Marshall Protocol Knowledge Base - home

Alternative models for chronic disease

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Autoimmunity Research Foundation

anonymous@undisclosed.example.com (Anonymous) — Mon, 04 Jul 2022 12:06:16 +0000

05.29.2020		current
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	====== Autoimmunity Research Foundation ======		====== Autoimmunity Research Foundation ======

-	The [[http://autoimmunityresearch.org\|Autoimmunity Research Foundation]] is a California-based non-profit organization formed to conduct scientific research into the cause and cure of autoimmune and other chronic non-autoimmune diseases, and to instruct the public on subjects related to disease, useful to individuals and beneficial to the community.	+	The [[https://autoimmunityresearch.org\|Autoimmunity Research Foundation]] is a California-based non-profit organization formed to conduct scientific research into the cause and cure of autoimmune and other chronic non-autoimmune diseases, and to instruct the public on subjects related to disease, useful to individuals and beneficial to the community.
-		+	* [[https://autoimmunityresearch.org/vision/about/\|About the Foundation]]
	* [[https://www.youtube.com/user/DrTrevorMarshall?feature=watch/\|Video Resources]]		* [[https://www.youtube.com/user/DrTrevorMarshall?feature=watch/\|Video Resources]]

Development

anonymous@undisclosed.example.com (Anonymous) — Tue, 03 Jan 2012 04:20:37 +0000

01.26.2011		current
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	====== Development ======		====== Development ======

-	<html>	+
-	<!--	+
-	* [[home:devel:customizations\|Customizations and plugins]]	+
-	* [[home:devel:styleguide\|Style Guidelines and Best Practices]]	+
-	* [[home:devel:legacyindex\|Marshall Protocol Legacy Link Index]]	+
-	* [[home:devel:joyful\|Joyful's Notes]]	+
-	* [[home:devel:paul\|Paul's Notes]]	+
-	* [[home:devel:logo\|Logo]]	+
-	-->	+
-	</html>	+

	{{pagequery>@home:devel;sort=name}}		{{pagequery>@home:devel;sort=name}}

Diseases

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

02.22.2019		current
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	Some diseases are represented by more patients trying the therapy than others. As more patients join the MP cohort, the Autoimmunity Research Foundation will gather more data about the efficacy of the treatment with respect to individual diseases. In the meantime, the MP may be an appropriate treatment option for some of the diseases listed below.		Some diseases are represented by more patients trying the therapy than others. As more patients join the MP cohort, the Autoimmunity Research Foundation will gather more data about the efficacy of the treatment with respect to individual diseases. In the meantime, the MP may be an appropriate treatment option for some of the diseases listed below.

-	[[home:patients:patient_interviews\|Approximately twenty patients]] have shared their stories of recovery on [[http://bacteriality.com/\|Bacteriality.com]].	+	[[home:patients:patient_interviews\|Many patients]] have shared their stories of recovery on [[https://www.marshallprotocol.com/\|Marshall protocol study site]].

	===== What is a chronic inflammatory disease? =====		===== What is a chronic inflammatory disease? =====
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	===== Microbial communication =====		===== Microbial communication =====

-	Here we show that an EHEC luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal to activate expression of its virulence genes. We have identified this signal as the hormone epinephrine and show that β- and α-adrenergic antagonists can block the bacterial response to this hormone. (({{pubmed>long:12847292}}))	+	Here we show that an EHEC luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal to activate expression of its virulence genes. We have identified this signal as the hormone epinephrine and show that β- and α-adrenergic antagonists can block the bacterial response to this hormone. (({{pmid>long:12847292}}))

-	The contribution of cell-cell signaling and motility to bacterial biofilm formation. (({{pubmed>long:22053126}}))	+	The contribution of cell-cell signaling and motility to bacterial biofilm formation. (({{pmid>long:22053126}}))

-	Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.(({{pubmed>long:28902153}}))	+	Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes.(({{pmid>long:28902153}}))


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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-	<blockquote>Does Helicobater pylori infection play a role in extragastric diseases?{{pubmed>long:18249521}}	+	<blockquote>Does Helicobater pylori infection play a role in extragastric diseases?{{pmid>long:18249521}}

	more options		more options
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	PMS:		PMS:
-	http://www.ncbi.nlm.nih.gov/pubmed/17468538?dopt=Abstract	+	https://www.ncbi.nlm.nih.gov/pubmed/17468538?dopt=Abstract



-	<blockquote>I just got the all clear from CNS Vasculitis in less than 2 years and I would like that to show in the MPKB for the benefit of any Savvy vasculitis members who come across, I write periodically on the Savvy chat site about the protocol though I haven't seen any evidence of people taking notice except Lew newmark who wrote about it here:- http://mlcss.com/2010/10/13/the-keith-waterhouse-interview-part-three/	+	<blockquote>I just got the all clear from CNS Vasculitis in less than 2 years and I would like that to show in the MPKB for the benefit of any Savvy vasculitis members who come across, I write periodically on the Savvy chat site about the protocol though I haven't seen any evidence of people taking notice except Lew newmark who wrote about it here:- https://mlcss.com/2010/10/13/the-keith-waterhouse-interview-part-three/
	</blockquote>		</blockquote>

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	<blockquote>From: Phillyguy		<blockquote>From: Phillyguy
	Date: 2011-05-10 13:23:42		Date: 2011-05-10 13:23:42
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13412	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13412

	Korean J Urol. 2011 vol. 52(3) pp. 194-9		Korean J Urol. 2011 vol. 52(3) pp. 194-9
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	From: ChrisMavo		From: ChrisMavo
	Date: 2011-05-10 13:29:58		Date: 2011-05-10 13:29:58
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13412	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13412

	Can someone explain what they mean by nanobacteria? This is the first time I've seen this term used for bacteria. Could this be the first indication of a whole new category of bacteria that has not been uncovered yet? Are these nanobacteria the main component of what we call the microbiota?		Can someone explain what they mean by nanobacteria? This is the first time I've seen this term used for bacteria. Could this be the first indication of a whole new category of bacteria that has not been uncovered yet? Are these nanobacteria the main component of what we call the microbiota?
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	From: Bane		From: Bane
	Date: 2011-05-10 14:14:45		Date: 2011-05-10 14:14:45
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13412	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13412

	ChrisMavo wrote: Can someone explain what they mean by nanobacteria?		ChrisMavo wrote: Can someone explain what they mean by nanobacteria?
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-	http://tiny.cc/1lxnw	+	https://tiny.cc/1lxnw

	</blockquote>		</blockquote>
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	High levels of Epstein–Barr virus in COPD		High levels of Epstein–Barr virus in COPD

-	http://erj.ersjournals.com/content/31/6/1221.long	+	https://erj.ersjournals.com/content/31/6/1221.long


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-	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854762/	+	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854762/


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	From: LeeDate: 2011-11-01 07:44:01		From: LeeDate: 2011-11-01 07:44:01
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13718	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13718


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	From: eClaire		From: eClaire
	Date: 2011-11-01 11:07:07		Date: 2011-11-01 11:07:07
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13718	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13718


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	PMID: 21376827		PMID: 21376827

-	</blockquote>	+	</blockquote></nodisp>

Health, food and drink

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Immune suppressive environments

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

09.23.2018		current
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	{{tag>incomplete}}	+	{{tag> }}
		+
		+	--- //Sallie Q 06.24.2018// new section using waves development pages containing materials info found by wirion and assembled material from MPSS>> How Radio Waves Make You Sicker - discussions</nodisp>

-	--- //Sallie Q 06.24.2018// new section using waves development pages containing materials info found by wirion and assembled material from MPSS>> How Radio Waves Make You Sicker - discussions

Site map

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

11.26.2018		current
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	====== Site map ======		====== Site map ======
		+
	~~NOCACHE~~		~~NOCACHE~~
	This page provides a folder/explore style site map that allows you to browse by category or simply search the page for key words of interest.		This page provides a folder/explore style site map that allows you to browse by category or simply search the page for key words of interest.

-	Following the site map there is a [[home:index#incomplete_articles\|list of incomplete articles]] that are awaiting editorial effort.	+	Following the site map there is a [[home:index#incomplete_articles\|list of incomplete articles]] that are awaiting editorial effort. Some of these articles can not be completed until the temporary forum [[https://www.curemyth1.org/forum2/2626.html\|CuremyTh1 disease]] is again available (not a current priority).


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	{{topic>incomplete}}		{{topic>incomplete}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	D debate https://www.marshallprotocol.com/forum43/12931.html		D debate https://www.marshallprotocol.com/forum43/12931.html

		+	</nodisp>

Lifestyle modifications

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

05.25.2019		current
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	For someone who is interested in facts and figures, member DJ compiled some in the following section including 5 Dx		For someone who is interested in facts and figures, member DJ compiled some in the following section including 5 Dx

-	[[home:mp#response_in_5_diagnoses\|MP]]	+	[[home:mp#recovery_figures\|MP data]]


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	To have all these switched off at power point when not in use will provide considerable benefit to the ill and protection for young or vulnerable people. Cell phones should be left in Flight mode when not calling out or expecting VIP call.		To have all these switched off at power point when not in use will provide considerable benefit to the ill and protection for young or vulnerable people. Cell phones should be left in Flight mode when not calling out or expecting VIP call.

-	[[http://magazine.nd.edu/news/i-am-an-emf-refugee/\|edu/news emf-refugee]]	+	[[https://magazine.nd.edu/news/i-am-an-emf-refugee/\|edu/news emf-refugee]]

	<blockquote>Just get rid of your DECT phones. No 'ifs' or 'buts'. Get rid of your WiFi routers, and enable Aircraft mode on everything (like Kindles) that send out WiFi 'beacons' every so often. All of these sources essentially operate at full power whenever they transmit. //Prof. Trevor Marshall May 2017//</blockquote>		<blockquote>Just get rid of your DECT phones. No 'ifs' or 'buts'. Get rid of your WiFi routers, and enable Aircraft mode on everything (like Kindles) that send out WiFi 'beacons' every so often. All of these sources essentially operate at full power whenever they transmit. //Prof. Trevor Marshall May 2017//</blockquote>
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	{{tag>summary lifestyle Lifestyle_modifications emf}}		{{tag>summary lifestyle Lifestyle_modifications emf}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	--- //Sallie Q 04.04.2017// adds para. on avoiding ingested immune suppressants and external pollution		--- //Sallie Q 04.04.2017// adds para. on avoiding ingested immune suppressants and external pollution

		+	</nodisp>

Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Non-MP therapies

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Science behind Pathogenesis

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

04.12.2018		current
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	<relatedarticles> [[home:protocol\|Science behind Protocol]], [[home:patients:pathogenesis_overview\|Introduction to the Marshall Pathogenesis]] </article>		<relatedarticles> [[home:protocol\|Science behind Protocol]], [[home:patients:pathogenesis_overview\|Introduction to the Marshall Pathogenesis]] </article>

-	The Marshall Pathogenesis, upon which the Marshall Protocol is grounded, is a description for how bacteria interfere with the innate immune response. These pathogens survive and reproduce by disrupting the Vitamin D Nuclear Receptor, an evolutionarily consistent mechanism for survival, which leads to the development of chronic inflammatory diseases. Because these diseases are fundamentally bacterial in nature, the conditions are referred to as the "Th1 diseases." The Marshall Pathogenesis is supported by an emerging array of evidence, including clinical evidence, evolutionary evidence, some //in silico// data, and environmental sampling studies.	+	The Marshall Paradigm, upon which the Marshall Protocol is grounded, is a description for how bacteria interfere with the innate immune response. These pathogens survive and reproduce by disrupting the Vitamin D Nuclear Receptor, an evolutionarily consistent mechanism for survival, which leads to the development of chronic inflammatory diseases. Because these diseases are fundamentally bacterial in nature, the conditions are referred to as the "Th1 diseases." The Marshall Pathogenesis is supported by an emerging array of evidence, including clinical evidence, evolutionary evidence, some //in silico// data, and environmental sampling studies.

	=====Microbes in the human body=====		=====Microbes in the human body=====
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	<blockquote> the effect of anthropogenic electromagnetic noise on bird migration is localised. However these findings should make us think -- both about the survival of migratory birds as well as about the potential effects for human beings, which have yet to be investigated,</blockquote>		<blockquote> the effect of anthropogenic electromagnetic noise on bird migration is localised. However these findings should make us think -- both about the survival of migratory birds as well as about the potential effects for human beings, which have yet to be investigated,</blockquote>

-	[[http://mieuxprevenir.blogspot.com.au/2014/01/france-law-on-electromagnetic-waves-in.html\|France is leading the world in the precautionary principle]]	+	[[https://mieuxprevenir.blogspot.com.au/2014/01/france-law-on-electromagnetic-waves-in.html\|France is leading the world in the precautionary principle]]
	=====Alternate models for chronic disease =====		=====Alternate models for chronic disease =====

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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	*		*

-	===== References =====	+	===== References =====</nodisp>

Resources for patients

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

09.01.2019		current
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	{{section>:home:patients:cohort_statistics#statistics_on_the_marshall_protocol&noheader}}		{{section>:home:patients:cohort_statistics#statistics_on_the_marshall_protocol&noheader}}
-
-
-	==== Patient interviews ====
-
-	<mainarticle> [[home:patients:patient_interviews\|Patient interviews]] </article>
-
-	Several dozen patients, representing a range of inflammatory diagnoses, have shared their stories of recovery on Bacteriality.com.


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	===== Making sense of the Marshall Protocol =====		===== Making sense of the Marshall Protocol =====

-	The explanation for why the Marshall Protocol works can get sophisticated. To help patients understand all of the terminology being used, a [[home:patients:glossary\|glossary of scientific terms]] is available, as well as a list of [[home:patients:abbreviations\|medical abbreviations]] used on the [[http://marshallprotocol.com\|Marshall Protocol Study Site]].	+	The explanation for why the Marshall Protocol works can get sophisticated. To help patients understand all of the terminology being used, a [[home:patients:glossary\|glossary of scientific terms]] is available, as well as a list of [[home:patients:abbreviations\|medical abbreviations]] used on the [[https://marshallprotocol.com\|Marshall Protocol Study Site]].


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	{{tag> resource}}		{{tag> resource}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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-	===== References =====	+	===== References =====</nodisp>

Resources for physicians

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Science behind Marshall Paradigm

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

08.23.2014		current
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-	====== Science behind Marshall Protocol ======	+	====== Science behind Marshall Paradigm ======

	The Marshall Protocol (MP) is based on the Marshall Pathogenesis, which posits that chronic diseases (termed [[.:pathogenesis:th1spectrum\|Th1 illnesses]]), are the result of infection by an intraphagocytic, [[.:pathogenesis:microbiota\|metagenomic microbiota]] of chronic microbial forms that we often refer to as the Th1 pathogens.		The Marshall Protocol (MP) is based on the Marshall Pathogenesis, which posits that chronic diseases (termed [[.:pathogenesis:th1spectrum\|Th1 illnesses]]), are the result of infection by an intraphagocytic, [[.:pathogenesis:microbiota\|metagenomic microbiota]] of chronic microbial forms that we often refer to as the Th1 pathogens.
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	{{topic>Science_behind_Protocol}}		{{topic>Science_behind_Protocol}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	<relatedsection> test </section>		<relatedsection> test </section>

-	===== References =====	+	===== References =====</nodisp>

Publications & presentations

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

10.08.2018		current
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-	===== Papers =====	+	===== Papers =====

	^Author(s) ^Date ^Journal ^Title ^		^Author(s) ^Date ^Journal ^Title ^
		+	\|Proal AD, Marshall TG \|2018\|//Frontiers in Pediatrics//\|[[home:publications/proal_frontiers_in_pediatrics_2018/\|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity]] \|
	\|Proal AD, Marshall TG \|2018\|//Discovery medicine// \|[[home:publications/proal_discoverymedicine_2018/\|Re-framing the Theory of Autoimmunity in the Era of the Microbiome: Persistent Pathogens, Autoantibodies, and Molecular Mimicry]] \|		\|Proal AD, Marshall TG \|2018\|//Discovery medicine// \|[[home:publications/proal_discoverymedicine_2018/\|Re-framing the Theory of Autoimmunity in the Era of the Microbiome: Persistent Pathogens, Autoantibodies, and Molecular Mimicry]] \|
	\|Proal AD, Lindseth IA, Marshall TG \|2017 \|//Discovery medicine// \|[[home:publications:Proal_discoverymedicine_2017\|Microbe-Microbe and Host-Microbe Interactions Drive Microbiome Dysbiosis and Inflammatory Processes]] \|		\|Proal AD, Lindseth IA, Marshall TG \|2017 \|//Discovery medicine// \|[[home:publications:Proal_discoverymedicine_2017\|Microbe-Microbe and Host-Microbe Interactions Drive Microbiome Dysbiosis and Inflammatory Processes]] \|
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	===== Blog =====		===== Blog =====

-	Dr Amy Proal: [[http://MicrobeMinded.com\|Microbe Minded]]	+	Dr Amy Proal: [[https://MicrobeMinded.com\|Microbe Minded]]

	===== Newsletters =====		===== Newsletters =====

	^Year ^Quarter ^ Theme ^Features ^		^Year ^Quarter ^ Theme ^Features ^
-	\|2012 \|3rd \| [[http://marshallprotocol.com/th1nkMP_2012q3.pdf\|Fatigue]] \|Diagnoses and Fatigue, 2012 In Progress, Studies and Stats, Patient Posts & Quotes, Our Community \|	+	\|2012 \|3rd \| [[https://marshallprotocol.com/th1nkMP_2012q3.pdf\|Fatigue]] \|Diagnoses and Fatigue, 2012 In Progress, Studies and Stats, Patient Posts & Quotes, Our Community \|
-	\|2012 \|2nd \| [[http://marshallprotocol.com/th1nkMP_2012q2.pdf\|Back To Basics]] \|Pathogenesis, Microbiota, Human VDR, Vitamin D, Olmesartan, Treatment Duration, Timeline \|	+	\|2012 \|2nd \| [[https://marshallprotocol.com/th1nkMP_2012q2.pdf\|Back To Basics]] \|Pathogenesis, Microbiota, Human VDR, Vitamin D, Olmesartan, Treatment Duration, Timeline \|
-	\|2011 \|4th \| [[http://marshallprotocol.com/th1nkMP_2011q4.pdf\|Brain Fog]] \|Welcome, Brain Fog, MP Knowledge Base Search Keys, Patient Posts & Quotes, 2011 In Review \|	+	\|2011 \|4th \| [[https://marshallprotocol.com/th1nkMP_2011q4.pdf\|Brain Fog]] \|Welcome, Brain Fog, MP Knowledge Base Search Keys, Patient Posts & Quotes, 2011 In Review \|


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	-->		-->
	</html>		</html>
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	<note>THE FOLLOWING LINKS ARE TO DATED MATERIAL THAT WE DON'T NEED TO MAKE VISIBLE TO THE PUBLIC, BUT MAY BE OF INTEREST TO OUR RESEARCH TEAM.</note>		<note>THE FOLLOWING LINKS ARE TO DATED MATERIAL THAT WE DON'T NEED TO MAKE VISIBLE TO THE PUBLIC, BUT MAY BE OF INTEREST TO OUR RESEARCH TEAM.</note>
-	A transcript of the presentation by Keisuke Arasaki MD,PhD, adjunct professor of clinical neurology at the Toho University School of Medicine, at the 2006 JSSOG (Japanese Pulmonology) conference titled "Report on a case of systemic sarcoidosis treated according to the Marshall Protocol" can be found at: http://autoimmunityresearch.org/transcripts/arasaki_jssog_2006.pdf	+	A transcript of the presentation by Keisuke Arasaki MD,PhD, adjunct professor of clinical neurology at the Toho University School of Medicine, at the 2006 JSSOG (Japanese Pulmonology) conference titled "Report on a case of systemic sarcoidosis treated according to the Marshall Protocol" can be found at: https://autoimmunityresearch.org/transcripts/arasaki_jssog_2006.pdf

	Additional (more dated) papers are published online at JOIMR.org (JOURNAL OF INDEPENDENT MEDICAL RESEARCH):		Additional (more dated) papers are published online at JOIMR.org (JOURNAL OF INDEPENDENT MEDICAL RESEARCH):
	^Author(s) ^Date ^Journal ^Title ^		^Author(s) ^Date ^Journal ^Title ^
-	\|Marshall TG, et al \|Oct '05 \|JOIMR \|[[http://www.joimr.org/phorum/read.php?f=2&i=107&t=107\| Antibacterial Therapy Induces Remission in Sarcoidosis]] \|	+	\|Marshall TG, et al \|Oct '05 \|JOIMR \|[[https://www.joimr.org/phorum/read.php?f=2&i=107&t=107\| Antibacterial Therapy Induces Remission in Sarcoidosis]] \|
-	\|Marshall TG, et al \|Mar '05 \|JOIMR \|[[http://www.joimr.org/phorum/read.php?f=2&i=53&t=53\|Putative Antibacterial Mechanisms for Angiotensin II Receptor Blockers]] \|	+	\|Marshall TG, et al \|Mar '05 \|JOIMR \|[[https://www.joimr.org/phorum/read.php?f=2&i=53&t=53\|Putative Antibacterial Mechanisms for Angiotensin II Receptor Blockers]] \|
-	\|TG and FE Marshall \|Aug '03 \|JOIMR \|[[http://www.joimr.org/phorum/read.php?f=2&i=38&t=38\|Antibiotics in Sarcoidosis - Reflections on the First Year]] \|	+	\|TG and FE Marshall \|Aug '03 \|JOIMR \|[[https://www.joimr.org/phorum/read.php?f=2&i=38&t=38\|Antibiotics in Sarcoidosis - Reflections on the First Year]] \|</nodisp>

Search the MPKB

anonymous@undisclosed.example.com (Anonymous) — Mon, 05 Dec 2016 21:11:51 +0000

10.29.2012		current
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		+	<style type="text/css">.breadcrumbs, h1 {display: none !important;} </style>
		+
		+
		+
		+	<div id="cse-search-results"></div>
		+	<script type="text/javascript">
		+	var googleSearchIframeName = "cse-search-results";
		+	var googleSearchFormName = "cse-search-box";
		+	var googleSearchFrameWidth = 580;
		+	var googleSearchDomain = "www.google.com";
		+	var googleSearchPath = "/cse";
		+	</script>
		+	<script type="text/javascript" src="/lib/scripts/show_afs_search.js"></script>

-	<!-- Place this tag where you want the search box to render -->
-	<gcse:searchbox></gcse:searchbox>

-	<!-- Place this tag where you want the search results to render -->
-	<gcse:searchresults></gcse:searchresults>


	</html>		</html>
		+

Search the MPKB

anonymous@undisclosed.example.com (Anonymous) — Mon, 29 Oct 2012 15:07:37 +0000

04.06.2026	current
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	+	====== Search the MPKB ======

	+	<html>
	+
	+
	+
	+
	+	<!-- Place this tag where you want the search box to render -->
	+	<gcse:searchbox></gcse:searchbox>
	+
	+	<!-- Place this tag where you want the search results to render -->
	+	<gcse:searchresults></gcse:searchresults>
	+
	+
	+	</html>

Social and psychological aspects

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

10.13.2018		current
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+
		+	===== References =====
		+	</nodisp>

Special issues

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

04.25.2020		current
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	[[home:special:emf:protective_materials\|Protective materials]]		[[home:special:emf:protective_materials\|Protective materials]]
		+
		+	[[home:special:emf:whitezones:faradaycage\|Faraday cage]]


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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-	=====References=====	+	=====References=====</nodisp>

Starting the Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Mon, 04 Jul 2022 12:06:16 +0000

10.17.2018		current
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	* [[home:mp\|One-article summary of the Marshall Protocol]] – links to a lot of helpful content in the Knowledge Base		* [[home:mp\|One-article summary of the Marshall Protocol]] – links to a lot of helpful content in the Knowledge Base

-	Important: <note warning>The Autoimmunity Research Foundation does not support or license the public use of this therapy for patients not actively participating on the Marshall Protocol study site at [[http://MarshallProtocol.com\|MarshallProtocol.com]].</note>	+	Important: <note warning>The Autoimmunity Research Foundation does not support or license the public use of this therapy for patients not actively participating on the Marshall Protocol study site at [[https://MarshallProtocol.com\|MarshallProtocol.com]].</note>

	The MP Knowledge Base is partly based on that ongoing longitudinal study supported by the ARF and described below.		The MP Knowledge Base is partly based on that ongoing longitudinal study supported by the ARF and described below.
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-	===== Read more =====

-	{{topic>Pathogenesis}}

	{{tag>Starting_the_Marshall_Protocol}}		{{tag>Starting_the_Marshall_Protocol}}

Symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

02.15.2019		current
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	<relatedarticle> [[home:diseases\|Diseases]]</article>		<relatedarticle> [[home:diseases\|Diseases]]</article>

-	Cytokines, Inflammation and Pain (({{pubmed>long:17426506}}))

	The following is a list of symptoms that are reviewed by the Knowledge Base. In practice, however, there is some overlap between symptoms and diseases. For example, anxiety and hypertension can be both. When in doubt, search the Knowledge Base.		The following is a list of symptoms that are reviewed by the Knowledge Base. In practice, however, there is some overlap between symptoms and diseases. For example, anxiety and hypertension can be both. When in doubt, search the Knowledge Base.
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	{{topic>symptoms}}		{{topic>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


-		+	</nodisp>

Laboratory tests

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Translations of Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

Members-Only Videos

anonymous@undisclosed.example.com (Anonymous) — Tue, 03 Jan 2012 04:24:04 +0000

06.04.2010		current
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	^Title ^Presenter ^Conference ^Date ^		^Title ^Presenter ^Conference ^Date ^
-	\|[[home:admin:firtel\|Spatiotemporal control of Chemotaxis]] \|Richard Firtel, UCSD \|SDCSB's 5th Systems to Synthesis Symposium\|21 May 2010 \|	+	\|[[home:videos:firtel\|Spatiotemporal control of Chemotaxis]] \|Richard Firtel, UCSD \|SDCSB's 5th Systems to Synthesis Symposium\|21 May 2010 \|
	\|[[home:videos:bourne\|Polypharmacology Meets Systems Biology]] \|Philip Bourne, UCSD \|SDCSB's 5th Systems to Synthesis Symposium\|21 May 2010 \|		\|[[home:videos:bourne\|Polypharmacology Meets Systems Biology]] \|Philip Bourne, UCSD \|SDCSB's 5th Systems to Synthesis Symposium\|21 May 2010 \|

Can Waves Make You Sicker?

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:39 +0000

06.23.2018		current
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	The use of 300-400MHz TETRA two-way radio in the UK has increased sickness in Ambulance and Police personnel using it.		The use of 300-400MHz TETRA two-way radio in the UK has increased sickness in Ambulance and Police personnel using it.

-	[[http://www.personneltoday.com/hr/occupational-health-effects-linked-terrestrial-trunked-radios-tetra/\|occupational health effects linked to TETRA]]	+	[[https://www.personneltoday.com/hr/occupational-health-effects-linked-terrestrial-trunked-radios-tetra/\|occupational health effects linked to TETRA]]


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	[[https://youtu.be/OMxfffqyDtc?t=2m40s\|intimidating press, suppressing science]]		[[https://youtu.be/OMxfffqyDtc?t=2m40s\|intimidating press, suppressing science]]

-	[[http://www.bmj.com/content/351/bmj.h4098/rr-17\|Should NHS premises provide access to wi-fi?]]	+	[[https://www.bmj.com/content/351/bmj.h4098/rr-17\|Should NHS premises provide access to wi-fi?]]

	[[https://www.youtube.com/watch?feature=player_embedded&v=F0NEaPTu9oI\|Wireless Wake-up call]]		[[https://www.youtube.com/watch?feature=player_embedded&v=F0NEaPTu9oI\|Wireless Wake-up call]]
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	The link for the report:		The link for the report:
-	[[http://web.archive.org/web/20060714175343/ieq.nibs.org/ieq_project.pdf\|NIBS report]]	+	[[https://web.archive.org/web/20060714175343/ieq.nibs.org/ieq_project.pdf\|NIBS report]]

	From Report (page 11):		From Report (page 11):
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	——————————–		——————————–
	Dafna Tachover		Dafna Tachover
-	EHS Fight Back: [[http://ehsfighback.blogspot.com\|blogspot]]	+	EHS Fight Back: [[https://ehsfighback.blogspot.com\|blogspot]]
-		+
-	EMF topics	+
-		+
-	[[home:waves:\|waves]]	+
-		+
-	[[home:waves:rf_overview\|radio frequency radiation]]	+
-		+
-		+
-	[[home:waves:effects\|Effects of EMF on the human body]]	+
-		+
-	[[home:waves:measuring:looking_for\|looking for sources of emf]]	+
-		+
-	[[home:waves:measuring\|measuring emf]]	+
-		+
-	[[home:waves:measuring:meters\|meters]]	+
-		+
-	[[home:waves:measuring:meters:buying\|buying meters]]	+
-		+
-	[[home:waves:measuring:meters:using\|using meters]]	+
-		+
-	[[home:waves:effects:clothing\|wearable protection]]	+
-		+
-	[[home:waves:protective_materials\|protective materials]]	+
-		+
-	[[home:waves:whitezones\|whitezones]]	+
-		+
-	[[home:waves:whitezones:accomodation\|housing]] among the gum trees	+
-		+
-	[[home:waves:whitezones:domestic\|home environment]]	+
-		+
-	[[home:waves:whitezones:healing_space\|healing space]]	+
-		+
-		+
-	[[home:waves:effects:films\|Effects on show videos]]	+

	==== Member's comment ====		==== Member's comment ====
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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		+	</nodisp>

02.13.2019		current
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	<mainarticle> [[home:alternate:environment\|Environmental causation of disease]] </article>		<mainarticle> [[home:alternate:environment\|Environmental causation of disease]] </article>

-	Chronic inflammatory diseases have existed for at least thousands of years. Manifestations of both arteriosclerosis can be observed in mummies of ancient Egypt. [[http://en.wikipedia.org/wiki/Ötzi_the_Iceman\|Ötzi the Neolithic Iceman]] who lived around 3300 BC was found to have arthritis.	+	Chronic inflammatory diseases have existed for at least thousands of years. Manifestations of both arteriosclerosis can be observed in mummies of ancient Egypt. [[https://en.wikipedia.org/wiki/Ötzi_the_Iceman\|Ötzi the Neolithic Iceman]] who lived around 3300 BC was found to have arthritis.

	This relative consistency of disease prevalence suggests that a number of the proposed environmental causes for disease, like man-made toxins and junk food are not the exclusive cause.		This relative consistency of disease prevalence suggests that a number of the proposed environmental causes for disease, like man-made toxins and junk food are not the exclusive cause.
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	There are currently a range of diseases for which there is [[home:pathogenesis:evidence_bacteria#epidemiological_evidence\|epidemiological evidence]], [[home:pathogenesis:evolution\|evolutionary evidence]], and [[home:pathogenesis:evidence_bacteria#other_evidence\|other kinds of evidence]] strongly suggesting bacterial involvement. [[home:pathogenesis:kochs_postulates\|Koch's postulates]] stipulate that chronic diseases caused by infections must be caused by a single species of pathogen, yet the minority of chronic diseases have been shown to be caused by a single species of pathogen.		There are currently a range of diseases for which there is [[home:pathogenesis:evidence_bacteria#epidemiological_evidence\|epidemiological evidence]], [[home:pathogenesis:evolution\|evolutionary evidence]], and [[home:pathogenesis:evidence_bacteria#other_evidence\|other kinds of evidence]] strongly suggesting bacterial involvement. [[home:pathogenesis:kochs_postulates\|Koch's postulates]] stipulate that chronic diseases caused by infections must be caused by a single species of pathogen, yet the minority of chronic diseases have been shown to be caused by a single species of pathogen.

-	Take Crohn's disease as an example. The following types and species of bacteria have been found in patients with Crohn's: L-form bacteria(({{pubmed>long:6134652}})), //Bacteroides fragilis//(({{pubmed>long:88760}})), //Chlamydia trachomatis//(({{pubmed>long:83465}})), //Listeria monocytogenes//(({{pubmed>long:7729631}})), //Mycobacterium avium//, subspecies paratuberculosis(({{pubmed>long:12843021}})), //Mycobacterium kansasii//(({{pubmed>long:80630}})), and //Pseudomonas maltophilia//(({{pubmed>long:780185}})). Yet none of these species are found consistently in Crohn's.	+	Take Crohn's disease as an example. The following types and species of bacteria have been found in patients with Crohn's: L-form bacteria(({{pmid>long:6134652}})), //Bacteroides fragilis//(({{pmid>long:88760}})), //Chlamydia trachomatis//(({{pmid>long:83465}})), //Listeria monocytogenes//(({{pmid>long:7729631}})), //Mycobacterium avium//, subspecies paratuberculosis(({{pmid>long:12843021}})), //Mycobacterium kansasii//(({{pmid>long:80630}})), and //Pseudomonas maltophilia//(({{pmid>long:780185}})). Yet none of these species are found consistently in Crohn's.

-	For a 19th century researcher, Robert Koch had a strong, even visionary, grasp of molecular biology, but he did not have access to molecular tools. Koch might be shocked to learn the extent to which different species engage in [[home:pathogenesis:horizontal_gene\|horizontal gene transfer]], to the point where the very definition of "species" may have to be reconsidered.(({{pubmed>long:15752428}}))	+	For a 19th century researcher, Robert Koch had a strong, even visionary, grasp of molecular biology, but he did not have access to molecular tools. Koch might be shocked to learn the extent to which different species engage in [[home:pathogenesis:horizontal_gene\|horizontal gene transfer]], to the point where the very definition of "species" may have to be reconsidered.(({{pmid>long:15752428}}))

	The best way to resolve this inconsistency is to say simply that Koch was wrong and that chronic diseases are caused by a multitude of species and forms – a [[:home:pathogenesis:microbiota\|metagenomic microbiota]].		The best way to resolve this inconsistency is to say simply that Koch was wrong and that chronic diseases are caused by a multitude of species and forms – a [[:home:pathogenesis:microbiota\|metagenomic microbiota]].
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	{{tag>Pathogenesis Alternate_models}}		{{tag>Pathogenesis Alternate_models}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+	//broken link//
		+	[[https://www.who.int/dietphysicalactivity/publications/facts/obesity/en/\|has termed]]


	* Legacy content		* Legacy content
-	* [[http://www.marshallprotocol.com/users/5.html]] f127	+	* [[https://www.marshallprotocol.com/users/5.html]] f127
	* s320a		* s320a
-	* [[http://www.marshallprotocol.com/view_topic.php?id=3220&forum_id=37&jump_to=76179#p76179]] s253	+	* [[https://www.marshallprotocol.com/view_topic.php?id=3220&forum_id=37&jump_to=76179#p76179]] s253
	* f169		* f169
-	* [[http://www.marshallprotocol.com/forum32/3010.html#p26580]] f206	+	* [[https://www.marshallprotocol.com/forum32/3010.html#p26580]] f206
-	* [[http://www.marshallprotocol.com/view_topic.php?id=3010&forum_id=32&jump_to=83422#p83422]] f207	+	* [[https://www.marshallprotocol.com/view_topic.php?id=3010&forum_id=32&jump_to=83422#p83422]] f207
-	* [[http://www.marshallprotocol.com/view_topic.php?id=2529&forum_id=32&jump_to=75793#p75793]] f238	+	* [[https://www.marshallprotocol.com/view_topic.php?id=2529&forum_id=32&jump_to=75793#p75793]] f238
-	* [[http://www.marshallprotocol.com/forum32/7329.html]] f222	+	* [[https://www.marshallprotocol.com/forum32/7329.html]] f222
-	* [[http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=128480#p128480]] f46	+	* [[https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=128480#p128480]] f46


-	===== References =====	+	===== References =====</nodisp>

04.28.2020		current
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	Some trace elements are altered with chronic kidney disease. Selenium, zinc, and manganese tend to be wasted, and there is growing evidence that selenium deficiency is associated with mortality on dialysis.		Some trace elements are altered with chronic kidney disease. Selenium, zinc, and manganese tend to be wasted, and there is growing evidence that selenium deficiency is associated with mortality on dialysis.

-	Other trace elements accumulate, such as chromium, cobalt, lead, molybdenum, and vanadium.(({{pubmed>long:31296778}}))	+	Other trace elements accumulate, such as chromium, cobalt, lead, molybdenum, and vanadium.(({{pmid>long:31296778}}))

	see also [[home:othertreatments:colloidal_silver\|colloidal silver]]		see also [[home:othertreatments:colloidal_silver\|colloidal silver]]


-	Three main areas of research have been identified (//in chronic heart failure//): 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF.(({{pubmed>long:31242838}}))	+	Three main areas of research have been identified (//in chronic heart failure//): 1) magnesium, electrolytes and CHF; 2) the transcriptional and antioxidant effects of zinc, selenium, copper; 3) iron-deficiency anemia and CHF.(({{pmid>long:31242838}}))


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	=== Zinc ===		=== Zinc ===

-	Zinc is an essential trace element that is crucial for growth, development, and maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors. Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. (({{pubmed>long:31305906}}))	+	Zinc is an essential trace element that is crucial for growth, development, and maintenance of immune function. Its influence reaches all organs and cell types, representing an integral component of approximately 10% of the human proteome, and encompassing hundreds of key enzymes and transcription factors. Zinc deficiency is strikingly common, affecting up to a quarter of the population in developing countries, but also affecting distinct populations in the developed world as a result of lifestyle, age, and disease-mediated factors. (({{pmid>long:31305906}}))

-	By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial.(({{pubmed>long:31303527}}))	+	"angiotensin 2 receptor antagonists can result in an increased urinary excretion of zinc with subsequent systemic zinc deficiency" therefore those on Olmesartan may be excreting Zinc.

-	Results suggest that zinc deficiency is associated with the presence of prehypertension in apparently healthy subjects.(({{pubmed>long: 31262235}}))	+	//see// Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions -a systematic review of zinc and antihypertensive therapy. Int J Clin Pract2013;67(8):717-25. doi: 10.1111/ijcp.12040 [published Online First: 2013/01/03
		+
		+	By modulating anti-inflammatory and antioxidant pathways, zinc supplementation is recommended for the treatment of several ailments, such as liver disease, male hypogonadism, cancers, heart disease (e.g. dyslipidemia) and central nervous system disorders; however, the topic of dietary vs. pharmacological doses of zinc remains controversial.(({{pmid>long:31303527}}))
		+
		+	Results suggest that zinc deficiency is associated with the presence of prehypertension in apparently healthy subjects.(({{pmid>long: 31262235}}))

	Zinc picolinate is easily absorbed, but this [[https://chrismasterjohnphd.com/lite-videos/2018/10/30/dont-recommend-zinc-picolinate/\|nutrition web site]] warns against it's use.		Zinc picolinate is easily absorbed, but this [[https://chrismasterjohnphd.com/lite-videos/2018/10/30/dont-recommend-zinc-picolinate/\|nutrition web site]] warns against it's use.
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	=== Ca/Mg ratio ===		=== Ca/Mg ratio ===

-	Ca/Mg ratio imbalance is associated with prostatic hyperplasia(({{pubmed>long: 28284204}}))	+	Ca/Mg ratio imbalance is associated with prostatic hyperplasia(({{pmid>long: 28284204}}))

-	Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA.(({{pubmed>long:21233058}}))	+	Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA.(({{pmid>long:21233058}}))

-	findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with metabolic syndrome in Chinese adults.(({{pubmed>long:27750224}}))	+	findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with metabolic syndrome in Chinese adults.(({{pmid>long:27750224}}))


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	=== Iodine ===		=== Iodine ===

-	Iodine is necessary for thyroid function. (({{pubmed>long:28160243}}))	+	Iodine is necessary for thyroid function. (({{pmid>long:28160243}}))

	If your thyroid does not come good after some time on MP, get your Iodine status checked, An occasional drop of iodine may be warranted. Your doctor will advise.		If your thyroid does not come good after some time on MP, get your Iodine status checked, An occasional drop of iodine may be warranted. Your doctor will advise.
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	=== Selenium (trace element) ===		=== Selenium (trace element) ===

-	Association of Selenium (Se) deficiency, an essential trace element, has been found with human diseases.(({{pubmed>long:31223567}}))	+	Association of Selenium (Se) deficiency, an essential trace element, has been found with human diseases.(({{pmid>long:31223567}}))

-	Review of recent progress in large-scale and systematic analyses of the relationship between selenium status or selenoproteins and several complex diseases, mainly including population-based cohort studies and meta-analyses, genetic association studies, and some other omics-based studies. Advances in ionomics and its application in studying the interaction between selenium and other trace elements in human health and diseases are also discussed.(({{pubmed>long:31236815}}))	+	Review of recent progress in large-scale and systematic analyses of the relationship between selenium status or selenoproteins and several complex diseases, mainly including population-based cohort studies and meta-analyses, genetic association studies, and some other omics-based studies. Advances in ionomics and its application in studying the interaction between selenium and other trace elements in human health and diseases are also discussed.(({{pmid>long:31236815}}))


	Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body.		Expression of some genes is changed with selenium deficiency. Consequently, growth and proliferation of cells, their movement, development, death, and survival, as well as the interaction between cells, the redox regulation of intracellular signaling cascades of inflammation and apoptosis, depend on the selenium status of the body.

-	Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pubmed>long: 31258141}}))	+	Organic selenium compounds have a high bioavailability and, depending on their concentration, can act both as selenium donors to prevent selenium deficiency and as antitumor drugs due to their toxicity and participation in the regulation of signaling pathways of apoptosis. (({{pmid>long: 31258141}}))


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	=== Boron (trace element) ===		=== Boron (trace element) ===

-	Via its effect on steroid hormones and interaction with mineral metabolism, boron may be involved in a number of clinical conditions such as arthritis. (({{pubmed>long:8140253}}))	+	Via its effect on steroid hormones and interaction with mineral metabolism, boron may be involved in a number of clinical conditions such as arthritis. (({{pmid>long:8140253}}))

	Experiments with boron supplementation or deprivation show that boron is involved in calcium and bone metabolism, and its effects are more marked when other nutrients (cholecalciferol, magnesium) are deficient. Boron supplementation increases the serum concentration of 17 beta-estradiol and testosterone but boron excess has toxic effects on reproductive function. Boron may be involved in cerebral function via its effects on the transport across membranes. It affects the synthesis of the extracellular matrix and is beneficial in wound healing.		Experiments with boron supplementation or deprivation show that boron is involved in calcium and bone metabolism, and its effects are more marked when other nutrients (cholecalciferol, magnesium) are deficient. Boron supplementation increases the serum concentration of 17 beta-estradiol and testosterone but boron excess has toxic effects on reproductive function. Boron may be involved in cerebral function via its effects on the transport across membranes. It affects the synthesis of the extracellular matrix and is beneficial in wound healing.
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	Usual dietary boron consumption in humans is 1-2 mg/day for adults.		Usual dietary boron consumption in humans is 1-2 mg/day for adults.

-	Boronated compounds have been shown to be potent anti-osteoporotic, anti-inflammatory, hypolipemic, anti-coagulant and anti-neoplastic agents both in vitro and in vivo in animals.(({{pubmed>long:9638606}}))	+	Boronated compounds have been shown to be potent anti-osteoporotic, anti-inflammatory, hypolipemic, anti-coagulant and anti-neoplastic agents both in vitro and in vivo in animals.(({{pmid>long:9638606}}))

	<blockquote>In reality the average intake in developed countries is 1-2 mg of boron per day. Institutionalized patients may receive only 0.25 mg of daily boron. Chemical fertilizers inhibit the uptake of boron from the soil: an organic apple grown in good soil may have 20 mg boron, but if grown with fertilizer it may have only 1 mg of boron. Fertilizers combined with poor food choices have greatly reduced our boron intake compared to 50 or 100 years ago.		<blockquote>In reality the average intake in developed countries is 1-2 mg of boron per day. Institutionalized patients may receive only 0.25 mg of daily boron. Chemical fertilizers inhibit the uptake of boron from the soil: an organic apple grown in good soil may have 20 mg boron, but if grown with fertilizer it may have only 1 mg of boron. Fertilizers combined with poor food choices have greatly reduced our boron intake compared to 50 or 100 years ago.
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	===== Research =====		===== Research =====

-	Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. (({{pubmed>long: 30130151}}))	+	Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. (({{pmid>long: 30130151}}))

-	Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults(({{pubmed>long:29726951}}))	+	Walnut Consumption Alters the Gastrointestinal Microbiota, Microbially Derived Secondary Bile Acids, and Health Markers in Healthy Adults(({{pmid>long:29726951}}))

-	Almond Consumption and Processing Affects the Composition of the Gastrointestinal Microbiota of Healthy Adult Men and Women (({{pubmed>long: 9373513}}))	+	Almond Consumption and Processing Affects the Composition of the Gastrointestinal Microbiota of Healthy Adult Men and Women (({{pmid>long: 9373513}}))

-	Broccoli consumption affects the human gastrointestinal microbiota. Functional prediction revealed that broccoli consumption increased the pathways involved in the functions of the endocrine system (P=.05), transport and catabolism (P=.04), and energy metabolism (P=.01). (({{pubmed>long:30317146}}))	+	Broccoli consumption affects the human gastrointestinal microbiota. Functional prediction revealed that broccoli consumption increased the pathways involved in the functions of the endocrine system (P=.05), transport and catabolism (P=.04), and energy metabolism (P=.01). (({{pmid>long:30317146}}))


	Dietary fats influence risk of developing peripheral metabolic diseases and cognitive disorders such as Alzheimer?s disease (AD). Inflammation of the brain (neuroinflammation), a state associated with progressive neuronal loss, is known to be heightened in cognitive decline and obesity.		Dietary fats influence risk of developing peripheral metabolic diseases and cognitive disorders such as Alzheimer?s disease (AD). Inflammation of the brain (neuroinflammation), a state associated with progressive neuronal loss, is known to be heightened in cognitive decline and obesity.
-	[[http://grantome.com/grant/NIH/I01-BX004146-01A1\|Obesity and associated comorbidities such as metabolic syndrome and diabetes affect up to 48% of Veterans]]. We hypothesize that dietary fats alter microglial metabolism to directly trigger dysregulated brain immune responses.	+	[[https://grantome.com/grant/NIH/I01-BX004146-01A1\|Obesity and associated comorbidities such as metabolic syndrome and diabetes affect up to 48% of Veterans]]. We hypothesize that dietary fats alter microglial metabolism to directly trigger dysregulated brain immune responses.

	Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia has specified that immune cells in the brain consume the synapses between brain neurons, when exposed to a high-fat diet.		Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia has specified that immune cells in the brain consume the synapses between brain neurons, when exposed to a high-fat diet.
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	===== Other =====		===== Other =====

-	[[http://nautil.us/issue/30/identity/how-the-western-diet-has-derailed-our-evolution\|how-the-western-diet-has-derailed-our-evolution]]	+	[[https://nautil.us/issue/30/identity/how-the-western-diet-has-derailed-our-evolution\|how-the-western-diet-has-derailed-our-evolution]]

	* food avoidance diets – Some patients have reported sensitivities to certain foods. Avoiding foods containing, for example, lactose or gluten may offer a decrease in symptom severity. Patients who feel this may be relevant to them should consult with a nutritionist.		* food avoidance diets – Some patients have reported sensitivities to certain foods. Avoiding foods containing, for example, lactose or gluten may offer a decrease in symptom severity. Patients who feel this may be relevant to them should consult with a nutritionist.
-	* salt avoidance – not recommended given that the body seems to naturally regulate sodium levels independently. Salt is also critical for kidney health. Sodium is used by the kidneys to excrete potassium. (({{pubmed>long:19833911}})) (({{pubmed>long:22071811}})) (for more see the //Times// article [[http://www.nytimes.com/2012/06/03/opinion/sunday/we-only-think-we-know-the-truth-about-salt.html\|Salt, we misjudged you]]	+	* salt avoidance – not recommended given that the body seems to naturally regulate sodium levels independently. Salt is also critical for kidney health. Sodium is used by the kidneys to excrete potassium. (({{pmid>long:19833911}})) (({{pmid>long:22071811}})) (for more see the //Times// article [[https://www.nytimes.com/2012/06/03/opinion/sunday/we-only-think-we-know-the-truth-about-salt.html\|Salt, we misjudged you]]
	* fasting – Fasting is not part of the MP. It is unknown whether it provides harm or benefit to a person on the treatment.		* fasting – Fasting is not part of the MP. It is unknown whether it provides harm or benefit to a person on the treatment.

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	2018 [[https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30313-9\|Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota]]		2018 [[https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30313-9\|Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota]]
-	(({{pubmed>long: 29874567}}))	+	(({{pmid>long: 29874567}}))

-	2019 [[https://newatlas.com/gut-bacteria-microbiome-virus-infection-immune-brain-degeneration/60623/\|Gut bacteria found to help protect brain and central nervous system from harmful viruses]] (({{pubmed>long: 31309928}}))	+	2019 [[https://newatlas.com/gut-bacteria-microbiome-virus-infection-immune-brain-degeneration/60623/\|Gut bacteria found to help protect brain and central nervous system from harmful viruses]] (({{pmid>long: 31309928}}))

-	2012 The migrating motor complex: control mechanisms and its role in health and disease. (({{pubmed>long: 22450306}}))	+	2012 The migrating motor complex: control mechanisms and its role in health and disease. (({{pmid>long: 22450306}}))

-	2018 Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension (({{pubmed>long:29779873}}))	+	2018 Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension (({{pmid>long:29779873}}))


	{{tag>Food_and_drink foods drinks summary foods_to_avoid}}		{{tag>Food_and_drink foods drinks summary foods_to_avoid}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	(({{pubmed>long:000}}))	+	(({{pmid>long:000}}))

	Gillyb's update TEXT without LINKS		Gillyb's update TEXT without LINKS
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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=94231#p94231 e179	+	* https://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=94231#p94231 e179
	*		*
-	=====References=====	+	=====References=====</nodisp>

04.02.2019		current
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	==== Avoid unanticipated side effects ====		==== Avoid unanticipated side effects ====
-	Every chemical one ingests affects the body in many ways, most of which are not yet fully understood. For example, consider tricolsan, a chemical found in everything from antibacterial soaps and lotions to socks and toothpaste. According to a [[http://www.physorg.com/news/2010-11-pregnancy-problems-antibacterial-agent.html\|2010 study]], it may disrupt sulfotransferase, an enzyme that plays an important role in pregnancy.(({{pubmed>long:19299018}}))	+	Every chemical one ingests affects the body in many ways, most of which are not yet fully understood. For example, consider tricolsan, a chemical found in everything from antibacterial soaps and lotions to socks and toothpaste. According to a [[https://www.physorg.com/news/2010-11-pregnancy-problems-antibacterial-agent.html\|2010 study]], it may disrupt sulfotransferase, an enzyme that plays an important role in pregnancy.(({{pmid>long:19299018}}))


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-	^Type of substance ^ Varieties ^ Recommendation ^Rationale ^	+	^ Type of substance ^ Varieties ^ Recommendation ^Rationale ^
	\| **[[.:othertreatments:anesthetics\|anesthetics for surgical procedures and allergic reactions		\| **[[.:othertreatments:anesthetics\|anesthetics for surgical procedures and allergic reactions
	]]** \| general anesthetics – epinephrine, norepinephrine, levonordefrine; local anesthetics – lidocaine (xylocaine), mepivicaine (Isocaine), prilocaine (Citanest) \|{{:home:warning.png?nolink}} avoid epinephrine and other general anesthetics when possible; consult with MD about epi-pen \|epinephrine can have side effects \|		]]** \| general anesthetics – epinephrine, norepinephrine, levonordefrine; local anesthetics – lidocaine (xylocaine), mepivicaine (Isocaine), prilocaine (Citanest) \|{{:home:warning.png?nolink}} avoid epinephrine and other general anesthetics when possible; consult with MD about epi-pen \|epinephrine can have side effects \|
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	\| [[home:othertreatments:antibacterials:betalactams\|antibiotics, beta-lactam]] \|amoxicillin, ampicillin, cephalosporin (Rocephin/Ceftriaxone), penicillin, imipenem/cilastatin (Primaxin) \|{{:home:stop.png?nolink}} wean \|leads to formation of L-form bacteria\|		\| [[home:othertreatments:antibacterials:betalactams\|antibiotics, beta-lactam]] \|amoxicillin, ampicillin, cephalosporin (Rocephin/Ceftriaxone), penicillin, imipenem/cilastatin (Primaxin) \|{{:home:stop.png?nolink}} wean \|leads to formation of L-form bacteria\|

-	\| [[home:othertreatments:antibacterials:takingnonmpantibiotics\|antibiotics, prefer]] \|Ceftin, Zinacef ( cefuroxime ), and Biaxin ( clarithromycin ) \|{{:home:ok.png?nolink}} these two \| are acceptable for acute infection\|	+	\| [[home:othertreatments:antibacterials:takingnonmpantibiotics\|antibiotics - prefer]] \|cefuroxime ( Ceftin, Zinacef ), and clarithromycin (Biaxin ) \|{{:home:ok.png?nolink}} these two \| are acceptable for acute infection\|
-		+
-		+
	\| [[home:othertreatments:antibacterials:fluoroquinolones\|antibiotics, fluoroquinolone]] \|ciprofloxacin (Cipro), gatifloxacin (Tequin), levofloxacin (Levaquin/Quixin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Ocuflox/Floxin/Floxacin) \|{{:home:warning.png?nolink}} can be used only for acute infections \|ineffective, possibility of resistance \|		\| [[home:othertreatments:antibacterials:fluoroquinolones\|antibiotics, fluoroquinolone]] \|ciprofloxacin (Cipro), gatifloxacin (Tequin), levofloxacin (Levaquin/Quixin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Ocuflox/Floxin/Floxacin) \|{{:home:warning.png?nolink}} can be used only for acute infections \|ineffective, possibility of resistance \|
	\| [[.:othertreatments:anticoagulants\|anticoagulants]] \|aspirin, Heparin, warfarin (Coumadin) \|{{:home:stop.png?nolink}} wean all use of anticoagulants except aspirin and only in the event of a cardiac emergency \|possibly unpredictable effects \|		\| [[.:othertreatments:anticoagulants\|anticoagulants]] \|aspirin, Heparin, warfarin (Coumadin) \|{{:home:stop.png?nolink}} wean all use of anticoagulants except aspirin and only in the event of a cardiac emergency \|possibly unpredictable effects \|
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	\| [[.:othertreatments:hypoglycemics\|hypoglycemics]] \|Avandamet (contains rosiglitazone), exenatide (Byetta), pioglitazone (Actos), metformin (Glucophage, Glumetza, Ratio-Metformin), nateglinide (Starlix), rosiglitazone (Avandia) \|{{:home:stop.png?nolink}} wean \|affects TNF-alpha secretion and atherosclerotic development, or interacts with olmesartan (Benicar) \|		\| [[.:othertreatments:hypoglycemics\|hypoglycemics]] \|Avandamet (contains rosiglitazone), exenatide (Byetta), pioglitazone (Actos), metformin (Glucophage, Glumetza, Ratio-Metformin), nateglinide (Starlix), rosiglitazone (Avandia) \|{{:home:stop.png?nolink}} wean \|affects TNF-alpha secretion and atherosclerotic development, or interacts with olmesartan (Benicar) \|
	\| [[.:othertreatments:immuneboosters\|immune boosters]] \|allergy shots (immunotherapy), gamma-Globulins, glyconutrients (D-mannose, D-ribose) \|{{:home:stop.png?nolink}} wean \|limited evidence of efficacy, the last thing the majority of MP patients need is an elevated immune response \|		\| [[.:othertreatments:immuneboosters\|immune boosters]] \|allergy shots (immunotherapy), gamma-Globulins, glyconutrients (D-mannose, D-ribose) \|{{:home:stop.png?nolink}} wean \|limited evidence of efficacy, the last thing the majority of MP patients need is an elevated immune response \|
-	\| **immunosuppressants** \|alefacept (Amevive), azathioprine (Imuran), basiliximab (Simulect), chlorambucil (Leukeran), cyclophosphamide (Cytoxan, Neosar, Revimmune), cyclosporine (Restasis), Muromonab-CD3, pentoxifylline (Trental), [[home:othertreatments:rapamycin\|sirolimus (rapamycin, Rapamune)]], tacrolimus (Advagraf, Prograf, Protopic) \|{{:home:stop.png?nolink}} wean \|immunomodulatory \|	+	\| **immunosuppressant** \|alefacept (Amevive), azathioprine (Imuran), basiliximab (Simulect), chlorambucil (Leukeran), cyclophosphamide (Cytoxan, Neosar, Revimmune), cyclosporine (Restasis), Muromonab-CD3, pentoxifylline (Trental), [[home:othertreatments:rapamycin\|sirolimus (rapamycin, Rapamune)]], tacrolimus (Advagraf, Prograf, Protopic) \|{{:home:stop.png?nolink}} wean \|immunomodulatory \|


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	\| [[.:othertreatments:homeopathy\|homeopathy]] \| \|{{:home:stop.png?nolink}} wean \|limited evidence \|		\| [[.:othertreatments:homeopathy\|homeopathy]] \| \|{{:home:stop.png?nolink}} wean \|limited evidence \|
	\| [[.:food:chlorogenic_acid#juicing\|juicing]] \| \|{{:home:stop.png?nolink}} wean \|may contain high levels of sugar and [[.:food:folic\|chlorogenic acid]], which is immunomodulatory \|		\| [[.:food:chlorogenic_acid#juicing\|juicing]] \| \|{{:home:stop.png?nolink}} wean \|may contain high levels of sugar and [[.:food:folic\|chlorogenic acid]], which is immunomodulatory \|
-	\| [[http://en.wikipedia.org/wiki/Magnet_therapy\|magnets]] \| \|{{:home:stop.png?nolink}} wean \|no evidence \|	+	\| [[https://en.wikipedia.org/wiki/Magnet_therapy\|magnets]] \| \|{{:home:stop.png?nolink}} wean \|no evidence \|
	\| [[home:othertreatments:massage\|massage and other manipulation therapies]] \| acupressure, chiropractic, craniosacral therapy, manual lymphatic drainage, massage, osteopathic manipulation, physical therapy \|{{:home:warning.png?nolink}} use judiciously \|can exacerbate immunopathology \|		\| [[home:othertreatments:massage\|massage and other manipulation therapies]] \| acupressure, chiropractic, craniosacral therapy, manual lymphatic drainage, massage, osteopathic manipulation, physical therapy \|{{:home:warning.png?nolink}} use judiciously \|can exacerbate immunopathology \|
	\| [[.:othertreatments:mouthwash\|mouthwash]] \|ACT, cepacol, cetylpyridinium chloride (Crest Pro-Health, Viadent, Pro-Health Night), Listerine, Scope \|{{:home:warning.png?nolink}} mouthwashes with cetylpyridinium chloride and without FD&C Yellow #5 or Tartrazine, E103 recommended \| \|		\| [[.:othertreatments:mouthwash\|mouthwash]] \|ACT, cepacol, cetylpyridinium chloride (Crest Pro-Health, Viadent, Pro-Health Night), Listerine, Scope \|{{:home:warning.png?nolink}} mouthwashes with cetylpyridinium chloride and without FD&C Yellow #5 or Tartrazine, E103 recommended \| \|
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	\| [[.:othertreatments:trigger\|trigger point therapy]] \| \|{{:home:ok.png?nolink}} can help with pain \| \|		\| [[.:othertreatments:trigger\|trigger point therapy]] \| \|{{:home:ok.png?nolink}} can help with pain \| \|
	\| visualization techniques \| \|{{:home:ok.png?nolink}} can help depression and anxiety \|		\| visualization techniques \| \|{{:home:ok.png?nolink}} can help depression and anxiety \|
-	\| Tai Chi \| \|{{:home:ok.png?nolink}} generally helpful \| [[http://heartinsight.heart.org/August-2014/How-Tai-Chi-Impacts-Cardiovascular-Health/\|heart health research]] \|	+	\| Tai Chi \| \|{{:home:ok.png?nolink}} generally helpful \| [[https://heartinsight.heart.org/August-2014/How-Tai-Chi-Impacts-Cardiovascular-Health/\|heart health research]] \|
	\| meditation \| \|{{:home:ok.png?nolink}} can develop coping skills \| \|		\| meditation \| \|{{:home:ok.png?nolink}} can develop coping skills \| \|

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	===== Read more =====		===== Read more =====

-	* [[http://nyti.ms/n99bk8\|Anti-bacterial soaps may lead to health problems]] – Regulators, consumer advocates and soap manufacturers are locked in a battle over triclosan, the active ingredient in antibacterial soaps like Dial Complete. It is so prevalent that a survey by the Centers for Disease Control and Prevention found the chemical present in the urine of 75 percent of Americans over the age of 5. Health problems may include hormonal regulation and antibiotic resistance.	+	* [[https://nyti.ms/n99bk8\|Anti-bacterial soaps may lead to health problems]] – Regulators, consumer advocates and soap manufacturers are locked in a battle over triclosan, the active ingredient in antibacterial soaps like Dial Complete. It is so prevalent that a survey by the Centers for Disease Control and Prevention found the chemical present in the urine of 75 percent of Americans over the age of 5. Health problems may include hormonal regulation and antibiotic resistance.


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	{{tag> Non-MP_therapies }}		{{tag> Non-MP_therapies }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3163&forum_id=32&jump_to=54410#p54410 f276	+	* https://www.marshallprotocol.com/view_topic.php?id=3163&forum_id=32&jump_to=54410#p54410 f276
-	* http://www.marshallprotocol.com/view_topic.php?id=10&forum_id=2&jump_to=42280#p42280 e16	+	* https://www.marshallprotocol.com/view_topic.php?id=10&forum_id=2&jump_to=42280#p42280 e16
-	* http://www.marshallprotocol.com/forum32/1092.html f350	+	* https://www.marshallprotocol.com/forum32/1092.html f350
-	* http://www.marshallprotocol.com/forum32/1078.html#p42275 f25	+	* https://www.marshallprotocol.com/forum32/1078.html#p42275 f25
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=43283#p43283 f26	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=43283#p43283 f26
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=55298#p55298 f29	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=55298#p55298 f29
-	* http://www.marshallprotocol.com/forum32/1768.html f332	+	* https://www.marshallprotocol.com/forum32/1768.html f332

	<blockquote>		<blockquote>
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	Resource for market drug information:		Resource for market drug information:
-	* http://dailymed.nlm.nih.gov/dailymed/about.cfm	+	* https://dailymed.nlm.nih.gov/dailymed/about.cfm

	Joyful: what's up with the section on bromelain? First of all, the body is full of enzymes. And how do we know that bromelain, etc. is immunomodulatory? --- //Paul Albert 07.05.2010//		Joyful: what's up with the section on bromelain? First of all, the body is full of enzymes. And how do we know that bromelain, etc. is immunomodulatory? --- //Paul Albert 07.05.2010//
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	As it has become more clear that the Benicar's role as a VDR agonist is the heart of the success of the Marshall Protocol, another key to an effective recovery is to avoid over-loading the body with the sometimes toxic results of immunopathology. This means appropriately lowering doses of antibiotics when necessary and a much stronger focus on defining what "tolerable" immunopathology looks like. It would seem to me that pacing your recovery such that your own body's ability to "detoxify" itself is not overwhelmed is, in fact, the "detoxification method" most compatible with the Marshall Protocol.		As it has become more clear that the Benicar's role as a VDR agonist is the heart of the success of the Marshall Protocol, another key to an effective recovery is to avoid over-loading the body with the sometimes toxic results of immunopathology. This means appropriately lowering doses of antibiotics when necessary and a much stronger focus on defining what "tolerable" immunopathology looks like. It would seem to me that pacing your recovery such that your own body's ability to "detoxify" itself is not overwhelmed is, in fact, the "detoxification method" most compatible with the Marshall Protocol.

-	All of that being said, There are some palliatives that seem to be more benign. When a palliative is found that seems to have minimal impact on the ultimate goals of restoring the innate immune system and promote it's activity in clearing the pathogens causing the Th1 diseases, then we do try to communicate that via the articles in the MP knowledge base. (See: http://mpkb.org/home/othertreatments.)	+	All of that being said, There are some palliatives that seem to be more benign. When a palliative is found that seems to have minimal impact on the ultimate goals of restoring the innate immune system and promote it's activity in clearing the pathogens causing the Th1 diseases, then we do try to communicate that via the articles in the MP knowledge base. (See: https://mpkb.org/home/othertreatments.)

	When someone wants to discuss a palliative that has been helpful to them, they are encouraged to post their own experience with it as part of their progress report where others in the support community can review and provide feedback. I also recommend searching for related scientific discussions and articles in the MP knowledge base and the forums (Prof. Marshall's Perspective, Prof. Marshall's Members' Only Topics, and General Questions and Discussion).		When someone wants to discuss a palliative that has been helpful to them, they are encouraged to post their own experience with it as part of their progress report where others in the support community can review and provide feedback. I also recommend searching for related scientific discussions and articles in the MP knowledge base and the forums (Prof. Marshall's Perspective, Prof. Marshall's Members' Only Topics, and General Questions and Discussion).
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-	===== References =====	+	===== References =====</nodisp>

12.18.2018		current
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	====== Resources for physicians ======		====== Resources for physicians ======

-	<relatedarticles> [[home:pathogenesis\|Science behind Pathogenesis]], [[home:protocol\|Science behind Protocol]], [[home:patients:grappling_uncertainty\|Grappling with uncertainty]] </article>	+	<relatedarticles> [[home:starting:usingforum:home_help_using_forums:a_a_href\|5 key elements]], [[home:pathogenesis\|Science behind Pathogenesis]], [[home:protocol\|Science behind Protocol]], [[home:patients:grappling_uncertainty\|Grappling with uncertainty]] </article>

	The Marshall Protocol (MP) is the name given to a therapy devised by Professor Trevor Marshall. Based on the pathogenesis Marshall has proposed for chronic inflammatory disease, the MP is aimed at targeting bacteria, fungi, viruses, and other microbes that appear to interact to cause chronic inflammatory diseases.		The Marshall Protocol (MP) is the name given to a therapy devised by Professor Trevor Marshall. Based on the pathogenesis Marshall has proposed for chronic inflammatory disease, the MP is aimed at targeting bacteria, fungi, viruses, and other microbes that appear to interact to cause chronic inflammatory diseases.

-	Marshall and colleagues have hypothesized that chronic inflammatory diseases, including many autoimmune diseases, are caused by dysbiosis of a metagenomic microbiota: communities of microbial pathogens, many of which persist intracellularly. A [[home:publications:proal_autoimmunity_reviews_2009\|recent (2009) peer-reviewed paper]] describes this [[home:pathogenesis\|Pathogenesis]] in more detail.(({{pubmed>long:19393196}}))	+	Marshall and colleagues have hypothesized that chronic inflammatory diseases, including many autoimmune diseases, are caused by dysbiosis of a metagenomic microbiota: communities of microbial pathogens, many of which persist intracellularly. A [[home:publications:proal_autoimmunity_reviews_2009\|recent (2009) peer-reviewed paper]] describes this [[home:pathogenesis\|Pathogenesis]] in more detail.(({{pmid>long:19393196}}))

	Supported by Autoimmunity Research Foundation, the MP has been available since 2002 and has [[home:publications:perez_congress_on_autoimmunity_2008\|been used]] in a wide range of chronic inflammatory illnesses.		Supported by Autoimmunity Research Foundation, the MP has been available since 2002 and has [[home:publications:perez_congress_on_autoimmunity_2008\|been used]] in a wide range of chronic inflammatory illnesses.
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	In determining whether a patient can be successfully treated with the MP, a specific chronic disease		In determining whether a patient can be successfully treated with the MP, a specific chronic disease
-	diagnosis is not as important as the clinical assessment by an interested health care provider, the results of a [[home:starting:therapeutic_probe\|therapeutic probe]], and outcome of the [[home:tests:vitdinterpretation\|vitamin D metabolites blood test]].(({{pubmed>long:19758177}}))	+	diagnosis is not as important as the clinical assessment by an interested health care provider, the results of a [[home:starting:therapeutic_probe\|therapeutic probe]], and outcome of the [[home:tests:vitdinterpretation\|vitamin D metabolites blood test]].(({{pmid>long:19758177}}))

-	According to the Marshall Pathogenesis, chronic inflammatory disease is characterized by dysregulation of the nuclear receptor pathways which control the innate immune response. For example, the Vitamin D nuclear receptor (VDR) expresses many of the body's antimicrobial peptides (along with TLR2). In addition to down-regulation of expression of the VDR itself by many common bacteria and viruses, antagonistic microbial metabolites incrementally block ligands from activating it. Ingested vitamin D slows activity of the receptor in this same manner, preventing the body from killing the pathogens at the heart of the disease state. That is why avoidance of ingested vitamin D (in food and supplements) is essential for the innate immune system to recover. (({{pubmed>long:19393200}})) ((Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. [[home:publications:waterhouse_new_research_2006\|High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor — Implications of dysregulated vitamin D for diagnosis and treatment of Chronic Disease]]. In //Vitamin D: New Research//.	+	According to the Marshall Pathogenesis, chronic inflammatory disease is characterized by dysregulation of the nuclear receptor pathways which control the innate immune response. For example, the Vitamin D nuclear receptor (VDR) expresses many of the body's antimicrobial peptides (along with TLR2). In addition to down-regulation of expression of the VDR itself by many common bacteria and viruses, antagonistic microbial metabolites incrementally block ligands from activating it. Ingested vitamin D slows activity of the receptor in this same manner, preventing the body from killing the pathogens at the heart of the disease state. That is why avoidance of ingested vitamin D (in food and supplements) is essential for the innate immune system to recover. (({{pmid>long:19393200}})) ((Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. [[home:publications:waterhouse_new_research_2006\|High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor — Implications of dysregulated vitamin D for diagnosis and treatment of Chronic Disease]]. In //Vitamin D: New Research//.
	Volume 1. Edited by: Stoltz VD. New York: Nova Science Publishers; 2006. ISBN: 1-60021-000-7.))		Volume 1. Edited by: Stoltz VD. New York: Nova Science Publishers; 2006. ISBN: 1-60021-000-7.))

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	However, some patients do not experience significant photosensitivity during recovery. Those who do often find it more manageable several years into the therapy.		However, some patients do not experience significant photosensitivity during recovery. Those who do often find it more manageable several years into the therapy.

-	<note warning>Important: The Autoimmunity Research Foundation does not support or license the public use of this therapy for patients not actively participating on the Marshall Protocol study site at [[http://www.marshallprotocol.com\|MarshallProtocol.com]].</note>	+	<note warning>Important: The Autoimmunity Research Foundation does not support or license the public use of this therapy for patients not actively participating on the Marshall Protocol study site at [[https://www.marshallprotocol.com\|MarshallProtocol.com]].</note>


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	==== Online forum ====		==== Online forum ====

-	Access to the Marshall Protocol study site is available for health professionals upon request. Health Professionals are welcome, and will be manually joined into the database after sending an email to Moderators@MarshallProtocol.com listing their desired username and password. Health professionals are granted access to the [[http://www.marshallprotocol.com/forum17/\|Private Section for Health Professionals]].	+	Access to the Marshall Protocol study site is available for health professionals upon request. Health Professionals are welcome, and will be manually joined into the database after sending an email to Moderators@MarshallProtocol.com listing their desired username and password. Health professionals are granted access to the [[https://www.marshallprotocol.com/forum17/\|Private Section for Health Professionals]].


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	==== Contact Trevor Marshall directly ====		==== Contact Trevor Marshall directly ====

-	In addition to the [[http://www.marshallprotocol.com/forum17/\|Private Section for Health Professionals]], health professionals have the option to contact Dr. Marshall at TM@AutoimmunityResearch.org or (818) 584-1201.	+	In addition to the [[https://www.marshallprotocol.com/forum17/\|Private Section for Health Professionals]], health professionals have the option to contact Dr. Marshall at TM@AutoimmunityResearch.org or (818) 584-1201.

	To ensure success, physicians are asked to encourage their patients to carefully study this Knowledge Base. This site provides additional instructions, helpful hints, and support that will greatly ease a practitioner’s emotional support workload and smooth the patient’s path to recovery.		To ensure success, physicians are asked to encourage their patients to carefully study this Knowledge Base. This site provides additional instructions, helpful hints, and support that will greatly ease a practitioner’s emotional support workload and smooth the patient’s path to recovery.
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum2/11458.html e73	+	* https://www.marshallprotocol.com/forum2/11458.html e73
-	* http://www.marshallprotocol.com/view_topic.php?id=238&forum_id=2&jump_to=81703#p81703 e145	+	* https://www.marshallprotocol.com/view_topic.php?id=238&forum_id=2&jump_to=81703#p81703 e145


	Trevor also mentioned that we probably do need to develop a "cover letter" which may take more time.		Trevor also mentioned that we probably do need to develop a "cover letter" which may take more time.

-	===== References =====	+	===== References =====</nodisp>

01.03.2012		current
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	* [[home:tests:electrolytes\|electrolytes]]		* [[home:tests:electrolytes\|electrolytes]]
	* kidney function – //see [[#kidney_renal_function\|above]]//		* kidney function – //see [[#kidney_renal_function\|above]]//
-	* [[home:tests:lipids\|lipid profile]] – Many observations that conflict with the LDL receptor hypothesis (i.e. high LDL cholesterol is the most important cause of atherosclerosis), may be explained by the idea that high serum cholesterol and/or high LDL is protective against infection and atherosclerosis.(({{pubmed>long:14631060}}))	+	* [[home:tests:lipids\|lipid profile]] – Many observations that conflict with the LDL receptor hypothesis (i.e. high LDL cholesterol is the most important cause of atherosclerosis), may be explained by the idea that high serum cholesterol and/or high LDL is protective against infection and atherosclerosis.(({{pmid>long:14631060}}))
	* [[home:tests:liver\|liver function]]		* [[home:tests:liver\|liver function]]
	* [[home:diseases:anemia#tests\|red blood cell measures]] – Low levels of iron or cells that transport iron reflect the body's attempt to limit infection.		* [[home:diseases:anemia#tests\|red blood cell measures]] – Low levels of iron or cells that transport iron reflect the body's attempt to limit infection.
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-	{{tag> }}	+	{{tag>tests }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/3833.html#p33979 f249	+	* https://www.marshallprotocol.com/forum32/3833.html#p33979 f249
-	* http://www.marshallprotocol.com/view_topic.php?id=2019&forum_id=32&jump_to=75795#p75795 f215	+	* https://www.marshallprotocol.com/view_topic.php?id=2019&forum_id=32&jump_to=75795#p75795 f215
-	* http://www.marshallprotocol.com/forum32/4264.html f188	+	* https://www.marshallprotocol.com/forum32/4264.html f188
-	* http://www.marshallprotocol.com/view_topic.php?id=3833&forum_id=32&jump_to=71683#p71683 f251	+	* https://www.marshallprotocol.com/view_topic.php?id=3833&forum_id=32&jump_to=71683#p71683 f251
-	* http://www.marshallprotocol.com/forum32/1198.html#p9329 f195	+	* https://www.marshallprotocol.com/forum32/1198.html#p9329 f195
-	* http://www.marshallprotocol.com/view_topic.php?id=1198&forum_id=32&jump_to=84710#p84710 f197	+	* https://www.marshallprotocol.com/view_topic.php?id=1198&forum_id=32&jump_to=84710#p84710 f197
-	* http://www.marshallprotocol.com/view_topic.php?id=3479&forum_id=32&jump_to=71473#p71473 f253	+	* https://www.marshallprotocol.com/view_topic.php?id=3479&forum_id=32&jump_to=71473#p71473 f253
-	* http://www.marshallprotocol.com/forum32/3178.html f317	+	* https://www.marshallprotocol.com/forum32/3178.html f317
-	* http://www.marshallprotocol.com/view_topic.php?id=7350&forum_id=32&jump_to=100406#p100406 f135	+	* https://www.marshallprotocol.com/view_topic.php?id=7350&forum_id=32&jump_to=100406#p100406 f135
-	* http://www.marshallprotocol.com/forum32/7350.html#p76298 f132	+	* https://www.marshallprotocol.com/forum32/7350.html#p76298 f132
-	* http://www.marshallprotocol.com/forum32/8622.html f145	+	* https://www.marshallprotocol.com/forum32/8622.html f145
-	* http://www.marshallprotocol.com/forum32/7728.html#p82521 f200	+	* https://www.marshallprotocol.com/forum32/7728.html#p82521 f200
-	* http://www.marshallprotocol.com/forum32/3471.html#p31063 f258	+	* https://www.marshallprotocol.com/forum32/3471.html#p31063 f258
-	* http://www.marshallprotocol.com/view_topic.php?id=3471&forum_id=32&jump_to=67119#p67119 f259	+	* https://www.marshallprotocol.com/view_topic.php?id=3471&forum_id=32&jump_to=67119#p67119 f259
-	* http://www.marshallprotocol.com/view_topic.php?id=7728&forum_id=32&jump_to=84635#p84635 f202	+	* https://www.marshallprotocol.com/view_topic.php?id=7728&forum_id=32&jump_to=84635#p84635 f202
-	* http://www.marshallprotocol.com/view_topic.php?id=3815&forum_id=32&jump_to=75778#p75778 f192	+	* https://www.marshallprotocol.com/view_topic.php?id=3815&forum_id=32&jump_to=75778#p75778 f192
-	* http://www.marshallprotocol.com/view_topic.php?id=4264&forum_id=32&jump_to=85235#p85235 f190	+	* https://www.marshallprotocol.com/view_topic.php?id=4264&forum_id=32&jump_to=85235#p85235 f190
-	* http://www.marshallprotocol.com/forum32/5450.html f282	+	* https://www.marshallprotocol.com/forum32/5450.html f282
-	* http://www.marshallprotocol.com/forum32/4264.html#p69981 f189	+	* https://www.marshallprotocol.com/forum32/4264.html#p69981 f189
-	* http://www.marshallprotocol.com/view_topic.php?id=10992&forum_id=32&jump_to=133747#p133747 f117	+	* https://www.marshallprotocol.com/view_topic.php?id=10992&forum_id=32&jump_to=133747#p133747 f117
-	* http://www.marshallprotocol.com/view_topic.php?id=2495&forum_id=32&jump_to=45595#p45595 f229	+	* https://www.marshallprotocol.com/view_topic.php?id=2495&forum_id=32&jump_to=45595#p45595 f229
-	* http://www.marshallprotocol.com/view_topic.php?id=3833&forum_id=32&jump_to=71474#p71474 f250	+	* https://www.marshallprotocol.com/view_topic.php?id=3833&forum_id=32&jump_to=71474#p71474 f250
-	* http://www.marshallprotocol.com/forum32/2019.html#p16519 f214	+	* https://www.marshallprotocol.com/forum32/2019.html#p16519 f214
-	* http://www.marshallprotocol.com/forum32/1200.html f343	+	* https://www.marshallprotocol.com/forum32/1200.html f343
-	* http://www.marshallprotocol.com/forum32/1599.html f338	+	* https://www.marshallprotocol.com/forum32/1599.html f338
-	* http://www.marshallprotocol.com/view_topic.php?id=2019&forum_id=32&jump_to=81508#p81508 f216	+	* https://www.marshallprotocol.com/view_topic.php?id=2019&forum_id=32&jump_to=81508#p81508 f216
-	* http://www.marshallprotocol.com/forum32/2880.html f321	+	* https://www.marshallprotocol.com/forum32/2880.html f321
-	* http://www.marshallprotocol.com/forum32/2155.html f326	+	* https://www.marshallprotocol.com/forum32/2155.html f326
-	* http://www.marshallprotocol.com/forum32/2487.html#p21648 f106	+	* https://www.marshallprotocol.com/forum32/2487.html#p21648 f106
-	* http://www.marshallprotocol.com/view_topic.php? id=2487&forum_id=32&jump_to=90167#p90167 f110	+	* https://www.marshallprotocol.com/view_topic.php? id=2487&forum_id=32&jump_to=90167#p90167 f110
	*		*

Line 142:		Line 143:


-	Total Protein test is [[http://labtestsonline.org/understanding/analytes/tp/test.html\|described here]].	+	Total Protein test is [[https://labtestsonline.org/understanding/analytes/tp/test.html\|described here]].

-	Albumin test is [[http://www.labtestsonline.org/understanding/analytes/albumin/test.html\|describedhere]].	+	Albumin test is [[https://www.labtestsonline.org/understanding/analytes/albumin/test.html\|describedhere]].

-	Calcium test is [[http://www.labtestsonline.org/understanding/analytes/calcium/test.html\|describedhere]].	+	Calcium test is [[https://www.labtestsonline.org/understanding/analytes/calcium/test.html\|describedhere]].

-	Alkaline Phosphatase test is [[http://www.labtestsonline.org/understanding/analytes/alp/test.html\|describedhere]].	+	Alkaline Phosphatase test is [[https://www.labtestsonline.org/understanding/analytes/alp/test.html\|describedhere]].

-	Aspartate Aminotransferase test is [[http://www.labtestsonline.org/understanding/analytes/ast/test.html\|describedhere]].	+	Aspartate Aminotransferase test is [[https://www.labtestsonline.org/understanding/analytes/ast/test.html\|describedhere]].

	Serum glutamic-oxaloacetic transaminase, SGOT		Serum glutamic-oxaloacetic transaminase, SGOT

-	Bilirubin test is [[http://www.labtestsonline.org/understanding/analytes/bilirubin/test.html\|describedhere]].	+	Bilirubin test is [[https://www.labtestsonline.org/understanding/analytes/bilirubin/test.html\|describedhere]].

-	CBC (complete blood count) with differential test is [[http://labtestsonline.org/understanding/analytes/cbc/test.html\|described here]].	+	CBC (complete blood count) with differential test is [[https://labtestsonline.org/understanding/analytes/cbc/test.html\|described here]].

	* basophils		* basophils
Line 181:		Line 182:


-	The cortisol test is [[http://labtestsonline.org/understanding/analytes/cortisol/test.html\|described here]].	+	The cortisol test is [[https://labtestsonline.org/understanding/analytes/cortisol/test.html\|described here]].

-	C-peptide test is [[http://labtestsonline.org/understanding/analytes/c_peptide/test.html\|described here]].	+	C-peptide test is [[https://labtestsonline.org/understanding/analytes/c_peptide/test.html\|described here]].

-	Gamma-Glutamyl Transferase (GGT) test is [[http://labtestsonline.org/understanding/analytes/ggt/test.html\|described here]].	+	Gamma-Glutamyl Transferase (GGT) test is [[https://labtestsonline.org/understanding/analytes/ggt/test.html\|described here]].

-	Lipase test is [[http://labtestsonline.org/understanding/analytes/lipase/test.html\|described here]].	+	Lipase test is [[https://labtestsonline.org/understanding/analytes/lipase/test.html\|described here]].


-	Insulin test is [[http://labtestsonline.org/understanding/analytes/insulin/test.html\|described here]].	+	Insulin test is [[https://labtestsonline.org/understanding/analytes/insulin/test.html\|described here]].


-	Phosphorous test is [[http://labtestsonline.org/understanding/analytes/phosphorus/test.html\|described here]].	+	Phosphorous test is [[https://labtestsonline.org/understanding/analytes/phosphorus/test.html\|described here]].


Line 211:		Line 212:
	</blockquote>		</blockquote>

-	[[http://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests\|Wikipedia's reference range for blood tests]]	+	[[https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests\|Wikipedia's reference range for blood tests]]


Line 221:		Line 222:
	Phillyguy		Phillyguy

-	http://dspace.creighton.edu/xmlui/handle/10504/7063	+	https://dspace.creighton.edu/xmlui/handle/10504/7063


Line 233:		Line 234:

	<blockquote>My own Doc wanted me to have a biopsy after my PSA doubled in 12 months at an early point in MP recovery... I dissuaded him by citing the European guidelines, which are much more conservative. Anyway, here is something we might want to help Paul put in the MPKB :) Maybe we also want the European guidelines in there too :)		<blockquote>My own Doc wanted me to have a biopsy after my PSA doubled in 12 months at an early point in MP recovery... I dissuaded him by citing the European guidelines, which are much more conservative. Anyway, here is something we might want to help Paul put in the MPKB :) Maybe we also want the European guidelines in there too :)
-	http://www.businessweek.com/lifestyle/content/healthday/650257.html..trevor..	+	https://www.businessweek.com/lifestyle/content/healthday/650257.html..trevor..
	</blockquote>		</blockquote>

	Is triglycerides any good indicator of immmuopathology? I suggest this is removed. Inge Lindseth		Is triglycerides any good indicator of immmuopathology? I suggest this is removed. Inge Lindseth

-	===== References =====	+	===== References =====</nodisp>

06.27.2012		current
Line 9:		Line 9:

	* [[home:translations:german\|Deutsch (German)]]		* [[home:translations:german\|Deutsch (German)]]
-	* [[http://mpkb.org/_media/home/translations/germanmetagenome.pdf\|Autoimmunkrankheit und das menschliche Metagenom (German translation)]]	+	* [[https://mpkb.org/_media/home/translations/germanmetagenome.pdf\|Autoimmunkrankheit und das menschliche Metagenom (German translation)]]
-	* [[http://mpkb.org/_media/home/translations/germanimmunostimulation.pdf\|Immunstimulierung im Zeitalter der Metagenome (German translation)]]	+	* [[https://mpkb.org/_media/home/translations/germanimmunostimulation.pdf\|Immunstimulierung im Zeitalter der Metagenome (German translation)]]
	* [[home:translations:spanish\|Español (Spanish) ]]		* [[home:translations:spanish\|Español (Spanish) ]]
	* Nederlandse (Dutch) – //Translation of Marshall Protocol guidelines not yet available//		* Nederlandse (Dutch) – //Translation of Marshall Protocol guidelines not yet available//
-	* [[http://mpkb.org/_media/home/translations/marshallwetenschap.pdf\|De wetenschap achter het Marshall Protocol]] – A basic introduction to the MP in Dutch	+	* [[https://mpkb.org/_media/home/translations/marshallwetenschap.pdf\|De wetenschap achter het Marshall Protocol]] – A basic introduction to the MP in Dutch
	* [[home:translations:norwegian\|Norsk (Norwegian)]]		* [[home:translations:norwegian\|Norsk (Norwegian)]]
		+	* [[home:translations:russian\|(Russian)]]
		+
	===== Machine translation (lower quality) =====		===== Machine translation (lower quality) =====

Line 26:		Line 28:
	===== Forums in non-English languages =====		===== Forums in non-English languages =====

-	* [[http://ugesa.org/forum/\|German language MP forum]] (independent of ARF)	+	* [[https://ugesa.org/forum/\|German language MP forum]] (independent of ARF)




		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 41:		Line 44:

	Dr. Elke Unmüssig, from Berlin, wrote an article for the German printed-journal "Borreliose Wissen" about the Marshall Protocol. It can be downloaded from Here::		Dr. Elke Unmüssig, from Berlin, wrote an article for the German printed-journal "Borreliose Wissen" about the Marshall Protocol. It can be downloaded from Here::
-	http://www.elke-unmuessig.de/wp-content/uploads/2010/10/Behandlung-durch-das-Marshall-Protocol_final.pdf	+	https://www.elke-unmuessig.de/wp-content/uploads/2010/10/Behandlung-durch-das-Marshall-Protocol_final.pdf


Line 62:		Line 65:

	--PA		--PA
-	</blockquote>	+	</blockquote></nodisp>