Marshall Protocol Knowledge Base - home:mp

Taking a break from the Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.24.2015		current
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	So, again, thank you, and do let us know how things are going from time to time.		So, again, thank you, and do let us know how things are going from time to time.

-	p.s., our new MP knowledge base provides links to recent papers, publications, and presentations by our research team that you may find to be of interest... http://mpkb.org/home/publications	+	p.s., our new MP knowledge base provides links to recent papers, publications, and presentations by our research team that you may find to be of interest... https://mpkb.org/home/publications

	//Joyful, MarshallProtocol.com// </blockquote>		//Joyful, MarshallProtocol.com// </blockquote>
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	//John McDonald, MarshallProtocol.com// </blockquote>		//John McDonald, MarshallProtocol.com// </blockquote>

		+
		+	{{tag>MP}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1128&forum_id=32&jump_to=39971#p39971 f300	+	* https://www.marshallprotocol.com/view_topic.php?id=1128&forum_id=32&jump_to=39971#p39971 f300
-	* http://www.marshallprotocol.com/forum32/5504.html#p52138 f279	+	* https://www.marshallprotocol.com/forum32/5504.html#p52138 f279
-	* http://www.marshallprotocol.com/forum32/1128.html f299	+	* https://www.marshallprotocol.com/forum32/1128.html f299


		+	</nodisp>

Expiration date of medications

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	===== Effective shelf life =====		===== Effective shelf life =====

-	The shelf life of medications is a matter of dispute with no clear answer. A large study of medications stockpiled by the military for decades revealed that most had not lost potency and were still safe well past the manufacturers expiration dates((Taylor JS, Lyon RC, Prasanna HR, Hussain AS. Stability profiles of drug products extended beyond labeled expiration dates. Program and abstracts of the 2002 FDA Science Forum; February 20-21, 2002; Washington, DC. Poster Abstract, Board AC-08. Available at: http://www.cfsan.fda.gov/~frf/forum02/a109ac8.htm. Accessed April 8, 2004)). There were only a few (insulin, nitroglycerin and liquid antibiotics) that lost potency. None were deemed unsafe. A [[http://www.medscape.com/viewarticle/472851_6\|Medscape article]] reviews this study and others in greater detail.	+	The shelf life of medications is a matter of dispute with no clear answer. A large study of medications stockpiled by the military for decades revealed that most had not lost potency and were still safe well past the manufacturers expiration dates((Taylor JS, Lyon RC, Prasanna HR, Hussain AS. Stability profiles of drug products extended beyond labeled expiration dates. Program and abstracts of the 2002 FDA Science Forum; February 20-21, 2002; Washington, DC. Poster Abstract, Board AC-08. Available at: https://www.cfsan.fda.gov/~frf/forum02/a109ac8.htm. Accessed April 8, 2004)). There were only a few (insulin, nitroglycerin and liquid antibiotics) that lost potency. None were deemed unsafe. A [[https://www.medscape.com/viewarticle/472851_6\|Medscape article]] reviews this study and others in greater detail.

	Although older medication may be safe to take, in this litigious society, no medical professional is going to suggest a patient takes any medication that is listed as expired.		Although older medication may be safe to take, in this litigious society, no medical professional is going to suggest a patient takes any medication that is listed as expired.
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	===== Exposure to moisture =====		===== Exposure to moisture =====

-	With regard to minocycline, the medication does not appear to degrade in air via oxidation – only water in a process known as hydrated oxidation. This is a problem with all the other MP antibiotics as well. One complication of taking antibiotics stored in a moist environment is [[http://www.emedicine.com/ped/topic756.htm\|Fanconi syndrome]].	+	With regard to minocycline, the medication does not appear to degrade in air via oxidation – only water in a process known as hydrated oxidation. This is a problem with all the other MP antibiotics as well. One complication of taking antibiotics stored in a moist environment is [[https://www.emedicine.com/ped/topic756.htm\|Fanconi syndrome]].


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		+	{{tag>MP}}


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	</blockquote>		</blockquote>

-	A copy of the article is here: http://www.medicalletter.org/freedocs/expdrugs.pdf	+	A copy of the article is here: https://www.medicalletter.org/freedocs/expdrugs.pdf

	===== References =====		===== References =====
		+	</nodisp>

Immunopathology

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Insurance coverage

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.05.2014		current
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	===== Doctors have a right to exercise their judgment =====		===== Doctors have a right to exercise their judgment =====

-	According to a [[http://www.fda.gov/OC/OHRT/IRBS/offlabel.html\|statement]] by the FDA, "Good medical practice and the best interests of the patient require that physicians use legally available drugs, biologics and devices according to their best knowledge and judgment."	+	According to a [[https://www.fda.gov/OC/OHRT/IRBS/offlabel.html\|statement]] by the FDA, "Good medical practice and the best interests of the patient require that physicians use legally available drugs, biologics and devices according to their best knowledge and judgment."

	It is the doctor who has the license to practice medicine – not the insurance company! With the consent of the patient, it is the doctor's right and responsibility to decide which therapies a patient receives. If a doctor is williing to accept responsibility for the way he or she practices medicine, an insurance company has no right to interfere.		It is the doctor who has the license to practice medicine – not the insurance company! With the consent of the patient, it is the doctor's right and responsibility to decide which therapies a patient receives. If a doctor is williing to accept responsibility for the way he or she practices medicine, an insurance company has no right to interfere.
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	* Experimental – Some insurers consciously do not cover medications considered experimental, so it is important not to use that word.		* Experimental – Some insurers consciously do not cover medications considered experimental, so it is important not to use that word.
	* Off-label use – In the context of the MP, referring Benicar use as off-label is ill-advised – even though off-label use of medications is [[home:mp:off-label\|expressly permitted and encouraged]] by the FDA.		* Off-label use – In the context of the MP, referring Benicar use as off-label is ill-advised – even though off-label use of medications is [[home:mp:off-label\|expressly permitted and encouraged]] by the FDA.
-	* If accurate, a diagnosis of hypertension is helpful – If a patient fits the criteria for diagnosis of hypertension, the FDA-approved indication for Benicar, and if the patient's blood pressure does not respond adequately to one 40mg tablet a day, then the package insert's [[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021286s020lbl.pdf\|prescribing instructions']] "Dosage and Administration" saying "dosage must be individualized."	+	* If accurate, a diagnosis of hypertension is helpful – If a patient fits the criteria for diagnosis of hypertension, the FDA-approved indication for Benicar, and if the patient's blood pressure does not respond adequately to one 40mg tablet a day, then the package insert's [[https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021286s020lbl.pdf\|prescribing instructions']] "Dosage and Administration" saying "dosage must be individualized."

	<html>		<html>
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	The label:		The label:

-	http://web.archive.org/web/20060309235055/http://www.fda.gov/medwatch/SAFETY/2004/nov_PI/Benicar_Tab_PI.pdf	+	https://web.archive.org/web/20060309235055/https://www.fda.gov/medwatch/SAFETY/2004/nov_PI/Benicar_Tab_PI.pdf

-	http://www.drugs.com/pro/benicar.html	+	https://www.drugs.com/pro/benicar.html
	-->		-->
	</html>		</html>
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-	* {{pubmed>long:11361048}}	+	* {{pmid>long:11361048}}
-	* {{pubmed>long:15291377}}	+	* {{pmid>long:15291377}}

-	Efficacy of Benicar has been described in various conditions by a [[home:publications:waterhouse_annals_2009\|forthcoming peer-reviewed paper]] in //Annals of the New York Academy of Sciences//. That paper will be available in the Fall of 2009. For a preprint – or for any other paper – ask on the [[http://marshallprotocol.com\|MP study site]].	+	Efficacy of Benicar has been described in various conditions by a [[home:publications:waterhouse_annals_2009\|forthcoming peer-reviewed paper]] in //Annals of the New York Academy of Sciences//. That paper will be available in the Fall of 2009. For a preprint – or for any other paper – ask on the [[https://marshallprotocol.com\|MP study site]].

	==== Letters to present to an insurance company ====		==== Letters to present to an insurance company ====
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	===== Read more =====		===== Read more =====

-	* [[http://www.cnn.com/2007/HEALTH/07/19/patient.insurance/\|Tips To Effectively Battle Your Insurance Company]]	+	* [[https://www.cnn.com/2007/HEALTH/07/19/patient.insurance/\|Tips To Effectively Battle Your Insurance Company]]


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-	{{tag>Starting_the_Marshall_Protocol}}	+	{{tag>MP Starting_the_Marshall_Protocol}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum2/304.html#p18560 e120	+	* https://www.marshallprotocol.com/forum2/304.html#p18560 e120
-	* http://www.marshallprotocol.com/forum2/304.html e122	+	* https://www.marshallprotocol.com/forum2/304.html e122
-	* http://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=43440#p43440 e127	+	* https://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=43440#p43440 e127
-	* http://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=111632#p111632 e132	+	* https://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=111632#p111632 e132
-	* http://www.marshallprotocol.com/forum2/398.html e255	+	* https://www.marshallprotocol.com/forum2/398.html e255
-	* http://www.marshallprotocol.com/forum2/304.html#p79942 e130	+	* https://www.marshallprotocol.com/forum2/304.html#p79942 e130
-	* http://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=84963#p84963 e131	+	* https://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=84963#p84963 e131
-	* http://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=35803#p35803 e126	+	* https://www.marshallprotocol.com/view_topic.php?id=304&forum_id=2&jump_to=35803#p35803 e126
-	* http://www.marshallprotocol.com/forum2/304.html#p51098 e128	+	* https://www.marshallprotocol.com/forum2/304.html#p51098 e128</nodisp>

Managing immunopathology (IP)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Minocycline

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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	Minocycline hydrochloride, also known as minocycline, is a broad spectrum tetracycline antibiotic, and was the base antibiotic of the Marshall Protocol.		Minocycline hydrochloride, also known as minocycline, is a broad spectrum tetracycline antibiotic, and was the base antibiotic of the Marshall Protocol.

-	Minocycline is recognized as a DMARD (Disease-Modifying Anti-Rheumatic Drug) by the American College of Rheumatology, which recommends its use as a treatment for mild rheumatoid arthritis.(({{pubmed>long:18512708}})) To minimize its [[home:othertreatments:antibacterials:highdose\|dose-dependent immunosuppressive effects]], the Marshall Protocol uses minocycline at doses [[home:protocol:mp_antibiotics:dosing\|much lower]] than otherwise prescribed by rheumatologists.	+	Minocycline is recognized as a DMARD (Disease-Modifying Anti-Rheumatic Drug) by the American College of Rheumatology, which recommends its use as a treatment for mild rheumatoid arthritis.(({{pmid>long:18512708}})) To minimize its [[home:othertreatments:antibacterials:highdose\|dose-dependent immunosuppressive effects]], the Marshall Protocol uses minocycline at pulsed doses [[home:protocol:mp_antibiotics:dosing\|much lower]] than otherwise prescribed by rheumatologists.

	Either generic or brand name is appropriate to use.		Either generic or brand name is appropriate to use.
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-	Minocycline has been in use for over 40 years yet continues to be effective against MRSA(({{pubmed>long:18221183}})) and to reduce disease severity even after follow-up several years later.(({{pubmed>long:10446869}}))	+	Minocycline has been in use for over 40 years yet continues to be effective against MRSA(({{pmid>long:18221183}})) and to reduce disease severity even after follow-up several years later.(({{pmid>long:10446869}}))


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	{{tag>Other_medication MP}}		{{tag>Other_medication MP}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	Chef Bama</blockquote>		Chef Bama</blockquote>

-	[[http://www.medscape.com/viewarticle/728141\|Minocycline Promising in Fragile X Syndrome]]	+	[[https://www.medscape.com/viewarticle/728141\|Minocycline Promising in Fragile X Syndrome]]


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	Minocycline, a clinically used tetracycline for over 40 years, crosses the blood-brain barrier and prevents caspase up-regulation. It reduces apoptosis in mouse models of Huntington's disease and familial amyotrophic lateral sclerosis (ALS) and is in clinical trial for sporadic ALS. Because apoptosis also occurs after brain and spinal cord (SCI) injury, its prevention may be useful in improving recovery. We analyzed minocycline's neuroprotective effects over 28 days following contusion SCI and found significant functional recovery compared to tetracycline. Histology, immunocytochemistry, and image analysis indicated statistically significant tissue sparing, reduced apoptosis and microgliosis, and less activated caspase-3 and substrate cleavage.		Minocycline, a clinically used tetracycline for over 40 years, crosses the blood-brain barrier and prevents caspase up-regulation. It reduces apoptosis in mouse models of Huntington's disease and familial amyotrophic lateral sclerosis (ALS) and is in clinical trial for sporadic ALS. Because apoptosis also occurs after brain and spinal cord (SCI) injury, its prevention may be useful in improving recovery. We analyzed minocycline's neuroprotective effects over 28 days following contusion SCI and found significant functional recovery compared to tetracycline. Histology, immunocytochemistry, and image analysis indicated statistically significant tissue sparing, reduced apoptosis and microgliosis, and less activated caspase-3 and substrate cleavage.

-	//BW Festoff// (({{pubmed>long:16638021}})) </blockquote>	+	//BW Festoff// (({{pmid>long:16638021}})) </blockquote>

-	Also, minocycline partially inhibits caspase-3 activation and photoreceptor degeneration after photic injury.(({{pubmed>long:15990464}}))	+	Also, minocycline partially inhibits caspase-3 activation and photoreceptor degeneration after photic injury.(({{pmid>long:15990464}}))

	<blockquote>		<blockquote>
-	Minocycline inhibits the growth of glioma by inducing autophagy.(({{pubmed>long:21079420}}))	+	Minocycline inhibits the growth of glioma by inducing autophagy.(({{pmid>long:21079420}}))

	Minocycline effectively inhibited tumor growth and induced autophagy in the xenograft tumor model of C6 glioma cells. These results suggest that minocycline may kill glioma cells by inducing autophagic cell death. When autophagy was inhibited, minocycline still induced cell death through the activation of caspase-3. Thus, minocycline is a promising agent in the treatment of malignant gliomas.		Minocycline effectively inhibited tumor growth and induced autophagy in the xenograft tumor model of C6 glioma cells. These results suggest that minocycline may kill glioma cells by inducing autophagic cell death. When autophagy was inhibited, minocycline still induced cell death through the activation of caspase-3. Thus, minocycline is a promising agent in the treatment of malignant gliomas.
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	* https://marshallprotocol.com/view_topic.php?id=55&forum_id=37		* https://marshallprotocol.com/view_topic.php?id=55&forum_id=37

-	===== References =====	+	===== References =====</nodisp>

Modifying the Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.19.2018		current
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	//Trevor Marshall, PhD// </blockquote>		//Trevor Marshall, PhD// </blockquote>

-	Unfortunately, it's not uncommon for a [[home:starting:physician\|physician]] to agree to support a patient on the MP without fully understanding all the ramifications. At present, no physician has been trained and certified to administer the MP. Patients must ensure that their physicians prescribe the MP correctly and understands the effectiveness of the MP, and the dangers inherent in deviation from the guidelines.	+	It is not uncommon for a [[home:starting:physician\|physician]] to agree to support a patient on the MP without fully understanding all the ramifications. At present, no physician has been trained and certified to administer the MP. Patients must ensure that their physicians prescribe the MP correctly and understands the effectiveness of the MP, and the dangers inherent in deviation from the guidelines.

	Note that just because a medication or supplement is available over-the-counter (without a prescription) does not mean that it will not interfere with immune function in the same way that prescription drugs do.		Note that just because a medication or supplement is available over-the-counter (without a prescription) does not mean that it will not interfere with immune function in the same way that prescription drugs do.
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	{{tag>MP}}		{{tag>MP}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/9765.html f130	+	* https://www.marshallprotocol.com/forum32/9765.html f130
-	* http://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=53983#p53983 f270	+	* https://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=53983#p53983 f270

-	===== References =====	+	===== References =====</nodisp>

Off-label prescribing of Marshall Protocol medications

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.29.2012		current
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	====== Off-label prescribing of Marshall Protocol medications ======		====== Off-label prescribing of Marshall Protocol medications ======

-	Many of the Marshall Protocol (MP) medications are prescribed "off-label", which is to say that they are employed for a purpose outside the drug's approved label. Other countries have different policies, but the US FDA has issued [[http://www.fda.gov/OC/OHRT/IRBS/offlabel.html\|clear Policy Guidance]] on off-label prescriptions, clearly stating that it is up to the physician's individual judgment to decide whether an off-label drug should be used.	+	Many of the Marshall Protocol (MP) medications are prescribed "off-label", which is to say that they are employed for a purpose outside the drug's approved label. Other countries have different policies, but the US FDA has issued [[https://www.fda.gov/OC/OHRT/IRBS/offlabel.html\|clear Policy Guidance]] on off-label prescriptions, clearly stating that it is up to the physician's individual judgment to decide whether an off-label drug should be used.

	<blockquote>Good medical practice and the best interests of the patient require that physicians use legally available drugs, biologics and devices according to their best knowledge and judgment. If physicians use a product for an indication not in the approved labeling, they have the responsibility to be well-informed about the product, to base its use on firm scientific rationale and on sound medical evidence, and to maintain records of the product's use and effects. Use of a marketed product in this manner __when the intent is the "practice of medicine"__ does not require the submission of an Investigational New Drug Application (IND), an Investigational Device Exemption (IDE) or a review by an Institutional Review Board (IRB). However, the institution at which the product will be used may, under its own authority, require IRB review or other institutional oversight.</blockquote>		<blockquote>Good medical practice and the best interests of the patient require that physicians use legally available drugs, biologics and devices according to their best knowledge and judgment. If physicians use a product for an indication not in the approved labeling, they have the responsibility to be well-informed about the product, to base its use on firm scientific rationale and on sound medical evidence, and to maintain records of the product's use and effects. Use of a marketed product in this manner __when the intent is the "practice of medicine"__ does not require the submission of an Investigational New Drug Application (IND), an Investigational Device Exemption (IDE) or a review by an Institutional Review Board (IRB). However, the institution at which the product will be used may, under its own authority, require IRB review or other institutional oversight.</blockquote>
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	===== Off-label prescribing is common ======		===== Off-label prescribing is common ======

-	Off-label prescribing is very common.(({{pubmed>long:22507695}})) Almost every physician will prescribe off-label occasionally, most will not even realize it.	+	Off-label prescribing is very common.(({{pmid>long:22507695}})) Almost every physician will prescribe off-label occasionally, most will not even realize it.
		+
		+
		+
		+	{{tag>MP}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	*Legacy Content		*Legacy Content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Olmesartan (Benicar)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.13.2018		current
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	====== Olmesartan (Benicar) ======		====== Olmesartan (Benicar) ======

		+	<relatedarticle> [[home:food:aim_health:aging\|Health maintenance and Olmesartan]] </article>

	Olmesartan medoxomil is often referred by its brand name equivalent, Benicar. Patients on the Marshall Protocol (MP) take 40mg of olmesartan four to six times daily. There is no substitute for olmesartan.		Olmesartan medoxomil is often referred by its brand name equivalent, Benicar. Patients on the Marshall Protocol (MP) take 40mg of olmesartan four to six times daily. There is no substitute for olmesartan.
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	{{tag>MP olmesartan}}		{{tag>MP olmesartan}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	*Inactive ingredients for generic Benicar:		*Inactive ingredients for generic Benicar:

-	Olmecip 40 tablets Ingredients Active Olmesartan Medoxomil INH Inactive Lactose IP (Lactose Monohydrate 200 mesh) Croscarmellose Sodium NF Hydroxy propyl cellulose Klucel LF Microcrystalline cellulose Purified talc Croscarmellose sodium Stearic acid Opadry II 33G28707 white	+	Olmecip 40 tablets Ingredients Active Olmesartan Medoxomil INH Inactive Lactose IP (Lactose Monohydrate 200 mesh) Croscarmellose Sodium NF Hydroxy propyl cellulose Klucel LF Microcrystalline cellulose Purified talc Croscarmellose sodium Stearic acid Opadry II 33G28707 white </nodisp>

Concerns about progress on the Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Stages of illness and recovery

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.13.2018		current
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-	[{{ :home:medications:ace.gif\|ACE (Angiotensin Converting Enzyme) is a marker, which reflects the severity of inflammatory diseases such as sarcoidosis. In this graphic, taken from a [[http://bacteriality.com/2008/03/02/interview17/\|patient interview]] on Bacteriality, it's possible to see how one patient's ACE, waxed and waned over the course of the MP. Note that the ACE continued to fall.}}]	+	[{{ :home:medications:ace.gif\|ACE (Angiotensin Converting Enzyme) is a marker, which reflects the severity of inflammatory diseases such as sarcoidosis. In this graphic, taken from a [[https://bacteriality.com/2008/03/02/interview17/\|patient interview]] on Bacteriality, it's possible to see how one patient's ACE, waxed and waned over the course of the MP. Note that the ACE continued to fall.}}]

	==== Using lab tests to track immunopathology ====		==== Using lab tests to track immunopathology ====
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-	Abnormal lab work or [[http://en.wikipedia.org/wiki/Electrocardiogram\|ECG tracing]] may reveal unacceptable "silent" immunopathology. In that case, monitor these signs regularly and use them as a guide to gauge pace of therapy.	+	Abnormal lab work or [[https://en.wikipedia.org/wiki/Electrocardiogram\|ECG tracing]] may reveal unacceptable "silent" immunopathology. In that case, monitor these signs regularly and use them as a guide to gauge pace of therapy.
	==== Other ways to assess immunopathology ====		==== Other ways to assess immunopathology ====

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-	{{tag>MP herx}}	+	{{tag>MP IP}}



		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123127#p123127 e103	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123127#p123127 e103
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123136#p123136 e105	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123136#p123136 e105
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123270#p123270 e106	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123270#p123270 e106
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=125033#p125033 e109	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=125033#p125033 e109
-	* http://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=80136#p80136 e212	+	* https://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=80136#p80136 e212
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=125095#p125095 e110	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=125095#p125095 e110
-	* http://www.marshallprotocol.com/forum32/4819.html#p44064 f268	+	* https://www.marshallprotocol.com/forum32/4819.html#p44064 f268
-	* http://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=51629#p51629 f269	+	* https://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=51629#p51629 f269
-	* http://www.marshallprotocol.com/view_topic.php?id=1134&forum_id=32&jump_to=69137#p69137 f255	+	* https://www.marshallprotocol.com/view_topic.php?id=1134&forum_id=32&jump_to=69137#p69137 f255
-	* http://www.marshallprotocol.com/forum2/2218.html#p18671 e208	+	* https://www.marshallprotocol.com/forum2/2218.html#p18671 e208
-	* http://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=54854#p54854 e210	+	* https://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=54854#p54854 e210
-	* http://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=48070#p48070 e209	+	* https://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=48070#p48070 e209
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123127#p123127 e103	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123127#p123127 e103
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123128#p123128 e104	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=32&jump_to=123128#p123128 e104
-	* http://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=88381#p88381 e213	+	* https://www.marshallprotocol.com/view_topic.php?id=2218&forum_id=32&jump_to=88381#p88381 e213
-	* http://www.marshallprotocol.com/view_topic.php?id=364&forum_id=2&jump_to=26372#p26372 e9	+	* https://www.marshallprotocol.com/view_topic.php?id=364&forum_id=2&jump_to=26372#p26372 e9

		+	</nodisp>

12.15.2018		current
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	==== Strategy #5: Take guaifenesin ====		==== Strategy #5: Take guaifenesin ====

-	The expectorant [[home:othertreatments:guaifenesin\|guaifenesin]] may help dampen inflammation a bit as well as liquefy mucus. Use a product that does not contain any other ingredients. One might find a slight surge of symptoms during "withdrawal" from periods of intense guaifenesin use.	+	The expectorant [[home:othertreatments:guaifenesin\|Guaifenesin]] may help dampen inflammation a bit as well as liquefy mucus. Use a product that does not contain any other ingredients. One might find a slight surge of symptoms during "withdrawal" from periods of intense guaifenesin use.
	==== Strategy #6: Re-examine food/supplement/medication intake and changes in response to light ====		==== Strategy #6: Re-examine food/supplement/medication intake and changes in response to light ====

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	==== Strategy #7: Re-examine sources of emf in your surroundings. ====		==== Strategy #7: Re-examine sources of emf in your surroundings. ====

-	[[http://www.sciencedirect.com/science/article/pii/S0891061815000599\|Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression.]]	+	[[https://www.sciencedirect.com/science/article/pii/S0891061815000599\|Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression.]]

	==== Strategy #8: examine Magnesium status ====		==== Strategy #8: examine Magnesium status ====
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	Asthma, chronic fatigue syndrome, osteoporosis, hypertension, altered glucose homeostasis. Pregnancy Pregnancy complications (e.g., miscarriage, premature labor, eclampsia).		Asthma, chronic fatigue syndrome, osteoporosis, hypertension, altered glucose homeostasis. Pregnancy Pregnancy complications (e.g., miscarriage, premature labor, eclampsia).

-	:?: Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. (({{pubmed>long:15724867}}))	+	:?: Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. (({{pmid>long:15724867}}))

	These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects.		These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects.

-	:?: Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism (({{pubmed>long:22611240}}))	+	:?: Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism (({{pmid>long:22611240}}))
	Following in vivo MgSO4[magnesium sulfate] treatment, we observed a reduced frequency of monocytes producing TNF-α and IL-6 in women receiving MgSO4[magnesium sulfate] for clinical indications.		Following in vivo MgSO4[magnesium sulfate] treatment, we observed a reduced frequency of monocytes producing TNF-α and IL-6 in women receiving MgSO4[magnesium sulfate] for clinical indications.

-	:?: The potential influence of magnesium (Mg) on inflammatory responses was assessed using an ex vivo model--human whole blood incubated with and without lipopolysaccharide (LPS). Addition of LPS leads to higher levels of cytokines including TNF-alpha and IL-6. No significant effect of Mg was observed following LPS stimulation whereas high concentration of Mg inhibited the baseline level (without LPS) of TNF-alpha and IL-6 production. (({{pubmed>long:19658279}}))	+	:?: The potential influence of magnesium (Mg) on inflammatory responses was assessed using an ex vivo model--human whole blood incubated with and without lipopolysaccharide (LPS). Addition of LPS leads to higher levels of cytokines including TNF-alpha and IL-6. No significant effect of Mg was observed following LPS stimulation whereas high concentration of Mg inhibited the baseline level (without LPS) of TNF-alpha and IL-6 production. (({{pmid>long:19658279}}))

	This observation contrasts with that of a previous one on Mg-deficient animals. Therefore, the weak efficiency of increasing Mg concentration in this study on the whole blood from healthy volunteers suggests that the efficiency of Mg supplementation on cytokine production induced by endotoxin challenge depends on Mg status.		This observation contrasts with that of a previous one on Mg-deficient animals. Therefore, the weak efficiency of increasing Mg concentration in this study on the whole blood from healthy volunteers suggests that the efficiency of Mg supplementation on cytokine production induced by endotoxin challenge depends on Mg status.


-	:?: During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. (({{pubmed>long:1384353}}))	+	:?: During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. (({{pmid>long:1384353}}))

	:?: [[https://phys.org/news/2016-04-bacteria-magnesium.html\|Bacteria use their own pumps to collect magnesium]]		:?: [[https://phys.org/news/2016-04-bacteria-magnesium.html\|Bacteria use their own pumps to collect magnesium]]
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-	:?: Researchers at NCMM, the Centre for Molecular Medicine Norway at UiO and Oslo University Hospital have shown exactly how sensitive the bacteria's transport system is. (({{pubmed>long: 26780187}}))	+	:?: Researchers at NCMM, the Centre for Molecular Medicine Norway at UiO and Oslo University Hospital have shown exactly how sensitive the bacteria's transport system is. (({{pmid>long: 26780187}}))

	Researcher Jens Preben Morth says, "We have identified a nano-sized magnesium pump."		Researcher Jens Preben Morth says, "We have identified a nano-sized magnesium pump."
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	"Magnesium also stabilises genetic material in both humans and bacteria," Morth elaborates.		"Magnesium also stabilises genetic material in both humans and bacteria," Morth elaborates.

-	:?: Bacterial Growth at the High Concentrations of Magnesium Sulfate Found in Martian Soils (({{pubmed>long:22248384}}))	+	:?: Bacterial Growth at the High Concentrations of Magnesium Sulfate Found in Martian Soils (({{pmid>long:22248384}}))

-	:?: [[http://www.microbiologyresearch.org/docserver/fulltext/micro/3/3/mic-3-3-418.pdf?expires=1544835323&id=id&accname=guest&checksum=D3562D1950E20CBA598B824272668EF5\|The Influence of Magnesium on Cell Division]]	+	:?: [[https://www.microbiologyresearch.org/docserver/fulltext/micro/3/3/mic-3-3-418.pdf?expires=1544835323&id=id&accname=guest&checksum=D3562D1950E20CBA598B824272668EF5\|The Influence of Magnesium on Cell Division]]

	SUMMARY: In simple chemically defined media all of 15 bacteria failed to grow in the complete absence of magnesium. The concentration of magnesium for maximum growth was dependent upon the Gram reaction of the individual species examined, the magnesium requirements of the Gram-positive organisms being some ten times greater than the requirements of the Gram-negative organisms. In contrast to the observations made in more complex media (peptone water), normal cell division occurred in chemically defined media containing suboptimal amounts of magnesium. It is suggested that magnesium is involved in the synthesis of bacterial protoplasm as well as cell division and, in simple chemically defined media, the synthetic reactions require the higher magnesium concentration.		SUMMARY: In simple chemically defined media all of 15 bacteria failed to grow in the complete absence of magnesium. The concentration of magnesium for maximum growth was dependent upon the Gram reaction of the individual species examined, the magnesium requirements of the Gram-positive organisms being some ten times greater than the requirements of the Gram-negative organisms. In contrast to the observations made in more complex media (peptone water), normal cell division occurred in chemically defined media containing suboptimal amounts of magnesium. It is suggested that magnesium is involved in the synthesis of bacterial protoplasm as well as cell division and, in simple chemically defined media, the synthetic reactions require the higher magnesium concentration.

-	:?: Myth or Reality—Transdermal Magnesium? (({{pubmed>long:28788060}}))	+	:?: Myth or Reality—Transdermal Magnesium? (({{pmid>long:28788060}}))


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	//PoochyMama, MarshallProtocol.com//</blockquote>		//PoochyMama, MarshallProtocol.com//</blockquote>

-	<blockquote>{{ http://i110.photobucket.com/albums/n112/knochen1/Marshall/CatCartoonSmall.jpg}}	+	<blockquote>{{ https://i110.photobucket.com/albums/n112/knochen1/Marshall/CatCartoonSmall.jpg}}
	Don't forget time with IP adjustments too.		Don't forget time with IP adjustments too.

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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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-	{{:home:mp:symptom-level-graph.gif\|}}	+	{{:home:mp:symptom-level-graph.gif\|}}</nodisp>

04.29.2019		current
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-	<relatedarticles> [[home:patients:grappling_uncertainty\|Grappling with uncertainty about the Marshall Protocol]], [[home:starting:physician:reluctant\|Helping a reluctant physician]], [[home:physicians:concerns\|Physicians' concerns and success rates for 5 Dx]]</article>	+	<relatedarticles> [[home:patients:grappling_uncertainty\|Confronting uncertainty about the Marshall Protocol]], [[home:starting:physician:reluctant\|Helping a reluctant physician]], [[home:physicians:concerns\|Physicians' concerns and success rates for 5 Dx]]</article>


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	Joyful 2015</blockquote>		Joyful 2015</blockquote>

-	[[http://www.greenmedinfo.com/blog/citizens-arms-against-5g-wireless-technology-roll-out-are-their-concerns-justifie\|Citizens oppose 5G technology over multiple risks to health including heart arrhythmias and 50% reduction in neutrophil (immune) activity in vertebrate research ]]	+	[[https://www.greenmedinfo.com/blog/citizens-arms-against-5g-wireless-technology-roll-out-are-their-concerns-justifie\|Citizens oppose 5G technology over multiple risks to health including heart arrhythmias and 50% reduction in neutrophil (immune) activity in vertebrate research ]]

	Women until past childbearing and boys not yet fully grown are particularly at risk.		Women until past childbearing and boys not yet fully grown are particularly at risk.
	Aware parents are learning how to improve their children's lives, right from the start		Aware parents are learning how to improve their children's lives, right from the start
-	[[http://www.emfanalysis.com/safe-baby-monitor/\|Safe Baby Monitor]]	+	[[https://www.emfanalysis.com/safe-baby-monitor/\|Safe Baby Monitor]]
	==== Troubleshooting a seemingly unresponsive immune system ====		==== Troubleshooting a seemingly unresponsive immune system ====

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	So long as symptoms of immunopathology continue and elevated blood markers of bacterial die-off (such as BUN), there are bacteria being killed and to be killed.		So long as symptoms of immunopathology continue and elevated blood markers of bacterial die-off (such as BUN), there are bacteria being killed and to be killed.

-	The [[home:patients:mp_duration\|range of time]] it takes seriously ill patients to recover on the Marshall Protocol is not entirely without precedent in medicine. The first-line treatment for for tuberculosis infection takes six months(({{pubmed>long:15982799}})) – and that's only a single genus as opposed to a [[home:pathogenesis:microbiota\|metagenomic microbiota]]. It's also worth noting that recovery from tuberculosis also involves an immunopathological-type reaction.(({{pubmed>long:18600241}}))	+	The [[home:patients:mp_duration\|range of time]] it takes seriously ill patients to recover on the Marshall Protocol is not entirely without precedent in medicine. The first-line treatment for for tuberculosis infection takes six months(({{pmid>long:15982799}})) – and that's only a single genus as opposed to a [[home:pathogenesis:microbiota\|metagenomic microbiota]]. It's also worth noting that recovery from tuberculosis also involves an immunopathological-type reaction.(({{pmid>long:18600241}}))

	Patients should try to consider their responses to the MP medications logically. The [[home:protocol:olmesartan:safety\|safety profile of olmesartan (Benicar)]] as well as the [[home:protocol:mp_antibiotics:antibiotics_concerns\|safety profile of the MP antibiotics]] are excellent. The single best explanation for why a patient symptoms are worse is that the immune system is becoming stronger and microbes are being killed.		Patients should try to consider their responses to the MP medications logically. The [[home:protocol:olmesartan:safety\|safety profile of olmesartan (Benicar)]] as well as the [[home:protocol:mp_antibiotics:antibiotics_concerns\|safety profile of the MP antibiotics]] are excellent. The single best explanation for why a patient symptoms are worse is that the immune system is becoming stronger and microbes are being killed.
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	{{tag>MP}}		{{tag>MP}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/2661.html f150	+	* https://www.marshallprotocol.com/forum32/2661.html f150
-	* http://www.marshallprotocol.com/forum32/1822.html f330	+	* https://www.marshallprotocol.com/forum32/1822.html f330
-	* http://www.marshallprotocol.com/forum32/5007.html f290	+	* https://www.marshallprotocol.com/forum32/5007.html f290
-	* http://www.marshallprotocol.com/view_topic.php?id=1146&forum_id=32&jump_to=64346#p64346 f262	+	* https://www.marshallprotocol.com/view_topic.php?id=1146&forum_id=32&jump_to=64346#p64346 f262
-	* http://www.marshallprotocol.com/forum32/1146.html#p9012 f261	+	* https://www.marshallprotocol.com/forum32/1146.html#p9012 f261
	* Maximum frequency/amount of mino and Benicar dosing suggested to dampen IP appear outdated. --- //Joe Trunk 2008/12/26 16:47//		* Maximum frequency/amount of mino and Benicar dosing suggested to dampen IP appear outdated. --- //Joe Trunk 2008/12/26 16:47//

-	===== References =====	+	===== References =====</nodisp>

12.15.2018		current
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	This article reviews the different stage of illness and recovery for patients struck by chronic inflammatory disease. A description of many of the terms used here and in the Knowledge Base is contained in the [[home:patients:glossary\|glossary]].		This article reviews the different stage of illness and recovery for patients struck by chronic inflammatory disease. A description of many of the terms used here and in the Knowledge Base is contained in the [[home:patients:glossary\|glossary]].

-	This article is depicted in [[http://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|this PDF]].	+	This article is depicted in [[https://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|this PDF]].


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	In Stage Five, the immune system becomes self-sustaining, and is fully able to combat chronic pathogens without antibiotics and even without Benicar. Benicar continues to be used, however, for its previously mentioned anti-inflammatory effect. At this point, vitamin D from ingestion or light exposure may be converted into 1,25-D, which now can drive the immune response since the vitamin D receptors are no longer blocked by bacterial ligands. For this reason, MP patients must be careful about exposing themselves to large amounts of light or sunshine.		In Stage Five, the immune system becomes self-sustaining, and is fully able to combat chronic pathogens without antibiotics and even without Benicar. Benicar continues to be used, however, for its previously mentioned anti-inflammatory effect. At this point, vitamin D from ingestion or light exposure may be converted into 1,25-D, which now can drive the immune response since the vitamin D receptors are no longer blocked by bacterial ligands. For this reason, MP patients must be careful about exposing themselves to large amounts of light or sunshine.

-	===== Return to healthy VDR, new pathogens eradicated =====	+	===== Return to healthy VDR, new pathogens eradicated if they become significant =====

	Stage 6 is like Stage 1, because the immune response is fully functional. Patients can wean or discontinue Benicar and even take in a reasonable amount of light.		Stage 6 is like Stage 1, because the immune response is fully functional. Patients can wean or discontinue Benicar and even take in a reasonable amount of light.
	===== Read more =====		===== Read more =====

-	* [[http://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|Visual description of stages of illness and recovery]]	+	* [[https://autoimmunityresearch.org/VDR-Time-Benicar.pdf\|Visual description of stages of illness and recovery]]
	* [[home:pathogenesis::vitamind\|Science behind vitamin D]]		* [[home:pathogenesis::vitamind\|Science behind vitamin D]]
	* [[home:pathogenesis:vitamind:metabolism\|Molecular activity of vitamin D and the Vitamin D Receptor in chronic disease]]		* [[home:pathogenesis:vitamind:metabolism\|Molecular activity of vitamin D and the Vitamin D Receptor in chronic disease]]
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

		+	</nodisp>