleno> [[home:tests\|Laboratorieforsøk]] </article>
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-	De fleste pasientene på MP oppleve midlertidig, men veldefinerte økninger i ulike markører for sykdom staten og inflammasjon, forenlig med en immunopathological respons. Det er nyttig, men ikke nødvendig, for å måle% lymfocytter, til C-reaktivt protein, alkalisk fosfatase, triglyserider, relevant autoantistoffer og serum ACE, spor systemisk inflammasjon. Legene kan være lurt å vurdere nyrefunksjonen ved testing kreatinin eller urinstoff og måle andre indikatorer som er spesifikke for hver pasient for en grunnlinje og retest etter behov. Noen lab arbeid - ofte HGB, HCT, EGFR, kreatinin og BUN - kan bli midlertidig unormal, på grunn av immunopathology reaksjoner, helt til betennelsen løser.
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-	For eksempel, er høyere enn vanlig BUN og kreatinin ikke at olmesartan bør avsluttes, men et tegn på at immunopathology ha oppstått i nyrene eller andre nærliggende organer. I de fleste tilfeller hvor leger har lov til slike nivåer for å være midlertidig ute av rekkevidde, BUN og kreatinin har returnert til område som bakteriell die-off i nyrene avtar. For så lenge de holdt seg på Olmesartan, har det ikke vært dialyse trengs i MP kohort.
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-	Hvis disse markørene indikerer dysfunksjon vedvarende i mer enn noen måneder, kan det være lurt å bruke en [[home:mp:managing_immunopathology\|eller flere metoder]] for å senke immunopathology nivåer.
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-	==== Vitamin D metabolitter ====
-	<relatedarticleno> [[home:tests:dtesting\|Vitamin D metabolite test instructions]] </article>
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-	Det er to viktigste vitamin D metabolitter:
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-	* 1,25-dihydroksyvitamin D (1,25-D) - Tilstedeværelse av høye nivåer av det aktive hormonet av vitamin D hos pasienter antyder en pågående kronisk betennelsessykdom prosessen.(({{pubmed>long:19758177}})) ni , men fravær av forhøyede nivåer betyr ikke at en pasient ikke kan nytte av behandlingen spesielt siden ikke-MP behandling som TNF-alfablokkere og andre ukjente medikamenter og inngrep kan påvirke 1,25-D nivåer. Når det er mulig, bruker laben Quest Diagnostics. Selv om de nylig har opphørt å rutinemessig fryse blodprøver, som vi finner nødvendig, hvis pasienten insisterer på at de gjør det, vil de fryse prøven. Merk at måle en pasients 1,25-D nivået er bare nyttig før begynnelsen olmesartan.
-	* 25-hydroksyvitamin D (25-D) - I motsetning til 1,25-D, prøver av 25-D trenger serum ikke fryses. 25-D, en immundempende secosteroid,(({{pubmed>long:17557889}})) 10 fungerer som en generell indikasjon på immunforsvar med nivåer høyere enn 25 ng / ml som tyder immunsuppresjon via tilskudd eller sollys eksponering. Pasienter på MP begrense forbruket av vitamin D for å redusere deres 25-D til terapeutiske område: ved eller under 12 ng / ml. Nivåene av 25-D bør testes hver 6-12 måneder. Vær oppmerksom på at som 25-D nivåene faller, kan immunopathology øke, noen ganger dramatisk.
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-	Hvis vitamin D-metabolitten testene ikke viser Th1 inflammasjon men klinisk observasjon tilsier noe annet, bør et kort kurs av MP (1 til 2 måneder) bli brukt som en terapeutisk probe. En lengre periode kan være nødvendig hvis 25-D er fortsatt høye, som en terapeutisk probe er ofte ikke effektivt med mindre 25-D nivåer faller under 25 ng / ml.
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-	Konsultere [[home:tests:vitdinterpretation\|Vitamin D metabolitten Kalkulator]] for forslag om å tolke dette lab data.
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-
-
-
-	==== Målinger av blodtrykk ====
-	<mainarticleno> [[home:symptoms:hormonal:blood_pressure\|Low blood pressure and dizziness]] </article>
-
-
-	Den primære indikasjon for olmesartan (Benicar) er som en mild hypotensjon stoff. Som man kan se fra FDA etiketten for Benicar (høyre), er dose respons kurve for Benicar asymptotiske, med høyere doser av stoffet ha trinnvis Mindre nedgang i blodtrykket. For eksempel, forskjellen mellom 40 mg og 80 mg of olmesartan resulterer i en nedgang på ikke mer enn 1 mm Hg.
-
-	Det er viktig å forstå at olmesartan effekt på blodtrykket er begrenset hvis vi skal forstå at en nedgang i systolisk trykk større enn 15 mm Hg av kvikksølv ikke kan utelukkende skyldes olmesartan's hypotensive action, men er også sannsynlig å inkludere resultatet av sykdomsprosesser.
-
-	Den omfattende ødeleggelse av bakterier og menneskelige celler infisert av bakterier kan senke blodtrykket. Selv om dette ikke gjelder alle bakterielle former, når noen former for bakterier er ødelagt, slipper de endotoksiner,(({{pubmed>long:7619330}})) biotilgjengeligheten av noe som kan føre til et kraftig fall i blodtrykket.(({{pubmed>long:8479465}}))
-
-	Hvis en pasient lider lavt blodtrykk før MP, vil lavt blodtrykk avkastning som et symptom på immunopathology mens på MP. I disse tilfellene har vi sett at pasienter som forblir på MP dosen av olmesartan se deres blodtrykket etter hvert tilbake til et normalt område som immunopathology avtar.
-
-	Medisiner som øker blodtrykket, slik som fludrocortisone og dopamin, er kontraindisert, både fordi de ville gjøre noe for å bremse bakteriell die-off og fordi de kan ha skadelige effekter på immunsystemet.
-	===== Olmesartan (Benicar) =====
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-
-
-	<relatedarticlesno> [[home:protocol:olmesartan\|Science behind olmesartan (Benicar)]], [[home:protocol:olmesartan:kidney_disease#benefits_of_olmesartan_for_patients_with_kidney_disease\|Benefits of olmesartan for patients with kidney disease]], [[home:protocol:olmesartan:safety\|Olmesartan safety]] </article>
-
-
-	For formålene med MP, har olmesartan to primære handlinger: det reduserer betennelse ved å blokkere Nuclear Factor-kappaB cytokin veien, og det er en agonist av Vitamin D Receptor (VDR). Som en VDR agonist, aktiverer olmesartan det medfødte immunforsvaret. Forskning støtter sikkerheten ved doser som brukes av MP pasienter. Olmesartan har minimal interaksjoner med andre legemidler og er en av de sikreste legemidler på markedet.
-
-	Halveringstiden av olmesartan er rapportert å være 13 timer. Dette skulle tilsi at stoffet ville være aktiv i denne perioden, har vi imidlertid funnet at i syke pasienter, er olmesartan mest effektivt når det gis hver 4-6 timer, med maksimum hver 8. time. Dette kan skyldes det faktum at noen intracellulære infeksjoner (spesielt //Shigella//), upregulate aktivitet av kaspaser, som er proteaser som cleave VDR.(({{pubmed>long:17696608}})) Når VDR er brutt i stykker av kaspaser, er det svært sannsynlig at noen ligander bundet til det (for eksempel olmesartan) ville bo bundet til fragmenter av protein. Derfor vil en VDR agonist være effektivt over kortere perioder hos pasienter med infiserte celler.
-
-	Den [[http://www.fda.gov/\|U.S. Food and Drug Administration]] har satt ingen sikker grense for olmesartanmedoksomil (Benicar), som ingen dose-relaterte bivirkninger er identifisert til dette punktet. FDA etter markedsføring-erfaring har vist at Olmesartan har en av de sikreste profiler av noe medikament på markedet. Merk at dette ikke gjelder kombinasjonen medisiner, for eksempel Benicar HCT, som inneholder en [[home:othertreatments:diuretics\|tiaziddiuretika]] og //er// skadelig, og bør //aldri// brukes med en MP doseringsregime.
-
-
-	Den [[http://www.benicar.com/pdf/prescribing_information.pdf\|label for olmesartanmedoksomil]] sier at stoffet er godt tolerert. Bivirkninger var lik de oppleves av placebo-gruppen. Uønskede hendelser var i alminnelighet "milde, forbigående og ikke relatert til dose." Hyppigheten av uønskede hendelser også hadde ingen forbindelse med den dosen av olmesartan.
-
-	En studie fra 2001 publisert i det //Journal av for farmakologi// funnet olmesartan å være trygt og godt tolerert ved doser på opptil 160 mg / dag .(({{pubmed>long:11361048}}))
-
-	I placebo-kontrollerte studier, eneste bivirkningen som skjedde i mer enn 1 prosent av olmesartan-behandlede pasienter vs placebo-behandlede pasienter var svimmelhet (3 prosent versus 1 prosent).(({{pubmed>long:15291377}}))
-
-	De [[home:protocol:olmesartan:safety\|relevante Knowledge Base-artikkel]] vurderer sikkerheten profilen til olmesartan/Benicar i større detalj.
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-	===== Antibiotika =====
-
-	<relatedarticlesno> [[home:protocol:mp_antibiotics\|Science behind Marshall Protocol antibiotics]], [[home:protocol:mp_antibiotics:dosing\|Pulsed low-dose antibiotics]], [[home:protocol:mp_antibiotics:antibiotics_concerns\|Safety of Marshall Protocol antibiotics]] </article>
-
-
-
-	The Marshall Protocol sysselsetter roterende kombinasjoner av subinhibitory bakteriostatisk antibiotika ved pulset doser for maksimal effektivitet. De antibiotika er dosert på denne måten å øke den antibakterielle egenskapene til disse legemidlene samtidig som det reduserer deres immmunosuppressive effekter.
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-	Antibiotika er vanligvis doseres på nivåer under minste hemmende konsentrasjon (MIC) for å redusere sannsynligheten for bakteriell resistens. Mens MIC kan være relevant for akutte infeksjoner, kan en slik dosering undertrykke immunforsvaret mot kronisk patogener og bistand deres vekst. For eksempel, noen antibiotika, når det gis på nivåer over MIC hemmer phagocyte funksjon.(({{pubmed>long:11023961}})) Disse effektene synes å være uavhengig av deres antibakterielle effekt.(({{pubmed>long:2177499}}))
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-	Dermed dosering på nivåer under MIC forbedrer Marshall protokollen effektivitet mot kroniske patogener og ytterligere reduserer sannsynligheten for bakteriell resistens. Samtidig, pulserende dosering modulerer mikrobiell transkripsjon(({{pubmed>long:16942902}})) og reduserer forekomsten av biofilm persister celler .(({{pubmed>long:17143318}}))
-	===== Starte en pasient på Marshall-protokollen =====
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-
-
-	- Test vitamin D metabolitter - Følg [[home:tests:dtesting\|vitamin D metabolitter måleinstruksjonene]]. Minn tegningen lab at 1,25-D prøven må være levret ikke mer enn 30 minutter før sentrifuge og den resulterende serum må fryses for forsendelse. Se [[home:tests:vitdinterpretation\|Vitamin D metabolitten Kalkulator]] for forslag på tolke denne lab data.
-	- Begrens kosttilskudd vitamin D-inntak - Pasient må begrense alle tillegg og mat med høyt vitamin D. Det anbefales at, i løpet av behandlingen, pasienten redusere 25-D til den terapeutiske målet på ca mindre enn 12 ng/ml. Retest 25-D regelmessig, slik at 25-D synker mot den nedre enden av det terapeutiske området. Mange MP pasienter har beholdt sin 25-D under 5 ng/ml i mange år, uten noen negativ effekt.
-	- For pasienter som tar kortikosteroider, begynner olmesartan - Kortikosteroider er kontraindisert for MP pasienter. Før avvenning dem, bør pasientene først begynner olmesartan (se nedenfor), som i stor grad kan lindre abstinenssymptomene og bidra til avvenning suksess. Det anbefales at olmesartan startes en uke eller to før du begynner å avvenne. Se [[home:othertreatments:corticosteroids:weaningoffsteroids\| avvenning retningslinjer]] for detaljerte instruksjoner.
-	- Trekke tilbake eller begynne å avvenne kontraindisert behandling
-	- Om nødvendig, unngå lys - Dersom det er nødvendig for å unngå symptomer på fotosensitivitet, bør pasienter unngå utelys og lys innendørs lys ved å bo innendørs så mye som mulig, med tunge gardiner eller persienner, og dekker opp godt hver gang begir utenom dagtid. Pasientene kan også trenger å beskytte øynene fra både utendørs og innendørs lys.
-	- Begynn olmesartan - Commence terapi ved forskrivning av 40 mg rene olmesartanmedoksomil hver sjette time (f.eks: 6am, middag, 18:00, midnatt) for å avbryte inflammatoriske syklusen og redusere alvorlighetsgraden av potensielle immunopathology. Våre observasjoner tyder på at olmesartanmedoksomil er den eneste angiotensin reseptorblokker (ARB) som aktiverer pasientens medfødte immunforsvar. "Ingen erstatninger" skal være skrevet på resepten. Unngå kombinasjon formulering som Benicar hydroklortiazid (Benicar HCT). Fordi pasientene ofte begynner å føle seg verre når avtagende lys og / eller vitamin D, bør olmesartan forskrives samtidig med de forrige trinnene, slik at det kan palliate eventuell immunopathology mens 25-D-nivåene er synkende. Pasienter bør holde flere ukers tilgang på olmesartan i reserve til bruk i tilfelle det er nødvendig å behandle utålelig immunopathology.
-	- Vent til pasienten å stabilisere på olmesartan - Det tar vanligvis en måned eller to til å stabilisere symptomer på olmesartan alene. Noen pasienter kan trenge mer tid. Avhengig av pasientens bakteriell belastning og en rekke andre faktorer, noen pasienter i utgangspunktet føler seg bedre på olmesartan, noen verre, og noen ikke oppleve noen endring. Alle tre reaksjoner er normale. En ufullstendig liste over typiske immunopathology symptomer inkluderer: depresjon, irritabilitet, mani, paranoia, tretthet, muskelsvakhet, utslett, hodepine, fotosensitivitet, smerter overalt, nummenhet, kvalme, diaré, forstoppelse, ringing i ørene, tannverk, Sinus congestion, nasal stuffiness, feber/frysninger, influensaliknende kroppen verke, hoste, søvnforstyrrelser og "hjerne-tåke."
-	- Begynn minocycline - Når pasienten er blitt helt stabil på Olmesartan, kan et for lavt nivå av immunopathology bøtes på ved å foreskrive den første MP antibiotika, merkenavn eller generiske minocycline, med 25 mg hver 48. time. Ikke bruk mindre eller noen erstatning for eksempel doxycyclin. Som med de andre MP antibiotika, kan pasienter må [[home:mp:dividingmeds\|dele innholdet]] ved å åpne en kapsel eller ved hjelp av en pille cutter. Mens du bruker minocycline og olmesartan alene, bør pasientene begynne å lære natur immunopathology deres, og hvordan, i forbindelse med sin lege, kan de justere sine antibiotika for å lokke fram tålelig immunopathology. //Plutselige økninger i immunopathological reaksjoner kan forekomme når som helst som immunresponser styrker// Pasienter bør gjøre seg kjent med [[home:mp:managing_immunopathology\|håndtere immunopathology]]. Artikkelen å håndtere symptomene. Responsen kan også nødvendiggjøre å redusere eller midlertidig stoppe noen eller alle av antibiotika for en lengre periode. Dette er ikke uvanlig, og bør ikke betraktes som et tilbakeslag, men heller som et tegn på fremskritt som det vanligvis signaliserer en mer robust immunrespons.
-	- Øke dosering av minocycline - Når pasienter føler seg i stand til å øke styrken på deres immunopathological reaksjon, de vanligvis øke dosen av minocycline, i trinn på 25 mg (q48h), helt til de når 100 mg. Det anbefales at pasienter skal bo på hver dose i minst en uke, og skal ikke øke antibiotika før immunopathology deres på en bestemt dosering har falt til et lavt nivå.
-	- Legg til en andre eller tredje antibiotika - Det er ingen hast for pasienter å ta mer eller høyere doser av antibiotika hvis symptomene blir ubehagelig. //Olmesartan spiller den mest kritiske rolle i gjenopprettingen.//
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-
-
-
-	===== Legge til en andre antibiotika =====
-
-	Pasienter som fremdeles har betydelige immunopathology fra 100mg av minocycline alene er ennå ikke klar til å legge en andre antibiotika, fordi en to antibiotika kombinasjon er mye sterkere enn minocycline alene. Som tidligere omtalt, er olmesartan den viktigste faktoren i å styrke det medfødte immunforsvaret. Faktisk er det mulig pasienter kan være i stand til å gjenopprette på olmesartan. Det er imidlertid forutsatt immunopathology holdes på et rimelig nivå, antibiotika kan akselerere prosessen.
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-	Det bør bemerkes at dersom nivået av 25-hydroksyvitamin-D i en pasients bloodwork er over 12 ng / ml terapeutiske target, kan pasienten oppleve en plutselig økning i immunopathology som deres på 25-D faller, og stor forsiktighet bør tas ikke å øke antibiotika for raskt.
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-	Hvis ytterligere immunopathology er ønsket, bør pasientene forskrevet en andre antibiotika i forbindelse med sitt minocycline (som bør fortsette på 100mg q48h). Historisk, at andre antibiotika har vært azitromycin - men dette stoffet har vært vanskelig å dosere, og veldig vanskelig å avvenne, så mange pasienter, og deres leger, nå velger å bruke klindamycin eller Bactrim.
-
-	* Når bruker klindamycin som andre antibiotika - Clindamycin er spesielt effektiv på økende nevrologiske og psykologiske immunopathology. Clindamycin er relativt lett å dose på et nivå som vil styre immunopathology, som det er dosert på en 48 timers intervall og ikke dvele ikke i vev. Klindamycin har vist seg å være den mest allment gjeldende andre antibiotika.
-	* Når bruker Bactrim som andre antibiotika - Bactrim er den minst aggressive andre antibiotika, og kan brukes som en primær antibiotika, erstatte minocycline, dersom immunopathology fra minocycline blir for aggressiv. Pasienter som har rapportert sensitivitet overfor sulfa narkotika i det siste ofte finne at denne følsomheten avtar når de går videre på MP.
-	* Når bruker azitromycin som andre antibiotika - Fordi klindamycin kan forverre psykologiske immunopathology, slik som depresjon, angst, påtrengende tanker, paranoia eller tvangslidelser atferd, kan pasienter som lider betydelig fra disse forholdene nytte av å bruke azitromycin som andre antibiotika. Dette er forutsatt at deres 25-D-nivåer i det terapeutiske området ved eller under 12 ng/ml. Imidlertid er azitromycin lagres i vev, noe som betyr at hvis det er avviklet kan ta opptil 45 dager. Som et resultat, kan det være mye vanskeligere å håndtere uventede bølger i immunopathology av pasienter som tar Azithromycin. //Pasienter med hjerteproblemer bør unngå azitromycin.//
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-	===== Ytterligere antibiotika for senere fasene av bedringen =====
-	Under Stage 4 av utvinning, kan pasienter med lave nivåer av immunopathology søke å legge til en tredje antibiotika, eller rotere blant antibiotika kombinasjoner. Kombinasjoner som har vist seg nyttige inkluderer:
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-	* CMZ – clindamycin + minocycline + Zithromax (bruk med forsiktighet - vurderes å gi de mest immunopathology)
-	* BCD – Bactrim DS + clindamycin + demeclocycline
-	* BCM – Bactrim DS + clindamycin + minocycline
-	* BDM – Bactrim DS + demeclocycline + minocycline
-	* BDZ – Bactrim DS + demeclocycline + Zithromax
-	* BMZ – Bactrim DS + minocycline + Zithromax
-	* CDM – clindamycin + demeclocycline + minocycline
-	* CDZ – clindamycin + demeclocycline + Zithromax
-	* DMZ – demeclocycline + minocycline + Zithromax
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-	<html></p><div id="pagebreakafter"></div></html>
-	===== Summary of Marshall Protocol medications and dosages =====
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-
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-	^Brand (GENERISK) ^Dose ^FREKVENS ^MOLEKYLÆR AKTIVITET ^EFFEKTIV HALVERINGSTID ^
-	\|Benicar (olmesartan) \|40mg \|hver 6 time \|Vitamin D Receptor agonist, [[home:protocol:olmesartan#potent_anti-inflammatory\|anti-inflammatorisk]] \|13 timer (i helse) 4-6 timer (i sykdom) \|
-	\|[[home:mp:minocycline\|minocycline (Minocin)]] \|25-100mg \|hver 2 dager \|antibiotika - binder seg til 30S ribosomal subenhet, kan binde seg til PXR kjernefysiske reseptor \|11-22 timer \|
-	\|[[home:mp:zithromax\|Zithromax (azithromycin)]] \|12-125mg \|hver 8-10 dager \|antibiotika - binder seg til 50S subenheten av det bakterielle ribosomet \|angivelig 68 timer, men noen studier(({{pubmed>long:9681095}})) (({{pubmed>long:21059616}})) og ARF pasienten rapporter tyder det forblir i vev i opptil 45 dager \|
-	\|[[home:mp:clindamycin\|clindamycin]] \|18mg-150mg \|hver 2 dager \|antibiotika - binder seg til 50S subenheten av det bakterielle ribosomet \|mer enn 12 timer(({{pubmed>long:10428927}}))\|
-	\|[[home:mp:bactrimds\|Bactrim DS (co-trimoxazole)]] \|125-1000mg \|hver 2 dager \|antibiotika - hemmer bakteriers evne til å syntetisere folat \|10 timer \|
-	\|Declomycin (demeclocycline) \|18-150mg \|hver 2 dager \|antibiotika - binder seg til 50S og 30S subenheten av det bakterielle ribosomet \|10-17 timer \|
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-	For en mer detaljert diskusjon om MP antibiotika inkludert kombinasjon strategier, eksempler på progresjon gjennom MP, og generelle tips, kan du lese Knowledge Base-artikkelen, [[home:mp:antibiotic_dosing\|Dosering og administrasjon av Marshall Protokollen antibiotika]].
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-	===== Administrere immunopathology=====
-	<mainarticleno> [[home:mp:managing_immunopathology\|Administrere immunopathology]] </article>
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-	Pasienter 'mål i løpet av MP bør være å opprettholde tålelig immunopathology som de får også. I tilfeller der IP er blitt utålelig, visse strategier er tilgjengelig, inkludert:
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-	* [[Home:mp:managing_immunopathology#strategy_1take_lower_doses_of_antibiotics\|Ta lavere doser av antibiotika]] - Vanligvis, redusere eller stoppe en eller flere antibiotika er den mest effektive måten å administrere immunopathology. Mange pasienter opplever at deres kjernefysiske reseptor funksjon stabiliseres, blir deres immunforsvar mer aktive og deres immunopathology kan øke. På dette punktet, de må kanskje redusere eller stoppe antibiotika mens du bor på olmesartan alene. Dette skjer som et resultat av bedre immunforsvar og er ikke et tegn på at en pasient er "[[home:mp:progress#my_disease_is_getting_worse\|verre]]." Merk at i å stoppe minocycline (eller andre antibiotika for den saks skyld), noen pasienter rapporterer flere symptomer, ikke mindre.
-	* [[Home:mp:managing_immunopathology#strategy_2adjust_olmesartan\|Juster olmesartan (Benicar )]] - Avhengig av hvilke av olmesartan to viktigste egenskapene en pasient opplever sterkest i løpet av en bestemt periode med behandling, vekselvis å øke eller redusere dosen kan å styre immunopathology. For noen kan ta olmesartan sublingually (under tungen) gir umiddelbar lindring.
-	* [[Home:mp:managing_immunopathology#strategy_3adjust_minocycline\|Hyppigere minocycline]] - Hvis minocycline ikke er pulset og tatt oftere, for eksempel hver 48. time, kan det bidra til å redusere symptomer på immunopathology.
-	* [[Home:mp:managing_immunopathology#strategy_4take_palliative_medications\|Ta palliativ medisin]] - En rekke symptom-spesifikke palliativ medisiner kan brukes som grunnlag ved utålelig immunopathology.
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-
-	Merk at tre former for IP er spesielt livstruende og må behandles med en //overflod av forsiktighet//: [[home:symptoms:cardiac\|hjertestans immunopathology]], [[home:symptoms:mental:neurological\|nevrologisk immunopathology]], og luftveiene immunopathology. Pasienter som er bekymret for noen av disse eller andre symptomer bør ikke nøle med å ringe lege.
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-	===== I nødstilfeller =====
-	<mainarticleno> [[home:physicians:emergency\|Notice for akuttmedisinsk personell]] </article>
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-
-	ARF har utarbeidet en [[home:physicians:emergency\|merknad for akutt medisinsk personell]] behandling av en Marshall protokoll pasient. Viktige poeng fra dette dokumentet omfatter følgende:
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-
-
-	* Ikke trekke olmesartan - I en kritisk situasjon omsorg, er det viktig å fortsette muntlige olmesartan, selv i nærvær av hypotensjon, som brå seponering kan være livstruende. Sammen med rutine livreddende prosedyrer, er det viktig å fortsette oral olmesartan 40 mg dosering hver fjerde time, med 20 mg SL prn, inntil symptomene avtar - selv om en NG tube er nødvendig. Hvis B / P er svært lav (gjennomsnittlig arterietrykk <55), fortsetter olmesartan som ovenfor og øke væskeinntaket med 0,9 NS eller pakket røde celler.
-	* antibiotika - mindre pasienter har nådd et sent stadium av behandlingen, ved hjelp av høye doser av MP antibiotika har potensial til å øke immunopathology som antibiotika forlater pasientene 'system. Vi anbefaler derfor pasienter som ikke behandles med antibiotika MP. Flouroquinolone antibiotika er generelt godt tolerert selv om tilfeller av sene skade er rapportert, bør pasienten rådes til FDA black-box advarsler. Cefalosporiner, Claforin, og makrolidantibiotikumet Biaxin er vanligvis tolereres.
-	* kortikosteroider - Ikke gi kortikosteroider i noen form eller på noen rute (injisert, inhalert, muntlig eller IV) som de vil føre til metabolsk ustabilitet.
-	* adrenalin eller noradrenalin - Bivirkninger kan oppstå hvis adrenalin eller noradrenalin blir brukt til å heve B / P eller godbit anafylaksi. Bruk adrenalin og noradrenalin kun for hjertestans. Lokalanestetika som inneholder adrenalin kan føre til bivirkninger (takykardi, psykose), og adrenalin kan hindre anestesi.
-	For detaljer om disse anbefalingene, ta kontakt [[home:physicians:emergency\|Notice for akuttmedisinsk personell]].
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-	I en nødsituasjon, kan legene ringe Trevor Marshall på 1-805-492-3693.
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-	===== Lengde på protokollen =====
-	<mainarticleno> [[home:patients:mp_duration\|Length of the Protocol]] </article>
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-	Den eksakte varigheten av Marshall protokollen (MP) er avhengig av en rekke faktorer, inkludert graden av sykdom, mengden av fibrose, subklinisk inflammasjon, funksjonaliteten av nyrene, og personlige preferanser å forbli på MP.
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-	Mens noen som er veldig syk kan forvente det MP for å ta fem år eller mer, er det ingen måte å vite sikkert hvor lenge behandlingen vil ta. På grunn av beskaffenheten til immunopathology, følelse av velvære og blod markører for sykdommen har en tendens til å være variabel på kort sikt og bedre på lang sikt. Også på grunn av beskaffenheten til infeksjon, vil ulike symptomer bedre på ulike priser.
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-	Så lenge man reagerer på antibiotika med symptomer som voks og avta, er det fortsatt bakterier for å bli drept.
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-	Merk at det ikke er krav om at pasienter nå maksimal dosering for all antibiotika eller gjør alle antibiotika kombinasjoner for å gjennomføre protokollen. I mange tilfeller kan pasienter få betydelige fremskritt på olmesatan (Benicar) alene på grunn av at kroppens egne antimikrobielle peptider. Det er imidlertid ansett som ideelt å holde seg på protokollen før man har prøvd alle kombinasjonene og ikke lenger erfaringer immunopathological reaksjoner fra antibiotika.
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-	==== Endepunkter av protokollen ====
-	I stor grad, pasienter som har fullført Marshall Protokollen kan vende tilbake til et normalt liv med følgende modifikasjoner:
-	* forbruk av vitamin D - MP pasienter er fri til å nyte mat som fisk som naturlig inneholder vitamin D. Likevel blir pasientene oppfordret til ikke å konsumere noen matvarer som er beriket med ekstra vitamin D.
-	lys - Selv om soling er ikke et alternativ, av MP kan veteraner velge å eksponere sine øyne og hud til å øke mengder av lys. Et ord av forsiktighet: noen pasienter i senere stadier av behandlingen kan oppleve en Stage Fem reaksjon når de utsettes for for mye lys. For å begrense muligheten for en alvorlig immunopathological reaksjon, alltid øke lys eksponering (og trening) etter hvert. Vær også oppmerksom på at noen ganger en økning i symptomer fra lett kan begynne en eller to dager etter eksponering og vare i flere dager eller enda lengre.
-	* antibiotika - I senere stadier av MP, immunsystemet er selvdrevet og kan utrydde bakterier uten antibiotika. Det er imidlertid ingen skade i å bruke et par uker igjen av MP antibiotika som en årlig sjekk.
-	* olmesartan (Benicar) - I senere stadier av MP, Vitamin D Receptor, som kontrollerer medfødt immunitet, er det riktig igjen og aktiveres uten hjelp fra olmesartan. Imidlertid er olmesartan likevel viktig å palliate symptomer og beskytte organer fra systemisk immunopathology.
-	* laboratorietester - Ulike tester er ventet å komme innen rekkevidde:
-	* retur av ACE, CRP, triglyserider, ALP til lave enden av normal
-	* Økningen i% lymfocytter, tilbake til det normale området
-	* 1,25-D på 25-35pg/ml målt over en seks måneders intervall
-	* tegn på inflammasjon oppløsning på CT og MR imaging
-
-
-
-
-	===== Stoppe protokollen =====
-
-	<relatedarticleno> [[home:mp:break\|Tar en pause fra Marshall-protokollen]] </article>
-
-
-	==== Stoppe antibiotika bare ====
-	Hvor lang tid det tar for antibiotika å ikke lenger ha en effekt er variabel. Bestemme faktorene er hvor lenge antibiotika opphold i ett system. På grunn av sin uvanlig lang halveringstid, kan zithromax forblir i vev for en måned eller mer. I tillegg er selvberging av immunsystemet en viktig faktor. Noen pasienter kan finne deres immunforsvar er relativt selvdreven på grunn av kroppens egen økt antimikrobielle peptid produksjon, og dermed det vil ta lenger tid før immunopathology å blekne. Hvis pasienten er stopper antibiotika for det formål å minimere immunopathology, i noen tilfeller kan det være å foretrekke å holde seg på enten 100 mg minocycline hver annen dag, eller ta det daglige for sin palliativ effekt (hvorav mange er resultatet av dens effekt på PXR kjernefysiske Receptor, se //Bioessay//(({{pubmed>long:18200565}})), figur 1).
-
-	==== Stoppe antibiotika og olmesartan ====
-	Å avvikle både antibiotika og olmesartan, bør pasientene først avvikle sine antibiotika følge instruksjonene ovenfor. Om nødvendig, olmesartan bør være avvent gradvis, kun etter at antibiotika har vært avviklet, og i løpet av flere uker. Merk at immunforsvaret kan være aktivert for en tid selv etter seponering olmesartan.
-
-	Et alternativ til avvikling olmesartan alene er å avvenne pasienten over til et annet ARB, valsartan (Diovan), 80 mg hver 6 timer (80 mg er en fjerdedel av en 320mg Diovan tablett). Pasienten reduserer olmesartan dose (f.eks, fra 40 mg til 30 mg til 20 mg to 10mg til 0), og samtidig gradvis valsartan (for eksempel 0 til 20 mg to 40 mg til 60mg to 80 mg). Lengden på tiden orgelet beskyttelsen fra valsartan vil være nødvendig, avhenger av hvor lang tid det tar immunsystemet slår seg av igjen. Dette ARB ikke aktiverer immunforsvaret, men beskytter organer og gir litt lindring. Pasienten kan bli avvent på tvers i 2 til 3 dager.
-
-	Pasienter som slutter olmesartan er sluttet utvinning.
-
-
-	===== Notes and comments =====
-
-	===== References =====

pubmed_.nbib - created - external edit

anonymous@undisclosed.example.com (Anonymous) — Fri, 02 Oct 2026 17:08:50 +0000

	current

pubmed_cross.nbib - created - external edit

anonymous@undisclosed.example.com (Anonymous) — Fri, 02 Oct 2026 14:04:05 +0000

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anonymous@undisclosed.example.com (Anonymous) — Fri, 02 Oct 2026 11:43:29 +0000

05.16.2011		current
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pubmed_9551512.nbib - created - external edit

anonymous@undisclosed.example.com (Anonymous) — Fri, 02 Oct 2026 11:39:52 +0000

	current

- removed - external edit (Unknown date)

anonymous@undisclosed.example.com (Anonymous) — Fri, 02 Oct 2026 10:55:52 +0000

11.11.2014		current

Formatting Syntax - external edit

anonymous@undisclosed.example.com (Anonymous) — Wed, 02 Sep 2026 18:53:27 +0000

09.28.2008	current
Line 1:	Line 1:
	+	====== Formatting Syntax ======
	+
	+	[[doku>DokuWiki]] supports some simple markup language, which tries to make the datafiles to be as readable as possible. This page contains all possible syntax you may use when editing the pages. Simply have a look at the source of this page by pressing "Edit this page". If you want to try something, just use the [[playground:playground\|playground]] page. The simpler markup is easily accessible via [[doku>toolbar\|quickbuttons]], too.
	+
	+	===== Basic Text Formatting =====
	+
	+	DokuWiki supports bold, //italic//, __underlined__ and ''monospaced'' texts. Of course you can __//''combine''//__ all these.
	+
	+	DokuWiki supports bold, //italic//, __underlined__ and ''monospaced'' texts.
	+	Of course you can __//''combine''//__ all these.
	+
	+	Note that the formatting markers have to directly enclose the text, so ''%% bold %%'' with spaces inside the markers will not be formatted.
	+
	+	You can use <sub>subscript</sub> and <sup>superscript</sup>, too.
	+
	+	You can use <sub>subscript</sub> and <sup>superscript</sup>, too.
	+
	+	You can mark something as <del>deleted</del> as well.
	+
	+	You can mark something as <del>deleted</del> as well.
	+
	+	Paragraphs are created from blank lines. If you want to force a newline without a paragraph, you can use two backslashes followed by a whitespace or the end of line.
	+
	+	This is some text with some linebreaks\\ Note that the
	+	two backslashes are only recognized at the end of a line\\
	+	or followed by\\ a whitespace \\this happens without it.
	+
	+	This is some text with some linebreaks\\ Note that the
	+	two backslashes are only recognized at the end of a line\\
	+	or followed by\\ a whitespace \\this happens without it.
	+
	+	You should use forced newlines only if really needed.
	+
	+	===== Links =====
	+
	+	DokuWiki supports multiple ways of creating links.
	+
	+	==== External ====
	+
	+	External links are recognized automagically: http://www.google.com or simply www.google.com - You can set the link text as well: [[http://www.google.com\|This Link points to google]]. Email addresses like this one: <andi@splitbrain.org> are recognized, too.
	+
	+	DokuWiki supports multiple ways of creating links. External links are recognized
	+	automagically: http://www.google.com or simply www.google.com - You can set
	+	link text as well: [[http://www.google.com\|This Link points to google]]. Email
	+	addresses like this one: <andi@splitbrain.org> are recognized, too.
	+
	+	==== Internal ====
	+
	+	Internal links are created by using square brackets. You can either just give a [[pagename]] or use an additional [[pagename\|link text]].
	+
	+	Internal links are created by using square brackets. You can either just give
	+	a [[pagename]] or use an additional [[pagename\|link text]].
	+
	+	[[doku>pagename\|Wiki pagenames]] are converted to lowercase automatically, special characters are not allowed.
	+
	+	You can use [[some:namespaces]] by using a colon in the pagename.
	+
	+	You can use [[some:namespaces]] by using a colon in the pagename.
	+
	+	For details about namespaces see [[doku>namespaces]].
	+
	+	Linking to a specific section is possible, too. Just add the section name behind a hash character as known from HTML. This links to [[syntax#internal\|this Section]].
	+
	+	This links to [[syntax#internal\|this Section]].
	+
	+	Notes:
	+
	+	* Links to [[syntax\|existing pages]] are shown in a different style from [[nonexisting]] ones.
	+	* DokuWiki does not use [[wp>CamelCase]] to automatically create links by default, but this behavior can be enabled in the [[doku>config]] file. Hint: If DokuWiki is a link, then it's enabled.
	+	* When a section's heading is changed, its bookmark changes, too. So don't rely on section linking too much.
	+
	+	==== Interwiki ====
	+
	+	DokuWiki supports [[doku>Interwiki]] links. These are quick links to other Wikis. For example this is a link to Wikipedia's page about Wikis: [[wp>Wiki]].
	+
	+	DokuWiki supports [[doku>Interwiki]] links. These are quick links to other Wikis.
	+	For example this is a link to Wikipedia's page about Wikis: [[wp>Wiki]].
	+
	+	==== Windows Shares ====
	+
	+	Windows shares like [[\\server\share\|this]] are recognized, too. Please note that these only make sense in a homogeneous user group like a corporate [[wp>Intranet]].
	+
	+	Windows Shares like [[\\server\share\|this]] are recognized, too.
	+
	+	Notes:
	+
	+	* For security reasons direct browsing of windows shares only works in Microsoft Internet Explorer per default (and only in the "local zone").
	+	* For Mozilla and Firefox it can be enabled through different workaround mentioned in the [[http://kb.mozillazine.org/Links_to_local_pages_do_not_work\|Mozilla Knowledge Base]]. However, there will still be a JavaScript warning about trying to open a Windows Share. To remove this warning (for all users), put the following line in ''conf/lang/en/lang.php'' (more details at [[doku>localization#changing_some_localized_texts_and_strings_in_your_installation\|localization]]): <code - conf/lang/en/lang.php>
	+	<?php
	+	/**
	+	* Customization of the english language file
	+	* Copy only the strings that needs to be modified
	+	*/
	+	$lang['js']['nosmblinks'] = '';
	+	</code>
	+
	+	==== Image Links ====
	+
	+	You can also use an image to link to another internal or external page by combining the syntax for links and [[#images_and_other_files\|images]] (see below) like this:
	+
	+	[[http://php.net\|{{wiki:dokuwiki-128.png}}]]
	+
	+	[[http://php.net\|{{wiki:dokuwiki-128.png}}]]
	+
	+	Please note: The image formatting is the only formatting syntax accepted in link names.
	+
	+	The whole [[#images_and_other_files\|image]] and [[#links\|link]] syntax is supported (including image resizing, internal and external images and URLs and interwiki links).
	+
	+	===== Footnotes =====
	+
	+	You can add footnotes ((This is a footnote)) by using double parentheses.
	+
	+	You can add footnotes ((This is a footnote)) by using double parentheses.
	+
	+	===== Sectioning =====
	+
	+	You can use up to five different levels of headlines to structure your content. If you have more than three headlines, a table of contents is generated automatically -- this can be disabled by including the string ''<nowiki>~~NOTOC~~</nowiki>'' in the document.
	+
	+	==== Headline Level 3 ====
	+	=== Headline Level 4 ===
	+	== Headline Level 5 ==
	+
	+	==== Headline Level 3 ====
	+	=== Headline Level 4 ===
	+	== Headline Level 5 ==
	+
	+	By using four or more dashes, you can make a horizontal line:
	+
	+	----
	+
	+	===== Media Files =====
	+
	+	You can include external and internal [[doku>images\|images, videos and audio files]] with curly brackets. Optionally you can specify the size of them.
	+
	+	Real size: {{wiki:dokuwiki-128.png}}
	+
	+	Resize to given width: {{wiki:dokuwiki-128.png?50}}
	+
	+	Resize to given width and height((when the aspect ratio of the given width and height doesn't match that of the image, it will be cropped to the new ratio before resizing)): {{wiki:dokuwiki-128.png?200x50}}
	+
	+	Resized external image: {{https://www.php.net/images/php.gif?200x50}}
	+
	+	Real size: {{wiki:dokuwiki-128.png}}
	+	Resize to given width: {{wiki:dokuwiki-128.png?50}}
	+	Resize to given width and height: {{wiki:dokuwiki-128.png?200x50}}
	+	Resized external image: {{https://www.php.net/images/php.gif?200x50}}
	+
	+
	+	By using left or right whitespaces you can choose the alignment.
	+
	+	{{ wiki:dokuwiki-128.png}}
	+
	+	{{wiki:dokuwiki-128.png }}
	+
	+	{{ wiki:dokuwiki-128.png }}
	+
	+	{{ wiki:dokuwiki-128.png}}
	+	{{wiki:dokuwiki-128.png }}
	+	{{ wiki:dokuwiki-128.png }}
	+
	+	You can also set the alignment explicitly with a ''?left'', ''?right'' or ''?center'' parameter. This takes precedence over the whitespace alignment above and can be combined with a size.
	+
	+	{{wiki:dokuwiki-128.png?100&right}}
	+
	+	{{wiki:dokuwiki-128.png?100&right}}
	+
	+	Of course, you can add a title (displayed as a tooltip by most browsers), too.
	+
	+	{{ wiki:dokuwiki-128.png \|This is the caption}}
	+
	+	{{ wiki:dokuwiki-128.png \|This is the caption}}
	+
	+	For linking an image to another page see [[#Image Links]] above.
	+
	+	==== Supported Media Formats ====
	+
	+	DokuWiki can embed the following media formats directly.
	+
	+	\| Image \| ''gif'', ''jpg'', ''png'' \|
	+	\| Video \| ''webm'', ''ogv'', ''mp4'' \|
	+	\| Audio \| ''ogg'', ''mp3'', ''wav'' \|
	+	\| Flash \| ''swf'' \|
	+
	+	If you specify a filename that is not a supported media format, then it will be displayed as a link instead.
	+
	+	By adding ''?linkonly'' you provide a link to the media without displaying it inline
	+
	+	{{wiki:dokuwiki-128.png?linkonly}}
	+
	+	{{wiki:dokuwiki-128.png?linkonly}} This is just a link to the image.
	+
	+	==== Fallback Formats ====
	+
	+	Unfortunately not all browsers understand all video and audio formats. To mitigate the problem, you can upload your file in different formats for maximum browser compatibility.
	+
	+	For example consider this embedded mp4 video:
	+
	+	{{video.mp4\|A funny video}}
	+
	+	When you upload a ''video.webm'' and ''video.ogv'' next to the referenced ''video.mp4'', DokuWiki will automatically add them as alternatives so that one of the three files is understood by your browser.
	+
	+	Additionally DokuWiki supports a "poster" image which will be shown before the video has started. That image needs to have the same filename as the video and be either a jpg or png file. In the example above a ''video.jpg'' file would work.
	+
	+	===== Lists =====
	+
	+	Dokuwiki supports ordered and unordered lists. To create a list item, indent your text by two spaces and use a ''*'' for unordered lists or a ''-'' for ordered ones.
	+
	+	* This is a list
	+	* The second item
	+	* You may have different levels
	+	* Another item
	+
	+	- The same list but ordered
	+	- Another item
	+	- Just use indention for deeper levels
	+	- That's it
	+
	+	<code>
	+	* This is a list
	+	* The second item
	+	* You may have different levels
	+	* Another item
	+
	+	- The same list but ordered
	+	- Another item
	+	- Just use indention for deeper levels
	+	- That's it
	+	</code>
	+
	+	Also take a look at the [[doku>faq:lists\|FAQ on list items]].
	+
	+	===== Text Conversions =====
	+
	+	DokuWiki can convert certain pre-defined characters or strings into images or other text or HTML.
	+
	+	The text to image conversion is mainly done for smileys. And the text to HTML conversion is used for typography replacements, but can be configured to use other HTML as well.
	+
	+	==== Text to Image Conversions ====
	+
	+	DokuWiki converts commonly used [[wp>emoticon]]s to their graphical equivalents. Those [[doku>Smileys]] and other images can be configured and extended. Here is an overview of Smileys included in DokuWiki:
	+
	+	* 8-) %% 8-) %%
	+	* 8-O %% 8-O %%
	+	* :-( %% :-( %%
	+	* :-) %% :-) %%
	+	* =) %% =) %%
	+	* :-/ %% :-/ %%
	+	* :-\ %% :-\ %%
	+	* :-? %% :-? %%
	+	* :-D %% :-D %%
	+	* :-P %% :-P %%
	+	* :-O %% :-O %%
	+	* :-X %% :-X %%
	+	* :-\| %% :-\| %%
	+	* ;-) %% ;-) %%
	+	* ^_^ %% ^_^ %%
	+	* m( %% m( %%
	+	* :?: %% :?: %%
	+	* :!: %% :!: %%
	+	* LOL %% LOL %%
	+	* FIXME %% FIXME %%
	+	* DELETEME %% DELETEME %%
	+
	+	==== Text to HTML Conversions ====
	+
	+	Typography: [[DokuWiki]] can convert simple text characters to their typographically correct entities. Here is an example of recognized characters.
	+
	+	-> <- <-> => <= <=> >> << -- --- 640x480 (c) (tm) (r)
	+	"He thought 'It's a man's world'..."
	+
	+	<code>
	+	-> <- <-> => <= <=> >> << -- --- 640x480 (c) (tm) (r)
	+	"He thought 'It's a man's world'..."
	+	</code>
	+
	+	The same can be done to produce any kind of HTML, it just needs to be added to the [[doku>entities\|pattern file]].
	+
	+	There are three exceptions which do not come from that pattern file: multiplication entity (640x480), 'single' and "double quotes". They can be turned off through a [[doku>config:typography\|config option]].
	+
	+	===== Quoting =====
	+
	+	Some times you want to mark some text to show it's a reply or comment. You can use the following syntax:
	+
	+	<code>
	+	I think we should do it
	+
	+	> No we shouldn't
	+
	+	>> Well, I say we should
	+
	+	> Really?
	+
	+	>> Yes!
	+
	+	>>> Then lets do it!
	+	</code>
	+
	+	I think we should do it
	+
	+	> No we shouldn't
	+
	+	>> Well, I say we should
	+
	+	> Really?
	+
	+	>> Yes!
	+
	+	>>> Then lets do it!
	+
	+	===== Tables =====
	+
	+	DokuWiki supports a simple syntax to create tables.
	+
	+	^ Heading 1 ^ Heading 2 ^ Heading 3 ^
	+	\| Row 1 Col 1 \| Row 1 Col 2 \| Row 1 Col 3 \|
	+	\| Row 2 Col 1 \| some colspan (note the double pipe) \|\|
	+	\| Row 3 Col 1 \| Row 3 Col 2 \| Row 3 Col 3 \|
	+
	+	Table rows have to start and end with a ''\|'' for normal rows or a ''^'' for headers.
	+
	+	^ Heading 1 ^ Heading 2 ^ Heading 3 ^
	+	\| Row 1 Col 1 \| Row 1 Col 2 \| Row 1 Col 3 \|
	+	\| Row 2 Col 1 \| some colspan (note the double pipe) \|\|
	+	\| Row 3 Col 1 \| Row 3 Col 2 \| Row 3 Col 3 \|
	+
	+	To connect cells horizontally, just make the next cell completely empty as shown above. Be sure to have always the same amount of cell separators!
	+
	+	Vertical tableheaders are possible, too.
	+
	+	\| ^ Heading 1 ^ Heading 2 ^
	+	^ Heading 3 \| Row 1 Col 2 \| Row 1 Col 3 \|
	+	^ Heading 4 \| no colspan this time \| \|
	+	^ Heading 5 \| Row 2 Col 2 \| Row 2 Col 3 \|
	+
	+	As you can see, it's the cell separator before a cell which decides about the formatting:
	+
	+	\| ^ Heading 1 ^ Heading 2 ^
	+	^ Heading 3 \| Row 1 Col 2 \| Row 1 Col 3 \|
	+	^ Heading 4 \| no colspan this time \| \|
	+	^ Heading 5 \| Row 2 Col 2 \| Row 2 Col 3 \|
	+
	+	You can have rowspans (vertically connected cells) by adding ''%%:::%%'' into the cells below the one to which they should connect.
	+
	+	^ Heading 1 ^ Heading 2 ^ Heading 3 ^
	+	\| Row 1 Col 1 \| this cell spans vertically \| Row 1 Col 3 \|
	+	\| Row 2 Col 1 \| ::: \| Row 2 Col 3 \|
	+	\| Row 3 Col 1 \| ::: \| Row 2 Col 3 \|
	+
	+	Apart from the rowspan syntax those cells should not contain anything else.
	+
	+	^ Heading 1 ^ Heading 2 ^ Heading 3 ^
	+	\| Row 1 Col 1 \| this cell spans vertically \| Row 1 Col 3 \|
	+	\| Row 2 Col 1 \| ::: \| Row 2 Col 3 \|
	+	\| Row 3 Col 1 \| ::: \| Row 2 Col 3 \|
	+
	+	You can align the table contents, too. Just add at least two whitespaces at the opposite end of your text: Add two spaces on the left to align right, two spaces on the right to align left and two spaces at least at both ends for centered text.
	+
	+	^ Table with alignment ^^^
	+	\| right\| center \|left \|
	+	\|left \| right\| center \|
	+	\| xxxxxxxxxxxx \| xxxxxxxxxxxx \| xxxxxxxxxxxx \|
	+
	+	This is how it looks in the source:
	+
	+	^ Table with alignment ^^^
	+	\| right\| center \|left \|
	+	\|left \| right\| center \|
	+	\| xxxxxxxxxxxx \| xxxxxxxxxxxx \| xxxxxxxxxxxx \|
	+
	+	Note: Vertical alignment is not supported.
	+
	+	===== No Formatting =====
	+
	+	If you need to display text exactly like it is typed (without any formatting), enclose the area either with ''%%<nowiki>%%'' tags or even simpler, with double percent signs ''<nowiki>%%</nowiki>''.
	+
	+	<nowiki>
	+	This is some text which contains addresses like this: http://www.splitbrain.org and formatting, but nothing is done with it.
	+	</nowiki>
	+	The same is true for %%//__this__ text// with a smiley ;-)%%.
	+
	+	<nowiki>
	+	This is some text which contains addresses like this: http://www.splitbrain.org and formatting, but nothing is done with it.
	+	</nowiki>
	+	The same is true for %%//__this__ text// with a smiley ;-)%%.
	+
	+	===== Code Blocks =====
	+
	+	You can include code blocks into your documents by either indenting them by at least two spaces (like used for the previous examples) or by using the tags ''%%<code>%%'' or ''%%<file>%%''.
	+
	+	This is text is indented by two spaces.
	+
	+	<code>
	+	This is preformatted code all spaces are preserved: like <-this
	+	</code>
	+
	+	<file>
	+	This is pretty much the same, but you could use it to show that you quoted a file.
	+	</file>
	+
	+	Those blocks were created by this source:
	+
	+	This is text is indented by two spaces.
	+
	+	<code>
	+	This is preformatted code all spaces are preserved: like <-this
	+	</code>
	+
	+	<file>
	+	This is pretty much the same, but you could use it to show that you quoted a file.
	+	</file>
	+
	+	==== Syntax Highlighting ====
	+
	+	[[wiki:DokuWiki]] can highlight sourcecode, which makes it easier to read. It uses the [[http://qbnz.com/highlighter/\|GeSHi]] Generic Syntax Highlighter -- so any language supported by GeSHi is supported. The syntax uses the same code and file blocks described in the previous section, but this time the name of the language syntax to be highlighted is included inside the tag, e.g. ''<nowiki><code java></nowiki>'' or ''<nowiki><file java></nowiki>''.
	+
	+	<code java>
	+	/**
	+	* The HelloWorldApp class implements an application that
	+	* simply displays "Hello World!" to the standard output.
	+	*/
	+	class HelloWorldApp {
	+	public static void main(String[] args) {
	+	System.out.println("Hello World!"); //Display the string.
	+	}
	+	}
	+	</code>
	+
	+	The following language strings are currently recognized: //4cs 6502acme 6502kickass 6502tasm 68000devpac abap actionscript3 actionscript ada aimms algol68 apache applescript apt_sources arm asm asp asymptote autoconf autohotkey autoit avisynth awk bascomavr bash basic4gl batch bf biblatex bibtex blitzbasic bnf boo caddcl cadlisp ceylon cfdg cfm chaiscript chapel cil c_loadrunner clojure c_mac cmake cobol coffeescript c cpp cpp-qt cpp-winapi csharp css cuesheet c_winapi dart dcl dcpu16 dcs delphi diff div dos dot d ecmascript eiffel email epc e erlang euphoria ezt f1 falcon fo fortran freebasic freeswitch fsharp gambas gdb genero genie gettext glsl gml gnuplot go groovy gwbasic haskell haxe hicest hq9plus html html4strict html5 icon idl ini inno intercal io ispfpanel java5 java javascript jcl j jquery julia kixtart klonec klonecpp kotlin latex lb ldif lisp llvm locobasic logtalk lolcode lotusformulas lotusscript lscript lsl2 lua m68k magiksf make mapbasic mathematica matlab mercury metapost mirc mk-61 mmix modula2 modula3 mpasm mxml mysql nagios netrexx newlisp nginx nimrod nsis oberon2 objc objeck ocaml-brief ocaml octave oobas oorexx oracle11 oracle8 oxygene oz parasail parigp pascal pcre perl6 perl per pf phix php-brief php pic16 pike pixelbender pli plsql postgresql postscript povray powerbuilder powershell proftpd progress prolog properties providex purebasic pycon pys60 python qbasic qml q racket rails rbs rebol reg rexx robots roff rpmspec rsplus ruby rust sas sass scala scheme scilab scl sdlbasic smalltalk smarty spark sparql sql sshconfig standardml stonescript swift systemverilog tclegg tcl teraterm texgraph text thinbasic tsql twig typoscript unicon upc urbi uscript vala vbnet vb vbscript vedit verilog vhdl vim visualfoxpro visualprolog whitespace whois winbatch wolfram xbasic xml xojo xorg_conf xpp yaml z80 zxbasic//
	+
	+	There are additional [[doku>syntax_highlighting\|advanced options]] available for syntax highlighting, such as highlighting lines or adding line numbers.
	+
	+	==== Downloadable Code Blocks ====
	+
	+	When you use the ''%%<code>%%'' or ''%%<file>%%'' syntax as above, you might want to make the shown code available for download as well. You can do this by specifying a file name after language code like this:
	+
	+	<code>
	+	<file php myexample.php>
	+	<?php echo "hello world!"; ?>
	+	</file>
	+	</code>
	+
	+	<file php myexample.php>
	+	<?php echo "hello world!"; ?>
	+	</file>
	+
	+	If you don't want any highlighting but want a downloadable file, specify a dash (''-'') as the language code: ''%%<code - myfile.foo>%%''.
	+
	+	===== RSS/ATOM Feed Aggregation =====
	+	[[DokuWiki]] can integrate data from external XML feeds. For parsing the XML feeds, [[http://simplepie.org/\|SimplePie]] is used. All formats understood by SimplePie can be used in DokuWiki as well. You can influence the rendering by multiple additional space separated parameters:
	+
	+	^ Parameter ^ Description ^
	+	\| any number \| will be used as maximum number items to show, defaults to 8 \|
	+	\| reverse \| display the last items in the feed first \|
	+	\| author \| show item authors names \|
	+	\| date \| show item dates \|
	+	\| description\| show the item description. All HTML tags will be stripped \|
	+	\| nosort \| do not sort the items in the feed \|
	+	\| //n//[dhm] \| refresh period, where d=days, h=hours, m=minutes. (e.g. 12h = 12 hours). \|
	+
	+	The refresh period defaults to 4 hours. Any value below 10 minutes will be treated as 10 minutes. [[wiki:DokuWiki]] will generally try to supply a cached version of a page, obviously this is inappropriate when the page contains dynamic external content. The parameter tells [[wiki:DokuWiki]] to re-render the page if it is more than //refresh period// since the page was last rendered.
	+
	+	By default the feed will be sorted by date, newest items first. You can sort it by oldest first using the ''reverse'' parameter, or display the feed as is with ''nosort''.
	+
	+	Example:
	+
	+	{{rss>http://slashdot.org/index.rss 5 author date 1h }}
	+
	+	{{rss>http://slashdot.org/index.rss 5 author date 1h }}
	+
	+
	+	===== Control Macros =====
	+
	+	Some syntax influences how DokuWiki renders a page without creating any output it self. The following control macros are availble:
	+
	+	^ Macro ^ Description \|
	+	\| %%~~NOTOC~~%% \| If this macro is found on the page, no table of contents will be created \|
	+	\| %%~~NOCACHE~~%% \| DokuWiki caches all output by default. Sometimes this might not be wanted (eg. when the %%<php>%% syntax above is used), adding this macro will force DokuWiki to rerender a page on every call \|
	+
	+	===== Syntax Plugins =====
	+
	+	DokuWiki's syntax can be extended by [[doku>plugins\|Plugins]]. How the installed plugins are used is described on their appropriate description pages. The following syntax plugins are available in this particular DokuWiki installation:
	+
	+	~~INFO:syntaxplugins~~

Th1 Spectrum Disorder

ron@undisclosed.example.com (ron) — Tue, 26 Aug 2025 10:17:57 +0000

01.13.2024		current
Line 1:		Line 1:
-
	====== Th1 Spectrum Disorder ======		====== Th1 Spectrum Disorder ======

Line 33:		Line 32:
	Epidemiological research may have its share of liabilities, but one contribution it has made is in demonstrating the strong connections between seemingly disparate diseases as evidenced by the number of patients who share diagnoses with two or more "unrelated" disease processes.		Epidemiological research may have its share of liabilities, but one contribution it has made is in demonstrating the strong connections between seemingly disparate diseases as evidenced by the number of patients who share diagnoses with two or more "unrelated" disease processes.

-	<nodisp>
	The following wheel shows how truly related chronic diseases are. Each "spoke" represents a published study which has demonstrated a significant statistical relationship between patients suffering from one disease and the next.		The following wheel shows how truly related chronic diseases are. Each "spoke" represents a published study which has demonstrated a significant statistical relationship between patients suffering from one disease and the next.

Line 364:		Line 362:
	</html>		</html>
	The following paragraph contains links to all the studies alluded to in the above chart.		The following paragraph contains links to all the studies alluded to in the above chart.
-	</nodisp>

	Please note that some of the disease names in the following paragraph are links to articles discussing those diseases in further detail.		Please note that some of the disease names in the following paragraph are links to articles discussing those diseases in further detail.

Science behind vitamin D - [Failing to control for biases inherent to observational studies]

ron@undisclosed.example.com (ron) — Sun, 06 Aug 2023 22:15:03 +0000

09.14.2022		current
Line 130:		Line 130:
	==== Failing to control for biases inherent to observational studies ====		==== Failing to control for biases inherent to observational studies ====

-	<mainrelatedarticles> [[.:vitamind:observational_bias\|Bias in observational epidemiological studies]], [[home:pathogenesis:vitamind:latitude\|Latitude studies]]</article>	+	<mainarticle> [[.:vitamind:observational_bias\|Bias in observational epidemiological studies]], [[home:pathogenesis:vitamind:latitude\|Latitude studies]]</article>

	{{section>:home:pathogenesis:vitamind:observational_bias#bias_in_observational_epidemiological_studies&noheader}}		{{section>:home:pathogenesis:vitamind:observational_bias#bias_in_observational_epidemiological_studies&noheader}}

Health, food and drink - external edit

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

09.14.2022		current
Line 202:		Line 202:
	Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body.		Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body.

-	Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pmid>long: 31258141}}))	+	Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pmid>long:31258141}}))

pubmed_10193375.xml.gz - created - external edit

anonymous@undisclosed.example.com (Anonymous) — Tue, 13 Sep 2022 20:13:32 +0000

	current

Chronic Lyme disease - [Caused by multiple microbes]

ron@undisclosed.example.com (ron) — Tue, 13 Sep 2022 18:38:43 +0000

09.13.2022		current
Line 54:		Line 54:
	<blockquote>Lyme disease is considered to be caused by //Borrelia// species of bacteria but slowly evidence is accumulating which suggests that Lyme disease is a far more complex condition than //Borreliosis// alone. This hypothesis suggests that it may be more appropriate to regard Lyme disease as a tick borne disease complex. Over recent years numerous different microbes have been found in ticks which are known to be zoonotic and can coinfect the human host. The hypothesis suggests that multiple coinfections are invariably present in the clinical syndromes associated with Lyme disease and it is suggested that these act synergistically in complex ways.		<blockquote>Lyme disease is considered to be caused by //Borrelia// species of bacteria but slowly evidence is accumulating which suggests that Lyme disease is a far more complex condition than //Borreliosis// alone. This hypothesis suggests that it may be more appropriate to regard Lyme disease as a tick borne disease complex. Over recent years numerous different microbes have been found in ticks which are known to be zoonotic and can coinfect the human host. The hypothesis suggests that multiple coinfections are invariably present in the clinical syndromes associated with Lyme disease and it is suggested that these act synergistically in complex ways.

-	//D.C. Owen// (({{pubmed>long:16814477}}))
	//D.C. Owen// (({{pmid>long:16814477}}))		//D.C. Owen// (({{pmid>long:16814477}}))
	</blockquote>		</blockquote>
Line 60:		Line 59:
	Since first being recognized as a disease in 1981, Lyme has been widely assumed to be caused by a single infectious agent: //Borrelia//. In fact, the very reason the diagnosis of chronic Lyme is so controversial is that blood tests of people with Lyme-like symptoms infrequently show ongoing //Borrelia// infection. The assumption that one and only species (or genus) of microbe could cause a given symptom presentation is the antiquated legacy of Koch's postulates. More recent research suggests that the symptoms of chronic Lyme are caused my many microbes.		Since first being recognized as a disease in 1981, Lyme has been widely assumed to be caused by a single infectious agent: //Borrelia//. In fact, the very reason the diagnosis of chronic Lyme is so controversial is that blood tests of people with Lyme-like symptoms infrequently show ongoing //Borrelia// infection. The assumption that one and only species (or genus) of microbe could cause a given symptom presentation is the antiquated legacy of Koch's postulates. More recent research suggests that the symptoms of chronic Lyme are caused my many microbes.

-	W. Ian Lipkin's team sampled 286 adult ticks from the two counties in New York State where Lyme disease is endemic, looking for the prevalence of polymicrobial infection with //Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi,// and Powassan virus.(({{pubmed>long:19725770}})) Seventy-one percent of the ticks harbored at least one organism; 30% had a polymicrobial infection. Infections with three microbes were detected in 5% of the ticks. One tick was infected with four organisms.	+	W. Ian Lipkin's team sampled 286 adult ticks from the two counties in New York State where Lyme disease is endemic, looking for the prevalence of polymicrobial infection with //Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi,// and Powassan virus.(({{pmid>long:19725770}})) Seventy-one percent of the ticks harbored at least one organism; 30% had a polymicrobial infection. Infections with three microbes were detected in 5% of the ticks. One tick was infected with four organisms.

-	We collected data from an online survey of 200 of our patients, which evaluated the efficacy of dapsone (diaminodiphenyl sulfone, ie, DDS) combined with other antibiotics and agents that disrupt biofilms for the treatment of chronic Lyme disease/post-treatment Lyme disease syndrome (PTLDS). We also collected aggregate data from direct retrospective chart review, including laboratory testing for Lyme, other infections, and associated tick-borne coinfections. (({{pubmed>long:30863136}}))	+	We collected data from an online survey of 200 of our patients, which evaluated the efficacy of dapsone (diaminodiphenyl sulfone, ie, DDS) combined with other antibiotics and agents that disrupt biofilms for the treatment of chronic Lyme disease/post-treatment Lyme disease syndrome (PTLDS). We also collected aggregate data from direct retrospective chart review, including laboratory testing for Lyme, other infections, and associated tick-borne coinfections. (({{pmid>long:30863136}}))

	=== Australian ticks ===		=== Australian ticks ===

-	Human Tick-Borne Diseases in Australia. (({{pubmed>long:30746341}}))	+	Human Tick-Borne Diseases in Australia. (({{pmid>long:30746341}}))

	==== Borrelia and the VDR ====		==== Borrelia and the VDR ====
Line 72:		Line 71:
	<relatedarticle> [[home:pathogenesis:vitamind:metabolism\|Metabolism of vitamin D and the Vitamin D Receptor]] </article>		<relatedarticle> [[home:pathogenesis:vitamind:metabolism\|Metabolism of vitamin D and the Vitamin D Receptor]] </article>

-	In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.(({{pubmed>long:21350579}}))	+	In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.(({{pmid>long:21350579}}))

	<blockquote>Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment.		<blockquote>Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment.

-	//Jun Sun// (({{pubmed>long:20639756}}))</blockquote>	+	//Jun Sun// (({{pmid>long:20639756}}))</blockquote>

-	Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is //Borrelia burgdorferi//. Live //Borrelia burgdorferi// reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates ("dead" //Borrelia//) reduced it by 8 times(({{pubmed>long:19461888}}))	+	Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is //Borrelia burgdorferi//. Live //Borrelia burgdorferi// reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates ("dead" //Borrelia//) reduced it by 8 times(({{pmid>long:19461888}}))

	Olmesartan is the main medication used by the Marshall Protocol and is believed to act as a VDR agonist, counteracting //Borrellia//'s effect on the Receptor and reversing the disease process.		Olmesartan is the main medication used by the Marshall Protocol and is believed to act as a VDR agonist, counteracting //Borrellia//'s effect on the Receptor and reversing the disease process.
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	==== Autoantibodies ====		==== Autoantibodies ====

-	Greco //et al.// claimed to find a variety of autoantibodies including antiphospholipid antibodies in patients with chronic Lyme disease.(({{pubmed>long:21729977}})) Autoantibodies have long been tied to persistent infections.	+	Greco //et al.// claimed to find a variety of autoantibodies including antiphospholipid antibodies in patients with chronic Lyme disease.(({{pmid>long:21729977}})) Autoantibodies have long been tied to persistent infections.

	===== Ticks, what to do when bitten =====		===== Ticks, what to do when bitten =====
Line 209:		Line 208:
	===== Research =====		===== Research =====

-	Many antimicrobial agents (antibiotics, antivirals, antifungals, anthelmintics or antiparasitics) used for treating other infections were found to have better activity than the current Lyme antibiotics. These include antibacterials such as rifamycins (3-formal-rifamycin, rifaximin, rifamycin SV), thiostrepton, quinolone drugs (sarafloxacin, clinafloxacin, tosufloxacin), and cell wall inhibitors carbenicillin, tazobactam, aztreonam; antifungal agents such as fluconazole, mepartricin, bifonazole, climbazole, oxiconazole, nystatin; antiviral agents zanamivir, nevirapine, tilorone; antimalarial agents artemisinin, methylene blue, and quidaldine blue; antihelmintic and antiparasitic agents toltrazuril, tartar emetic, potassium antimonyl tartrate trihydrate, oxantel, closantel, hycanthone, pyrimethamine, and tetramisole. Interestingly, drugs used for treating other non-infectious conditions including verteporfin, oltipraz, pyroglutamic acid, pidolic acid, and dextrorphan tartrate, that act on the glutathione/γ-glutamyl pathway involved in protection against free radical damage, and also the antidepressant drug indatraline, were found to have high activity against stationary phase B. burgdorferi. (({{pubmed>long: 27025631}}))	+	Many antimicrobial agents (antibiotics, antivirals, antifungals, anthelmintics or antiparasitics) used for treating other infections were found to have better activity than the current Lyme antibiotics. These include antibacterials such as rifamycins (3-formal-rifamycin, rifaximin, rifamycin SV), thiostrepton, quinolone drugs (sarafloxacin, clinafloxacin, tosufloxacin), and cell wall inhibitors carbenicillin, tazobactam, aztreonam; antifungal agents such as fluconazole, mepartricin, bifonazole, climbazole, oxiconazole, nystatin; antiviral agents zanamivir, nevirapine, tilorone; antimalarial agents artemisinin, methylene blue, and quidaldine blue; antihelmintic and antiparasitic agents toltrazuril, tartar emetic, potassium antimonyl tartrate trihydrate, oxantel, closantel, hycanthone, pyrimethamine, and tetramisole. Interestingly, drugs used for treating other non-infectious conditions including verteporfin, oltipraz, pyroglutamic acid, pidolic acid, and dextrorphan tartrate, that act on the glutathione/γ-glutamyl pathway involved in protection against free radical damage, and also the antidepressant drug indatraline, were found to have high activity against stationary phase B. burgdorferi. (({{pmid>long: 27025631}}))

	===== Read more =====		===== Read more =====
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	* [[https://www.medscape.com/viewarticle/586226\|Chronic Lyme Disease and the "Axis of Evil"]] – A 2009 //Future Microbiology// paper written from the perspective of ILADS and LLMDs.		* [[https://www.medscape.com/viewarticle/586226\|Chronic Lyme Disease and the "Axis of Evil"]] – A 2009 //Future Microbiology// paper written from the perspective of ILADS and LLMDs.

-	* SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pubmed>long:22889796}}))	+	* SPECT scans are abnormal in chronic Lyme patients – According to a 2012 study, 75% of brain SPECT scans are abnormal in patients with chronic Lyme disease.(({{pmid>long:22889796}}))


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	While there is general agreement on the optimal treatment for early Lyme disease, there is considerable controversy over the existence, prevalence, diagnostic criteria, and treatment of chronic Lyme disease.		While there is general agreement on the optimal treatment for early Lyme disease, there is considerable controversy over the existence, prevalence, diagnostic criteria, and treatment of chronic Lyme disease.

-	Over the past decade, two opposing camps have emerged in the battle over Lyme. One camp is represented by the International Lyme and Associated Diseases Society (ILADS), which argues that Lyme disease is not rare because its spread is facilitated by rodents, deer and birds, and can be found in an unpredictable distribution around the world accompanied by other tick-borne coinfections that may complicate the clinical presentation. According to the ILADS, tick bites often go unnoticed and commercial laboratory testing for Lyme disease is inaccurate. Consequently, the disease is often not recognized and may persist in a large number of patients, requiring prolonged antibiotic therapy to eradicate persistent infection with the evasive Lyme spirochete.(({{pubmed>long:19072179}}))	+	Over the past decade, two opposing camps have emerged in the battle over Lyme. One camp is represented by the International Lyme and Associated Diseases Society (ILADS), which argues that Lyme disease is not rare because its spread is facilitated by rodents, deer and birds, and can be found in an unpredictable distribution around the world accompanied by other tick-borne coinfections that may complicate the clinical presentation. According to the ILADS, tick bites often go unnoticed and commercial laboratory testing for Lyme disease is inaccurate. Consequently, the disease is often not recognized and may persist in a large number of patients, requiring prolonged antibiotic therapy to eradicate persistent infection with the evasive Lyme spirochete.(({{pmid>long:19072179}}))

-	The opposing camp is represented by the Infectious Diseases Society of America (IDSA), which maintains that Lyme disease is a rare illness localized to well-defined areas of the world. According to the IDSA, the disease is "hard to catch and easy to cure" because the infection is rarely encountered, easily diagnosed in its early stage by distinctive clinical features and in more advanced stages by accurate commercial laboratory tests, and effectively treated with a short course of antibiotics over 2-4 weeks. Chronic infection with the Lyme spirochete, //Borrelia burgdorferi//, is rare or nonexistent, and the concept of chronic Lyme disease rests on "faith-based" opinion rather than "evidence-based" science.(({{pubmed>long:19072179}}))	+	The opposing camp is represented by the Infectious Diseases Society of America (IDSA), which maintains that Lyme disease is a rare illness localized to well-defined areas of the world. According to the IDSA, the disease is "hard to catch and easy to cure" because the infection is rarely encountered, easily diagnosed in its early stage by distinctive clinical features and in more advanced stages by accurate commercial laboratory tests, and effectively treated with a short course of antibiotics over 2-4 weeks. Chronic infection with the Lyme spirochete, //Borrelia burgdorferi//, is rare or nonexistent, and the concept of chronic Lyme disease rests on "faith-based" opinion rather than "evidence-based" science.(({{pmid>long:19072179}}))

-	This mainstream view is exemplified by a 2007 review in the //New England Journal of Medicine//, which noted the diagnosis of chronic Lyme disease is used by a few physicians despite a lack of "reproducible or convincing scientific evidence", leading the authors to describe this diagnosis as "the latest in a series of syndromes that have been postulated in an attempt to attribute medically unexplained symptoms to particular infections."(({{pubmed>long:17914043}}))	+	This mainstream view is exemplified by a 2007 review in the //New England Journal of Medicine//, which noted the diagnosis of chronic Lyme disease is used by a few physicians despite a lack of "reproducible or convincing scientific evidence", leading the authors to describe this diagnosis as "the latest in a series of syndromes that have been postulated in an attempt to attribute medically unexplained symptoms to particular infections."(({{pmid>long:17914043}}))

	<blockquote>Chronic Lyme disease is the most recent in a continuing series of "medically unexplained symptoms" syndromes. These syndromes, such as fibromyalgia, chronic fatigue syndrome, and multiple chemical sensitivity, meet the need for a societally and morally acceptable explanation for ill-defined symptoms in the absence of objective physical and laboratory findings. We describe factors involved in the psychopathogenesis of chronic Lyme disease and focus on the confusion and insecurity these patients feel, which gives rise to an inability to adequately formulate and articulate their health concerns and to deal adequately with their medical needs, a state of disorganization termed aporia.		<blockquote>Chronic Lyme disease is the most recent in a continuing series of "medically unexplained symptoms" syndromes. These syndromes, such as fibromyalgia, chronic fatigue syndrome, and multiple chemical sensitivity, meet the need for a societally and morally acceptable explanation for ill-defined symptoms in the absence of objective physical and laboratory findings. We describe factors involved in the psychopathogenesis of chronic Lyme disease and focus on the confusion and insecurity these patients feel, which gives rise to an inability to adequately formulate and articulate their health concerns and to deal adequately with their medical needs, a state of disorganization termed aporia.

-	//L.H. Sigal// (({{pubmed>long:12194894}})) </blockquote>	+	//L.H. Sigal// (({{pmid>long:12194894}})) </blockquote>

	Groups of patients, patient advocates, and the small number of physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy, which most insurers deny, as it is at odds with the guidelines of the major medical organizations.		Groups of patients, patient advocates, and the small number of physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy, which most insurers deny, as it is at odds with the guidelines of the major medical organizations.
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	* [[home:othertreatments:rife\|Rife]] – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.		* [[home:othertreatments:rife\|Rife]] – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.

-	Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability (({{pubmed>long: 29075628}}))	+	Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability (({{pmid>long: 29075628}}))

	=== Disulfiram ===		=== Disulfiram ===
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	[[https://clinicaltrials.gov/ct2/show/NCT03891667\|Study to examine the safety of disulfiram among patients with post-treatment Lyme disease Sx]]		[[https://clinicaltrials.gov/ct2/show/NCT03891667\|Study to examine the safety of disulfiram among patients with post-treatment Lyme disease Sx]]

-	Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pubmed>long:27103785}}))	+	Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pmid>long:27103785}}))

-	Not suitable for children (({{pubmed>long:6470872}})), (({{pubmed>long:9093309}}))	+	Not suitable for children (({{pmid>long:6470872}})), (({{pmid>long:9093309}}))

-	may be possible for some adolescents (({{pubmed>long:27613346}}))	+	may be possible for some adolescents (({{pmid>long:27613346}}))

	=== ===		=== ===
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	Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of 3 antibiotic drugs in combination, as single drugs and 2-drug combinations appear to be ineffective with some PTLDS Borrelia biofilm.		Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of 3 antibiotic drugs in combination, as single drugs and 2-drug combinations appear to be ineffective with some PTLDS Borrelia biofilm.

-	the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long: 12073540}}))	+	the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pmid>long: 12073540}}))

-	Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. (({{pubmed>long: 25806811}}))	+	Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. (({{pmid>long: 25806811}}))

-	Sulpha drugs and their combinations(({{pubmed>long:28327498}}))	+	Sulpha drugs and their combinations(({{pmid>long:28327498}}))

	{{tag>diseases}}		{{tag>diseases}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	\|Diagnosis \|Diagnosed clinically based on symptoms, objective physical findings – such as erythema migrans (bulls eye rash), facial palsy or arthritis – or a history of possible exposure to infected ticks, as well as blood tests. Living in a tick-endemic area increases the likelihood of a Lyme diagnosis. \|For those with a negative test for //Borrelia//, getting a diagnosis of chronic Lyme depends largely on whether the doctor is "Lyme literate", that is if he/she even acknowledges the existence of chronic Lyme. \|		\|Diagnosis \|Diagnosed clinically based on symptoms, objective physical findings – such as erythema migrans (bulls eye rash), facial palsy or arthritis – or a history of possible exposure to infected ticks, as well as blood tests. Living in a tick-endemic area increases the likelihood of a Lyme diagnosis. \|For those with a negative test for //Borrelia//, getting a diagnosis of chronic Lyme depends largely on whether the doctor is "Lyme literate", that is if he/she even acknowledges the existence of chronic Lyme. \|
	\|Controversy over legitimacy of diagnosis \|Some disagreement over validity of tests, but controversy is relatively minimal. \|Diagnosis is most controversially applied to patients with nonspecific symptoms (e.g., fatigue), who show no objective evidence they have been infected with Lyme disease in the past, since the standard diagnostic tests for infection are negative. Most physicians [[#chronic_controversy_over_chronic_lyme_disease\|do not accept]] chronic Lyme as a legitimate diagnosis. \|		\|Controversy over legitimacy of diagnosis \|Some disagreement over validity of tests, but controversy is relatively minimal. \|Diagnosis is most controversially applied to patients with nonspecific symptoms (e.g., fatigue), who show no objective evidence they have been infected with Lyme disease in the past, since the standard diagnostic tests for infection are negative. Most physicians [[#chronic_controversy_over_chronic_lyme_disease\|do not accept]] chronic Lyme as a legitimate diagnosis. \|
-	\|Treatment \|Widely believed to be "readily curable." Conventional approach according to 2008 Infectious Diseases Society of America guidelines(({{pubmed>long:18452688}})) – antibiotics of choice are doxycycline (in adults), amoxicillin (in children), erythromycin (for pregnant women) and ceftriaxone \|"Lyme-literate" MDs often prescribe high-dose, often intravenous antibiotics such as Rocephin \|	+	\|Treatment \|Widely believed to be "readily curable." Conventional approach according to 2008 Infectious Diseases Society of America guidelines(({{pmid>long:18452688}})) – antibiotics of choice are doxycycline (in adults), amoxicillin (in children), erythromycin (for pregnant women) and ceftriaxone \|"Lyme-literate" MDs often prescribe high-dose, often intravenous antibiotics such as Rocephin \|


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	* [[home:othertreatments:rife\|Rife]] – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.		* [[home:othertreatments:rife\|Rife]] – There is no scientific evidence that the use of a Rife device has the intended effect on infectious bacteria. Instead, most patients using Rife are likely administering themselves nothing more than an expensive placebo.

-	Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability (({{pubmed>long: 29075628}}))	+	Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi. Some highly active essential oils were found to have excellent anti-biofilm ability (({{pmid>long: 29075628}}))

	=== Disulfiram ===		=== Disulfiram ===
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	[[https://clinicaltrials.gov/ct2/show/NCT03891667\|Study to examine the safety of disulfiram among patients with post-treatment Lyme disease Sx]]		[[https://clinicaltrials.gov/ct2/show/NCT03891667\|Study to examine the safety of disulfiram among patients with post-treatment Lyme disease Sx]]

-	Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pubmed>long:27103785}}))	+	Screening to identify potent candidate drugs that can target the Borrelia persisters.(({{pmid>long:27103785}}))

-	Not suitable for children (({{pubmed>long:6470872}})), (({{pubmed>long:9093309}}))	+	Not suitable for children (({{pmid>long:6470872}})), (({{pmid>long:9093309}}))

-	May be for adolescents (({{pubmed>long:27613346}}))	+	May be for adolescents (({{pmid>long:27613346}}))

	=== ===		=== ===
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	Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of 3 antibiotic drugs in combination		Those affected by persistent Lyme disease, who are unable to follow the Marshall Protocol, could ask a medical practitioner about use of 3 antibiotic drugs in combination

-	the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pubmed>long: 12073540}}))	+	the combination of different antiborrelial agents with synergistic effect seems to be a meaningful alternative and should be included in future studies in vitro as well as in vivo.(({{pmid>long: 12073540}}))

-	Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. (({{pubmed>long: 25806811}}))	+	Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline. (({{pmid>long: 25806811}}))

-	Sulpha drugs and their combinations(({{pubmed>long:28327498}}))	+	Sulpha drugs and their combinations(({{pmid>long:28327498}}))

	===== References =====		===== References =====
		+	</nodisp>

News and highlights - guilt tripping emotional appeal removed

ron@undisclosed.example.com (ron) — Wed, 07 Sep 2022 06:05:39 +0000

07.04.2022		current
Line 38:		Line 38:
	* [[home:physicians:vitamin_d_leaflet\|Testing your vitamin D Metabolites]]		* [[home:physicians:vitamin_d_leaflet\|Testing your vitamin D Metabolites]]
	* see below		* see below
-
-
-
-
-	==== IMPORTANT ====
-
-	//Wear a face mask when out//
-
-	The life you save may be your friend
-
-
-
-

Mistaking correlation for causation in vitamin D studies - [Researchers should also measure 1,25-D]

sallieq@undisclosed.example.com (sallieq) — Thu, 03 Sep 2020 21:55:43 +0000

The over-exuberant Stage-Five immune response - [Antibiotics]

sallieq@undisclosed.example.com (sallieq) — Fri, 24 Jul 2020 21:50:45 +0000

07.24.2020		current
Line 28:		Line 28:


-	<blockquote>Very few have experienced any problems with Stage Five. I think it mainly gives trouble when pathogens other than the Th1 pathogens are present, and have escaped the antibiotics. I got hit when the fibrosis in my lungs began to remodel, but I doubt that anybody else in the cohort was afflicted with fibrotic tissue [[http://sarcinfo.com/xrays\|as badly as I]]. Additionally, I hadn't been exercising (at all) during my recovery, so the remodelling began quite suddenly. On the other hand, the other early adopters have not had identifiable problems. We put out the documentation partly over an abundance of caution, and partly because we had to change the model to account for this (unexpected) glitch in recovery trajectory.	+	<blockquote>Very few have experienced any problems with Stage Five. I think it mainly gives trouble when pathogens other than the Th1 pathogens are present, and have escaped the antibiotics. I got hit when the fibrosis in my lungs began to remodel, but I doubt that anybody else in the cohort was afflicted with fibrotic tissue [[https://sarcinfo.com/xrays\|as badly as I]]. Additionally, I hadn't been exercising (at all) during my recovery, so the remodelling began quite suddenly. On the other hand, the other early adopters have not had identifiable problems. We put out the documentation partly over an abundance of caution, and partly because we had to change the model to account for this (unexpected) glitch in recovery trajectory.

	Unless your X-rays show the degree of damage which mine did, you should be fine with a very nominal amount of exercise. Do not do anything which tires you out. Walking around the neighborhood in the late evenings is probably a good choice (depending on your neighborhood, of course).		Unless your X-rays show the degree of damage which mine did, you should be fine with a very nominal amount of exercise. Do not do anything which tires you out. Walking around the neighborhood in the late evenings is probably a good choice (depending on your neighborhood, of course).
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	causing too much immunopathology, it is necessary to stop them. For many members, indeed, ABx are used only to provoke IP when it has dwindled.		causing too much immunopathology, it is necessary to stop them. For many members, indeed, ABx are used only to provoke IP when it has dwindled.

-	Please ask for moderator assistance on the [[http://marshallprotocol.com\|MarshallProtocol.com]] study site before antibiotic use is modified. We are happy to assist you in any way we can.	+	Please ask for moderator assistance on the [[https://marshallprotocol.com\|MarshallProtocol.com]] study site before antibiotic use is modified. We are happy to assist you in any way we can.


Line 111:		Line 111:
	===== Read more =====		===== Read more =====

-	* [[http://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|Visual description of all stages of recovery]]	+	* [[https://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|Visual description of all stages of recovery]]


Line 119:		Line 119:


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 125:		Line 126:
	*		*

-	http://autoimmunityresearch.org/VDR-Time-Benicar.pdf	+	https://autoimmunityresearch.org/VDR-Time-Benicar.pdf

-	http://autoimmunityresearch.org/stage5.pdf	+	https://autoimmunityresearch.org/stage5.pdf

	* There's confusion among members re stage 5, leading to fear of it from early in their MP journey. This page swings from painting a fearful picture of unrestrainable immune reaction to assurances that only some of the most ill experience this. It's self-contradictory as to whether the term 'stage 5' refers to anyone who continues to herx without abx, or only to those whose immune system is 'over-exuberant'. --- //Julia 2009/01/31 05:20//		* There's confusion among members re stage 5, leading to fear of it from early in their MP journey. This page swings from painting a fearful picture of unrestrainable immune reaction to assurances that only some of the most ill experience this. It's self-contradictory as to whether the term 'stage 5' refers to anyone who continues to herx without abx, or only to those whose immune system is 'over-exuberant'. --- //Julia 2009/01/31 05:20//
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	* IMO, Stage 5 should refer to everyone who continues to herx without abx - i.e. their own immune system is functioning properly. Then there could be a warning that a few people have had this runaway reaction, while many are having a much more gentle stage 5. --- //Julia 2009/02/04 17:51//		* IMO, Stage 5 should refer to everyone who continues to herx without abx - i.e. their own immune system is functioning properly. Then there could be a warning that a few people have had this runaway reaction, while many are having a much more gentle stage 5. --- //Julia 2009/02/04 17:51//

-	===== References =====	+	===== References =====</nodisp>

Resources for patients - [Patient interviews]

sallieq@undisclosed.example.com (sallieq) — Tue, 14 Jul 2020 02:20:57 +0000

07.14.2020		current
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	===== Making sense of the Marshall Protocol =====		===== Making sense of the Marshall Protocol =====

-	The explanation for why the Marshall Protocol works can get sophisticated. To help patients understand all of the terminology being used, a [[home:patients:glossary\|glossary of scientific terms]] is available, as well as a list of [[home:patients:abbreviations\|medical abbreviations]] used on the [[http://marshallprotocol.com\|Marshall Protocol Study Site]].	+	The explanation for why the Marshall Protocol works can get sophisticated. To help patients understand all of the terminology being used, a [[home:patients:glossary\|glossary of scientific terms]] is available, as well as a list of [[home:patients:abbreviations\|medical abbreviations]] used on the [[https://marshallprotocol.com\|Marshall Protocol Study Site]].


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	{{tag> resource}}		{{tag> resource}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 97:		Line 98:


-	===== References =====	+	===== References =====</nodisp>

Patient interviews - [Patient interviews]

sallieq@undisclosed.example.com (sallieq) — Tue, 14 Jul 2020 02:17:58 +0000

07.14.2020		current
Line 3:		Line 3:
	//N.B. the below recorded interviews are no longer available online//		//N.B. the below recorded interviews are no longer available online//

-	You may be interested in http://microbeminded.com/author/amyproal/	+	You may be interested in https://microbeminded.com/author/amyproal/

	However, dozens of different patients have shared their stories of recovery on the [[https://www.marshallprotocol.com/\|Marshall protocol Study site]].		However, dozens of different patients have shared their stories of recovery on the [[https://www.marshallprotocol.com/\|Marshall protocol Study site]].
Line 23:		Line 23:
	sarcoidosis, bladder cancer		sarcoidosis, bladder cancer

-	Read the [[http://bacteriality.com/2008/07/18/interview24/\|interview]]	+	Read the [[https://bacteriality.com/2008/07/18/interview24/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	lupus, Sjogren’s Syndrome		lupus, Sjogren’s Syndrome

-	Read the [[http://bacteriality.com/2008/07/02/interview23/\|interview]]	+	Read the [[https://bacteriality.com/2008/07/02/interview23/\|interview]]

	<html></div></div></html>		<html></div></div></html>
Line 50:		Line 50:
	diabetes, sarcoidosis, irritable bowel syndrome		diabetes, sarcoidosis, irritable bowel syndrome

-	Read the [[http://bacteriality.com/2008/06/19/interview22/\|interview]]	+	Read the [[https://bacteriality.com/2008/06/19/interview22/\|interview]]

	<html></div></div></html>		<html></div></div></html>
Line 63:		Line 63:
	sarcoidosis, rheumatoid arthritis		sarcoidosis, rheumatoid arthritis

-	Read the [[http://bacteriality.com/2008/06/03/interview21/\|interview]]	+	Read the [[https://bacteriality.com/2008/06/03/interview21/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis, cat scratch fever, restless leg syndrome		sarcoidosis, cat scratch fever, restless leg syndrome

-	Read the [[http://bacteriality.com/2007/11/19/interview13/\|interview]]	+	Read the [[https://bacteriality.com/2007/11/19/interview13/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	chronic fatigue syndrome (CFS), multiple chemical sensitivities		chronic fatigue syndrome (CFS), multiple chemical sensitivities

-	Read the [[http://bacteriality.com/2008/05/23/interview20/\|interview]]	+	Read the [[https://bacteriality.com/2008/05/23/interview20/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)		autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)

-	Read the [[http://bacteriality.com/2008/03/15/interview18/\|interview]]	+	Read the [[https://bacteriality.com/2008/03/15/interview18/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis		sarcoidosis

-	Read the [[http://bacteriality.com/2007/11/17/interview11/\|interview]]	+	Read the [[https://bacteriality.com/2007/11/17/interview11/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement		neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement

-	Read the [[http://bacteriality.com/2008/03/02/interview17/\|interview]]	+	Read the [[https://bacteriality.com/2008/03/02/interview17/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	chronic borreliosis ("Lyme"), multiple chemical sensitivities, chronic spinal inflammation, peripheral neuropathy		chronic borreliosis ("Lyme"), multiple chemical sensitivities, chronic spinal inflammation, peripheral neuropathy

-	Read the [[http://bacteriality.com/2007/12/28/interview14/\|interview]]	+	Read the [[https://bacteriality.com/2007/12/28/interview14/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis of the heart, coronary artery disease, atrial fibrillation		sarcoidosis of the heart, coronary artery disease, atrial fibrillation

-	Read the [[http://bacteriality.com/2008/01/18/interview15/\|interview]]	+	Read the [[https://bacteriality.com/2008/01/18/interview15/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis		Lyme disease, irritable bowel syndrome/ulcerative colitis, radiculitis

-	Read the [[http://bacteriality.com/2008/02/17/interview16/\|interview]]	+	Read the [[https://bacteriality.com/2008/02/17/interview16/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	Post Treatment Lyme Disease Syndrome (PTLDS)		Post Treatment Lyme Disease Syndrome (PTLDS)

-	Read the [[http://bacteriality.com/2008/03/31/interview19/\|interview]]	+	Read the [[https://bacteriality.com/2008/03/31/interview19/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis (Hedfort Syndrome), uveitis		sarcoidosis (Hedfort Syndrome), uveitis

-	Read the [[http://bacteriality.com/2007/11/19/interview12\|interview]]	+	Read the [[https://bacteriality.com/2007/11/19/interview12\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	rheumatoid arthritis, dyslexia		rheumatoid arthritis, dyslexia

-	Read the [[http://bacteriality.com/2007/09/01/interview2/\|interview]]	+	Read the [[https://bacteriality.com/2007/09/01/interview2/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis, fibromyalgia, chronic fatigue syndrome (CFS)		sarcoidosis, fibromyalgia, chronic fatigue syndrome (CFS)

-	Read the [[http://bacteriality.com/2007/11/08/interview8//\|interview]]	+	Read the [[https://bacteriality.com/2007/11/08/interview8//\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis		sarcoidosis

-	Read the [[http://bacteriality.com/2007/11/04/interview7/\|interview]]	+	Read the [[https://bacteriality.com/2007/11/04/interview7/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	chronic fatigue syndrome (CFS), depression, food sensitivities, insomnia		chronic fatigue syndrome (CFS), depression, food sensitivities, insomnia

-	Read the [[http://bacteriality.com/2007/11/10/interview10/\|interview]]	+	Read the [[https://bacteriality.com/2007/11/10/interview10/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	Lyme, myoclonus		Lyme, myoclonus

-	Read the [[http://bacteriality.com/2007/10/28/interview6/\|interview]]	+	Read the [[https://bacteriality.com/2007/10/28/interview6/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	Lyme, //Babesia//		Lyme, //Babesia//

-	Read the [[http://bacteriality.com/2007/09/22/interview3/\|interview]]	+	Read the [[https://bacteriality.com/2007/09/22/interview3/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	sarcoidosis, psoriasis, insomnia, kidney stones		sarcoidosis, psoriasis, insomnia, kidney stones

-	Read the [[http://bacteriality.com/2007/08/10/interview1/\|interview]]	+	Read the [[https://bacteriality.com/2007/08/10/interview1/\|interview]]

	<html></div></div>		<html></div></div>
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	sarcoidosis, obsessive compulsive disorder, uveitis		sarcoidosis, obsessive compulsive disorder, uveitis

-	Read the [[http://bacteriality.com/2007/11/10/interview9\|interview]]	+	Read the [[https://bacteriality.com/2007/11/10/interview9\|interview]]

	<html></div></div></html>		<html></div></div></html>


-	[[http://www.marshallprotocol.com/forum30/7473.html\|Other people who are doing well]]	+	[[https://www.marshallprotocol.com/forum30/7473.html\|Other people who are doing well]]</nodisp>

Members & Diagnoses - [All patient interviews]

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-	Many vitamin D studies suffer from methodological errors including [[home:pathogenesis:vitamind:observational_bias\|bias inherent to using self-selected subjects]] and [[home:pathogenesis:vitamind:longterm\|insufficient followup]], but perhaps their most egregious liability comes in mistaking correlation for causation. (({{pubmed>long:27610068}}))	+	Many vitamin D studies suffer from methodological errors including [[home:pathogenesis:vitamind:observational_bias\|bias inherent to using self-selected subjects]] and [[home:pathogenesis:vitamind:longterm\|insufficient followup]], but perhaps their most egregious liability comes in mistaking correlation for causation. (({{pmid>long:27610068}}))

-	It's undisputed that a wide array of studies point to the fact that 25-hydroxyvitamin D (25-D) – typically referred to in the media as vitamin D – is low in people with numerous chronic inflammatory diseases. However, these studies fail to prove that low 25-D //causes// disease. Even so, some studies assume that doubling serum levels of 25-D would drastically reduce mortality.(({{pubmed>long:21731036}}))	+	It's undisputed that a wide array of studies point to the fact that 25-hydroxyvitamin D (25-D) – typically referred to in the media as vitamin D – is low in people with numerous chronic inflammatory diseases. However, these studies fail to prove that low 25-D //causes// disease. Even so, some studies assume that doubling serum levels of 25-D would drastically reduce mortality.(({{pmid>long:21731036}}))

	In fact, molecular science has revealed that the levels of the vitamin D metabolites through a [[home:pathogenesis:vitamind:mechanisms\|series of intricate and carefully controlled feedback pathways]], mechanisms that belie the simplistic first-order mass-action model used to guide the short-sighted vitamin studies. Also, epidemiological evidence suggests that while 25-D is low in chronic disease, 1,25-D (1,25-dihydroxyvitamin D) tends to be very high, an observation which is at odds with the theory that vitamin D deficiency causes or exacerbates disease.		In fact, molecular science has revealed that the levels of the vitamin D metabolites through a [[home:pathogenesis:vitamind:mechanisms\|series of intricate and carefully controlled feedback pathways]], mechanisms that belie the simplistic first-order mass-action model used to guide the short-sighted vitamin studies. Also, epidemiological evidence suggests that while 25-D is low in chronic disease, 1,25-D (1,25-dihydroxyvitamin D) tends to be very high, an observation which is at odds with the theory that vitamin D deficiency causes or exacerbates disease.
Line 14:		Line 14:
	<blockquote>There have been lots of observational studied showing an association between various diseases and vitamin D deficiency, but there is not any evidence yet that that is a casual relationship… it may be that vitamin D deficiency is a marker of ill health.		<blockquote>There have been lots of observational studied showing an association between various diseases and vitamin D deficiency, but there is not any evidence yet that that is a casual relationship… it may be that vitamin D deficiency is a marker of ill health.

-	//Dr. Ruth McQuillan, [[http://www.nutraingredients.com/Product-Categories/Vitamins-premixes/Scottish-islands-selected-for-new-vitamin-D-study\|University of Edinburgh]]//</blockquote>	+	//Dr. Ruth McQuillan, [[https://www.nutraingredients.com/Product-Categories/Vitamins-premixes/Scottish-islands-selected-for-new-vitamin-D-study\|University of Edinburgh]]//</blockquote>

	[{{ :home:pathogenesis:vitamind:enhanced-buzz-9201-1313871611-3.jpeg?350\|A classic mistake in correlation vs. causation. This vintage advertisement implies that children are skinny because they eat and drink sugar. In the current age of skyrocketing obesity rates, sugar probably gets more blame than it deserves, but no one would say that sugar protects against obesity.}}]		[{{ :home:pathogenesis:vitamind:enhanced-buzz-9201-1313871611-3.jpeg?350\|A classic mistake in correlation vs. causation. This vintage advertisement implies that children are skinny because they eat and drink sugar. In the current age of skyrocketing obesity rates, sugar probably gets more blame than it deserves, but no one would say that sugar protects against obesity.}}]
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	There are a number of examples where low levels of a substance are known to be associated with but not cause disease.		There are a number of examples where low levels of a substance are known to be associated with but not cause disease.
-	* Folic acid – Low levels of folic acid often lead to an increase in the amino acid homocysteine – a compound that at high levels has been linked to increased incidence of cardiovascular disease (CVD). Yet, extensive studies have revealed that giving patients with CVD folic acid supplements does not lower levels of homocysteine, and that high levels of homocysteine in patients with CVD is simply a result of the disease process.(({{pubmed>long:17309931}}))	+	* Folic acid – Low levels of folic acid often lead to an increase in the amino acid homocysteine – a compound that at high levels has been linked to increased incidence of cardiovascular disease (CVD). Yet, extensive studies have revealed that giving patients with CVD folic acid supplements does not lower levels of homocysteine, and that high levels of homocysteine in patients with CVD is simply a result of the disease process.(({{pmid>long:17309931}}))
-	* Estradiol – In a recent study, both low and high serum levels of estradiol (a type of sex hormone), compared with mid-range levels, are significantly and independently associated with increased all-cause mortality in men with chronic systolic heart failure.(({{pubmed>long:19436016}})) Yet, lead author Dr. Ewa Jankowska would quickly dismiss the idea that supplementation with estradiol reduces the risk of heart failure.	+	* Estradiol – In a recent study, both low and high serum levels of estradiol (a type of sex hormone), compared with mid-range levels, are significantly and independently associated with increased all-cause mortality in men with chronic systolic heart failure.(({{pmid>long:19436016}})) Yet, lead author Dr. Ewa Jankowska would quickly dismiss the idea that supplementation with estradiol reduces the risk of heart failure.

	<blockquote>Of course, the study does not suggest that low and high estradiol concentrations themselves were the cause of increased mortality.		<blockquote>Of course, the study does not suggest that low and high estradiol concentrations themselves were the cause of increased mortality.
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-	Even among those who support widespread supplementation with vitamin D on the basis of the "deficiency" studies, there is wide acknowledgement that the understanding of vitamin D metabolism is “imprecise.”(({{pubmed>long:17867374}}))	+	Even among those who support widespread supplementation with vitamin D on the basis of the "deficiency" studies, there is wide acknowledgement that the understanding of vitamin D metabolism is “imprecise.”(({{pmid>long:17867374}}))

-	Causation should never be assumed to be self-evident.(({{pubmed>long:11080970}})) Rigorous analysis is required, especially for a system as complicated as vitamin D metabolism.	+	Causation should never be assumed to be self-evident.(({{pmid>long:11080970}})) Rigorous analysis is required, especially for a system as complicated as vitamin D metabolism.

	<blockquote>Actually, there is no experience of causation: events do not wear their causal credentials on their faces.		<blockquote>Actually, there is no experience of causation: events do not wear their causal credentials on their faces.

-	//L.R. Karhausen// (({{pubmed>long:11080970}}))</blockquote>	+	//L.R. Karhausen// (({{pmid>long:11080970}}))</blockquote>

-	In the absence of an understanding grounded in molecular and clinical evidence, the comprehension of how vitamin D affects disease becomes "black box epidemiology." (({{pubmed>long:11080970}}))	+	In the absence of an understanding grounded in molecular and clinical evidence, the comprehension of how vitamin D affects disease becomes "black box epidemiology." (({{pmid>long:11080970}}))


Line 46:		Line 46:
	* sunshine exposure causes teenage pregnancy		* sunshine exposure causes teenage pregnancy

-	{{:home:pathogenesis:vitamind:teenpregnancy.001.gif\|Image from American Human Development Project of the Social Science Research Council. URL: http://measureofamerica.org/maps/}}	+	{{:home:pathogenesis:vitamind:teenpregnancy.001.gif\|Image from American Human Development Project of the Social Science Research Council. URL: https://measureofamerica.org/maps/}}


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	The practice of failing to measure 1,25-D is pervasive: the NIH continues to accept studies and a number of journals continue to publish papers.		The practice of failing to measure 1,25-D is pervasive: the NIH continues to accept studies and a number of journals continue to publish papers.

-	Further, mistaking 1,25-D for other forms is more common than one might think. A 2011 study actually gave "cholecalciferol" but called it elsewhere "1,25-dihydroxyvitamin-D."(({{pubmed>long:22004229}}))	+	Further, mistaking 1,25-D for other forms is more common than one might think. A 2011 study actually gave "cholecalciferol" but called it elsewhere "1,25-dihydroxyvitamin-D."(({{pmid>long:22004229}}))

	One of the reasons that 1,25-D isn't measured may be that it is harder to test. But another reason may be that a high 1,25-D is inconsistent with reports of vitamin D "deficiency." How can patients be said to be "deficient" in vitamin D when one of its metabolites, 1,25-D, is often several standard deviations greater than normal?		One of the reasons that 1,25-D isn't measured may be that it is harder to test. But another reason may be that a high 1,25-D is inconsistent with reports of vitamin D "deficiency." How can patients be said to be "deficient" in vitamin D when one of its metabolites, 1,25-D, is often several standard deviations greater than normal?
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	broken link [[http://www.theheart.org/article/971237.do\|Heartwire]]	+	broken link [[https://www.theheart.org/article/971237.do\|Heartwire]]

	* Jigsaw suggests:		* Jigsaw suggests:
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	Last edited on 18 Jul 2013 04:46 pm by Jigsaw		Last edited on 18 Jul 2013 04:46 pm by Jigsaw

-	===== References =====	+	===== References =====</nodisp>

07.14.2020		current
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	===== Attention Deficit =====		===== Attention Deficit =====

-	* [[http://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]	+	* [[https://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]


	===== Anxiety =====		===== Anxiety =====

-	* [[http://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]	+	* [[https://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]


	===== Arthritis =====		===== Arthritis =====

-	* [[http://bacteriality.com/2007/09/01/interview2/\|Interview with Ival Meyer - Arthritis, dyslexia]]	+	* [[https://bacteriality.com/2007/09/01/interview2/\|Interview with Ival Meyer - Arthritis, dyslexia]]

-	* [[http://bacteriality.com/2008/06/03/interview21/\|Interview with Roy P. - sarcoidosis, rheumatoid arthritis]]	+	* [[https://bacteriality.com/2008/06/03/interview21/\|Interview with Roy P. - sarcoidosis, rheumatoid arthritis]]


	===== Atrial fibrillation =====		===== Atrial fibrillation =====

-	* [[http://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]	+	* [[https://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]


	===== Autism =====		===== Autism =====

-	* [[http://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]	+	* [[https://bacteriality.com/2008/03/15/interview18/\|Interview with Doreen V. - autism, ADHD depression, severe anxiety, CFS]]


	===== Babesia =====		===== Babesia =====

-	* [[http://bacteriality.com/2007/09/22/interview3/\|Interview with Sue Andorn - Lyme, Babesia]]	+	* [[https://bacteriality.com/2007/09/22/interview3/\|Interview with Sue Andorn - Lyme, Babesia]]


	===== Bartonella (cat scratch disease) =====		===== Bartonella (cat scratch disease) =====

-	* [[http://bacteriality.com/2007/11/19/interview13/\|Interview with Sherry Cook - Sarcoidosis, Cat Scratch Fever, Restless Leg Syndrome]]	+	* [[https://bacteriality.com/2007/11/19/interview13/\|Interview with Sherry Cook - Sarcoidosis, Cat Scratch Fever, Restless Leg Syndrome]]


	===== Cancer =====		===== Cancer =====

-	* [[http://bacteriality.com/2008/07/18/interview24/\|Interview with Gene Johnson - sarcoidosis, bladder cancer]]	+	* [[https://bacteriality.com/2008/07/18/interview24/\|Interview with Gene Johnson - sarcoidosis, bladder cancer]]


	===== CFS (chronic fatigue syndrome) =====		===== CFS (chronic fatigue syndrome) =====

-	* [[http://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[http://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].	+	* [[https://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[https://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].

-	* [[http://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]	+	* [[https://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]

-	* [[http://bacteriality.com/2008/05/23/interview20/\|Interview with Peter de Jager: chronic fatigue syndrome, multiple chemical sensitivity]]	+	* [[https://bacteriality.com/2008/05/23/interview20/\|Interview with Peter de Jager: chronic fatigue syndrome, multiple chemical sensitivity]]


	===== Chronic spinal inflammation =====		===== Chronic spinal inflammation =====

-	* [[http://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]	+	* [[https://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]


	===== Coronary artery disease =====		===== Coronary artery disease =====

-	* [[http://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]	+	* [[https://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]

	===== Depression =====		===== Depression =====

-	* [[http://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[http://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].	+	* [[https://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[https://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].


	===== Diabetes =====		===== Diabetes =====

-	* [[http://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]	+	* [[https://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]


	===== Dyslexia =====		===== Dyslexia =====

-	* [[http://bacteriality.com/2007/09/01/interview2/\|Interview with Ival Meyer - Arthritis, dyslexia]]	+	* [[https://bacteriality.com/2007/09/01/interview2/\|Interview with Ival Meyer - Arthritis, dyslexia]]


	===== EMF sensitivities =====		===== EMF sensitivities =====

-	* [[http://www.marshallprotocol.com/view_user.php?id=12432&posts=1\|Recent posts by mvanwink5]]	+	* [[https://www.marshallprotocol.com/view_user.php?id=12432&posts=1\|Recent posts by mvanwink5]]

	===== Fibromyalgia =====		===== Fibromyalgia =====

-	* [[http://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]	+	* [[https://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]


	===== Food sensitivities =====		===== Food sensitivities =====

-	* [[http://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[http://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].	+	* [[https://bacteriality.com/2007/11/10/interview10/\|Interview with Paul Albert - CFS, depression, food sensitivities]]. [[https://www.marshallprotocol.com/view_user.php?id=41&posts=1\|Recent posts by PaulAlbert]].


	===== Insomnia =====		===== Insomnia =====

-	* [[http://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]	+	* [[https://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]


	===== Irritable bowel syndrome =====		===== Irritable bowel syndrome =====

-	* [[http://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]	+	* [[https://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]

-	* [[http://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]	+	* [[https://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]


	===== Lupus =====		===== Lupus =====

-	* [[http://bacteriality.com/2008/07/02/interview23/\|Interview with Bonnie B - lupus, Sjogren’s Syndrome]]	+	* [[https://bacteriality.com/2008/07/02/interview23/\|Interview with Bonnie B - lupus, Sjogren’s Syndrome]]


	===== Lyme disease =====		===== Lyme disease =====

-	* [[http://bacteriality.com/2007/09/22/interview3/\|Interview with Sue Andorn - Lyme, Babesia]]	+	* [[https://bacteriality.com/2007/09/22/interview3/\|Interview with Sue Andorn - Lyme, Babesia]]

-	* [[http://bacteriality.com/2007/10/28/interview6/\|Interview with Robyn Russell - Lyme, myoclonus]]	+	* [[https://bacteriality.com/2007/10/28/interview6/\|Interview with Robyn Russell - Lyme, myoclonus]]

-	* [[http://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]	+	* [[https://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]

-	* [[http://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]	+	* [[https://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]

-	* [[http://bacteriality.com/2008/03/31/interview19/\|Interview with Ken L. - Post Treatment Lyme Disease Syndrome (PTLDS)]]	+	* [[https://bacteriality.com/2008/03/31/interview19/\|Interview with Ken L. - Post Treatment Lyme Disease Syndrome (PTLDS)]]

-	* [[http://www.marshallprotocol.com/view_user.php?id=4677&posts=1\|Recent posts by jcocain]] - Lyme	+	* [[https://www.marshallprotocol.com/view_user.php?id=4677&posts=1\|Recent posts by jcocain]] - Lyme


	===== MCS (multiple chemical sensitivities) =====		===== MCS (multiple chemical sensitivities) =====

-	* [[http://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]	+	* [[https://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]

-	* [[http://bacteriality.com/2008/05/23/interview20/\|Interview with Peter de Jager: chronic fatigue syndrome, multiple chemical sensitivity]]	+	* [[https://bacteriality.com/2008/05/23/interview20/\|Interview with Peter de Jager: chronic fatigue syndrome, multiple chemical sensitivity]]


	===== Myoclonus =====		===== Myoclonus =====

-	* [[http://bacteriality.com/2007/10/28/interview6/\|Interview with Robyn Russell - Lyme, myoclonus]]	+	* [[https://bacteriality.com/2007/10/28/interview6/\|Interview with Robyn Russell - Lyme, myoclonus]]


	===== OCD (obsessive compulsive disorder) =====		===== OCD (obsessive compulsive disorder) =====

-	* [[http://bacteriality.com/2007/11/10/interview9/\|Interview with Julia Grier — Sarcoidosis, OCD, uveitis]]	+	* [[https://bacteriality.com/2007/11/10/interview9/\|Interview with Julia Grier — Sarcoidosis, OCD, uveitis]]

	===== Peripheral Neuropathy =====		===== Peripheral Neuropathy =====

-	* [[http://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]	+	* [[https://bacteriality.com/2007/12/28/interview14/\|Interview with P. Bear R.N. – Chronic Borreliosis (”Lyme”), MCS (multiple chemical sensitivities), Chronic Spinal Inflammation, Peripheral Neuropathy]]


	===== Psoriasis =====		===== Psoriasis =====

-	* [[http://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]	+	* [[https://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]


	===== Radiculitis =====		===== Radiculitis =====

-	* [[http://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]	+	* [[https://bacteriality.com/2008/02/17/interview16/\|Interview with Melinda Stiles – Lyme, Irritable bowel syndrome/colitis, Radiculitis (inflammation of the nerve roots)]]


	===== Restless leg syndrome =====		===== Restless leg syndrome =====

-	* [[http://bacteriality.com/2007/11/19/interview13/\|Interview with Sherry Cook - Sarcoidosis, Cat Scratch Fever, Restless Leg Syndrome]]	+	* [[https://bacteriality.com/2007/11/19/interview13/\|Interview with Sherry Cook - Sarcoidosis, Cat Scratch Fever, Restless Leg Syndrome]]


	===== Sarcoidosis =====		===== Sarcoidosis =====

-	* [[http://bacteriality.com/2007/11/04/interview7/\|Interview with Shirley J. (Saj) - Sarcoidosis]]	+	* [[https://bacteriality.com/2007/11/04/interview7/\|Interview with Shirley J. (Saj) - Sarcoidosis]]

-	* [[http://bacteriality.com/2007/11/17/interview11/\|Interview with Mirek Wozga - sarcoidosis]]	+	* [[https://bacteriality.com/2007/11/17/interview11/\|Interview with Mirek Wozga - sarcoidosis]]

-	* [[http://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]	+	* [[https://bacteriality.com/2008/01/18/interview15/\|Interview with Freddie Ash - Sarcoidosis of the heart, coronary artery disease, atrial fibrillation]]

-	* [[http://bacteriality.com/2008/03/02/interview17/\|Interview with JST: Neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement]]	+	* [[https://bacteriality.com/2008/03/02/interview17/\|Interview with JST: Neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement]]

-	* [[http://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]	+	* [[https://bacteriality.com/2007/08/10/interview1/\|Interview with Guss Wilkinson - Sarcoidosis, psoriasis, insomnia]]

-	* [[http://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]	+	* [[https://bacteriality.com/2007/11/08/interview8/\|Interview with Carole Morgan - Sarcoidosis, fibromyalgia, CFS]]

-	* [[http://bacteriality.com/2008/07/18/interview24/\|Interview with Gene Johnson - sarcoidosis, bladder cancer]]	+	* [[https://bacteriality.com/2008/07/18/interview24/\|Interview with Gene Johnson - sarcoidosis, bladder cancer]]

-	* [[http://bacteriality.com/2007/11/19/interview12/\|Interview with Leesa Shanahan - Sarcoidosis (Hedfort Syndrome), Uveitis]]	+	* [[https://bacteriality.com/2007/11/19/interview12/\|Interview with Leesa Shanahan - Sarcoidosis (Hedfort Syndrome), Uveitis]]

-	* [[http://bacteriality.com/2008/06/03/interview21/\|Interview with Roy P. - sarcoidosis, rheumatoid arthritis]]	+	* [[https://bacteriality.com/2008/06/03/interview21/\|Interview with Roy P. - sarcoidosis, rheumatoid arthritis]]

-	* [[http://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]	+	* [[https://bacteriality.com/2008/06/19/interview22/\|Interview with Chris Eastlund - diabetes, sarcoidosis, irritable bowel syndrome]]

-	* [[http://www.marshallprotocol.com/view_user.php?id=10560&posts=1\|Recent posts by didierchretien]] - Sarcoidosis	+	* [[https://www.marshallprotocol.com/view_user.php?id=10560&posts=1\|Recent posts by didierchretien]] - Sarcoidosis


	===== Sjogren’s Syndrome =====		===== Sjogren’s Syndrome =====

-	* [[http://bacteriality.com/2008/07/02/interview23/\|Interview with Bonnie B - lupus, Sjogren’s Syndrome]]	+	* [[https://bacteriality.com/2008/07/02/interview23/\|Interview with Bonnie B - lupus, Sjogren’s Syndrome]]


	===== Uveitis =====		===== Uveitis =====

-	* [[http://bacteriality.com/2007/11/10/interview9/\|Interview with Julia Grier — Sarcoidosis, OCD, uveitis]]	+	* [[https://bacteriality.com/2007/11/10/interview9/\|Interview with Julia Grier — Sarcoidosis, OCD, uveitis]]

-	* [[http://bacteriality.com/2007/11/19/interview12/\|Interview with Leesa Shanahan - Sarcoidosis (Hedfort Syndrome), Uveitis]]	+	* [[https://bacteriality.com/2007/11/19/interview12/\|Interview with Leesa Shanahan - Sarcoidosis (Hedfort Syndrome), Uveitis]]


Line 204:		Line 204:


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 212:		Line 213:
	\\		\\
	TEMPLATES		TEMPLATES
-	* <nowiki>[[http://www.marshallprotocol.com/view_user.php?id=oooooo&posts=1\|Recent posts by ScreenNAME]] - DIAGNOSES</nowiki>	+	* <nowiki>[[https://www.marshallprotocol.com/view_user.php?id=oooooo&posts=1\|Recent posts by ScreenNAME]] - DIAGNOSES</nowiki>
	* <nowiki>[[interviewLINK\|InterviewTITLE]]</nowiki>		* <nowiki>[[interviewLINK\|InterviewTITLE]]</nowiki>
-	* <nowiki>[[interviewLINK\|InterviewTITLE]]. [[http://www.marshallprotocol.com/view_user.php?id=oooooo&posts=1\|Recent posts by ScreenNAME]]</nowiki>	+	* <nowiki>[[interviewLINK\|InterviewTITLE]]. [[https://www.marshallprotocol.com/view_user.php?id=oooooo&posts=1\|Recent posts by ScreenNAME]]</nowiki></nodisp>