Marshall Protocol Knowledge Base

Publications & presentations - [Blog]

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	===== Blog =====		===== Blog =====

-	Dr Amy Proal: [[https://MicrobeMinded.com\|Microbe Minded]]	+	Dr Amy Proal: [[https://MicrobeMinded2.com\|Microbe Minded]]

	===== Newsletters =====		===== Newsletters =====

Site map - external edit

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	{{topic>incomplete}}		{{topic>incomplete}}

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Presentation - Immune Disease and the Microbiome: PPPM Healthcare in response to New Knowledge

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marshall_moscow-pppm_2016_1_.pdf - created

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vestnik_spbsu_tm_preprint_1_.pdf - created

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Travel and outdoor activities

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radiofrequencies_in_cars-automobiles_1_.pdf - created

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Aiming at Health

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Autoimmunity Research Foundation

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	====== Autoimmunity Research Foundation ======		====== Autoimmunity Research Foundation ======

-	The [[https://autoimmunityresearch.org\|Autoimmunity Research Foundation]] is a California-based non-profit organization formed to conduct scientific research into the cause and cure of autoimmune and other chronic non-autoimmune diseases, and to instruct the public on subjects related to disease, useful to individuals and beneficial to the community.	+	The [[.:arf:\|Autoimmunity Research Foundation]] is a California-based non-profit organization formed to conduct scientific research into the cause and cure of autoimmune and other chronic non-autoimmune diseases, and to instruct the public on subjects related to disease, useful to individuals and beneficial to the community.
-	* [[https://autoimmunityresearch.org/vision/about/\|About the Foundation]]	+
	* [[https://www.youtube.com/user/DrTrevorMarshall?feature=watch/\|Video Resources]]		* [[https://www.youtube.com/user/DrTrevorMarshall?feature=watch/\|Video Resources]]

Hormonal symptoms - [hormonal changes]

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	<note>Dear MPKB Reader: You have arrived at one of the articles that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we are still working on. Thanks for your patience.</note>		<note>Dear MPKB Reader: You have arrived at one of the articles that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we are still working on. Thanks for your patience.</note>

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Site organization - [Site organization]

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Marshall Protocol forum policies - [Marshall Protocol forum policies]

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Forum Etiquette - [Relevant topics]

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About Radio Frequency Radiation - [About Radio Frequency Radiation]

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	{{tag>EMF Lifestyle_modifications protection meter}}		{{tag>EMF Lifestyle_modifications protection meter}}

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building_a_diy_faraday-cage_1_.pdf - created

ron@undisclosed.example.com (ron) — Wed, 11 Nov 2026 07:27:04 +0000

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Metabolism of vitamin D and the Vitamin D Receptor

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	{{tag>pathogenesis Science_behind_vitamin_D}}		{{tag>pathogenesis Science_behind_vitamin_D}}
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The over-exuberant Stage-Five immune response - [Read more]

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Poster - Molecular static and dynamic analyses reveal flaw in murine model used by US FDA to ...

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	from PCs based on Core-2-duo CPU technologies. The		from PCs based on Core-2-duo CPU technologies. The
	difference in steady-state ligand conformation between		difference in steady-state ligand conformation between
-	human and rat VDR can clearly be seen at in {{ :home:publications:dmm2007.rm \|}}, many of which are	+	human and rat VDR can clearly be seen at {{ :home:publications:dmm2007.rm \|}}, many of which are
	known to be associated with cancer pathogenesis, good homology		known to be associated with cancer pathogenesis, good homology
	between human VDR, and the animal model VDR, is exceedingly		between human VDR, and the animal model VDR, is exceedingly

Applications to the FDA for orphan drug status for Marshall Protocol medications - [Clindamycin]

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-	* submitted by ARF (September 2005) - [[https://autoimmunityresearch.org/orphan-clindamycin-25jul06.pdf\|Application for Orphan Drug Status]] for clindamycin in treatment of sarcoidosis and Post-Treatment Lyme Disease Syndrome	+	* submitted by ARF (September 2005) - {{ :home:publications:orphan-minocycline-25jul06.pdf \|Application for Orphan Drug Status}} for clindamycin in treatment of sarcoidosis and Post-Treatment Lyme Disease Syndrome
	* FDA approval (August 2006) - [[https://www.fda.gov/orphan/designat/alldes.rtf\|clindamycin]] as an orphan drug for sarcoidosis		* FDA approval (August 2006) - [[https://www.fda.gov/orphan/designat/alldes.rtf\|clindamycin]] as an orphan drug for sarcoidosis

Poster - VDR nuclear receptor is key to recovery from cognitive dysfunction

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-	During DMM 2006 we reported that chronic inflammatory disease, including much 'autoimmune' disease, was caused by an intraphagocytic biofilm-like microbiota. Recovery followed activation of the VDR with Olmesartan, and long-term administration of subinhibitory antibiotics. Surprisingly, as the inflammatory disease disappeared from the subjects in that cohort, manifestations of comorbid neurological disease also receded. Memory and cognition returned as the inflammation waned, while suicidal ideation, depression, bipolar disorder, peripheral neuropathies and even obsessive compulsive disorder, receded. Additionally, we found that the neurological symptoms fluctuated with the level of Immunopathology during the healing process, presenting special problems with cohort management. The VDR is at the heart of the innate immune system, responsible for expression of a majority of the body's antimicrobial peptides(({{pmid>long:18200565}})). Changes in lifestyle and medicine during the 20th century have created an environment favorable to the proliferation of pathogens which evade the immune system by suppressing activation of the VDR((Marshall TG: Bacterial Capnine Blocks Transcription of Human Antimicrobial Peptides. Abstract presentation, Metagenomics 2007, San Diego, July 11-13, 2007. DOI 10.1038/npre.2007.164.1 Available from URL https://autoimmunityresearch.org/transcripts/metagenomics2007.pdf)). Kandel identified that short term memory involves activation of PKA((Eric R Kandel: The Molecular Biology of Memory Storage: A Dialog between Genes and Synapses. Nobel Lecture, Dec 8, 2000.)). We have determined that activation of PKA is regulated by the process of VDR homeostasis in chronic immune disease, pointing towards a putative mechanism whereby immune dysfunction can directly suppress short-term memory. However the above subjects not only reported the return of short term memory, but also of mid-term and long-term memory. The molecular mechanisms linking immune dysfunction and cognitive dysfunction are clearly profound. We propose that studies of linked dysfunction will provide more insight than studies of neurological manifestations alone.	+	During DMM 2006 we reported that chronic inflammatory disease, including much 'autoimmune' disease, was caused by an intraphagocytic biofilm-like microbiota. Recovery followed activation of the VDR with Olmesartan, and long-term administration of subinhibitory antibiotics. Surprisingly, as the inflammatory disease disappeared from the subjects in that cohort, manifestations of comorbid neurological disease also receded. Memory and cognition returned as the inflammation waned, while suicidal ideation, depression, bipolar disorder, peripheral neuropathies and even obsessive compulsive disorder, receded. Additionally, we found that the neurological symptoms fluctuated with the level of Immunopathology during the healing process, presenting special problems with cohort management. The VDR is at the heart of the innate immune system, responsible for expression of a majority of the body's antimicrobial peptides(({{pmid>long:18200565}})). Changes in lifestyle and medicine during the 20th century have created an environment favorable to the proliferation of pathogens which evade the immune system by suppressing activation of the VDR((Marshall TG: Bacterial Capnine Blocks Transcription of Human Antimicrobial Peptides. Abstract presentation, Metagenomics 2007, San Diego, July 11-13, 2007. DOI 10.1038/npre.2007.164.1 {{ :home:arf:metagenomics2007.pdf \|}}. Kandel identified that short term memory involves activation of PKA((Eric R Kandel: The Molecular Biology of Memory Storage: A Dialog between Genes and Synapses. Nobel Lecture, Dec 8, 2000.)). We have determined that activation of PKA is regulated by the process of VDR homeostasis in chronic immune disease, pointing towards a putative mechanism whereby immune dysfunction can directly suppress short-term memory. However the above subjects not only reported the return of short term memory, but also of mid-term and long-term memory. The molecular mechanisms linking immune dysfunction and cognitive dysfunction are clearly profound. We propose that studies of linked dysfunction will provide more insight than studies of neurological manifestations alone.
	{{tag>posters videos Trevor_Marshall_PhD DMM 2008}}		{{tag>posters videos Trevor_Marshall_PhD DMM 2008}}

	===== References =====		===== References =====

Presentation - Vitamins D in chronic disease - [Presentation - Vitamins D in chronic disease]

ron@undisclosed.example.com (ron) — Tue, 10 Nov 2026 21:18:33 +0000

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	Location: Los Angeles, CA\\		Location: Los Angeles, CA\\
	Date: June 17-18, 2006\\		Date: June 17-18, 2006\\
-	Related content: [[https://autoimmunityresearch.org/transcripts/waterhouse_lax2006.pdf\|slides and transcript]]\\	+	Related content: {{ :home:publications:waterhouse_lax2006.pdf \|slides and transcript}}\\

waterhouse_lax2006.pdf - created

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Poster - Cognitive dysfunction in women with chronic fatigue syndrome: examining the role of ...

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	Location: Karolinska Institue, Sweden\\		Location: Karolinska Institue, Sweden\\
	Date: April 17-19, 2008\\		Date: April 17-19, 2008\\
-	Additional content: [[https://autoimmunityresearch.org/dmm2008/DMM2008_Amy_Poster.pdf\|poster]]; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/04/25/dmm/\|Notes from the Conference]] by Amy Proal\\	+	Additional content: {{ :home:publications:dmm2008_amy_poster.pdf \|poster}}; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/04/25/dmm/\|Notes from the Conference]] by Amy Proal\\
	Notes: presentation begins at 28:13;		Notes: presentation begins at 28:13;

dmm2008_amy_poster.pdf - created

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Presentation - Bacteria induced vitamin D receptor dysfunction in autoimmune disease: ...

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	Location: Porto, Portugal\\		Location: Porto, Portugal\\
	Date: September 11, 2008\\		Date: September 11, 2008\\
-	See also:	+	See also: {{ :home:publications:ica2008_transcript_tomperez.pdf \|Transcript and slides}}; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/09/22/coa/\|Notes from the 2008 International Congress on Autoimmunity]] by Amy Proal; [[mp2008_survey\|More study results]]
-	[[https://autoimmunityresearch.org/transcripts/ICA2008_Transcript_TomPerez.pdf\|Transcript and slides]]; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/09/22/coa/\|Notes from the 2008 International Congress on Autoimmunity]] by Amy Proal; [[mp2008_survey\|More study results]]	+

ica2008_transcript_tomperez.pdf - created

ron@undisclosed.example.com (ron) — Tue, 10 Nov 2026 21:09:43 +0000

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Poster - Bacterial capnine blocks transcription of human antimicrobial peptides

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	to Recovery from Chronic Inflammatory and Autoimmune		to Recovery from Chronic Inflammatory and Autoimmune
	Disease. Abstract presentation, DMM2006, Karolinska		Disease. Abstract presentation, DMM2006, Karolinska
-	Institute, May 2006. Copy available from URL	+	Institute, May 2006. {{ :home:publications:karolinska-handout.pdf \|}}
-	https://autoimmunityresearch.org/karolinska-handout.pdf))	+

	{{tag>posters Trevor_Marshall_PhD Metagenomics capnine antimicrobial_peptides 2007}}		{{tag>posters Trevor_Marshall_PhD Metagenomics capnine antimicrobial_peptides 2007}}

	===== References =====		===== References =====

metagenomics2007.pdf - created

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Presentation - What can microbial genomes tell us about human health?

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	Location: Saint Petersburg, Russia\\		Location: Saint Petersburg, Russia\\
	Date: June, 2012\\		Date: June, 2012\\
-	Additional content: [[https://autoimmunityresearch.org/transcripts/StPetersburg_2012_Marshall.pdf\|PDF Transcript]]	+	Additional content: {{ :home:publications:stpetersburg_2012_marshall.pdf \|PDF Transcript}}

	{{tag>presentations videos Trevor_Marshall_PhD 2012}}		{{tag>presentations videos Trevor_Marshall_PhD 2012}}

stpetersburg_2012_marshall.pdf - created

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	Location: Los Angeles, CA\\		Location: Los Angeles, CA\\
	Date: June 17-18, 2006\\		Date: June 17-18, 2006\\
-	Related content: [[https://autoimmunityresearch.org/transcripts/waterhouse_lax2006.pdf\|slides and transcript]]\\	+	Related content: {{ :home:publications:waterhouse_lax2006.pdf \|slides and transcript}}\\

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	Location: Karolinska Institue, Sweden\\		Location: Karolinska Institue, Sweden\\
	Date: April 17-19, 2008\\		Date: April 17-19, 2008\\
-	Additional content: [[https://autoimmunityresearch.org/dmm2008/DMM2008_Amy_Poster.pdf\|poster]]; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/04/25/dmm/\|Notes from the Conference]] by Amy Proal\\	+	Additional content: {{ :home:publications:dmm2008_amy_poster.pdf \|poster}}; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/04/25/dmm/\|Notes from the Conference]] by Amy Proal\\
	Notes: presentation begins at 28:13;		Notes: presentation begins at 28:13;

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	Location: Porto, Portugal\\		Location: Porto, Portugal\\
	Date: September 11, 2008\\		Date: September 11, 2008\\
-	See also:	+	See also: {{ :home:publications:ica2008_transcript_tomperez.pdf \|Transcript and slides}}; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/09/22/coa/\|Notes from the 2008 International Congress on Autoimmunity]] by Amy Proal; [[mp2008_survey\|More study results]]
-	[[https://autoimmunityresearch.org/transcripts/ICA2008_Transcript_TomPerez.pdf\|Transcript and slides]]; [[https://web.archive.org/web/20090105185842/http://bacteriality.com/2008/09/22/coa/\|Notes from the 2008 International Congress on Autoimmunity]] by Amy Proal; [[mp2008_survey\|More study results]]	+