Marshall Protocol Knowledge Base - home:othertreatments

Acupuncture

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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-	Marshall Protocol (MP) patients have reported increased immunopathology symptoms following acupuncture, which suggests some acupuncture treatments affect the immune system. While [[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Acupuncture+Therapy%22[MAJR]+AND+immunomod*[All+Fields]\|some preliminary research]] supports the contention that acupuncture is immunomodulatory, MP patients may use acupuncture for pain control if it is effective and does not increase other symptoms. Acupuncture is contraindicated, however, if the intent of the treatment is other than pain control.	+	Marshall Protocol (MP) patients have reported increased immunopathology symptoms following acupuncture, which suggests some acupuncture treatments affect the immune system. While [[https://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Acupuncture+Therapy%22[MAJR]+AND+immunomod*[All+Fields]\|some preliminary research]] supports the contention that acupuncture is immunomodulatory, MP patients may use acupuncture for pain control if it is effective and does not increase other symptoms. Acupuncture is contraindicated, however, if the intent of the treatment is other than pain control.


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-	{{tag>Non-MP_treatments}}	+	{{tag>Non-MP_therapies}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	*		*

-	===== References =====	+	===== References =====</nodisp>

Air purifiers

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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	====== Air purifiers ======		====== Air purifiers ======

-	Some patients with multiple chemical sensitivities and asthma have benefited from using air purifiers, but only those that use an [[http://en.wikipedia.org/wiki/Electrostatic_precipitator\|electrostatic precipitator]]. Those filtration devices with a Hepa filter do not seem to be effective as it does filter small enough particles to be of much help.	+	Some patients with multiple chemical sensitivities and asthma have benefited from using air purifiers, but only those that use an [[https://en.wikipedia.org/wiki/Electrostatic_precipitator\|electrostatic precipitator]]. Those filtration devices with a Hepa filter do not seem to be effective as it does filter small enough particles to be of much help.


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-	{{tag>Non-MP_treatments}}	+	{{tag>Non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum37/4661.html#p42380 s284	+	* https://www.marshallprotocol.com/forum37/4661.html#p42380 s284
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	*		*
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-	===== References =====	+	===== References =====</nodisp>

Aloe vera

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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	Some Marshall Protocol (MP) patients have reported that using aloe vera resulted in symptom palliation. This suggests that aloe vera may contain substances which suppress the immune response. For that reason, consistent use of aloe vera by MP patients is contraindicated.		Some Marshall Protocol (MP) patients have reported that using aloe vera resulted in symptom palliation. This suggests that aloe vera may contain substances which suppress the immune response. For that reason, consistent use of aloe vera by MP patients is contraindicated.

-	{{tag>supplements herbs Non-MP_therapies}}	+	{{tag>herbs Non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=140326#p140326 f50	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=140326#p140326 f50
	*		*
	*		*
	===== References =====		===== References =====
		+	</nodisp>

Anesthetics for surgical procedures and allergic reactions

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	===== Epinephrine =====		===== Epinephrine =====

-	Epinephrine (also known as adrenaline), norepinephrine or one of its analogs called levonordefrine, is commonly added to local anesthetics given for dental procedures and other minor surgical procedures requiring a local anesthestic. Some people with Th1 inflammatory diseases react abnormally to epinephrine in a local anesthetic. One reason why this may be is that //E. coli// produces epinephrine for communication with other members of the species in a process known as quorum sensing.(({{pubmed>long:12847292}})) This may be because pathogens are able to more effectively communicate and spread during times when the body is weakened.	+	Epinephrine (also known as adrenaline), norepinephrine or one of its analogs called levonordefrine, is commonly added to local anesthetics given for dental procedures and other minor surgical procedures requiring a local anesthestic. Some people with Th1 inflammatory diseases react abnormally to epinephrine in a local anesthetic. One reason why this may be is that //E. coli// produces epinephrine for communication with other members of the species in a process known as quorum sensing.(({{pmid>long:12847292}})) This may be because pathogens are able to more effectively communicate and spread during times when the body is weakened.

	There are many anecdotal accounts of patients with Th1 inflammatory diseases experiencing increased local inflammation (redness), local tissue damage, decreased anesthetic effect (numbness) and systemic reactions such as palpitations, rapid heart rate, anxiety, tremor and headache following injection with a local anesthetic containing epinephrine.		There are many anecdotal accounts of patients with Th1 inflammatory diseases experiencing increased local inflammation (redness), local tissue damage, decreased anesthetic effect (numbness) and systemic reactions such as palpitations, rapid heart rate, anxiety, tremor and headache following injection with a local anesthetic containing epinephrine.
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		+	{{tag>allergy}}

		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/4638.html f284-6	+	* https://www.marshallprotocol.com/forum32/4638.html f284-6
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-	===== References =====	+	===== References =====</nodisp>

Non-MP antibacterials

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.13.2018		current
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-	{{tag>non-MP_therapies antibiotics}}	+	{{tag>Other_medication}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=43935#p43935	+	* https://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=43935#p43935
-	* http://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=56251#p56251	+	* https://www.marshallprotocol.com/view_topic.php?id=4819&forum_id=32&jump_to=56251#p56251
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		+	===== References =====</nodisp>

-	===== References =====

Anticoagulants

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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	<relatedarticle> [[home:patients:assessing_literature:palliative\|Palliative vs. curative treatments]] </article>		<relatedarticle> [[home:patients:assessing_literature:palliative\|Palliative vs. curative treatments]] </article>

-	Anticoagulant therapy has been proposed by some as a way of resolving the "sticky blood" seen in some patients with chronic diseases. Generally speaking, anticoagulants introduce a certain amount of unpredictability. All of the anticoagulants contribute to hormonal instability, and heparin has some antimicrobial effects.(({{pubmed>long:17536984}}))	+	Anticoagulant therapy has been proposed by some as a way of resolving the "sticky blood" seen in some patients with chronic diseases. Generally speaking, anticoagulants introduce a certain amount of unpredictability. All of the anticoagulants contribute to hormonal instability, and heparin has some antimicrobial effects.(({{pmid>long:17536984}}))

	<blockquote>		<blockquote>
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	* warfarin (Coumadin)		* warfarin (Coumadin)

-	{{tag>Non-MP_treatments}}	+	{{tag>Non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1781.html f331	+	* https://www.marshallprotocol.com/forum32/1781.html f331
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	Copyright © 2009 Churchill Livingstone, An Imprint of Elsevier</blockquote>		Copyright © 2009 Churchill Livingstone, An Imprint of Elsevier</blockquote>

-	===== References =====	+	===== References =====</nodisp>

Anticonvulsant and anti-seizure agents

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.05.2018		current
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	<blockquote> I'm still dealing with some protracted withdrawal symptoms (even though its been almost 3 months since I stopped the Klonopin), but am feeling soooo much better than I have in years. I'm sleeping much better and my brain fog has mostly lifted. Also, I've been able to get out and do more errands and walks. So I'm basically just easing back towards a more normal life although I still feel some generalized inflammation internally and pulse pounding in ears. I think things will get better and better with time. The Klonopin was causing a LOT of my problems and I'm so glad to be off of it. I would advise anyone to stay away from it and any related Benzodiazepines! //SanDiegoJoy//</blockquote>		<blockquote> I'm still dealing with some protracted withdrawal symptoms (even though its been almost 3 months since I stopped the Klonopin), but am feeling soooo much better than I have in years. I'm sleeping much better and my brain fog has mostly lifted. Also, I've been able to get out and do more errands and walks. So I'm basically just easing back towards a more normal life although I still feel some generalized inflammation internally and pulse pounding in ears. I think things will get better and better with time. The Klonopin was causing a LOT of my problems and I'm so glad to be off of it. I would advise anyone to stay away from it and any related Benzodiazepines! //SanDiegoJoy//</blockquote>
		+
		+	//Cairo// I think it is a good idea before one takes an SSRI or benzo to have an exit strategy.
		+
		+	https://en.wikipedia.org/wiki/SSRI_discontinuation_syndrome
		+
		+	https://www.neurosoup.com/ssridiscontinuationsyndrome.htm
		+
		+	https://en.wikipedia.org/wiki/Benzodiazepine_withdrawal_syndrome
	=====Types of anticonvulsant and anti-seizure agents =====		=====Types of anticonvulsant and anti-seizure agents =====

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	{{tag>Other_medication}}		{{tag>Other_medication}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Antidepressants and other psychotropic medications

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Antifungal agents

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.02.2017		current
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	Antifungal agents such as fluconazole (Diflucan) are sometimes prescribed to treat fungal infections, of which //Candida// is one kind. While some patients have reported feeling better after taking antifungal agents, antifungals interfere with immune function.		Antifungal agents such as fluconazole (Diflucan) are sometimes prescribed to treat fungal infections, of which //Candida// is one kind. While some patients have reported feeling better after taking antifungal agents, antifungals interfere with immune function.

-	The antifungals directly inhibit the enzyme CYP27B1, which is needed for the mitichondria in the macrophages to convert 25-D to 1,25-D.(({{pubmed>long:12520539}})) With an artificially depressed rate of generating 1,25-D, patients taking antifungals tend to feel better for a period and then relapse worse than before.	+	The antifungals directly inhibit the enzyme CYP27B1, which is needed for the mitichondria in the macrophages to convert 25-D to 1,25-D.(({{pmid>long:12520539}})) With an artificially depressed rate of generating 1,25-D, patients taking antifungals tend to feel better for a period and then relapse worse than before.

	By increasing levels of 25-D and therefore inhibiting immunopathology, long-term use of antifungal drugs may delay progress on the Marshall Protocol (MP).		By increasing levels of 25-D and therefore inhibiting immunopathology, long-term use of antifungal drugs may delay progress on the Marshall Protocol (MP).
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	Patient symptom scores were a poor predictor of yeast infections based on yeast culture results. ... Self-reported symptoms are not reliable for diagnosis.		Patient symptom scores were a poor predictor of yeast infections based on yeast culture results. ... Self-reported symptoms are not reliable for diagnosis.

-	//Susan Hoffstetter et al.// (({{pubmed>long:18664056}})) </blockquote>	+	//Susan Hoffstetter et al.// (({{pmid>long:18664056}})) </blockquote>


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	//bobi August 2017//</blockquote>		//bobi August 2017//</blockquote>

		+	<blockquote>I put coconut oil, with crushed, powdered olmesartan tabs in it, on my toenails and the rest of my feet daily. It's taken 9 years! but the fungusy nails are gone except for a slight hint on one nail. Itchiness between the toes resolved in the first few months of this topical olmesartan. I was recently told by the "pedi care" nurse who cuts nails at the senior center by appointment that she recommends coconut oil as an antifungal. Also a podiatrist commented on the surprisingly good health of my feet's skin compared to most of the elder feet she sees, and attributed it to the coconut oil. I personally think the olmesartan gets the credit, but I guess coconut oil as a vehicle for the olmesartan was a good choice.

		+	Grateful Survivor August 2017</blockquote>

		+
		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	From: Dr. Greg Blaney		From: Dr. Greg Blaney
	Date: 2010-07-04 14:39:15		Date: 2010-07-04 14:39:15
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=13184	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=13184

	<blockquote>If candida is suspected, I usually treat prior to starting MP. This is often helpful also as gives a mild herx reaction and can prepare them for MP herx. Occasionally, I have used nystatin with patients on Benicar. These are usually patients who have had high dose antibiotics for Lyme disease in the past. This is very rare though.		<blockquote>If candida is suspected, I usually treat prior to starting MP. This is often helpful also as gives a mild herx reaction and can prepare them for MP herx. Occasionally, I have used nystatin with patients on Benicar. These are usually patients who have had high dose antibiotics for Lyme disease in the past. This is very rare though.
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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=34393#p34393 s226	+	* https://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=34393#p34393 s226
	*		*

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-	1. Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergoste http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876427/	+	1. Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergoste https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876427/



-	2. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. http://www.jbc.org/content/283/10/6393.long	+	2. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. https://www.jbc.org/content/283/10/6393.long


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	While a search in wikapedia states under natamycin saftety that, “Natamycin lacks acute toxicity" it then goes on to state that “In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.”		While a search in wikapedia states under natamycin saftety that, “Natamycin lacks acute toxicity" it then goes on to state that “In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.”
	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Antihistamines

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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-	{{tag>Non-MP_therapies}}	+	{{tag>Other_medication}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Antimetabolite

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.19.2018		current
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	It competes with, replaces, or antagonizes a particular metabolite; for example, ethionine is an antimetabolite of methionine.		It competes with, replaces, or antagonizes a particular metabolite; for example, ethionine is an antimetabolite of methionine.

-	[[http://medical-dictionary.thefreedictionary.com/antimetabolite\|thefreedictionary definition]]	+	[[https://medical-dictionary.thefreedictionary.com/antimetabolite\|thefreedictionary definition]]

	Wikipedia says		Wikipedia says
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	antifolates		antifolates

-	{{tag>non-MP_therapies }}	+	{{tag>Other_medication}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

		+	</nodisp>

Antioxidant supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

07.03.2011		current
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	Evidence supporting the efficacy of antioxidants against disease is limited.		Evidence supporting the efficacy of antioxidants against disease is limited.

-	Supplementation with antioxidants beyond the [[http://en.wikipedia.org/wiki/Reference_Daily_Intake\|Recommended Daily Intake]] is contraindicated for Marshall Protocol (MP) patients. One exception is quercetin. Quercetin has well-defined molecular actions, and is used by MP patients for its palliative effects.	+	Supplementation with antioxidants beyond the [[https://en.wikipedia.org/wiki/Reference_Daily_Intake\|Recommended Daily Intake]] is contraindicated for Marshall Protocol (MP) patients. One exception is quercetin. Quercetin has well-defined molecular actions, and is used by MP patients for its palliative effects.


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	==== Interference with apoptosis ====		==== Interference with apoptosis ====

-	Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Reactive oxygen species (ROS) are chemically-reactive molecules containing oxygen that act to neutralize antioxidants. In their 2000 study, Salganki //et al.// reasoned that since ROS act as essential apoptotic mediators, increasing the ROS level might enhance apoptosis and thereby slow down tumor growth.(({{pubmed>long:10783311}})) Provocatively, that team showed that tumor growth was inhibited in mice fed an antioxidant-depleted diet while an antioxidant-rich diet had no impact on tumor growth. This work, while preliminary, offers one mechanism how megadoses of antioxidants are not protective against cancer and may actually exacerbate it.	+	Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Reactive oxygen species (ROS) are chemically-reactive molecules containing oxygen, which act to neutralize antioxidants, regulate apoptosis(({{pmid>long:11256882}})). In their 2000 study, Salganki //et al.// reasoned that since ROS act as essential apoptotic mediators, increasing the ROS level might enhance apoptosis and thereby slow down tumor growth.(({{pmid>long:10783311}})) Provocatively, that team showed that tumor growth was inhibited in mice fed an antioxidant-depleted diet while an antioxidant-rich diet had no impact on tumor growth. This work, while preliminary, offers one mechanism how megadoses of antioxidants are not protective against cancer and may actually exacerbate unchecked cell growth.


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	Since the early 1990s scientists have been putting antioxidants through their paces, using double-blind randomised controlled trials - the gold standard for medical intervention studies. Time and again, however, the supplements failed to pass the test. True, they knock the wind out of free radicals in a test tube. But once inside the human body, they seem strangely powerless. Not only are they bad at preventing oxidative damage, they can even make things worse. At worst, antioxidants may even have the opposite effect, promoting the very problems they are supposed to stamp out.		Since the early 1990s scientists have been putting antioxidants through their paces, using double-blind randomised controlled trials - the gold standard for medical intervention studies. Time and again, however, the supplements failed to pass the test. True, they knock the wind out of free radicals in a test tube. But once inside the human body, they seem strangely powerless. Not only are they bad at preventing oxidative damage, they can even make things worse. At worst, antioxidants may even have the opposite effect, promoting the very problems they are supposed to stamp out.

-	//Lisa Melton, [[http://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>	+	//Lisa Melton, [[https://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>


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	<blockquote>		<blockquote>
-	In 1992 researchers at the US National Cancer Institute set about testing beta carotene. They recruited more than 18,000 people at high risk of developing lung cancer, either because they smoked or had been exposed to asbestos, and gave around half of them beta carotene supplements.(({{pubmed>long:8602180}})) The trial was supposed to run for six years, but the researchers pulled the plug two-thirds of the way through after discovering, to their surprise and horror, that those taking supplements were faring worse than the controls. Their lung cancer rate was 28 per cent higher, and the overall death rate was up 17 per cent. "It was a shock. It not only did no good but had the potential to do harm," Halliwell says.	+	In 1992 researchers at the US National Cancer Institute set about testing beta carotene. They recruited more than 18,000 people at high risk of developing lung cancer, either because they smoked or had been exposed to asbestos, and gave around half of them beta carotene supplements.(({{pmid>long:8602180}})) The trial was supposed to run for six years, but the researchers pulled the plug two-thirds of the way through after discovering, to their surprise and horror, that those taking supplements were faring worse than the controls. Their lung cancer rate was 28 per cent higher, and the overall death rate was up 17 per cent. "It was a shock. It not only did no good but had the potential to do harm," Halliwell says.

-	//Lisa Melton, [[http://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>	+	//Lisa Melton, [[https://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>

	==== Vitamin E ====		==== Vitamin E ====
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	It's a similar story with the world's most popular antioxidant.... Several [vitamin E studies] found no protective effect and one even concluded that vitamin E increased the risk of heart failure.		It's a similar story with the world's most popular antioxidant.... Several [vitamin E studies] found no protective effect and one even concluded that vitamin E increased the risk of heart failure.

-	//Lisa Melton, [[http://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>	+	//Lisa Melton, [[https://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>

	====Vitamin C ====		====Vitamin C ====
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	Vitamin C is another disappointment. "People are still trying to defend it, but you don't get an effect on free radical damage unless you start with people with a vitamin C deficiency," says Halliwell. "I think it is a lost cause." In fact, results from a vast US trial probing the links between diet and health, called the Women's Health Study, suggest that vitamin C supplements may accelerate atherosclerosis in some people with diabetes.		Vitamin C is another disappointment. "People are still trying to defend it, but you don't get an effect on free radical damage unless you start with people with a vitamin C deficiency," says Halliwell. "I think it is a lost cause." In fact, results from a vast US trial probing the links between diet and health, called the Women's Health Study, suggest that vitamin C supplements may accelerate atherosclerosis in some people with diabetes.

-	//Lisa Melton, [[http://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>	+	//Lisa Melton, [[https://www.newscientist.com/article/mg19125631.500-the-antioxidant-myth-a-medical-fairy-tale.html\|New Scientist]]// </blockquote>


-	Researchers at Memorial Sloan-Kettering Cancer Center studied the effects of vitamin C on cancer cells.(({{pubmed>long:18829561}})) As it turns out, the vitamin seems to protect not just healthy cells, but cancer cells, too. “The use of vitamin C supplements could have the potential to reduce the ability of patients to respond to therapy,” said Dr. Mark Heaney, an associate attending physician at the cancer center.	+	Researchers at Memorial Sloan-Kettering Cancer Center studied the effects of vitamin C on cancer cells.(({{pmid>long:18829561}})) As it turns out, the vitamin seems to protect not just healthy cells, but cancer cells, too. “The use of vitamin C supplements could have the potential to reduce the ability of patients to respond to therapy,” said Dr. Mark Heaney, an associate attending physician at the cancer center.

	Dr. Heaney and his colleagues tested five different chemotherapy drugs on cancer cells in the laboratory. Some of the cells were first treated with vitamin C. In each case and in dose-dependent fashion, chemotherapy did not work as well if cells had been exposed to vitamin C. The chemotherapy agents killed 30 to 70 percent fewer cancer cells when the cells were treated with the vitamin.		Dr. Heaney and his colleagues tested five different chemotherapy drugs on cancer cells in the laboratory. Some of the cells were first treated with vitamin C. In each case and in dose-dependent fashion, chemotherapy did not work as well if cells had been exposed to vitamin C. The chemotherapy agents killed 30 to 70 percent fewer cancer cells when the cells were treated with the vitamin.
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	==== Selenium ====		==== Selenium ====

-	A food frequency questionaire administered to 7,182 women in Northern Italy found that increased dietary selenium intake was associated with an increased risk of type 2 diabetes.(({{pubmed>long:20858268}}))	+	A food frequency questionaire administered to 7,182 women in Northern Italy found that increased dietary selenium intake was associated with an increased risk of type 2 diabetes.(({{pmid>long:20858268}}))

	==== Other compounds ====		==== Other compounds ====
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	===== Read more =====		===== Read more =====

-	* [[http://well.blogs.nytimes.com/2008/10/01/vitamin-c-may-interfere-with-cancer-treatment/\|Vitamin C May Interfere With Cancer Treatment]]	+	* [[https://well.blogs.nytimes.com/2008/10/01/vitamin-c-may-interfere-with-cancer-treatment/\|Vitamin C May Interfere With Cancer Treatment]]


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT	+

	"It may well be that the only one benefiting from supplements is the one making the profits."		"It may well be that the only one benefiting from supplements is the one making the profits."
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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=86524#p86524 f33	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=86524#p86524 f33
	*		*
	* This whole article is awkward reading. Can some of the block quotes be worked into text blocks or the sources be made more evident? --- //Joyful 06.29.2009//		* This whole article is awkward reading. Can some of the block quotes be worked into text blocks or the sources be made more evident? --- //Joyful 06.29.2009//
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	Another important mechanism involved in the host response to infection is oxidative stress, which plays a major role in the systemic inflammatory response in bacterial(16178750) and viral infections.(15944946)(Olteanu, see EndNote)		Another important mechanism involved in the host response to infection is oxidative stress, which plays a major role in the systemic inflammatory response in bacterial(16178750) and viral infections.(15944946)(Olteanu, see EndNote)

-	===== References =====	+	===== References =====</nodisp>

Anti-TNF drugs

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Antiviral agents

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Bacteriophage therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	There is no evidence to suggest that the introduction of additional organisms with their DNA and RNA could have any long-term benefit.		There is no evidence to suggest that the introduction of additional organisms with their DNA and RNA could have any long-term benefit.

-	In fact, the [[home:pathogenesis:horizontal_gene\|horizontal gene transfer]] of DNA and RNA between organisms represents the primary mechanism by which the microbiota causing Th1 disease accumulates its pathogenic capability. Adding new pathogens only increases statistical risk: the practice might reduce overall pathogenicity or it might increase it.	+	Indeed, the [[home:pathogenesis:horizontal_gene\|horizontal gene transfer]] of DNA and RNA between organisms represents the primary mechanism by which the microbiota causing Th1 disease accumulates its pathogenic capability. Adding new pathogens only increases statistical risk: the practice might reduce overall pathogenicity or it might increase it.

	Some patients do experience improvement of symptoms during an acute infection, but not cure. In the long run, the extra pathogens can only present more problems.		Some patients do experience improvement of symptoms during an acute infection, but not cure. In the long run, the extra pathogens can only present more problems.
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	{{tag>non-MP_therapies horizontal_gene_transfer koch's_postulates}}		{{tag>non-MP_therapies horizontal_gene_transfer koch's_postulates}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Baths

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

09.29.2017		current
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	Patients should not use hot tubs with temperatures above 104 degrees.</note>		Patients should not use hot tubs with temperatures above 104 degrees.</note>

-	===== Hot baths may provoke lightheadedness or dizziness =====	+	===== Hot baths may provoke light-headedness or dizziness =====

	Taking a hot bath or shower (or spending time in a hot room) can lead to increased body temperature and cause blood vessels to dilate, which lowers blood pressure and can cause lightheadedness or dizziness.		Taking a hot bath or shower (or spending time in a hot room) can lead to increased body temperature and cause blood vessels to dilate, which lowers blood pressure and can cause lightheadedness or dizziness.
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	from an article in [[https://theconversation.com/health-check-do-we-have-to-clean-out-our-pores-75288\|Theconversation]]		from an article in [[https://theconversation.com/health-check-do-we-have-to-clean-out-our-pores-75288\|Theconversation]]
-	[[https://link.springer.com/referenceworkentry/10.1007%2F978-3-540-89656-2_42\|Infrared A-induced Skin Aging]]	+
	<blockquote>heating the face can make the blood vessels stand out and cause rosacea (a red rash) in those who are prone to it. The oils are dissolved more readily and stripped from the face, which means, unless you really have very oily skin, it will dry out. We now know heat ages the skin so it makes sense to avoid this type of treatment for most people.		<blockquote>heating the face can make the blood vessels stand out and cause rosacea (a red rash) in those who are prone to it. The oils are dissolved more readily and stripped from the face, which means, unless you really have very oily skin, it will dry out. We now know heat ages the skin so it makes sense to avoid this type of treatment for most people.
	</blockquote>		</blockquote>
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	===== Epsom Salt baths may be palliative =====		===== Epsom Salt baths may be palliative =====

-	Epsom Salts are a combination of magnesium and sulfate (MgSO<sub>4</sub>). Research indicates that 500g (2 cups) in an average size bath for 15-20 minutes a couple times a week can modestly increase levels of both magnesium and sulfate.(([[http://www.mgwater.com/transdermal.shtml\|Report on Absorption of magnesium sulfate (Epsom salts) across the skin]], Dr RH Waring, School of Biosciences, University of Birmingham. B15 2TT, U.K.)) Both can be palliative during immunopathology. Magnesium can sooth sore muscles and sulfate may help with some sensitivities.(({{pubmed>long:8711748}}))	+	Epsom Salts are a combination of magnesium and sulfate (MgSO<sub>4</sub>). Research indicates that 500g (2 cups) in an average size bath for 15-20 minutes a couple times a week can modestly increase levels of both magnesium and sulfate.(([[https://www.mgwater.com/transdermal.shtml\|Report on Absorption of magnesium sulfate (Epsom salts) across the skin]], Dr RH Waring, School of Biosciences, University of Birmingham. B15 2TT, U.K.)) Both can be palliative during immunopathology. Magnesium can sooth sore muscles and sulfate may help with some sensitivities.(({{pmid>long:8711748}}))

	However, if you have a lot of sensitivities, or have not responded well to Epsom salt baths in the past, you may do better with a smaller amount of Epsom salts (e.g., 1/4 cup) as a starting point. Only use as much as appears beneficial. The Epsom salts may be drying to the skin.		However, if you have a lot of sensitivities, or have not responded well to Epsom salt baths in the past, you may do better with a smaller amount of Epsom salts (e.g., 1/4 cup) as a starting point. Only use as much as appears beneficial. The Epsom salts may be drying to the skin.
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1146.html	+	* https://www.marshallprotocol.com/forum32/1146.html
	*		*
-	* http://emedicine.medscape.com/article/766604-overview (reference for last sentence)	+	* https://emedicine.medscape.com/article/766604-overview (reference for last sentence)
		+
		+	===== References =====</nodisp>

-	===== References =====

Birth control

anonymous@undisclosed.example.com (Anonymous) — Tue, 03 Jan 2012 04:22:03 +0000

09.21.2011		current
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	<relatedarticles> [[home:special:pregnancy\|Pregnancy and fertility]], [[home:othertreatments:female_hormones\|Female hormone supplementation]] </article>		<relatedarticles> [[home:special:pregnancy\|Pregnancy and fertility]], [[home:othertreatments:female_hormones\|Female hormone supplementation]] </article>

-	Women of childbearing age on the MP who do not want to risk the chance of bearing a child suffering from fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, etc. should take precautions to prevent pregnancy, as the FDA package insert lists these as complications of taking olmesartan during the second or third trimesters. According to the FDA, these adverse effects do not appear to have resulted from intrauterine drug exposure that has occurred only during the first trimester.	+	Women of childbearing age on the MP who do not want to risk the chance of bearing a child suffering from fetal or neonatal injury should take precautions to prevent pregnancy, as the FDA package insert lists these as complications of taking olmesartan during the second or third trimesters. According to the FDA, these adverse effects do not appear to have resulted from intrauterine drug exposure that has occurred only during the first trimester.

	Because the MP can increase or restore fertility, women of childbearing age who are on the MP and sexually active are advised to use adequate precautions to avoid getting pregnant.		Because the MP can increase or restore fertility, women of childbearing age who are on the MP and sexually active are advised to use adequate precautions to avoid getting pregnant.
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	PMID: 9627916</blockquote>		PMID: 9627916</blockquote>

-	EDIT	+

Bone density conservation agents

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Techniques to help improve breathing

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.13.2019		current
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	//"Smell the rose; blow out the candle."//		//"Smell the rose; blow out the candle."//

-	//Deborah Leader, RN//, [[http://copd.about.com/od/glossaryofcopdterms/f/pursedlip.htm\|About.com Guide]]</blockquote>	+	//Deborah Leader, RN//, [[https://copd.about.com/od/glossaryofcopdterms/f/pursedlip.htm\|About.com Guide]]</blockquote>
	===== The Buteyko Breathing Technique =====		===== The Buteyko Breathing Technique =====

-	The Buteyko Breathing Technique is a holistic health philosophy, primarily for the treatment of asthma, that includes a set of breathing exercises developed by the late Russian doctor, Konstantin Pavlovich Buteyko. The method is taught as a complementary therapy, and several small clinical trials have shown that it can safely reduce asthma symptoms and the need for reliever medication in some people, as well as increasing quality of life scores. However, improvement takes time and commitment, requiring daily exercises over a period of weeks or months, and tuition can be expensive. [[http://www.doctorbuteykodiscoverytrilogy.com/buteyko-breathing-exercises.php\|This page]] explains the actual method in full.	+	The Buteyko Breathing Technique is a holistic health philosophy, primarily for the treatment of asthma, that includes a set of breathing exercises developed by the late Russian doctor, Konstantin Pavlovich Buteyko. The method is taught as a complementary therapy, and several small clinical trials have shown that it can safely reduce asthma symptoms and the need for reliever medication in some people, as well as increasing quality of life scores. However, improvement takes time and commitment, requiring daily exercises over a period of weeks or months, and tuition can be expensive. [[https://www.doctorbuteykodiscoverytrilogy.com/buteyko-breathing-exercises.php\|This page]] explains the actual method in full.


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+
		+	link may be broken or site down ?
		+	[[https://www.olivija.com/exercise/\|Pursed lip breathing]]

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum23/4175.html	+	* https://www.marshallprotocol.com/forum23/4175.html
	*		*
	*		*
		+	</nodisp>

Bronchiodilator inhalers

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 50:		Line 50:

	===== Read more =====		===== Read more =====
-	* [[http://familydoctor.org/online/famdocen/home/common/asthma/medications/040.html\|Metered-Dose Inhaler: How to Use It Correctly]]	+	* [[https://familydoctor.org/online/famdocen/home/common/asthma/medications/040.html\|Metered-Dose Inhaler: How to Use It Correctly]]


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-	{{tag>non-MP_therapies}}	+	{{tag>Other_medication}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	*	+	* </nodisp>

Chemotherapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

11.13.2011		current
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	There are variety of kinds of chemotherapy, but all chemotherapeutic regimens can cause depression of the immune system, often by paralyzing the bone marrow and leading to a decrease of white blood cells, red blood cells, and platelets. While some of the human cells which die are infected by intracellular pathogens, many are not. Chemotherapy's immunosuppressive effects are especially problematic when one considers that patients with cancer are already in a state of immunosuppression. In fact, according to the Marshall Pathogenesis, patients develop cancer because they are immunosuppressed.		There are variety of kinds of chemotherapy, but all chemotherapeutic regimens can cause depression of the immune system, often by paralyzing the bone marrow and leading to a decrease of white blood cells, red blood cells, and platelets. While some of the human cells which die are infected by intracellular pathogens, many are not. Chemotherapy's immunosuppressive effects are especially problematic when one considers that patients with cancer are already in a state of immunosuppression. In fact, according to the Marshall Pathogenesis, patients develop cancer because they are immunosuppressed.

-	When the body is immunosuppressed, there are a number of important genes that are not properly expressed including those transcribed by the Vitamin D Receptor (VDR). One such gene is tumor metastasis suppressor protein,(({{pubmed>long:16002434}})) a protein which acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer.(({{pubmed>long:2405170}}))	+	When the body is immunosuppressed, there are a number of important genes that are not properly expressed including those transcribed by the Vitamin D Receptor (VDR). One such gene is tumor metastasis suppressor protein,(({{pmid>long:16002434}})) a protein which acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer.(({{pmid>long:2405170}}))

-	The additional immunosuppression caused by chemotherapy can cause symptoms over the long-term such as "chemo brain."(({{pubmed>long:16381547}}))	+	The additional immunosuppression caused by chemotherapy can cause symptoms over the long-term such as "chemo brain."(({{pmid>long:16381547}}))

		+	==== Chemo brain ====

		+	Brain fog (also known as "chemo brain") is a common side effect of chemotherapy. As demonstrated in a [[https://www.reuters.com/article/2011/11/14/us-cancer-breast-brain-idUSTRE7AD26V20111114\|2011 study]], women with breast cancer, compared with healthy controls, had significantly reduced activation in several regions of the brain including the left middle dorsolateral prefrontal cortex, premotor cortex and left caudal lateral prefrontal cortex activation.(({{pmid>long:22084128}}))

-	===== Methotrexate =====

-	Methotrexate (MTX) is an antibiotic, which interferes with bacteria's ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol antibiotic, Bactrim DS:

-	<blockquote>MTX is an anti-folate – actually it is an anti-dihydrofolate reductase (anti-DHFR) – which inhibits one stage in the formation of DNA. Thus any bacteria dwelling within a body which has MTX in the bloodstream will find it more difficult to replicate, and hopefully the bacteria will gradually die off. Bactrim (Sulfa/trimeth) not only blocks DHFR (with trimethoprim) but also blocks P-ABA with Sulfonamide. Here is a diagram showing the Folate biochemistry in more detail. As you know, Bactrim is not a terribly effective antibiotic against intracellular pathogens, at least acting on its own. Neither is MTX especially effective acting on its own.

-	The interesting thing is that Folic Acid supplements are often given to ease the "side effects" of MTX. Folic Acid directly reduces the antibiotic action of both Trimethoprim and MTX. Sure, this may reduce pain from the immunopathology, but wouldn't it be more sensible to just lower the dose of MTX and reduce the risk of liver damage.

-	//Trevor Marshall, PhD// </blockquote>
-	==== Discontinuing methotrexate ====

-	The antibiotic action of MTX is likely to increase the immunopathology associated with olmesartan (Benicar) therapy, which is why patients should discontinue MTX before starting the Marshall Protocol.	+	===== Methotrexate =====
		+
		+	<mainarticle> [[home:othertreatments:antibacterials:methotrexate\|Methotrexate]] </article>
		+
		+	Methotrexate (MTX) is an antibiotic, which interferes with bacteria's ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol antibiotic, Bactrim DS.

-	It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation.

	===== Rituximab =====		===== Rituximab =====


-	In 2011, a Norwegian study published in //PLoS One// studied the effect of Rituximab – a monoclonal antibody otherwise used in cancers and anti-rejection treatment for organ transplants – on patients with chronic fatigue syndrome. In the 25-week study period, fatigue improved significantly in 10 out of 15 patients versus 2 out of 15 controls.(({{pubmed>long:22039471}})) This positive result may be due to the fact that Rituximab is a strong immunosuppressant. It may be telling to see a follow up of the patients who received the drug ten or even fifteen years from now.	+	In 2011, a Norwegian study published in //PLoS One// studied the effect of Rituximab – a monoclonal antibody otherwise used in cancers and anti-rejection treatment for organ transplants – on patients with chronic fatigue syndrome. In the 25-week study period, fatigue improved significantly in 10 out of 15 patients versus 2 out of 15 controls.(({{pmid>long:22039471}})) This positive result may be due to the fact that Rituximab is a strong immunosuppressant. It may be telling to see a follow up of the patients who received the drug ten or even fifteen years from now.

	===== Patient interviews =====		===== Patient interviews =====
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	sarcoidosis, bladder cancer		sarcoidosis, bladder cancer

-	Read the [[http://bacteriality.com/2008/07/18/interview24/\|interview]]	+	Read the [[https://bacteriality.com/2008/07/18/interview24/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	TECHEDIT	+


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=45587#p45587 s43	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=45587#p45587 s43
-	* http://www.marshallprotocol.com/view_topic.php?id=4285&forum_id=37&jump_to=91300#p91300 s132	+	* https://www.marshallprotocol.com/view_topic.php?id=4285&forum_id=37&jump_to=91300#p91300 s132
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=28072#p28072 s31	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=28072#p28072 s31
	*		*

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	3. SavageL.High-intensitychemotherapydoesnotimprovesurvivalinsmallcelllung cancer. J Natl Cancer Inst. 2008;100:519. 4. BearHD.Earlierchemotherapyforbreastcancer:perhapstoolatebutstilluseful. Ann Surg Oncol. 2003;10(4):334-335.		3. SavageL.High-intensitychemotherapydoesnotimprovesurvivalinsmallcelllung cancer. J Natl Cancer Inst. 2008;100:519. 4. BearHD.Earlierchemotherapyforbreastcancer:perhapstoolatebutstilluseful. Ann Surg Oncol. 2003;10(4):334-335.

-	//H.H. Weng//(({{pubmed>long:18827215}}))	+	//H.H. Weng//(({{pmid>long:18827215}}))

	Some more interesting stuff here:		Some more interesting stuff here:
-	http://jama.ama-assn.org/cgi/content/full/300/13/1580	+	https://jama.ama-assn.org/cgi/content/full/300/13/1580

	In cancer research, system behavior has been monitored during cancer progression, demonstrating that cancer evolution is driven by multiple cycles of transition between genome system stability and instability.9-10 Chemotherapy, by and large, induces a relatively stable system to enter into a chaotic phase. This drastic treatment might be more harmful at the individual level than had been expected. Clearly, understanding the entire system response in the context of any specific treatment is key.		In cancer research, system behavior has been monitored during cancer progression, demonstrating that cancer evolution is driven by multiple cycles of transition between genome system stability and instability.9-10 Chemotherapy, by and large, induces a relatively stable system to enter into a chaotic phase. This drastic treatment might be more harmful at the individual level than had been expected. Clearly, understanding the entire system response in the context of any specific treatment is key.
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-	<blockquote>Chemo: http://www.cancerdecisions.com/030506.html http://www.australianprescriber.com/magazine/29/1/2/3/</blockquote>	+	<blockquote>Chemo: https://www.cancerdecisions.com/030506.html https://www.australianprescriber.com/magazine/29/1/2/3/</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Chlorine dioxide

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
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	//Jay, healthsalon.org// </blockquote>		//Jay, healthsalon.org// </blockquote>

-	{{tag>Non-MP_therapies supplements}}	+	{{tag> supplements}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	===== References =====		===== References =====

		+	</nodisp>

Colloidal silver

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

07.25.2019		current
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	The use of colloidal silver is not approved while on the Marshall Protocol. Colloidal silver may interfere with the body's absorption of tetracyclines, and thus could affect absorption of minocycline. It also affects absorption of thyroxine & several other classes of drugs.((Natural Medicines Comprehensive Database. Colloidal silver. Natural Medicines Comprehensive Database Web site. Accessed on December 11, 2006.))		The use of colloidal silver is not approved while on the Marshall Protocol. Colloidal silver may interfere with the body's absorption of tetracyclines, and thus could affect absorption of minocycline. It also affects absorption of thyroxine & several other classes of drugs.((Natural Medicines Comprehensive Database. Colloidal silver. Natural Medicines Comprehensive Database Web site. Accessed on December 11, 2006.))

-	While colloidal silver is marketed for internal and external use as an alternative medical remedy, and there is some in vitro evidence suggesting that it has antibiotic effects, there is currently no scientific evidence of its effectiveness in vivo.(([[http://nccam.nih.gov/health/silver\|National Center for Complementary and Alternative Medicine, National Institutes of Health]])) In vivo antibiotic effectiveness could make colloidal silver dangerous in someone using the Marshall Protocol: it is not regulated as a pharmaceutical, and its effectiveness could therefore vary widely between batches, leading to unpredictable levels of immunopathology.	+	While colloidal silver is marketed for internal and external use as an alternative medical remedy, and there is some in vitro evidence suggesting that it has antibiotic effects, there is currently no scientific evidence of its effectiveness in vivo.(([[https://nccam.nih.gov/health/silver\|National Center for Complementary and Alternative Medicine, National Institutes of Health]])) In vivo antibiotic effectiveness could make colloidal silver dangerous in someone using the Marshall Protocol: it is not regulated as a pharmaceutical, and its effectiveness could therefore vary widely between batches, leading to unpredictable levels of immunopathology.

	Although colloidal silver as a trace element, rather than as ABx may have some validity in a very small number of patients, an excess of silver may becomes dangerous.		Although colloidal silver as a trace element, rather than as ABx may have some validity in a very small number of patients, an excess of silver may becomes dangerous.

-	Colloidal silver products can have serious side effects.(([[http://nccam.nih.gov/health/silver/#d\|NCCAM-NIH]])) In rare cases of excessive long-term use, it use can result in argyria, a form of silver toxicity.(({{pubmed>long:12780705}})) (({{pubmed>long:12361115}}))	+	Colloidal silver products can have serious side effects.(([[https://nccam.nih.gov/health/silver/#d\|NCCAM-NIH]])) In rare cases of excessive long-term use, it use can result in argyria, a form of silver toxicity.(({{pmid>long:12780705}})) (({{pmid>long:12361115}}))

	<html><!--		<html><!--
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	Many cases of argyria occurred during the pre-antibiotic era when silver was a common ingredient in nosedrops. When the cause became apparent, doctors stopped recommending their use, and reputable manufacturers stopped producing them. The official drug guidebooks (United States Pharmacopeia and National Formulary) have not listed colloidal silver products since 1975.		Many cases of argyria occurred during the pre-antibiotic era when silver was a common ingredient in nosedrops. When the cause became apparent, doctors stopped recommending their use, and reputable manufacturers stopped producing them. The official drug guidebooks (United States Pharmacopeia and National Formulary) have not listed colloidal silver products since 1975.

-	//[[http://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html\|Quackwatch.com]]// </blockquote>	+	//[[https://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html\|Quackwatch.com]]// </blockquote>
	--></html>		--></html>

-	see also https://mpkb.org/home/food#minerals	+	see also [[home:food#minerals\|minerals]]


	{{tag> supplements }}		{{tag> supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118161#p118161 f40	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118161#p118161 f40
	*		*
	THIS ARTICLE MAY NOT BE ACCURATE... https://www.youtube.com/watch?v=oKFov8YlzJA		THIS ARTICLE MAY NOT BE ACCURATE... https://www.youtube.com/watch?v=oKFov8YlzJA
	===== References =====		===== References =====

		+	</nodisp>

Corticosteroids

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.09.2011		current
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	===== Corticosteroids are ineffective ======		===== Corticosteroids are ineffective ======

-	There are no studies which show that steroids improve long-term prognosis in the treatment of illness. Van den Bosch and Grutters write(({{pubmed>long:16946094}})), "Remarkably, despite over 50 years of use, there is no proof of long-term (survival) benefit from corticosteroid treatment."	+	There are no studies which show that steroids improve long-term prognosis in the treatment of illness. Van den Bosch and Grutters write(({{pmid>long:16946094}})), "Remarkably, despite over 50 years of use, there is no proof of long-term (survival) benefit from corticosteroid treatment."

-	The 2003 NIH ACCESS study(({{pubmed>long:14620163}})), the largest and most ambitious to date, validates that these drugs are ineffective for sarcoidosis patients, even for a time period as short as two years.	+	The 2003 NIH ACCESS study(({{pmid>long:14620163}})), the largest and most ambitious to date, validates that these drugs are ineffective for sarcoidosis patients, even for a time period as short as two years.

	Table 3 in the paper shows how, for the majority of patients, markers of the disease process remained unchanged.		Table 3 in the paper shows how, for the majority of patients, markers of the disease process remained unchanged.
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	Latent pathogens grow slowly and accumulate over the course of decades. There is every reason to believe that a longer-term study as well as one looking at dose would further demonstrate how corticosteroids are worse than ineffective – they're dangerous. A more comprehensive paper would also have examined the range of negative side effects associated with coriticosteroid use.		Latent pathogens grow slowly and accumulate over the course of decades. There is every reason to believe that a longer-term study as well as one looking at dose would further demonstrate how corticosteroids are worse than ineffective – they're dangerous. A more comprehensive paper would also have examined the range of negative side effects associated with coriticosteroid use.

-	A systematic review(({{pubmed>long:15846612}})) of studies looking at the efficacy of inhaled and oral corticosteroids for pulmonary sarcoidosis concluded:	+	A systematic review(({{pmid>long:15846612}})) of studies looking at the efficacy of inhaled and oral corticosteroids for pulmonary sarcoidosis concluded:

	<blockquote>		<blockquote>
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	==== Corticosteroids cause relapse =====		==== Corticosteroids cause relapse =====

-	According to a comparative study(({{pubmed>long:9118698}})), 74% of patients relapse after trying to ease up their Prednisone dose, a significantly higher percentage of the time, and:	+	According to a comparative study(({{pmid>long:9118698}})), 74% of patients relapse after trying to ease up their Prednisone dose, a significantly higher percentage of the time, and:

	<blockquote>		<blockquote>
Line 126:		Line 126:
	===== Side effects of corticosteroid therapy =====		===== Side effects of corticosteroid therapy =====

-	Corticosteroid therapy can produce a range of negative side effects in humans. Side effects tend to be dose- and duration-dependent. The table below summarizes some of the more common side effects. A more [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&term=%22Glucocorticoids%2Fadverse%20effects%22[MAJR]\|complete and up-to-date list]] of such studies is available at PubMed.	+	Corticosteroid therapy can produce a range of negative side effects in humans. Side effects tend to be dose- and duration-dependent. The table below summarizes some of the more common side effects. A more [[https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&term=%22Glucocorticoids%2Fadverse%20effects%22[MAJR]\|complete and up-to-date list]] of such studies is available at PubMed.


	^System or function ^ Side effect^		^System or function ^ Side effect^
-	\|brain \|loss of brain tissue(({{pubmed>long:15882880}})) loss of cognition(({{pubmed>long:12013026}})) \|	+	\|brain \|loss of brain tissue(({{pmid>long:15882880}})) loss of cognition(({{pmid>long:12013026}})) \|
-	\|bone \|avascular necrosis of the bone(({{pubmed>long:11850924}})) (({{pubmed>long:10099819}})) osteoporosis(({{pubmed>long:15732231}})) osteonecrosis(({{pubmed>long:18757967}}))\|	+	\|bone \|avascular necrosis of the bone(({{pmid>long:11850924}})) (({{pmid>long:10099819}})) osteoporosis(({{pmid>long:15732231}})) osteonecrosis(({{pmid>long:18757967}}))\|
-	\|endocrine \|suppression of adrenal response(({{pubmed>long:10683005}})) (({{pubmed>long:9623166}})) widespread endocrine dysfunction(({{pubmed>long:2320881}})) Cushing's Syndrome(({{pubmed>long:15850848}})) \|	+	\|endocrine \|suppression of adrenal response(({{pmid>long:10683005}})) (({{pmid>long:9623166}})) widespread endocrine dysfunction(({{pmid>long:2320881}})) Cushing's Syndrome(({{pmid>long:15850848}})) \|
-	\|eyes \|cataracts(({{pubmed>long:3541262}})) glaucoma(({{pubmed>long:10641955}})) (({{pubmed>long:7701998}})) range of other side effects(({{pubmed>long:11820911}})) \|	+	\|eyes \|cataracts(({{pmid>long:3541262}})) glaucoma(({{pmid>long:10641955}})) (({{pmid>long:7701998}})) range of other side effects(({{pmid>long:11820911}})) \|
-	\|gastrointestinal \|gastrointestinal hemorrhage(({{pubmed>long:8927965}})) \|	+	\|gastrointestinal \|gastrointestinal hemorrhage(({{pmid>long:8927965}})) \|
-	\|muscle \|loss of skeletal muscle(({{pubmed>long: 12843161}})) myopathy (muscle weakness)(({{pubmed>long: 6851197}})) (({{pubmed>long: 9551512}})) (({{pubmed>long: 10939120}})) \|	+	\|muscle \|loss of skeletal muscle(({{pmid>long: 12843161}})) myopathy (muscle weakness)(({{pmid>long: 6851197}})) (({{pmid>long: 9551512}})) (({{pmid>long: 10939120}})) \|
-	\|psychological \|dementia(({{pubmed>long:15677408}})) \|	+	\|psychological \|dementia(({{pmid>long:15677408}})) \|
-	\|sexual, female \|menstruation disturbance(({{pubmed>long:2815743}}))\|	+	\|sexual, female \|menstruation disturbance(({{pmid>long:2815743}}))\|
-	\|sexual, male \|decrease testosterone(({{pubmed>long: 3083749}})) (({{pubmed>long: 7983641}})) \|	+	\|sexual, male \|decrease testosterone(({{pmid>long: 3083749}})) (({{pmid>long: 7983641}})) \|
-	\|skin \|skin atrophy(({{pubmed>long:11393207}})) \|	+	\|skin \|skin atrophy(({{pmid>long:11393207}})) \|


	==== Side effects in children ====		==== Side effects in children ====

-	Whether taking injectable or inhaled corticosteroids, children are particularly susceptible to the negative long-term effects of the drugs. The table below summarizes some of the more common side effects in children. A more [[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Glucocorticoids%2Fadverse+effects%22[MAJR]+AND+%22Child%22[MeSH]\|complete and up-to-date list]] of such studies is available at PubMed.	+	Whether taking injectable or inhaled corticosteroids, children are particularly susceptible to the negative long-term effects of the drugs. The table below summarizes some of the more common side effects in children. A more [[https://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Glucocorticoids%2Fadverse+effects%22[MAJR]+AND+%22Child%22[MeSH]\|complete and up-to-date list]] of such studies is available at PubMed.

	^System or function ^ Side effect^		^System or function ^ Side effect^
-	\|bone \|higher risk of fractures(({{pubmed>long:12733732}})) loss of density(({{pubmed>long:18595975}})) \|	+	\|bone \|higher risk of fractures(({{pmid>long:12733732}})) loss of density(({{pmid>long:18595975}})) \|
-	\|dental \|eruption of permanent molars(({{pubmed>long:15470830}})) \|	+	\|dental \|eruption of permanent molars(({{pmid>long:15470830}})) \|
-	\|endocrine \|suppression of adrenal response(({{pubmed>long:15269067}})(({{pubmed>long:12904139}})) growth suppression(({{pubmed>long:1823076}})) (({{pubmed>long:9709954}})) (({{pubmed>long:11826253}})) Cushing's syndrome(({{pubmed>long:18183788}})) \|	+	\|endocrine \|suppression of adrenal response(({{pmid>long:15269067}})(({{pmid>long:12904139}})) growth suppression(({{pmid>long:1823076}})) (({{pmid>long:9709954}})) (({{pmid>long:11826253}})) Cushing's syndrome(({{pmid>long:18183788}})) \|
-	\|immunological \|allergies(({{pubmed>long:11456363}})) \|	+	\|immunological \|allergies(({{pmid>long:11456363}})) \|
-	\|psychological \|psychosis(({{pubmed>long:15851433}})) poor attention(({{pubmed>long:14577022}})) \|	+	\|psychological \|psychosis(({{pmid>long:15851433}})) poor attention(({{pmid>long:14577022}})) \|
-	\|skin \|skin death(({{pubmed>long:1806315}})) \|	+	\|skin \|skin death(({{pmid>long:1806315}})) \|
-	\|urinary \|kidney stones(({{pubmed>long:8576746}})) \|	+	\|urinary \|kidney stones(({{pmid>long:8576746}})) \|


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	==== Images of side effects ====		==== Images of side effects ====

-	Courtesy the [[http://vasculitis.med.jhu.edu/treatments/prednisone.html\|Johns Hopkins Vasculitis Center]], these images are of corticosteroid users. (Click for a larger image and description.)	+	Courtesy the [[https://vasculitis.med.jhu.edu/treatments/prednisone.html\|Johns Hopkins Vasculitis Center]], these images are of corticosteroid users. (Click for a larger image and description.)

	{{gallery>home:othertreatments:sideeffects?showtitle&150x150&3&lightbox&nodirect }}		{{gallery>home:othertreatments:sideeffects?showtitle&150x150&3&lightbox&nodirect }}
Line 199:		Line 199:

	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	OVERSEER	+
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum2/12438.html	+	* https://www.marshallprotocol.com/forum2/12438.html
		+
		+
		+	* SARS and mental health problems – In a 2009 study, many survivors of the severe acute respiratory syndrome (SARS) pandemic of 2003 suffer from persistent mental health problems and chronic fatigue years later.(({{pmid>long:20008700}})) Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, with 27.1% meeting the modified 1994 CDC criteria for chronic fatigue syndrome. Also, being a health care worker at the time of SARS infection more than tripled the risk of psychiatric morbidities at follow-up. This may be because corticoteroids were used heavily during the recent SARS outbreak.(({{pmid>long:16172857}}))
		+
		+
		+	<blockquote>Hip necrosis can occur with a single dose of just 30mg of prednisone:

		+	https://www.ncbi.nlm.nih.gov/pubmed/12189457

-	* SARS and mental health problems – In a 2009 study, many survivors of the severe acute respiratory syndrome (SARS) pandemic of 2003 suffer from persistent mental health problems and chronic fatigue years later.(({{pubmed>long:20008700}})) Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, with 27.1% meeting the modified 1994 CDC criteria for chronic fatigue syndrome. Also, being a health care worker at the time of SARS infection more than tripled the risk of psychiatric morbidities at follow-up. This may be because corticoteroids were used heavily during the recent SARS outbreak.(({{pubmed>long:16172857}}))	+	..Trevor..
		+	</blockquote>
		+	===== References =====</nodisp>

-	===== References =====

Detoxification

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Diet pills

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 10:		Line 10:


-	{{tag>supplements }}	+	{{tag>non-mp_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=9764&forum_id=37&jump_to=112549#p112549 s269	+	* https://www.marshallprotocol.com/view_topic.php?id=9764&forum_id=37&jump_to=112549#p112549 s269
	*		*
	*		*
-	===== References =====	+	===== References =====</nodisp>

Diuretics

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
Line 13:		Line 13:
	==== Side effects of thiazides ====		==== Side effects of thiazides ====

-	Thiazide diuretics are [[http://www.rxlist.com/dyazide-drug.htm#wcp\|too hard]] on the kidneys and liver, organs in which patients with Th1 disease may have both diagnosed and subclinical problems. Thiazide drugs are contraindicated for patients on the Marshall Protocol, and especially for those with kidney disease.	+	Thiazide diuretics are [[https://www.rxlist.com/dyazide-drug.htm#wcp\|too hard]] on the kidneys and liver, organs in which patients with Th1 disease may have both diagnosed and subclinical problems. Thiazide drugs are contraindicated for patients on the Marshall Protocol, and especially for those with kidney disease.

-	Also, thiazides can exacerbate diabetes.(({{pubmed>long:12556647}}))	+	Also, thiazides can exacerbate diabetes.(({{pmid>long:12556647}}))

-	Patients can read the precautions about HCT on the [[http://www.rxlist.com/cgi/generic/hctz_wcp.htm\|RxList: the Internet Drug Index]].	+	Patients can read the precautions about HCT on the [[https://www.rxlist.com/cgi/generic/hctz_wcp.htm\|RxList: the Internet Drug Index]].


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	Lasix (furosemide) however, does not cause potassium-retention and is compatible with the Marshall Protocol. Anyone on Lasix with cardiorespiratory symptoms exacerbation should be evaluated by their doctor for congesitve heart failure to see if their cardiac medications need to be adjusted.		Lasix (furosemide) however, does not cause potassium-retention and is compatible with the Marshall Protocol. Anyone on Lasix with cardiorespiratory symptoms exacerbation should be evaluated by their doctor for congesitve heart failure to see if their cardiac medications need to be adjusted.

-	{{tag>non-MP_therapies}}	+	{{tag>Other_medication}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	broken [[http://www.bmj.com/cgi/eletters/327/7413/0-e#36257\|can exacerbate]]	+	broken [[https://www.bmj.com/cgi/eletters/327/7413/0-e#36257\|can exacerbate]]


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	*		*

-	===== References =====	+	===== References =====</nodisp>

Fish oil and omega 3 fatty acids

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 29:		Line 29:


-	Greater consumption of omega 3's has been shown to reduce inflammation and immune activity.(({{pubmed>long:19359242}}))	+	Greater consumption of omega 3's has been shown to reduce inflammation and immune activity.(({{pmid>long:19359242}}))

	* Omega 3's contain components which suppress TNF-alpha – Cytokines are regulatory proteins, such as TNF-alpha, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. The omega 3 fatty acids, for example, contain several components which may interfere with the activity of TNF-alpha and other important cytokines.		* Omega 3's contain components which suppress TNF-alpha – Cytokines are regulatory proteins, such as TNF-alpha, that are released by cells of the immune system and act as intercellular mediators in the generation of an immune response. The omega 3 fatty acids, for example, contain several components which may interfere with the activity of TNF-alpha and other important cytokines.
Line 35:		Line 35:
	<blockquote>Arachidonic acid (AA) significantly decreased TNFalpha production.... The results show that docosahexaenoic acid (DHA) induces a Th-1-like immune response and that AA has anti-inflammatory effects by decreasing the production of TNFalpha. Thus, the immune effects of omega3 polysaturated fatty acids are not compatible with what is expected from antidepressive substances. The results of the present study show that treatment with fish oils, containing DHA, should be avoided in the treatment of depression. Toward this end, highly concentrated and pure EPA seems to be indicated.		<blockquote>Arachidonic acid (AA) significantly decreased TNFalpha production.... The results show that docosahexaenoic acid (DHA) induces a Th-1-like immune response and that AA has anti-inflammatory effects by decreasing the production of TNFalpha. Thus, the immune effects of omega3 polysaturated fatty acids are not compatible with what is expected from antidepressive substances. The results of the present study show that treatment with fish oils, containing DHA, should be avoided in the treatment of depression. Toward this end, highly concentrated and pure EPA seems to be indicated.

-	//M. Maes et al// (({{pubmed>long:18063921}}))</blockquote>	+	//M. Maes et al// (({{pmid>long:18063921}}))</blockquote>


Line 42:		Line 42:
	<blockquote>A high eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake changed the expression of 1,040 genes.... EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling.		<blockquote>A high eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake changed the expression of 1,040 genes.... EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling.

-	//M. Bouwens// (({{pubmed>long:19515734}}))</blockquote>	+	//M. Bouwens// (({{pmid>long:19515734}}))</blockquote>

-	* EPA and DHA switch off a key receptor responsible for innate immunity in fat cells. Olefsky and colleagues identified a key receptor on macrophages abundantly found in obese body fat: the GPR120 receptor.(({{pubmed>long:20813258}})) The team showed that omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects. [[http://www.eurekalert.org/pub_releases/2010-09/uoc--wfo083010.php\|Commenting about his work]], Olefsky said, "It's just an incredibly potent effect. The omega-3 fatty acids switch on the receptor, killing the inflammatory response."	+	* EPA and DHA switch off a key receptor responsible for innate immunity in fat cells. Olefsky and colleagues identified a key receptor on macrophages abundantly found in obese body fat: the GPR120 receptor.(({{pmid>long:20813258}})) The team showed that omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects. [[https://www.eurekalert.org/pub_releases/2010-09/uoc--wfo083010.php\|Commenting about his work]], Olefsky said, "It's just an incredibly potent effect. The omega-3 fatty acids switch on the receptor, killing the inflammatory response."

	* Fish oil-fed mice have impaired resistance to influenza infection.		* Fish oil-fed mice have impaired resistance to influenza infection.
Line 50:		Line 50:
	<blockquote>Although fish oil-fed mice had lower lung inflammation compared with controls, fish oil feeding also resulted in a 40% higher mortality rate, a 70% higher lung viral load at d 7 post infection, and a prolonged recovery period following infection.... Additionally, lungs of infected fish oil-fed mice had significantly fewer CD8+ T cells and decreased mRNA expression of macrophage inflammatory protein-1-alpha, tumor necrosis factor-alpha, and interleukin-6. These results suggest that the antiinflammatory properties of fish oil feeding can alter the immune response to influenza infection, resulting in increased morbidity and mortality.		<blockquote>Although fish oil-fed mice had lower lung inflammation compared with controls, fish oil feeding also resulted in a 40% higher mortality rate, a 70% higher lung viral load at d 7 post infection, and a prolonged recovery period following infection.... Additionally, lungs of infected fish oil-fed mice had significantly fewer CD8+ T cells and decreased mRNA expression of macrophage inflammatory protein-1-alpha, tumor necrosis factor-alpha, and interleukin-6. These results suggest that the antiinflammatory properties of fish oil feeding can alter the immune response to influenza infection, resulting in increased morbidity and mortality.

-	//Schwerbrock et al.//(({{pubmed>long:19549756}}))</blockquote>	+	//Schwerbrock et al.//(({{pmid>long:19549756}}))</blockquote>


	===== Omega 3 fatty acids may cause disease =====		===== Omega 3 fatty acids may cause disease =====

-	* Mice given omega‐3's are more susceptible to pulmonary tuberculosis – Bonilla //et al.// showed that transgenic mice engineered to produce omega-3's endogenously (internally) increased their susceptibility to tuberculosis, which they explained by noting the corresponding reduction in antimycobacterial responses in cells. The researchers concluded, "These data suggest that n‐3 PUFA–supplemented [dietary omega‐3 fatty acids] diets might have a detrimental effect on immunity to //M. tuberculosis// and raise concerns regarding the safety of omega‐3 dietary supplementation in humans."(({{pubmed>long:20053136}}))	+	* Mice given omega‐3's are more susceptible to pulmonary tuberculosis – Bonilla //et al.// showed that transgenic mice engineered to produce omega-3's endogenously (internally) increased their susceptibility to tuberculosis, which they explained by noting the corresponding reduction in antimycobacterial responses in cells. The researchers concluded, "These data suggest that n‐3 PUFA–supplemented [dietary omega‐3 fatty acids] diets might have a detrimental effect on immunity to //M. tuberculosis// and raise concerns regarding the safety of omega‐3 dietary supplementation in humans."(({{pmid>long:20053136}}))




-	{{tag>supplements}}	+	{{tag>non-mp_therapies supplements}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=45960#p45960 f28	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=45960#p45960 f28

	Are there any new references here?\\		Are there any new references here?\\
Line 75:		Line 76:

	It has been shown that it is down regulating the immune system function in dealing		It has been shown that it is down regulating the immune system function in dealing
-	with viral pathogens. http://www.lakartidningen.se/07engine.php?articleId=12663	+	with viral pathogens. https://www.lakartidningen.se/07engine.php?articleId=12663

	Here are the sources;\\		Here are the sources;\\
Line 108:		Line 109:

	"A comprehensive understanding of the effects of nutrients on a broad range of diseases will be necessary before making recommendations for dietary changes or use of individual dietary supplements for disease prevention," the team concludes.</blockquote>		"A comprehensive understanding of the effects of nutrients on a broad range of diseases will be necessary before making recommendations for dietary changes or use of individual dietary supplements for disease prevention," the team concludes.</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Erythropoiesis-stimulating agents (EPO)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.22.2011		current
Line 10:		Line 10:


		+	===== Read more =====

		+	* [[https://www.sciencedaily.com/releases/2011/01/110120151641.htm\|Red Blood Cell Hormone Modulates the Immune System]]
		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


-	===== References =====	+	===== References =====</nodisp>

Ergot alkaloids

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

11.17.2009		current
Line 5:		Line 5:
	Some ergot alkaloid medications include:		Some ergot alkaloid medications include:

-	* [[http://en.wikipedia.org/wiki/Hydergine\|hydergine]]	+	* [[https://en.wikipedia.org/wiki/Hydergine\|hydergine]]
-	* [[http://en.wikipedia.org/wiki/Ergotamine\|ergotamine]]	+	* [[https://en.wikipedia.org/wiki/Ergotamine\|ergotamine]]
-	* [[http://en.wikipedia.org/wiki/Cafergot\|cafergot]]	+	* [[https://en.wikipedia.org/wiki/Cafergot\|cafergot]]

		+	Of particular concern is the danger of [[https://en.wikipedia.org/wiki/Ergotism\|ergotism]]. The deleterious side-effects occur either under high dose or when moderate doses interact with potentiators such as azithromycin.

-	{{tag>}}

		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT

-	some FDA data on this drug ... [[http://www.drugs.com/cons/hydergine.html\|Hydergine]]	+
		+	some FDA data on this drug ... [[https://www.drugs.com/cons/hydergine.html\|Hydergine]]

	ACTIONS		ACTIONS
Line 52:		Line 54:
	* Slow heartbeat—Ergoloid mesylates may make the condition worse		* Slow heartbeat—Ergoloid mesylates may make the condition worse

-	===== References =====	+	===== References =====</nodisp>

Eye medications and eye drops

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

05.02.2011		current
Line 32:		Line 32:
	==== Corticosteroids ====		==== Corticosteroids ====

-	Patients should work with their doctor or ophthalmologist to limit their use of substances which affect the proper functioning of the immune system. Patients' doctors who believe they need immunosuppressant eye drops to temorarily control inflammation may use the drugs while on the MP.	+	Patients should work with their doctor or ophthalmologist to limit their use of substances which affect the proper functioning of the immune system. Patients' doctors who believe they need immunosuppressant eye drops to temorarily control inflammation may use the drugs while on the MP.

-	Be advised that use of steroids delays resolution of original disease symptoms while on the MP, and can have serious side effects. These side effects include glaucoma,(({{pubmed>long:5953285}})) cataracts,(({{pubmed>long:16905028}})) ocular hypertension,(({{pubmed>long: 1559550}})) and [[antidepressants#side_effects_of_corticosteroid_therapy\|various other side effects]].(({{pubmed>long:11820911}}))	+	Be advised that use of steroids delays resolution of original disease symptoms while on the MP, and can have serious side effects. These side effects include glaucoma,(({{pmid>long:5953285}})) cataracts,(({{pmid>long:16905028}})) ocular hypertension,(({{pmid>long: 1559550}})) and [[antidepressants#side_effects_of_corticosteroid_therapy\|various other side effects]].(({{pmid>long:11820911}}))

	<blockquote>		<blockquote>
	Although newer corticosteroids with lesser pressure elevating characteristics have been developed, corticosteroid-induced ocular hypertension and glaucoma continue to be significant risks of local and systemic administration.		Although newer corticosteroids with lesser pressure elevating characteristics have been developed, corticosteroid-induced ocular hypertension and glaucoma continue to be significant risks of local and systemic administration.

-	//McGhee et al.//(({{pubmed>long:11820911}})) </blockquote>	+	//McGhee et al.//(({{pmid>long:11820911}})) </blockquote>

-	Regular use of olmesartan as per the MP guidelines can help a patient [[home:othertreatments:corticosteroids:weaningoffsteroids\|wean from higher doses of prednisolone (Prednisone)]].	+	When possible, physicians should try weaning their patients from immunosuppressive eye drops. Try going down one drop a day. Regular use of olmesartan as per the MP guidelines can help a patient [[home:othertreatments:corticosteroids:weaningoffsteroids\|wean from higher doses of prednisolone (Prednisone)]].


Line 69:		Line 69:

	<blockquote>		<blockquote>
-	I use [[http://www.amazon.com/Allergan-Refresh-Lubricant-Ointment-Nighttime/dp/B0013NHRAY\|Refresh PM gel]] by Allergan, a night-time product for soothing dry eyes. It is actually an ointment developed for dry eyes that bathes the eyes all night. It lasts much longer than the gel drops. Refresh PM causes blurry vision which is why it was developed for night time use. Works great!	+	I use [[https://www.amazon.com/Allergan-Refresh-Lubricant-Ointment-Nighttime/dp/B0013NHRAY\|Refresh PM gel]] by Allergan, a night-time product for soothing dry eyes. It is actually an ointment developed for dry eyes that bathes the eyes all night. It lasts much longer than the gel drops. Refresh PM causes blurry vision which is why it was developed for night time use. Works great!

	//DNStog, MarshallProtocol.com// </blockquote>		//DNStog, MarshallProtocol.com// </blockquote>
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	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT	+

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4429&forum_id=37&jump_to=43748#p43748	+	* https://www.marshallprotocol.com/view_topic.php?id=4429&forum_id=37&jump_to=43748#p43748
		+
		+	===== References =====</nodisp>

-	===== References =====

Female hormone supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 34:		Line 34:


		+	{{tag>supplements}}

-		+	<nodisp>
-		+
-		+
-		+
-		+
-		+
-	{{tag>non-MP_therapies Hormone_Supplementation}}	+
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum37/9800.html	+	* https://www.marshallprotocol.com/forum37/9800.html


Line 62:		Line 56:

	On Tue, Apr 5, 2011 at 2:45 PM, Trevor Marshall <Trevor@trevormarshall.com> wrote:		On Tue, Apr 5, 2011 at 2:45 PM, Trevor Marshall <Trevor@trevormarshall.com> wrote:
-	http://www.ucsf.edu/news/2011/04/9664/study-finds-link-between-chronic-depression-and-accelerated-immune-cell-aging	+	https://www.ucsf.edu/news/2011/04/9664/study-finds-link-between-chronic-depression-and-accelerated-immune-cell-aging

-	http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017837	+	https://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017837

	..Trevor..		..Trevor..
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	</blockquote>		</blockquote>

-	===== References =====	+	===== References =====</nodisp>

Frankincense

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Glucosamine, chondroitin, and MSM

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.12.2011		current
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	~~NOTOC~~		~~NOTOC~~

-	====== Glucosamine, chondroitin and MSM ======	+	====== Glucosamine, chondroitin, and MSM ======

	<html><!--{{ :home:othertreatments:gluco3.gif\|Glucosamine and chondriotin with MSM]]}}--></html>		<html><!--{{ :home:othertreatments:gluco3.gif\|Glucosamine and chondriotin with MSM]]}}--></html>
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	Glucosamine, often taken in conjunction with chondroitin and MSM (methylsulfonylmethane), is an over-the-counter supplement used to relieve symptoms of osteoarthritis. Some patients report temporary improvement after taking the supplement, however, there is no evidence that its use resolves joint inflammation.		Glucosamine, often taken in conjunction with chondroitin and MSM (methylsulfonylmethane), is an over-the-counter supplement used to relieve symptoms of osteoarthritis. Some patients report temporary improvement after taking the supplement, however, there is no evidence that its use resolves joint inflammation.

-	Worse, there is the distinct possibility that the supplement actually inhibits progress, and, for this reason, Marshall Protocol patients must avoid using it. According to [[http://www.townsendletter.com/FebMar2006/lyme0206.htm\|an article]] by Prof. Robert W. Bradford and Henry W. Allen in the //Townsend Letter//:	+	Worse, there is the distinct possibility that the supplement actually inhibits progress, and, for this reason, Marshall Protocol patients must avoid using it. According to [[https://www.townsendletter.com/FebMar2006/lyme0206.htm\|an article]] by Prof. Robert W. Bradford and Henry W. Allen in the //Townsend Letter//:

	<blockquote>		<blockquote>
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	<blockquote>Just a word of caution about sulfur supplements, MSM in particular. You may just end up “feeding” certain bacteria in the process. From my own personal experience with MSM supplementation prior to starting the MP and what I now know about some bacteria’s ability to reduce sulfur to hydrogen sulfide , I would not recommend MSM.		<blockquote>Just a word of caution about sulfur supplements, MSM in particular. You may just end up “feeding” certain bacteria in the process. From my own personal experience with MSM supplementation prior to starting the MP and what I now know about some bacteria’s ability to reduce sulfur to hydrogen sulfide , I would not recommend MSM.

-	Shortly after I discontinued MSM , when I started the MP, I experienced what I believe was a certain degree of [[http://en.wikipedia.org/wiki/Hydrogen_sulfide#Toxicity\|hydrogen sulfide toxicity]] as my body released excess sulfur (probably through the die-off of bacteria dependent on sulfur or simply an excess of sulfur). I could not wear metallic jewelry (copper, gold or silver) without my skin turning black for over a year, one sign of hydrogen sulfide toxicity.	+	Shortly after I discontinued MSM , when I started the MP, I experienced what I believe was a certain degree of [[https://en.wikipedia.org/wiki/Hydrogen_sulfide#Toxicity\|hydrogen sulfide toxicity]] as my body released excess sulfur (probably through the die-off of bacteria dependent on sulfur or simply an excess of sulfur). I could not wear metallic jewelry (copper, gold or silver) without my skin turning black for over a year, one sign of hydrogen sulfide toxicity.

	Not to mention the fatigue, headaches, cough, brain fog I experienced while on MSM. IMHO, the potential for ill-effects with MSM supplementation far outweigh the benefits of reduction of joint pain (palliation)		Not to mention the fatigue, headaches, cough, brain fog I experienced while on MSM. IMHO, the potential for ill-effects with MSM supplementation far outweigh the benefits of reduction of joint pain (palliation)
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	OVERSEER	+


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=55392#p55392 f30	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=55392#p55392 f30
	*		*
	*		*

-	===== References =====	+	===== References =====</nodisp>

Guaifenesin

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
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	Many drug and health food store sells guaifensin. It is also available at a number of online retailers.		Many drug and health food store sells guaifensin. It is also available at a number of online retailers.

-	* United States – [[http://www.amazon.com/s/ref=nb_ss_gw_0_9?url=search-alias%3Daps&field-keywords=guaifenesin+capsules&x=0&y=0&sprefix=guaifenesin\|Amazon.com]]	+	* United States – [[https://www.amazon.com/s/ref=nb_ss_gw_0_9?url=search-alias%3Daps&field-keywords=guaifenesin+capsules&x=0&y=0&sprefix=guaifenesin\|Amazon.com]]

	{{tag>supplements }}		{{tag>supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+	broke * Australia – [[https://www.pharmacyonline.com.au/robitussin-chesty-cough-p-11637.html\|Pharmacy Online]]


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=161881#p161881 f55	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=161881#p161881 f55

	Sedona has some worthwhile stuff to say about Guaifenesin		Sedona has some worthwhile stuff to say about Guaifenesin
-	http://www.marshallprotocol.com/view_topic.php?id=6262&forum_id=35&highlight=sedona+guaifenesin	+	https://www.marshallprotocol.com/view_topic.php?id=6262&forum_id=35&highlight=sedona+guaifenesin

	===== References =====		===== References =====
-	*	+	* </nodisp>

Herbs, spices and other plants as supplements

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.15.2018		current
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	==== Curcumin, tumeric, curry and mustard ====		==== Curcumin, tumeric, curry and mustard ====

-	MP patients are advised to avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pubmed>long:20680030}})) According to a 2006 Food Technology article:	+	MP patients are advised to avoid significant use of curcumin as well as its derivatives. A 2010 by Choi //et al.// showed that curcumin decreases androgen receptor expression in a dose-dependent manner.(({{pmid>long:20680030}})) According to a 2006 Food Technology article:

	<blockquote>		<blockquote>
	Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote>		Twelve scientific, peer-reviewed publications since 1999 suggest that curcumin, the major yellow pigment in tumeric, curry and mustard, may potentiate apoptosis or inhibit growth of selected cancer cells or function as a COX-2 inhibitor in several in-vitro and animal models.</blockquote>

-	Cucurmin certainly appears to impact the immune system, and therefore it is possible that high usage may increase IP in an unpredictable way. (({{pubmed>long:27874279}})) (({{pubmed>long:21461234}}))	+	Cucurmin certainly appears to impact the immune system, and therefore it is possible that high usage may increase IP in an unpredictable way. (({{pmid>long:27874279}})) (({{pmid>long:21461234}}))


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	==== Garlic ====		==== Garlic ====

-	Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pubmed>long:2469386}})) Allicin is known to inhibit bacterial cell growth. Garlic tablets taken as a supplement may interact unpredictably with MP medications and could be potentially detrimental. Eating moderate amounts of garlic as part of one's diet, however, is probably not detrimental to progress on the MP.	+	Garlic contains a chemical called allicin, which is a natural antibiotic.(({{pmid>long:2469386}})) Allicin is known to inhibit bacterial cell growth. Garlic tablets taken as a supplement may interact unpredictably with MP medications and could be potentially detrimental. Eating moderate amounts of garlic as part of one's diet, however, is probably not detrimental to progress on the MP.

		+	[[https://aac.asm.org/content/56/5/2314\|Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing]]

		+	We identified four anti-inflammatory sulfur-containing compounds from garlic, and their chemical structures were identified as Z- and E-ajoene and oxidized sulfonyl derivatives of ajoene. The sulfur compounds inhibited the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and the expression of the pro-inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 in lipopolysaccharide (LPS)-activated macrophages. (({{pmid>long:23057778}}))
		+
		+	The optimum conditions for the formation of E- and Z-ajoene from garlic juice (({{pmid>long:25473520}}))
		+
		+	The treatment of macrophages with ajoene resulted in the activation of JNK, induction of ROS synthesis and accumulation of ROS, possibly leading to the activation of ER stress and autophagy. These results reveal the mechanism of the antimycobacterial effects of ajoene against Mtb H37Rv. Our findings might facilitate the development of novel therapies for patients with TB (({{pmid>long:29239661}}))
		+
		+	In vitro, Ajoene is toxic for several tumoral cell lines, and exert an antiproliferative effect on T. cruzi and murine malaria parasites. Here we show that Ajoene strongly inhibited the proliferation induced in human lymphocytes by the mitogens phytohemagglutinin (PHA), phorbol myristate acetate (PMA) and anti-CD3, and the capping formation induced in B lymphocytes by anti-IgM antibodies. On macrophages, Ajoene was also found to partially inhibit the lypopolysaccharide-induced production of Tumor Necrosis Factor (TNF), and to decrease the phagocytic activity of thioglycolate-elicited mouse peritoneal macrophages for IgG-opsonized, human erythrocytes. Ajoene also partially prevented the lytic effect of human and rabbit TNF on Actinomycin D-treated WEHI 164 cells. These results strongly suggest that Ajoene is a potent modulator of membrane-dependent functions of immune cells. (({{pmid>long:9049657}}))
		+
		+	Ajoene induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB (({{pmid>long:9495804}}))
		+
		+	In this study, we identified 18 essential oils (at 0.2% concentration) that are more active than 40 µM daptomycin (a persister drug control that could eradicate B. burgdorferi stationary phase cells), from which 10 essential oils stand out as having a remarkable activity even at 0.1% concentration (Table 1). Among them, garlic essential oil exhibited the best activity as shown by the lowest residual viability of B. burgdorferi at 0.1%. (({{pmid>long:30332754}}))
	==== Grapefruit seed extract ====		==== Grapefruit seed extract ====

	Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated.		Grapefruit seed extract is a powerful, broad-spectrum antimicrobial and anti-viral agent and is therefore contraindicated.

-	Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[http://www.globalrph.com/gfruit.htm\|drug-grapefruit interactions]]	+	Grapefruit juice inhibits CYP3A4 - mediated drug metabolism [[https://www.globalrph.com/gfruit.htm\|drug-grapefruit interactions]]
-	This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. (({{pubmed>long:10688276}}))	+	This interaction can lead to increases in bioavailability and corresponding increases in serum drug levels. (({{pmid>long:10688276}}))


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	==== Milk thistle ====		==== Milk thistle ====

-	Right upper quadrant pain (which corresponds to the liver's location) is often relieved with the use of Silymarin/milk thistle, which is available in capsule form. Milk thistle is made from //Silybum marianum// seeds. Some researchers believe that milk thistle supplements have a detoxifying action reducing toxicity of the liver.(({{pubmed>long:17548794}}))	+	Right upper quadrant pain (which corresponds to the liver's location) is often relieved with the use of Silymarin/milk thistle, which is available in capsule form. Milk thistle is made from //Silybum marianum// seeds. Some researchers believe that milk thistle supplements have a detoxifying action reducing toxicity of the liver.(({{pmid>long:17548794}}))

	With herbs such as this, it is difficult to measure the active ingredient potency. Since it all comes from plants, they vary with growing conditions. For that reason, some brands may seem to work better than others.		With herbs such as this, it is difficult to measure the active ingredient potency. Since it all comes from plants, they vary with growing conditions. For that reason, some brands may seem to work better than others.
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	For quick relief (especially when the digestive system is not working well), liquid milk thistle drops, which are usually available from a local health food store, may be helpful. Drops can be used in addition to the capsules, if needed.		For quick relief (especially when the digestive system is not working well), liquid milk thistle drops, which are usually available from a local health food store, may be helpful. Drops can be used in addition to the capsules, if needed.

-	The Natural Medicines Comprehensive Database describes [[http://naturaldatabaseconsumer.therapeuticresearch.com/nd/Search.aspx?cs=KAISER&s=NDC&pt=100&sh=1&id=138#safety\|safety and drug interactions]] that anyone considering its use may want to review.	+	The Natural Medicines Comprehensive Database describes [[https://naturaldatabaseconsumer.therapeuticresearch.com/nd/Search.aspx?cs=KAISER&s=NDC&pt=100&sh=1&id=138#safety\|safety and drug interactions]] that anyone considering its use may want to review.
	==== Olive leaf extract ====		==== Olive leaf extract ====

-	Olive leaf extract (not to be confused with olive oil) is touted as an anti-viral, especially to patients suffering from CFS. Olive leaf extract may contain vitamin D according to at least one [[http://www.patentstorm.us/patents/5776461-description.html\|application for patent]]. As a result, MP patients should not consume olive leaf extract. (The use of olive //oil// is not contraindicated, however.)	+	Olive leaf extract (not to be confused with olive oil) is touted as an anti-viral, especially to patients suffering from CFS. Olive leaf extract may contain vitamin D according to at least one [[https://www.patentstorm.us/patents/5776461-description.html\|application for patent]]. As a result, MP patients should not consume olive leaf extract. (The use of olive //oil// is not contraindicated, however.)


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	==== EFA and Unsaturated oils ====		==== EFA and Unsaturated oils ====

-	<blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote> [[http://raypeat.com/articles/articles/unsaturated-oils.shtml\|article by Ray Peat]]	+	<blockquote>Unsaturated oils, especially polyunsaturates, weaken the immune system's function in ways that are similar to the damage caused by radiation, hormone imbalance, cancer, aging, or viral infections.</blockquote> [[https://raypeat.com/articles/articles/unsaturated-oils.shtml\|article by Ray Peat]]

	<blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote>		<blockquote>Essential fatty acids (EFA) are, according to the textbooks, linoleic acid and linolenic acid, and they are supposed to have the status of "vitamins," which must be taken in the diet to make life possible. However, we are able to synthesize our own unsaturated fats when we don't eat the "EFA," so they are not "essential." The term thus appears to be a misnomer. [M. E. Hanke, "Biochemistry," Encycl. Brit. Book of the Year, 1948.]</blockquote>
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	{{tag>supplements }}		{{tag>supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	broke [[http://tinyurl.com/nflgz\|2006 Food Technology article]]	+	broke [[https://tinyurl.com/nflgz\|2006 Food Technology article]]


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=71232#p71232 f32	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=71232#p71232 f32
	*		*
	*		*
Line 100:		Line 113:
	From: BIGDOG		From: BIGDOG
	Date: 2011-03-27 22:00:50		Date: 2011-03-27 22:00:50
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=14054	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=14054

	Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes		Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes
Line 143:		Line 156:
	From: BIGDOG		From: BIGDOG
	Date: 2011-03-27 22:06:44		Date: 2011-03-27 22:06:44
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=14054	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=14054

	Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.		Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.
Line 175:		Line 188:


-	http://www.jstage.jst.go.jp/article/bpb/33/12/1977/_pdf	+	https://www.jstage.jst.go.jp/article/bpb/33/12/1977/_pdf


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	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Human growth hormone (HGH) supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 5:		Line 5:


-	Human growth hormone (HGH) is a peptide hormone which stimulates growth and cell reproduction. Regular use of HGH may lead to several negative side effects such as joint swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes.(({{pubmed>long:17227934}})) It may also interfere with immune function.	+	Human growth hormone (HGH) is a peptide hormone which stimulates growth and cell reproduction. Regular use of HGH may lead to several negative side effects such as joint swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes.(({{pmid>long:17227934}})) It may also interfere with immune function.

	Not enough is known with regard to how HGH impacts on immune function, but there is some reason to believe that may have a negative impact on cellular homeostasis. For this reason, use of HGH is not recommended for Marshall Protocol patients.		Not enough is known with regard to how HGH impacts on immune function, but there is some reason to believe that may have a negative impact on cellular homeostasis. For this reason, use of HGH is not recommended for Marshall Protocol patients.
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-	{{tag>non-MP_therapies Hormone_Supplementation}}	+	{{tag>supplements}}




		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 33:		Line 34:

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/5725.html#p55037	+	* https://www.marshallprotocol.com/forum32/5725.html#p55037

	<blockquote>Any drug you introduce to your body will affect it profoundly. If HGH reportedly induces palliation, then it most probably would be doing that by suppressing the immune system. Which will affect progress on the MP.		<blockquote>Any drug you introduce to your body will affect it profoundly. If HGH reportedly induces palliation, then it most probably would be doing that by suppressing the immune system. Which will affect progress on the MP.
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	</blockquote>		</blockquote>

-	===== References =====	+	===== References =====</nodisp>

Homeopathy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.02.2010		current
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	Homeopathy is a method of treating disease based on the administration of minute doses of a drug that in massive amounts produces symptoms in healthy persons similar to those of the disease.		Homeopathy is a method of treating disease based on the administration of minute doses of a drug that in massive amounts produces symptoms in healthy persons similar to those of the disease.

-	Claims to the efficacy of homeopathic treatment beyond the placebo effect are unsupported by the collective weight of scientific and clinical evidence.(({{pubmed>long:12492603}})) (({{pubmed>long:14973954}})) (({{pubmed>long:12535487}})) (({{pubmed>long:11416076}}))	+	Claims to the efficacy of homeopathic treatment beyond the placebo effect are unsupported by the collective weight of scientific and clinical evidence.(({{pmid>long:12492603}})) (({{pmid>long:14973954}})) (({{pmid>long:12535487}})) (({{pmid>long:11416076}}))

-	Though homeopathic remedies are not likely to be harmful, there is always the chance, as with any ingested [[home:othertreatments:#over-the-counter_supplements\|supplement]] or [[home:othertreatments:#other_therapies\|therapy]], that they contain substances which interfere with nuclear receptors or vitamin D metabolism. For this reason, homeopathic remedies are contraindicated for patients on the Marshall Protocol.	+	Though homeopathic remedies are not likely to be harmful, there is always the chance, as with any ingested [[antidepressants#over-the-counter_supplements\|supplement]] or [[antidepressants#other_therapies\|therapy]], that they contain substances which interfere with nuclear receptors or vitamin D metabolism. For this reason, homeopathic remedies are contraindicated for patients on the Marshall Protocol.


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	OVERSEER	+

	* Legacy content		* Legacy content
	*		*

-	===== References =====	+	===== References =====</nodisp>

Hormone and pro-hormone therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.25.2018		current
Line 36:		Line 36:


-	When the Vitamin D Receptor (VDR) becomes blocked by 25-D, bacterial ligands, or other compounds, the Receptor can no longer transcribe an important enzyme that keeps the active D metabolite, 1,25-D, in the correct range. As 1,25-D rises without a feedback system to keep it in check, the hormone dysregulates the nuclear receptors including PPAR-gamma which control the body's hormones and affects the levels of hormones including the male, female, and thyroid hormones.(({{pubmed>long:19758159}}))	+	When the Vitamin D Receptor (VDR) becomes blocked by 25-D, bacterial ligands, or other compounds, the Receptor can no longer transcribe an important enzyme that keeps the active D metabolite, 1,25-D, in the correct range. As 1,25-D rises without a feedback system to keep it in check, the hormone dysregulates the nuclear receptors including PPAR-gamma which control the body's hormones and affects the levels of hormones including the male, female, and thyroid hormones.(({{pmid>long:19758159}}))
	===== Hormone replacement therapy upsets cellular homeostasis =====		===== Hormone replacement therapy upsets cellular homeostasis =====

	When a patient takes exogenous (supplemental) hormones including the male, female, and thyroid hormones, those hormones enter the blood stream with some leaching into the cell. It is not known how exactly hormones affect activity of the body's nuclear receptors. However, it may be the case that just as with elevated levels of 1,25-D, the presence of supplemental hormones triggers a feedback pathway which leads to reduced production of that hormone.		When a patient takes exogenous (supplemental) hormones including the male, female, and thyroid hormones, those hormones enter the blood stream with some leaching into the cell. It is not known how exactly hormones affect activity of the body's nuclear receptors. However, it may be the case that just as with elevated levels of 1,25-D, the presence of supplemental hormones triggers a feedback pathway which leads to reduced production of that hormone.

-	For example, if a patient is given testosterone, some of that testosterone enters the cell. Increased levels of testosterone may reduce the transcriptional activity of the Androgen Receptor, the nuclear receptor which produces it. One possibility is that with reduced production of testosterone, the Androgen Receptor also reduces transcription in other ways, leading to a reduction in the production of certain families of antimicrobial peptides, which many active Type I nuclear receptors also produce.(({{pubmed>long:17254313}})) Therefore, hormone replacement therapy //may// compromise innate immune function in dose-dependent fashion. Research is needed to validate this theory.	+	For example, if a patient is given testosterone, some of that testosterone enters the cell. Increased levels of testosterone may reduce the transcriptional activity of the Androgen Receptor, the nuclear receptor which produces it. One possibility is that with reduced production of testosterone, the Androgen Receptor also reduces transcription in other ways, leading to a reduction in the production of certain families of antimicrobial peptides, which many active Type I nuclear receptors also produce.(({{pmid>long:17254313}})) Therefore, hormone replacement therapy //may// compromise innate immune function in dose-dependent fashion. Research is needed to validate this theory.
		+
		+	Research into estrogen plus progestin therapy showed increased risks, 7 more CHD events, 8 more strokes, 8 more PEs, and 8 more invasive breast cancers. (16608 healthy postmenopausal women studied over 5 years) (({{pmid>long:12117397}}))


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Hypoglycemics

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	The goal of a hypoglycemic is to lower the concentration of glucose in the blood. The action of these drugs is inconsistent with the goal of the Marshall Protocol (MP), namely to destroy the pathogenic bacteria causing glucose imbalance in the first place.		The goal of a hypoglycemic is to lower the concentration of glucose in the blood. The action of these drugs is inconsistent with the goal of the Marshall Protocol (MP), namely to destroy the pathogenic bacteria causing glucose imbalance in the first place.

-	Hypoglycemics work, at least in part, by interfering with immune function. One study found that metformin artificially decreased concentrations of both interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in type 2 diabetic patients.(({{pubmed>long: 17022850}}))	+	Hypoglycemics work, at least in part, by interfering with immune function. One study found that metformin artificially decreased concentrations of both interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in type 2 diabetic patients.(({{pmid>long: 17022850}}))

-	Certain adverse effects are associated with use of hyplogycemics. For example, metformin is associated with lactic acidosis. (({{pubmed>long:17140168}}))	+	Certain adverse effects are associated with use of hyplogycemics. For example, metformin is associated with lactic acidosis. (({{pmid>long:17140168}}))
	===== Types of hypoglycemics =====		===== Types of hypoglycemics =====

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-	{{tag>non-MP_therapies}}	+	{{tag>Other_medication}}



		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 30:		Line 31:
	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Immune boosters

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

07.23.2019		current
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	An effort to determine which carbohydrates //Borrelia burgdorferi// consumes revealed that the organism utilizes the monosaccharides glucose, mannose and N-acetylglucosamine, as well as the disaccharides maltose and chitobiose.		An effort to determine which carbohydrates //Borrelia burgdorferi// consumes revealed that the organism utilizes the monosaccharides glucose, mannose and N-acetylglucosamine, as well as the disaccharides maltose and chitobiose.

-	//Robert Bradford et al.//((Bradford, RW and Allen, HW. (2006). //Townsend Letter: The Examiner of Alternative Medicine//. [[http://www.highbeam.com/doc/1G1-143164503.html\|Biochemistry of Lyme disease: Borrelia burgdorferi spirochete/cyst]].)) </blockquote>	+	//Robert Bradford et al.//((Bradford, RW and Allen, HW. (2006). //Townsend Letter: The Examiner of Alternative Medicine//. [[https://www.highbeam.com/doc/1G1-143164503.html\|Biochemistry of Lyme disease: Borrelia burgdorferi spirochete/cyst]].)) </blockquote>

	==== Whey proteins ====		==== Whey proteins ====
Line 29:		Line 29:
	Whey proteins and numerous growth factors that regulate insulin secretion, differentiation of intestine epithelium cells, and also tissue restoration, are priceless in stimulating the immune system.		Whey proteins and numerous growth factors that regulate insulin secretion, differentiation of intestine epithelium cells, and also tissue restoration, are priceless in stimulating the immune system.

-	Lactoferrin shows the most comprehensive pro-health properties: antioxidative, anticancer, immune stimulative and even chemopreventive. Also peptides and amino acids formed from casein and whey proteins possess immune stimulative activity. The most valuable proteins, i.e. lactoferrin, immune globulins, lactoperoxidase and lisozyme, together with bioactive peptides, are resistant to pepsin and trypsin activity. This is why they maintain their exceptional biological activity. (({{pubmed>long:24720113}}))	+	Lactoferrin shows the most comprehensive pro-health properties: antioxidative, anticancer, immune stimulative and even chemopreventive. Also peptides and amino acids formed from casein and whey proteins possess immune stimulative activity. The most valuable proteins, i.e. lactoferrin, immune globulins, lactoperoxidase and lisozyme, together with bioactive peptides, are resistant to pepsin and trypsin activity. This is why they maintain their exceptional biological activity. (({{pmid>long:24720113}}))


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	==== Primary immunodeficiency ====		==== Primary immunodeficiency ====

-	If immunopathology does not occur when carefully following the MP over a period of a few years, discuss with your doctor the possibility of one of these disorders. (({{pubmed>long:15096561}})) (({{pubmed>long:9044508}}))	+	If immunopathology does not occur when carefully following the MP over a period of a few years, discuss with your doctor the possibility of one of these disorders. (({{pmid>long:15096561}})) (({{pmid>long:9044508}}))

	From https://encyclopedia.thefreedictionary.com/Primary+immunodeficiency:-		From https://encyclopedia.thefreedictionary.com/Primary+immunodeficiency:-
Line 47:		Line 47:
	When no longer on MP it would still be advisable to avoid RF radiation, vitamin D supplementation, heavy metal contaminants and any other immune suppressants.		When no longer on MP it would still be advisable to avoid RF radiation, vitamin D supplementation, heavy metal contaminants and any other immune suppressants.

-	(({{pubmed>long:30462964}}))	+	(({{pmid>long:30462964}}))
-	(({{pubmed>long:11501879}}))	+	(({{pmid>long:11501879}}))
-	(({{pubmed>long:31222843}}))	+	(({{pmid>long:31222843}}))
-	(({{pubmed>long:28755025}}))	+	(({{pmid>long:28755025}}))


-	{{tag>non-MP_therapies}}	+	see also {{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	*		*

-	===== References =====	+	===== References =====</nodisp>

Immune Suppression

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.09.2020		current
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	...		...
	In 1990, Martin called Newsholme’s Oxford University office but by then Newsholme had retired. Martin spoke to his successor to find that they were still treating autoimmune diseases with PUFs. By then they were using fish oil. The Oxford doctor said the reason for the fish oil was that the degree of immunosuppression increased with the degree of unsaturation and fish oil was much more unsaturated than sunflower oil. Martin asked the doctor why they were not talking about PUFs causing cancer. The doctor replied that if he did that he would be run out of Oxford.		In 1990, Martin called Newsholme’s Oxford University office but by then Newsholme had retired. Martin spoke to his successor to find that they were still treating autoimmune diseases with PUFs. By then they were using fish oil. The Oxford doctor said the reason for the fish oil was that the degree of immunosuppression increased with the degree of unsaturation and fish oil was much more unsaturated than sunflower oil. Martin asked the doctor why they were not talking about PUFs causing cancer. The doctor replied that if he did that he would be run out of Oxford.
-	//Above paragraphs quoted from blog// [[http://www.functionalps.com/blog/2011/09/22/polyunsaturated-fats-suppress-the-immune-system/\|Team FPS]]	+	//Above paragraphs quoted from blog// [[https://www.functionalps.com/blog/2011/09/22/polyunsaturated-fats-suppress-the-immune-system/\|Team FPS]]

-	Miller JHD, et al. Double blind trial of linoleate supplementation in the diet in multiple sclerosis. BMJ 1973; i: 765-8.(({{pubmed>long:4571680}}))	+	Miller JHD, et al. Double blind trial of linoleate supplementation in the diet in multiple sclerosis. BMJ 1973; i: 765-8.(({{pmid>long:4571680}}))
	<blockquote>Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.		<blockquote>Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
	</blockquote>		</blockquote>

-	Uldall PR, et al. Unsaturated fatty acids and renal transplantation. Lancet 1974; ii: 514.(({{pubmed>long:4137027}}))	+	Uldall PR, et al. Unsaturated fatty acids and renal transplantation. Lancet 1974; ii: 514.(({{pmid>long:4137027}}))

-	Pearce M L, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971; i: 464.(({{pubmed>long:4100347}}))	+	Pearce M L, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971; i: 464.(({{pmid>long:4100347}}))
	<blockquote>In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).		<blockquote>In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).
	</blockquote>		</blockquote>


-	Newsholme EA. Mechanism for starvation suppression and refeeding activation of infection.(({{pubmed>long:66458}}))	+	Newsholme EA. Mechanism for starvation suppression and refeeding activation of infection.(({{pmid>long:66458}}))


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	are being added to this Knowledge database.		are being added to this Knowledge database.

-	Hydroxychloroquine is an immune sppressant

	{{tag>immunosuppressant non-MP_therapies Special_issues special }}		{{tag>immunosuppressant non-MP_therapies Special_issues special }}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 83:		Line 83:


		+	</nodisp>

Interferon therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

05.20.2009	current
Line 1:	Line 1:
	+	====== Interferon therapy ======
	+	<relatedarticle> [[home:patients:assessing_literature:palliative\|Palliative vs. curative treatments]] </article>
	+
	+
	+
	+
	+	Interferons (IFNs) are types of cytokines, natural cell-signaling proteins produced by the cells of the immune system, in response to challenges from pathogens and tumor cells. Interferon therapy is immunosuppressive, reducing in number both Th1 cytokines and immune cells.(({{pmid>long:15177779}}))
	+
	+	Interferons are used in a variety of diseases including cancer, hepatitis C infections, rheumatoid arthritis, osteoporosis, and Crohn's disease for these immunomodulatory effects. In the absence of a robust immune response to bacterial pathogens and the accompanying immunopathological reaction, patients feel temporarily better, however:
	+
	+	<blockquote>
	+	The immune system is activated by a delicate balance of many, many hormones, cytokines, proteins and steroids. To affect any one of these will suppress proper action of the immune system. If you give somebody exogenous interferon then their endogenous production will be cut back.
	+
	+	//Trevor Marshall, PhD// </blockquote>
	+
	+
	+	The immunosuppression brought about by interferon therapy contributes to leads to numerous side effects and poor long-term outcome. It is not uncommon for the efficacy of interferon treatment to disappear within six months following discontinuation of therapy.(({{pmid>long:10102427}}))
	+
	+	The most common side effects of interferon are: alopecia (hair loss), insomnia and sleep disturbances, psychiatric symptoms including suicidal ideation, and flu-like symptoms.
	+
	+
	+	===== Types of interferon =====
	+
	+	* interferon alpha 2a (Roferon A)
	+	* interferon alpha 2b (Intron A)
	+	* human leukocyte interferon-alpha (Multiferon)
	+	* interferon beta 1a, liquid form (Rebif)
	+	* interferon beta 1a, lyophilized (Avonex)
	+	* interferon beta 1b SubQ (Betaseron)
	+	* interferon gamma 1b (Actimmune)
	+	* pegylated interferon alpha 2a (Pegasys)
	+	* pegylated interferon alpha 2b (PegIntron)
	+
	+
	+
	+	{{tag>non-MP_therapies}}
	+
	+	<nodisp>
	+	===== Notes and comments =====
	+
	+
	+	* Legacy content
	+	* https://www.marshallprotocol.com/forum37/7957.html#p55272
	+	===== References =====</nodisp>

Iodine

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
Line 6:		Line 6:
	Some doctors have suggested that iodine is needed in greater amounts by patients with chronic disease. But, fairly modest increases in iodine intake have been reported to cause thyroid dysfunction, particularly hypothyroidism.		Some doctors have suggested that iodine is needed in greater amounts by patients with chronic disease. But, fairly modest increases in iodine intake have been reported to cause thyroid dysfunction, particularly hypothyroidism.

-	In an editorial on high-dose iodine supplementation, Alan R. Gaby, MD writes((Gaby, A.R. (2006). //Townsend Letter for Doctors & Patients.// [[http://www.townsendletter.com/AugSept2005/gabyiodine0805.htm\|Iodine: A Lot to Swallow]].)):	+	In an editorial on high-dose iodine supplementation, Alan R. Gaby, MD writes((Gaby, A.R. (2006). //Townsend Letter for Doctors & Patients.// [[https://www.townsendletter.com/AugSept2005/gabyiodine0805.htm\|Iodine: A Lot to Swallow]].)):

	<blockquote>The possibility that high-dose iodine/iodide can relieve certain common conditions is intriguing. Considering the positive anecdotal reports, an empirical trial of iodine/iodide therapy, based on the clinical picture, seems reasonable. The case has not been made, however, that the average person should markedly increase his or her iodine intake in an attempt to saturate the tissues with iodine. Nor has the case been made that the iodine-load test can provide reliable guidance regarding the need for iodine therapy. Thyroid function should be monitored in patients receiving more than 1 mg of iodine per day.</blockquote>		<blockquote>The possibility that high-dose iodine/iodide can relieve certain common conditions is intriguing. Considering the positive anecdotal reports, an empirical trial of iodine/iodide therapy, based on the clinical picture, seems reasonable. The case has not been made, however, that the average person should markedly increase his or her iodine intake in an attempt to saturate the tissues with iodine. Nor has the case been made that the iodine-load test can provide reliable guidance regarding the need for iodine therapy. Thyroid function should be monitored in patients receiving more than 1 mg of iodine per day.</blockquote>
Line 16:		Line 16:
	{{tag>supplements }}		{{tag>supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+
		+	broke [[https://www.med.umich.edu/1libr/aha/umioddef.htm\|widespread distribution]]

	List of references for iodine research that may contradict the quoted article:		List of references for iodine research that may contradict the quoted article:
-	http://www.womentowomen.com/hypothyroidism/iodinedeficiency-thyroidhealth-references.aspx	+	https://www.womentowomen.com/hypothyroidism/iodinedeficiency-thyroidhealth-references.aspx

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=94046#p94046	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=94046#p94046
	*		*
	*		*
	===== References =====		===== References =====
		+	</nodisp>

Male hormone supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	====DHEA ====		====DHEA ====

-	Dehydroepiandrosterone (DHEA) is a hormonal steroid, the production of which is controlled by the Vitamin D Receptor.(({{pubmed>long:11972301}})) DHEA is available as an over-the-counter supplement in some locations. Taking DHEA supplements directly affects the operation of the nuclear receptors and will delay or prevent recovery from Th1 disease.	+	Dehydroepiandrosterone (DHEA) is a hormonal steroid, the production of which is controlled by the Vitamin D Receptor.(({{pmid>long:11972301}})) DHEA is available as an over-the-counter supplement in some locations. Taking DHEA supplements directly affects the operation of the nuclear receptors and will delay or prevent recovery from Th1 disease.


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-		+	{{tag> supplements}}
-		+
-		+
-	{{tag>non-MP_therapies Hormone_Supplementation}}	+


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/12512.html	+	* https://www.marshallprotocol.com/forum32/12512.html
	* Deleted some content from above link. Saving it for libido article.		* Deleted some content from above link. Saving it for libido article.

-	===== References =====	+	===== References =====</nodisp>

Massage and other manipulation therapies

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.02.2010		current
Line 19:		Line 19:

	* Acupressure – A traditional Chinese medicine technique derived from acupuncture. In acupressure physical pressure is applied to acupuncture points by the hand, elbow, or with various devices.		* Acupressure – A traditional Chinese medicine technique derived from acupuncture. In acupressure physical pressure is applied to acupuncture points by the hand, elbow, or with various devices.
-	* Chiropractic – A health care profession that focuses on diagnosis, treatment and prevention of mechanical disorders of the musculoskeletal system, with special emphasis on the spine, under the hypothesis that these disorders affect general health via the nervous system. Collectively, systematic reviews of chiropractic have not demonstrated that spinal manipulation is effective, with the possible exception of treatment of back pain.(({{pubmed>long:18280103}}))	+	* Chiropractic – A health care profession that focuses on diagnosis, treatment and prevention of mechanical disorders of the musculoskeletal system, with special emphasis on the spine, under the hypothesis that these disorders affect general health via the nervous system. Collectively, systematic reviews of chiropractic have not demonstrated that spinal manipulation is effective, with the possible exception of treatment of back pain.(({{pmid>long:18280103}}))
-	* Craniosacral therapy – Gentle manipulation technique somewhat similar to light massage that is directed towards freeing the flow of cerebrospinal fluid. Some believe impeded flow of this fluid can cause face pain. Evidence for the efficacy of craniosacral therapy is limited.(({{pubmed>long:10709302}}))	+	* Craniosacral therapy – Gentle manipulation technique somewhat similar to light massage that is directed towards freeing the flow of cerebrospinal fluid. Some believe impeded flow of this fluid can cause face pain. Evidence for the efficacy of craniosacral therapy is limited.(({{pmid>long:10709302}}))
	* Manual lymphatic drainage – A massage technique which uses gentle, rhythmic pressure to stimulate lymphatic flow.		* Manual lymphatic drainage – A massage technique which uses gentle, rhythmic pressure to stimulate lymphatic flow.
	* Massage – Massage, particular Swedish or deep-tissue massage, may increase circulation and, thus, increase immunopathology. A number of patients have reported feeling //much// worse after a massage. Use with caution.		* Massage – Massage, particular Swedish or deep-tissue massage, may increase circulation and, thus, increase immunopathology. A number of patients have reported feeling //much// worse after a massage. Use with caution.
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	{{tag>non-MP_therapies }}		{{tag>non-MP_therapies }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT	+

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum37/3947.html	+	* https://www.marshallprotocol.com/forum37/3947.html
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=142804#p142804	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=142804#p142804
-	* http://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=81622#p81622	+	* https://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=81622#p81622


		+	===== References =====</nodisp>

-	===== References =====

Mouthwash

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.27.2017		current
Line 14:		Line 14:
	* Crest Pro-Health and Pro-Health Night (some have concerns about it staining teeth)		* Crest Pro-Health and Pro-Health Night (some have concerns about it staining teeth)

-	Take a look at the ingredients of the store or generic brands where you shop. There may be a low cost product that still has CPC as an ingredient..	+	Take a look at the ingredients of the store or generic brands where you shop. There may be a low cost product that still has CPC as an ingredient.

	===== Mouthwashes which are not recommended =====		===== Mouthwashes which are not recommended =====
Line 36:		Line 36:


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=47127#p47127 s166	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=47127#p47127 s166

	These are good:		These are good:
	<blockquote>A real ultrasonic toothbrush - not one with vibrating bristles but one which also 'vibrates' ultrasonically - will help dislodge the plaque really quickly. Not sure if there are any in Australia, but we can get them in the USA from:		<blockquote>A real ultrasonic toothbrush - not one with vibrating bristles but one which also 'vibrates' ultrasonically - will help dislodge the plaque really quickly. Not sure if there are any in Australia, but we can get them in the USA from:

-	http://www.aawsales.com/search.asp?keyword=ultrasonex&search.x=14&search.y=15	+	https://www.aawsales.com/search.asp?keyword=ultrasonex&search.x=14&search.y=15

-	more info here: http://www.ultrasonex.com.hk/su100.htm	+	more info here: https://www.ultrasonex.com.hk/su100.htm

-	and here: http://www.ultrasonex.com.hk/info.htm	+	and here: https://www.ultrasonex.com.hk/info.htm

	..Trevor..		..Trevor..
	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Nebulizers

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
Line 13:		Line 13:
	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+
		+	del - Read more-
		+	for broken * [[https://www.getasthmahelp.org/nebulizers.asp\|All About Nebulizers]] – using and cleaning a nebulizer

	* Legacy content		* Legacy content
	*		*
-	===== References =====	+	===== References =====</nodisp>

Supplemental oxygen

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	===== Rationale for use =====		===== Rationale for use =====

-	Using supplemental oxygen is not a step backward nor an admission of failure. It is a palliative treatment to prevent the heart muscle from overworking. Supplemental oxygen can relieve the distressing symptom of dyspnea (shortness of breath).(({{pubmed>long:9740573}})) Dyspnea is not lethal but patients who are able to control it are more comfortable and perhaps able to tolerate additional immunopathology while lung inflammation is resolving.	+	Using supplemental oxygen is not a step backward nor an admission of failure. It is a palliative treatment to prevent the heart muscle from overworking. Supplemental oxygen can relieve the distressing symptom of dyspnea (shortness of breath).(({{pmid>long:9740573}})) Dyspnea is not lethal but patients who are able to control it are more comfortable and perhaps able to tolerate additional immunopathology while lung inflammation is resolving.

	Oxygen therapy may help a patient feel better, sleep better, be more alert, and be in a better mood. Patients may be able to carry out your daily activities without feeling as tired or as short of breath and may have less intercostal pain.		Oxygen therapy may help a patient feel better, sleep better, be more alert, and be in a better mood. Patients may be able to carry out your daily activities without feeling as tired or as short of breath and may have less intercostal pain.

-	According to an [[http://www.emedicine.com/EMERG/topic516.htm\|\|e-medicine article on sarcoidosis]], supplemental oxygen should be provided to all patients prior to hospital care. So, ask your doctor for a trial of home oxygen to attempt to avoid a deterioration that might possible lead to a hospital stay, if possible.	+	According to an [[https://www.emedicine.com/EMERG/topic516.htm\|\|e-medicine article on sarcoidosis]], supplemental oxygen should be provided to all patients prior to hospital care. So, ask your doctor for a trial of home oxygen to attempt to avoid a deterioration that might possible lead to a hospital stay, if possible.

	<blockquote>		<blockquote>
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-	{{tag>non-MP_therapies}}	+	{{tag>non-MP_therapies oxygen}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	* need to discuss "oxygen concentrator" as per Trevor's suggestion here: http://curemyth1.org/view_topic.php?id=1548&forum_id=2&jump_to=11170#p11170	+	* need to discuss "oxygen concentrator" as per Trevor's suggestion here: https://curemyth1.org/view_topic.php?id=1548&forum_id=2&jump_to=11170#p11170
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/7899.html f139-44	+	* https://www.marshallprotocol.com/forum32/7899.html f139-44
		+
		+	===== References =====</nodisp>

-	===== References =====

Pain medications and muscle relaxants

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Pet therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	====== Pet therapy ======		====== Pet therapy ======

-	Patients suffering from even mild forms of stress, anxiety, or depression may want to consider getting or interacting with a pet. Interaction with pets has a well-defined positive favorable effect on psychopathological status and perception of quality of life.(({{pubmed>long:16191447}}))	+	Patients suffering from even mild forms of stress, anxiety, or depression may want to consider getting or interacting with a pet. Interaction with pets has a well-defined positive favorable effect on psychopathological status and perception of quality of life.(({{pmid>long:16191447}}))

	===== Patient experiences =====		===== Patient experiences =====
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	//Lee, MarshallProtocol.com// </blockquote>		//Lee, MarshallProtocol.com// </blockquote>
		+
		+	===== Read more =====
		+
		+	Dognitive therapy by Laura Vissaritis
		+	<blockquote>To change your dog's behaviour, you must first change your own</blockquote>
		+
		+
		+
		+


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=46210#p46210 s98	+	* https://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=46210#p46210 s98

		+	===== References =====</nodisp>

-	===== References =====

pH balancing

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.02.2010		current
Line 24:		Line 24:


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT	+
	* Legacy content		* Legacy content
	*		*
Line 33:		Line 34:

	===== References =====		===== References =====
		+	</nodisp>

Potassium supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

06.02.2013		current
Line 1:		Line 1:
-	{{tag>non-MP_therapies}}	+


Line 8:		Line 8:
	====== Potassium supplementation ======		====== Potassium supplementation ======

		+	{{tag>supplements}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 17:		Line 18:
	– Study after study shows that the most successful patient is a well-educated one. She need not do what she is told, but she does have a responsibility to think critically about what we say and about what her doctor says.		– Study after study shows that the most successful patient is a well-educated one. She need not do what she is told, but she does have a responsibility to think critically about what we say and about what her doctor says.
	– The general principle articulated throughout the KB is to avoid supplements unless they are absolutely necessary for controlling IP. This is an interesting case because the doctor is advising the patient to take potassium.		– The general principle articulated throughout the KB is to avoid supplements unless they are absolutely necessary for controlling IP. This is an interesting case because the doctor is advising the patient to take potassium.
-	– There is no DRI for potassium because it is so darn common in the food supply: http://www.mayoclinic.com/health/drug-information/DR602373	+	– There is no DRI for potassium because it is so darn common in the food supply: https://www.mayoclinic.com/health/drug-information/DR602373
	– Nor are there many (any?) examples of hypokalemia of patients on the MP.		– Nor are there many (any?) examples of hypokalemia of patients on the MP.
	– If a doctor prescribes potassium, that doctor should make provision to carefully monitor levels of potassium.		– If a doctor prescribes potassium, that doctor should make provision to carefully monitor levels of potassium.
-	– In cases where potassium is elevated, patient and doctor should work to reduce levels of potassium intake.	+	– In cases where potassium is elevated, patient and doctor should work to reduce levels of potassium intake.</nodisp>

Probiotics and commensal bacteria

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.22.2019		current
Line 17:		Line 17:
	The goal of the Marshall Protocol is to eradicate the pathogens which cause inflammatory diseases. The bacterial die-off reaction is known as immunopathology, and it is a necessary part of recovery. Epidemiological evidence has shown that substances which interfere with immunopathology decrease symptoms in the near term and increase disease over the long term. Drugs or substances which interfere with immunopathology – whether they be prescription medications such as TNF-alpha inhibitors, corticosteroids, interferon, or a vitamin D supplement – are limiting progress.		The goal of the Marshall Protocol is to eradicate the pathogens which cause inflammatory diseases. The bacterial die-off reaction is known as immunopathology, and it is a necessary part of recovery. Epidemiological evidence has shown that substances which interfere with immunopathology decrease symptoms in the near term and increase disease over the long term. Drugs or substances which interfere with immunopathology – whether they be prescription medications such as TNF-alpha inhibitors, corticosteroids, interferon, or a vitamin D supplement – are limiting progress.

-	When bacteria enter the body – whether described as “friendly” or pathogenic – the innate immune system mounts a response to that presence. Even commensal bacteria can activate innate immune responses.(({{pubmed>long:19161412}})) (({{pubmed>long:12960260}})) One research team found that treatment with probiotics doubles levels of the inflammatory cytokine Interferon-gamma,(({{pubmed>long:18272539}})) confirming that the bacteria do generate a Th1 inflammatory reaction upon their entry into the gut.	+	When bacteria enter the body – whether described as “friendly” or pathogenic – the innate immune system mounts a response to that presence. Even commensal bacteria can activate innate immune responses.(({{pmid>long:19161412}})) (({{pmid>long:12960260}})) One research team found that treatment with probiotics doubles levels of the inflammatory cytokine Interferon-gamma,(({{pmid>long:18272539}})) confirming that the bacteria do generate a Th1 inflammatory reaction upon their entry into the gut.

	It is possible that probiotics' seeming effectiveness is that patients taking them are overloading their immune response and reducing the amount of bacteria killed, a process which itself leads to diminished immunopathology and relative symptom improvement.		It is possible that probiotics' seeming effectiveness is that patients taking them are overloading their immune response and reducing the amount of bacteria killed, a process which itself leads to diminished immunopathology and relative symptom improvement.
Line 28:		Line 28:
	===== Commensal microbes have been shown to be harmful in some patients =====		===== Commensal microbes have been shown to be harmful in some patients =====

-	Supporting the above hypothesis is one study which showed that patients with acute pancreatitis (inflammation of the pancreas) that were given probiotics were more than twice as likely to die as compared to those who received placebos.(({{pubmed>long:18438065}}))	+	Supporting the above hypothesis is one study which showed that patients with acute pancreatitis (inflammation of the pancreas) that were given probiotics were more than twice as likely to die as compared to those who received placebos.(({{pmid>long:18438065}}))

	One compelling explanation for this unexpected result is that the patients who were given probiotics effectively diverted their immune system from fighting infection at the site of the pancreatitis to the bowel. Perhaps the additional bacteria load was enough to increase the burden on the immune response to the point where a significant number of additional patients was no longer able to effectively muster a response to the acute pancreatitis, a condition which itself is caused by the Th1 pathogens.		One compelling explanation for this unexpected result is that the patients who were given probiotics effectively diverted their immune system from fighting infection at the site of the pancreatitis to the bowel. Perhaps the additional bacteria load was enough to increase the burden on the immune response to the point where a significant number of additional patients was no longer able to effectively muster a response to the acute pancreatitis, a condition which itself is caused by the Th1 pathogens.

-	* sepsis in infants – According to a pair of studies, //Lactobacillus//, the probiotic found in yogurt – while rare – has been shown to cause sepsis in infants and children.(({{pubmed>long:11533845}})) (({{pubmed>long:15629999}}))	+	* sepsis in infants – According to a pair of studies, //Lactobacillus//, the probiotic found in yogurt – while rare – has been shown to cause sepsis in infants and children.(({{pmid>long:11533845}})) (({{pmid>long:15629999}}))
-	* asthma and hay fever in children born to pregnant women – Pregnant women who [[http://www.bbc.co.uk/news/health-14948261\|ate low-fat yogurt]] with fruit once a day were found to be 1.6 times more likely to have children who developed asthma by age seven, compared with children of women who did not eat low-fat yogurt. The study also found that the children of these women were more likely to have allergic rhinitis (hay fever) and current asthma symptoms. But the results showed that milk intake during pregnancy was not linked to any increased risk of asthma.	+	* asthma and hay fever in children born to pregnant women – Pregnant women who [[https://www.bbc.co.uk/news/health-14948261\|ate low-fat yogurt]] with fruit once a day were found to be 1.6 times more likely to have children who developed asthma by age seven, compared with children of women who did not eat low-fat yogurt. The study also found that the children of these women were more likely to have allergic rhinitis (hay fever) and current asthma symptoms. But the results showed that milk intake during pregnancy was not linked to any increased risk of asthma.


Line 40:		Line 40:


-	Developing gum disease may require not only bad bacteria but also a benign background microbiota, researchers reported in //Cell Host and Microbe//.(({{pubmed>long:22036469}})) When the gingivitis-associated //Porphyromonas gingivalis// was introduced at low levels into the mouths of normal mice, it triggered a substantial growth in the healthy bacteria already there, and the ensuing periodontal disease led to bone loss.	+	Developing gum disease may require not only bad bacteria but also a benign background microbiota, researchers reported in //Cell Host and Microbe//.(({{pmid>long:22036469}})) When the gingivitis-associated //Porphyromonas gingivalis// was introduced at low levels into the mouths of normal mice, it triggered a substantial growth in the healthy bacteria already there, and the ensuing periodontal disease led to bone loss.

	But no such thing happened when the gingivitis bacteria were introduced to mice with sterile mouths that harbored no normal bacteria. It seems that a single species, even at low levels, can disrupt the stability of the bacterial ecosystem in the mouth, the researchers noted.		But no such thing happened when the gingivitis bacteria were introduced to mice with sterile mouths that harbored no normal bacteria. It seems that a single species, even at low levels, can disrupt the stability of the bacterial ecosystem in the mouth, the researchers noted.
Line 46:		Line 46:
	===== Effects of probiotics may be subtle =====		===== Effects of probiotics may be subtle =====

-	One 2011 study which administered fermented milk to mice concluded that the effects of probiotics on gut bacteria may be subtle.(({{pubmed>long:22030749}})) "Cocktails of classic probiotics, which people have been trying for years, may have some benefit but the effect seems to be quite small," [[http://www.nature.com/news/microbiome-sequencing-offers-hope-for-diagnostics-1.10299\|according to David Relman]].	+	One 2011 study which administered fermented milk to mice concluded that the effects of probiotics on gut bacteria may be subtle.(({{pmid>long:22030749}})) "Cocktails of classic probiotics, which people have been trying for years, may have some benefit but the effect seems to be quite small," [[https://www.nature.com/news/microbiome-sequencing-offers-hope-for-diagnostics-1.10299\|according to David Relman]].

		+	==== Kefir ====
		+
		+	Lactic acid bacteria and yeasts in kefir grains and kefir made from them. (({{pmid>long:11938463}}))
		+
		+	In an investigation of the changes in the microflora along the pathway:
		+
		+	* kefir grains (A)
		+	* kefir made from kefir grains (B)
		+	* kefir made from kefir as inoculum (C)
		+
		+	the following species of lactic acid bacteria (83-90%) of the microbial count in the grains) were identified: Lactococcus lactis subsp. lactis, Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus helveticus, Lactobacillus casei subsp. pseudoplantarum and Lactobacillus brevis. Yeasts (10-17%) identified were Kluyveromyces marxianus var. lactis, Saccharomyces cerevisiae, Candida inconspicua and Candida maris.
		+
		+	In the microbial population of kefir grains and kefir made from them the homofermentative lactic streptococci (52-65% and 79-86%, respectively) predominated. Within the group of lactobacilli, the homofermentative thermophilic species L. delbrueckii subsp. bulgaricus and L. helveticus (70-87% of the isolated bacilli) predominated.
		+
		+	Along the pathway A-->B-->C, the streptococcal proportion in the total kefir microflora increased by 26-30% whereas the lactobacilli decreased by 13-23%. K. marxianus var. lactis was permanently present in kefir grains and kefirs, whereas the dominant lactose-negative yeast in the total yeast flora of the kefir grains dramatically decreased in kefir C.
	===== Read more =====		===== Read more =====

-	* [[http://the-scientist.com/2011/10/26/how-probiotic-yogurt-works/\|How Probiotic Yogurt Works]] – Researchers show that the bacterial species in probiotic, fermented dairy products may alter gene expression and metabolism in native gut microbiota.	+	* [[https://the-scientist.com/2011/10/26/how-probiotic-yogurt-works/\|How Probiotic Yogurt Works]] – Researchers show that the bacterial species in probiotic, fermented dairy products may alter gene expression and metabolism in native gut microbiota.


Line 56:		Line 71:
	{{tag>supplements }}		{{tag>supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1196&forum_id=32&jump_to=39930 f301-4	+	* https://www.marshallprotocol.com/view_topic.php?id=1196&forum_id=32&jump_to=39930 f301-4
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118168#p118168 f43	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118168#p118168 f43
-	* http://www.marshallprotocol.com/view_topic.php?id=9764&forum_id=37&jump_to=112546#p112546 s266	+	* https://www.marshallprotocol.com/view_topic.php?id=9764&forum_id=37&jump_to=112546#p112546 s266
	*		*

	<blockquote>Blaney: "Prebiotics article may explain negative effects of probiotics that contain FOS etc."		<blockquote>Blaney: "Prebiotics article may explain negative effects of probiotics that contain FOS etc."
-	http://www.biomedcentral.com/1471-2180/9/245	+	https://www.biomedcentral.com/1471-2180/9/245

	BMC Microbiol. 2009 Nov 30;9:245.		BMC Microbiol. 2009 Nov 30;9:245.
Line 91:		Line 107:
	<blockquote>Is Yogurt Good for You?		<blockquote>Is Yogurt Good for You?

-	http://www.slate.com/id/2299545	+	https://www.slate.com/id/2299545


-	http://www.boingboing.net/2011/07/20/probiotics-and-scien.html	+	https://www.boingboing.net/2011/07/20/probiotics-and-scien.html

	Probiotics and "Science by Product Release"		Probiotics and "Science by Product Release"
Line 107:		Line 123:
	In an astonishing new study published in Nature today, researchers at the Max Planck Institute of Neurobiology in Martinsried in Munich, Germany say they have found evidence that suggests multiple sclerosis (MS) is triggered by natural intestinal flora, the so-called friendly bacteria that reside in the gut. They found genetically engineered mice with normal gut bacteria developed brain inflammation similar to MS in humans. They say the bacteria first activated the immune T-cells, then the B-cells, which resulted in an attack on the myelin layer in the brain. The same could happen in humans with a corresponding genetic predisposition, they say.		In an astonishing new study published in Nature today, researchers at the Max Planck Institute of Neurobiology in Martinsried in Munich, Germany say they have found evidence that suggests multiple sclerosis (MS) is triggered by natural intestinal flora, the so-called friendly bacteria that reside in the gut. They found genetically engineered mice with normal gut bacteria developed brain inflammation similar to MS in humans. They say the bacteria first activated the immune T-cells, then the B-cells, which resulted in an attack on the myelin layer in the brain. The same could happen in humans with a corresponding genetic predisposition, they say.

-	http://www.medicalnewstoday.com/articles/236776.php	+	https://www.medicalnewstoday.com/articles/236776.php


Line 122:		Line 138:
	<blockquote>The first description of the possible involvement of bacterial flora in the pathology of arthritis came in the late 1970s when rats raised under germ-free conditions developed severe joint inflammation with 100% penetrance in an adjuvant-induced arthritis model, while conventionally raised controls showed only mild disease at a very low incidence.67 This finding suggests that, although a microbiota is not necessary for the development of arthritis, its presence has a potential suppressive effect through modulation of the immune response. The mechanism behind this suppressive effect remains unclear. The humoral immune system is not a prerequisite for arthritis, as germ-free rats do not produce specific autoantibodies to heat-shock protein (hsp) 65 and yet do develop clinical disease. This observation seems to indicate that immunity to hsp65 in experimental arthritis is unrelated to disease and may instead be regarded as an epiphenomenon dependent on the presence of gut flora.68		<blockquote>The first description of the possible involvement of bacterial flora in the pathology of arthritis came in the late 1970s when rats raised under germ-free conditions developed severe joint inflammation with 100% penetrance in an adjuvant-induced arthritis model, while conventionally raised controls showed only mild disease at a very low incidence.67 This finding suggests that, although a microbiota is not necessary for the development of arthritis, its presence has a potential suppressive effect through modulation of the immune response. The mechanism behind this suppressive effect remains unclear. The humoral immune system is not a prerequisite for arthritis, as germ-free rats do not produce specific autoantibodies to heat-shock protein (hsp) 65 and yet do develop clinical disease. This observation seems to indicate that immunity to hsp65 in experimental arthritis is unrelated to disease and may instead be regarded as an epiphenomenon dependent on the presence of gut flora.68

-	"The microbiome and rheumatoid arthritis", (({{pubmed>long:21862983}}))	+	"The microbiome and rheumatoid arthritis", (({{pmid>long:21862983}}))

	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Prolotherapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 6:		Line 6:

	* it increases inflammation		* it increases inflammation
-	* if dextrose is used, this substance will encourage the growth of CWD	+	* if dextrose is used, this substance will encourage the growth of CWD (cell wall deficient bacteria)
	* any injection involves the potential to introduce more CWD into the body		* any injection involves the potential to introduce more CWD into the body


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=130759#p130759 f47	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=130759#p130759 f47
	*		*
	*		*
Line 20:		Line 21:
	===== References =====		===== References =====

		+	</nodisp>

Propolis

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 3:		Line 3:


-	Propolis is currently marketed as a helpful antimicrobial agent. It's mode of action is likely to be contraindicated for persons on the MP.	+	Propolis is currently marketed as a helpful antimicrobial agent. Its mode of action is likely to be contraindicated for persons on the MP.

	Rather than using this in chewing gum for it's antimicrobial action, using a [[home:othertreatments:mouthwash\|mouthwash]] is generally considered to be a better alternative.		Rather than using this in chewing gum for it's antimicrobial action, using a [[home:othertreatments:mouthwash\|mouthwash]] is generally considered to be a better alternative.
Line 15:		Line 15:
	===== Read more =====		===== Read more =====

-	* [[http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-propolis.html\|MedlinePlus Supplements: Propolis ]]	+	* [[https://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-propolis.html\|MedlinePlus Supplements: Propolis ]]

	{{tag>supplements }}		{{tag>supplements }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 25:		Line 26:
	*		*

-	===== References =====	+	===== References =====</nodisp>

Quercetin

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

07.18.2019		current
Line 12:		Line 12:


-	Quercetin is a kinase inhibitor and it binds to many, if not all, of the kinases. The most important action of quercetin is the ability to inhibit I-kappaB kinase, the dimer protein which migrates to the phagocyte nucleus. When the I-kappaB kinase is inhibited, production of Nuclear Factor-kappa B (NF-kB) is downregulated.(({{pubmed>long:17184768}})) I-kappa B and NF-kB are at the heart of the Th1 inflammatory reaction.	+	Quercetin is a kinase inhibitor and it binds to many, if not all, of the kinases. The most important action of quercetin is the ability to inhibit I-kappaB kinase, the dimer protein which migrates to the phagocyte nucleus. When the I-kappaB kinase is inhibited, production of Nuclear Factor-kappa B (NF-kB) is downregulated.(({{pmid>long:17184768}})) I-kappa B and NF-kB are at the heart of the Th1 inflammatory reaction.

	Note that olmesartan also acts on NF-kB, but by a different pathway. Quercetin is therefore synergistic with the NF-kappaB-calming actions of olmesartan. It is this synergistic action combined with the anti-inflammatory effects of olmesartan which can reduce some immunopathology, especially fatigue, muscle pain and mind-fog.		Note that olmesartan also acts on NF-kB, but by a different pathway. Quercetin is therefore synergistic with the NF-kappaB-calming actions of olmesartan. It is this synergistic action combined with the anti-inflammatory effects of olmesartan which can reduce some immunopathology, especially fatigue, muscle pain and mind-fog.
		+
		+	Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane. (({{pmid>long:25050823}}))
		+

	===== Using quercetin in conjunction with the Marshall Protocol =====		===== Using quercetin in conjunction with the Marshall Protocol =====
Line 30:		Line 33:
	[{{:home:othertreatments:merchandizer-68003.jpg\|Quercetin can offer some reduction in symptom severity to patients on the Marshall Protocol.}}]		[{{:home:othertreatments:merchandizer-68003.jpg\|Quercetin can offer some reduction in symptom severity to patients on the Marshall Protocol.}}]

-	Quercetin, not caffeine, is a major neuroprotective component in coffee. (({{pubmed>long:27479153}}))	+	Quercetin, not caffeine, is a major neuroprotective component in coffee. (({{pmid>long:27479153}}))


Line 40:		Line 43:
	These medications include:		These medications include:

-	* fluoroquinolone antibiotics – Based on laboratory study, quercetin may bind to the DNA gyrase site on bacteria and competitively inhibit quinolone antibiotics.(({{pubmed>long:8718602}}))	+	* fluoroquinolone antibiotics – Based on laboratory study, quercetin may bind to the DNA gyrase site on bacteria and competitively inhibit quinolone antibiotics.(({{pmid>long:8718602}}))
	* warfarin (Coumadin) – Patients need to seek professional advice if they are using warfarin //prior// to taking quercetin.		* warfarin (Coumadin) – Patients need to seek professional advice if they are using warfarin //prior// to taking quercetin.

Line 72:		Line 75:
	//Trevor Marshall, PhD// </blockquote>		//Trevor Marshall, PhD// </blockquote>

-	Quercetin, not caffeine, is a major neuroprotective component in coffee. (({{pubmed>long:27479153}}))	+	Quercetin, not caffeine, is a major neuroprotective component in coffee. (({{pmid>long:27479153}}))


Line 81:		Line 84:


-	The Loranthus genus has been demonstrated to be used in the treatment of wide range of diseases e.g. diabetes, inflammations and cancers. (({{pubmed>long:31297028}}))	+	The Loranthus genus has been demonstrated to be used in the treatment of wide range of diseases e.g. diabetes, inflammations and cancers. (({{pmid>long:31297028}}))
	===== Buying quercetin =====		===== Buying quercetin =====

Line 96:		Line 99:
	Ask regarding the method of shipping. Patients have had trouble with shipments sent by courier which incurred an unavoidable very high extra charge.		Ask regarding the method of shipping. Patients have had trouble with shipments sent by courier which incurred an unavoidable very high extra charge.

-	* [[http://www.purecaps.net/at/\|Pure Encapsulations]] – European distributor for pure encapsulations	+	* [[https://www.purecaps.net/at/\|Pure Encapsulations]] – European distributor for pure encapsulations
-	* [[http://www.freedavitamins.com/\|Freeda Vitamins]] - U.S. based, ships abroad	+	* [[https://www.freedavitamins.com/\|Freeda Vitamins]] - U.S. based, ships abroad



	{{tag>supplements }}		{{tag>supplements }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=127970#p127970	+	* https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=127970#p127970
	*		*

Line 116:		Line 120:
	At 11:58 AM 9/8/2010, you wrote:		At 11:58 AM 9/8/2010, you wrote:
	Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims		Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims
-	http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf101580j	+	https://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf101580j


Line 132:		Line 136:
	PMID: 21228504 [PubMed - in process]		PMID: 21228504 [PubMed - in process]
	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Rapamycin (sirolimus)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 4:		Line 4:
	<relatedarticle> [[home:patients:assessing_literature:palliative\|Palliative vs. curative treatments]] </article>		<relatedarticle> [[home:patients:assessing_literature:palliative\|Palliative vs. curative treatments]] </article>

-	Sirolimus, also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation and has recently been prescribed for patients with certain chronic inflammatory diseases such as Alzheimers disease.(({{pubmed>long:20862226}}))	+	Sirolimus, also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation and has recently been prescribed for patients with certain chronic inflammatory diseases such as Alzheimers disease.(({{pmid>long:20862226}}))


Line 12:		Line 12:


-	//Trevor Marshall, PhD [[http://www.marshallprotocol.com/view_topic.php?id=13795&forum_id=39&jump_to=207432#p207432\|MarshallProtocol.com]]//</blockquote>	+	//Trevor Marshall, PhD [[https://www.marshallprotocol.com/view_topic.php?id=13795&forum_id=39&jump_to=207432#p207432\|MarshallProtocol.com]]//</blockquote>

	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}


-	===== References =====	+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
		+
		+	===== References =====
		+	</nodisp>

Rife

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

09.01.2011		current
Line 6:		Line 6:
	The smaller 'Rife Frequency Generator' (these days sometimes also known simply as "Rife") is a machine that allegedly generates radio waves with precisely the same frequency as the "vibratory rates" of infectious bacteria, allegedly causing the offending bacteria to shatter in the same manner as a crystal glass breaks in response to sound waves at a certain frequency.		The smaller 'Rife Frequency Generator' (these days sometimes also known simply as "Rife") is a machine that allegedly generates radio waves with precisely the same frequency as the "vibratory rates" of infectious bacteria, allegedly causing the offending bacteria to shatter in the same manner as a crystal glass breaks in response to sound waves at a certain frequency.

-	There is no scientific evidence that the use of a 'Rife Frequency Generator' has the intended effect on infectious bacteria. Further, if bacteria were being 'shattered', significant Immunopathology would be expected, yet little, or none, is observed. Prof Marshall suggests it is better to consider the use of [[.:tens\|TENS]] machines to palliate symptoms.	+	There is no scientific evidence that the use of a 'Rife Frequency Generator' has the intended effect on infectious bacteria. Further, if bacteria were being 'shattered', potentially life-threatening Immunopathology would be expected, yet little, or none, is observed. Prof Marshall suggests it is better to consider the use of [[.:tens\|TENS]] machines to palliate symptoms.

	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	OVERSEER	+
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118546#p118546 f44	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=118546#p118546 f44

	=====References=====		=====References=====
		+	</nodisp>

Salvestrols

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.25.2017		current
Line 2:		Line 2:

	Salvestrols are a new class of natural anticancer chemicals, which are found in plants and safely eaten in the diet*. Initially non-toxic to the body’s normal cells, Salvestrols become activated inside human cancer cells by an enzyme, CYP1B1 (pronounced “sip one bee one”). The activated Salvestrols then cause the cancer cells to stop growing or die, without harming normal cells. This specificity of action is possible because CYP1B1 is an intrinsic component of cancer cells and occurs in all of the wide range of different types of cancer that have been studied to date, but is absent from normal cells.		Salvestrols are a new class of natural anticancer chemicals, which are found in plants and safely eaten in the diet*. Initially non-toxic to the body’s normal cells, Salvestrols become activated inside human cancer cells by an enzyme, CYP1B1 (pronounced “sip one bee one”). The activated Salvestrols then cause the cancer cells to stop growing or die, without harming normal cells. This specificity of action is possible because CYP1B1 is an intrinsic component of cancer cells and occurs in all of the wide range of different types of cancer that have been studied to date, but is absent from normal cells.
		+
		+	==== sources ====

	* blackcurrant, blueberry, strawberry, and tangerine peel have been used as the basis of commercial products.		* blackcurrant, blueberry, strawberry, and tangerine peel have been used as the basis of commercial products.

		+	==== extracts and pharmaceuticals ====
	<blockquote>“ A 2007 BBC News story reported on a laboratory study that had found salvestrols extracted from tangerine peel show anti-cancer effects… on cells ..in the laboratory”		<blockquote>“ A 2007 BBC News story reported on a laboratory study that had found salvestrols extracted from tangerine peel show anti-cancer effects… on cells ..in the laboratory”

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	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
	GETCONTENT		GETCONTENT
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-	===== References =====	+	===== References =====</nodisp>

sample page layout

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

11.21.2018		current
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	=== Place to practise page construction ===		=== Place to practise page construction ===

-	[[http://mpkb.org/playground/checkout\|checkout folder in playground]]	+	[[https://mpkb.org/playground/checkout\|checkout folder in playground]]


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	=== WIP ===		=== WIP ===

-	//authors et al.//(({{pubmed>long:88888888}}))	+	//authors et al.//(({{pmid>long:88888888}}))


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	insert		insert

-	//authors et al.// (({{pubmed**>long:99999999}}))	+	//authors et al.// (({{pmid**>long:99999999}}))
	</blockquote>		</blockquote>

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	===== Further reading =====		===== Further reading =====
-	possible comprehensive tags resources_for_physicians resource Starting_the_Marshall_Protocol disease diseases symptoms tests MP supplements Non-MP_therapies Other_medication Food_and_drink Lifestyle_modifications Special_issues social_and_psychological science pathogenesis alternate_models	+	possible comprehensive tags: resources_for_physicians resource Starting_the_Marshall_Protocol disease diseases symptoms tests MP supplements Non-MP_therapies Other_medication Food_and_drink Lifestyle_modifications Special_issues social_and_psychological science pathogenesis alternate_models

	{{tag>}}		{{tag>}}
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	tags {{tag>checkout }}		tags {{tag>checkout }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	=====References=====		=====References=====
		+	</nodisp>

Saunas

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.24.2009	current
Line 1:	Line 1:
	+
	+	====== Saunas ======
	+
	+
	+	Far infrared (FIR) saunas raise body temperature to cause sweating which is touted to get rid of body toxins and metabolic wastes, promote weight loss, provide the equivalent of a cardiovascular workout and relieve pain.
	+
	+	The use of infrared saunas is contraindicated because the heat they produce catalyzes the creation of vitamin D.
	+
	+	The use of non-infrared saunas is acceptable, provided that body temperature is not raised more than one degree or so. Increased body temperature may cause increased tissue perfusion of the antibiotics, which could increase immunopathology symptoms.
	+
	+	<blockquote>
	+	The quanta of energy do not vary that much between near-UV and visible and Far-IR. Maybe by a factor of 3 or so, but nobody has shown that the 7-dehydrocholesterol steroid ring cleavage requires that much energy. In fact, all the current pragma about UV has been based on in-vitro work, which is subject to many, many errors.
	+
	+	We know TNF-alpha catalyzes the production of 1,25-D in keratinocytes. That speaks to a continuous process, not a quantized reaction. The hundreds of folks on the MP are keeping away from UV like the plague, yet they continue to produce 1,25-D.
	+
	+	//Trevor Marshall, PhD// </blockquote>
	+
	+
	+
	+	{{tag>non-MP_therapies}}
	+	<nodisp>
	+	===== Notes and comments =====
	+
	+	* Legacy content
	+	* https://www.marshallprotocol.com/view_topic.php?id=33&forum_id=2&jump_to=37025#p37025 e222
	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=144452#p144452 f52
	+	*
	+	*
	+	=====References=====</nodisp>

Sleep medications

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

05.02.2011		current
Line 15:		Line 15:

	* clonazepam (Klonopin, PMS-Clonazepam, Rivotril, Rivotril drops)		* clonazepam (Klonopin, PMS-Clonazepam, Rivotril, Rivotril drops)
		+	* doxylamine (Dozile, Donormyl, Dormidina, NyQuil, Restavit, Sleep Aid, Somnil, Unisom-2)
	* doxepin (Silenor)		* doxepin (Silenor)
	* eszopiclone (Lunesta)		* eszopiclone (Lunesta)
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	===== Melatonin =====		===== Melatonin =====

-	Melatonin is a naturally-occurring hormone found in most animals, including humans, and some other living organisms. In low levels, not unlike [[home:othertreatments:hormone_therapy\|other supplemented hormones]], melatonin is immunosuppressive.(({{pubmed>long:15589268}}))	+	Melatonin is a naturally-occurring hormone found in most animals, including humans, and some other living organisms. In low levels, not unlike [[home:othertreatments:hormone_therapy\|other supplemented hormones]], melatonin is immunosuppressive.(({{pmid>long:15589268}}))

-	Humans do not "get melatonin from the sun." Melatonin is produced by the pineal gland in a process which occurs more actively during the night.(({{pubmed>long:17218758}}))	+	Humans do not "get melatonin from the sun." Melatonin is produced by the pineal gland in a process which occurs more actively during the night.(({{pmid>long:17218758}}))

	Normally, the production of melatonin by the pineal gland is inhibited by light and permitted by darkness. For this reason melatonin has been called "the hormone of darkness." Avoidance of sunlight will not inhibit the production of melatonin. The production of melatonin diminishes with age.		Normally, the production of melatonin by the pineal gland is inhibited by light and permitted by darkness. For this reason melatonin has been called "the hormone of darkness." Avoidance of sunlight will not inhibit the production of melatonin. The production of melatonin diminishes with age.
Line 42:		Line 43:


		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	OVERSEER	+
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=91834#p91834	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=91834#p91834
	*		*
	*		*

-	===== References =====	+	===== References =====</nodisp>

Baking soda

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

06.30.2019		current
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	taken with water has been used for shortness of breath, kidney immunopathology, as well as many other intolerable or bothersome symptoms reported by members on the Marshall protocol. Not everyone can tolerate it but many have found it to be helpful. Be sure not to confuse baking //powder// with baking //soda//.		taken with water has been used for shortness of breath, kidney immunopathology, as well as many other intolerable or bothersome symptoms reported by members on the Marshall protocol. Not everyone can tolerate it but many have found it to be helpful. Be sure not to confuse baking //powder// with baking //soda//.

-	In one study it was found to slow progression of chronic kidney disease for those patients who could tolerate it.(({{pubmed>long:19608703}})) In this study, the patients were given very small doses (600 mg) of oral sodium bicarbonate tablets daily for two years. (600 mg is a just little over 1/2 a gram. A very small amount considering some athletes are reported as taking multiple grams prior to events.)	+	In one study it was found to slow progression of chronic kidney disease for those patients who could tolerate it.(({{pmid>long:19608703}})) In this study, the patients were given very small doses (600 mg) of oral sodium bicarbonate tablets daily for two years. (600 mg is a just little over 1/2 a gram. A very small amount considering some athletes are reported as taking multiple grams prior to events.)

	<blockquote>It is not dangerous, but it tastes appalling and can make you want to retch. It can make some people nauseous when it hits their stomach and a few suffer an upset stomach or diarrhoea when they take it.		<blockquote>It is not dangerous, but it tastes appalling and can make you want to retch. It can make some people nauseous when it hits their stomach and a few suffer an upset stomach or diarrhoea when they take it.

-	//Dr. Folland, [[http://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece\|Times Online]]// </blockquote>	+	//Dr. Folland, [[https://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece\|Times Online]]// </blockquote>

	<blockquote>It was summer here when I determined that I really needed to drink 'Jigsaw water' everyday. I made and stored in the freezer a series of bottles with a very little bicarb in each, I did not know it was supposed to taste terrible, for me it had no taste until cold weather set in and I drank some at room temperature ...ugh! //Sallie Q//</blockquote>		<blockquote>It was summer here when I determined that I really needed to drink 'Jigsaw water' everyday. I made and stored in the freezer a series of bottles with a very little bicarb in each, I did not know it was supposed to taste terrible, for me it had no taste until cold weather set in and I drank some at room temperature ...ugh! //Sallie Q//</blockquote>

-	A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say. (({{pubmed>long:29661827}}))	+	A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say. (({{pmid>long:29661827}}))

	They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease.		They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease.
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	==== Bicarbonate supplementation ====		==== Bicarbonate supplementation ====

-	slows progression of CKD(({{pubmed>long:19608703}}))	+	slows progression of CKD(({{pmid>long:19608703}}))

-	[[https://www.science20.com/news_articles/baking_soda_linked_to_better_vision-154079\|linked to better vision]] (({{pubmed>long:25767116}}))	+	[[https://www.science20.com/news_articles/baking_soda_linked_to_better_vision-154079\|linked to better vision]] (({{pmid>long:25767116}}))

	==== Baking soda use compared to fruits and vegetables ====		==== Baking soda use compared to fruits and vegetables ====

-	A study making a comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate showed similar positive results.(({{pubmed>long:23393104}}))	+	A study making a comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate showed similar positive results.(({{pmid>long:23393104}}))

	<blockquote>Current guidelines recommend Na(+)-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM. Because diets in industrialized societies are typically acid-producing, we compared base-producing fruits and vegetables with oral NaHCO3 (HCO3) regarding the primary outcome of follow-up estimated GFR (eGFR) and secondary outcomes of improved metabolic acidosis and reduced urine indices of kidney injury.		<blockquote>Current guidelines recommend Na(+)-based alkali for CKD with metabolic acidosis and plasma total CO2 (PTCO2) < 22 mM. Because diets in industrialized societies are typically acid-producing, we compared base-producing fruits and vegetables with oral NaHCO3 (HCO3) regarding the primary outcome of follow-up estimated GFR (eGFR) and secondary outcomes of improved metabolic acidosis and reduced urine indices of kidney injury.
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	===== Read more =====		===== Read more =====

-	* [[http://www.nlm.nih.gov/medlineplus/ency/article/002749.htm\|Baking Soda Overdose]]	+	* [[https://www.nlm.nih.gov/medlineplus/ency/article/002749.htm\|Baking Soda Overdose]]
-	* [[http://en.wikipedia.org/wiki/Sodium_bicarbonate#Medical_uses\|Medicinal Uses of Sodium Bicarbonate]]	+	* [[https://en.wikipedia.org/wiki/Sodium_bicarbonate#Medical_uses\|Medicinal Uses of Sodium Bicarbonate]]. Bicarbonate of soda may even contribute to cancer prevention.(({{pmid>long:28083722}}))
-	* [[http://www.jimmunol.org/content/early/2018/04/14/jimmunol.1701605\|Splenic Anti-Inflammatory Pathway]]	+	* [[https://www.jimmunol.org/content/early/2018/04/14/jimmunol.1701605\|Splenic Anti-Inflammatory Pathway]]
-	* [[http://www.medscape.com/viewarticle/706043\|Baking Soda May Slow Progression of Chronic Kidney Disease]] - article reviewing study referenced above(({{pubmed>long:19608703}}))	+	* [[https://www.medscape.com/viewarticle/706043\|Baking Soda May Slow Progression of Chronic Kidney Disease]] - article reviewing study referenced above(({{pmid>long:19608703}}))
-	* [[http://www.mayoclinic.com/health/first-aid-insect-bites/fa00046\|Insect bites and stings: First aid]] - can be applied topically as a paste, with three parts baking soda to one part water, to relieve insect bites	+	* [[https://www.mayoclinic.com/health/first-aid-insect-bites/fa00046\|Insect bites and stings: First aid]] - can be applied topically as a paste, with three parts baking soda to one part water, to relieve insect bites
-	* [[http://macularhope.org/a-pinch-of-baking-soda-for-better-vision/\|A pinch of baking soda for better vision]]	+	* [[https://macularhope.org/a-pinch-of-baking-soda-for-better-vision/\|A pinch of baking soda for better vision]]

	{{tag>kidneys}} {{tag>supplements}}		{{tag>kidneys}} {{tag>supplements}}
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
	*		*
-	More here: [[http://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece?print=yes&randnum=1262600251907\|Times Online]]	+	More here: [[https://women.timesonline.co.uk/tol/life_and_style/women/body_and_soul/article4539000.ece?print=yes&randnum=1262600251907\|Times Online]]

	<blockquote>		<blockquote>
Line 165:		Line 166:
	I wrote an article for the MP KB on using baking soda, but perhaps you would say I was being overly cautious in my wording?		I wrote an article for the MP KB on using baking soda, but perhaps you would say I was being overly cautious in my wording?

-	http://mpkb.org/home/othertreatments/sodium_bicarbonate	+	https://mpkb.org/home/othertreatments/sodium_bicarbonate

	Thanks!		Thanks!
Line 185:		Line 186:
	Jigsaw posted on study site:		Jigsaw posted on study site:

-	http://www.marshallprotocol.com/forum43/14870-3.html	+	https://www.marshallprotocol.com/forum43/14870-3.html

	Olmesartan and CKD		Olmesartan and CKD
Line 195:		Line 196:


-	===== References =====	+	===== References =====</nodisp>

Statins and other anti-cholesterol drugs

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.23.2019		current
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	Statins interfere with the actions of Olmesartan, as they are a very similar molecule, and compete with Olmesartan for many of Olmesartan's molecular binding sites. The actions of statins on the Nuclear Receptors are therefore competitive with Olmesartan, as they reduce or negate Olmesartan's therapeutic activities.		Statins interfere with the actions of Olmesartan, as they are a very similar molecule, and compete with Olmesartan for many of Olmesartan's molecular binding sites. The actions of statins on the Nuclear Receptors are therefore competitive with Olmesartan, as they reduce or negate Olmesartan's therapeutic activities.

-	As the 2008 ENHANCE trial illustrates, while high cholesterol is //correlated// with increased incidence of diseases, lowering cholesterol does not appear to improve human health.(({{pubmed>long:18376000}})) Indeed, there is some evidence this type of intervention does the opposite.(({{pubmed>long:14631060}}))	+	As the 2008 ENHANCE trial illustrates, while high cholesterol is //correlated// with increased incidence of diseases, lowering cholesterol does not appear to improve human health.(({{pmid>long:18376000}})) Indeed, there is some evidence this type of intervention does the opposite.(({{pmid>long:14631060}}))


Line 39:		Line 39:
	====Other cholesterol drugs====		====Other cholesterol drugs====
	The following is a list of common non-statin cholesterol-lowering drugs:		The following is a list of common non-statin cholesterol-lowering drugs:
-	* cholestyramine (Questran) – Part of another treatment protocol, cholestyramine is touted to relieve symptoms supposedly caused by the release of toxins as the Lyme spirochete is killed. However, cholestyramine is [[http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=Que1366.html&contentName=Questran&contentId=484\|known to interfere]] with the action of tetracycline, an antibiotic in the same class – the tetracycline family of antibiotics – used by many of the MP antibiotics.	+	* cholestyramine (Questran) – Part of another treatment protocol, cholestyramine is touted to relieve symptoms supposedly caused by the release of toxins as the Lyme spirochete is killed. However, cholestyramine is [[https://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=Que1366.html&contentName=Questran&contentId=484\|known to interfere]] with the action of tetracycline, an antibiotic in the same class – the tetracycline family of antibiotics – used by many of the MP antibiotics.
	* gemfibrozil (Lopid, Gemcor)		* gemfibrozil (Lopid, Gemcor)
	* Omacor		* Omacor
Line 48:		Line 48:
	Large numbers of patients at risk for cardiovascular disease or stroke are prescribed statins – drugs that are marketed as improving health by lowering cholesterol. There’s no question that statins can effectively lower cholesterol. But, does lowering cholesterol actually benefit patients with coronary artery disease, and more importantly, are the effects of statins on patients with heart disease even related to their ability to lower cholesterol?		Large numbers of patients at risk for cardiovascular disease or stroke are prescribed statins – drugs that are marketed as improving health by lowering cholesterol. There’s no question that statins can effectively lower cholesterol. But, does lowering cholesterol actually benefit patients with coronary artery disease, and more importantly, are the effects of statins on patients with heart disease even related to their ability to lower cholesterol?

-	<blockquote>The fact that statin treatment lowers both total and cardiovascular mortality in high-risk individuals is taken as evidence that cholesterol lowering is effective. However, statins are just as effective whether cholesterol is lowered by a small amount (as in the unsuccessful non-statin trials) or by more than 40%. In addition, statin treatment is effective whether the initial LDL-C is high or low.(({{pubmed>long:9576424}})) (({{pubmed>long:11277825}})) If high LDL-C were causal, the greatest effect should have been seen in patients with the highest LDL-C, and in patients whose LDL-C was lowered the most, but this is not the case. Lack of dose-response cannot be attributed to the knowledge that the statins have other effects on plaque stabilization, as this would not have masked the effect of cholesterol-lowering, considering the pronounced lowering that was achieved.	+	<blockquote>The fact that statin treatment lowers both total and cardiovascular mortality in high-risk individuals is taken as evidence that cholesterol lowering is effective. However, statins are just as effective whether cholesterol is lowered by a small amount (as in the unsuccessful non-statin trials) or by more than 40%. In addition, statin treatment is effective whether the initial LDL-C is high or low.(({{pmid>long:9576424}})) (({{pmid>long:11277825}})) If high LDL-C were causal, the greatest effect should have been seen in patients with the highest LDL-C, and in patients whose LDL-C was lowered the most, but this is not the case. Lack of dose-response cannot be attributed to the knowledge that the statins have other effects on plaque stabilization, as this would not have masked the effect of cholesterol-lowering, considering the pronounced lowering that was achieved.

-	//U. Ravnskov// (({{pubmed>long:14631060}}))</blockquote>	+	//U. Ravnskov// (({{pmid>long:14631060}}))</blockquote>

-	Ravnskov compares two separate trials of a single statin, simvastatin: a 2002 trial (nicknamed HPS)(({{pubmed>long:12114036}})) and a 1994 study (nicknamed 4S)(({{pubmed>long:7968073}})). The 4S research team reported a three times greater risk of coronary death in the HPS trial, even though patients' total cholesterol in the 4S trial was decreased to a much lower extent.(({{pubmed>long:14631060}}))	+	Ravnskov compares two separate trials of a single statin, simvastatin: a 2002 trial (nicknamed HPS)(({{pmid>long:12114036}})) and a 1994 study (nicknamed 4S)(({{pmid>long:7968073}})). The 4S research team reported a three times greater risk of coronary death in the HPS trial, even though patients' total cholesterol in the 4S trial was decreased to a much lower extent.(({{pmid>long:14631060}}))

-	A seminal study called the ENHANCE trial was published in 2008. The trial tested the effects of a new cholesterol-lowering medication called Zetia (which, as opposed to the statins, works by decreasing cholesterol absorption in the intestine) on patients with cardiovascular disease. It found that Vytorin, a combination pill containing both Zetia and the statin Zocor (simvastatin), proved better than the statin alone at reducing levels of cholesterol. However, ENHANCE collaborators reported that Vytorin resulted in //growth// of plaque.(({{pubmed>long:18376000}}))	+	A seminal study called the ENHANCE trial was published in 2008. The trial tested the effects of a new cholesterol-lowering medication called Zetia (which, as opposed to the statins, works by decreasing cholesterol absorption in the intestine) on patients with cardiovascular disease. It found that Vytorin, a combination pill containing both Zetia and the statin Zocor (simvastatin), proved better than the statin alone at reducing levels of cholesterol. However, ENHANCE collaborators reported that Vytorin resulted in //growth// of plaque.(({{pmid>long:18376000}}))

-	All together, this evidence suggests statins' ability to (slightly) improve health outcomes is independent of their ability to lower cholesterol.(({{pubmed>long:12562541}}))	+	All together, this evidence suggests statins' ability to (slightly) improve health outcomes is independent of their ability to lower cholesterol.(({{pmid>long:12562541}}))


Line 65:		Line 65:
	<blockquote>Statins have been demonstrated to increase CYP3A expression in vitro, most likely because they are ligands to nuclear receptors (pregnane X receptor and constitutive androsterone receptor) that form heterodimers with retinoid X receptors and bind to responsive elements in the CYP3A4 and CYP3A5 promoter regions.		<blockquote>Statins have been demonstrated to increase CYP3A expression in vitro, most likely because they are ligands to nuclear receptors (pregnane X receptor and constitutive androsterone receptor) that form heterodimers with retinoid X receptors and bind to responsive elements in the CYP3A4 and CYP3A5 promoter regions.

-	//M.A. Willrich// (({{pubmed>long:19530969}}))	+	//M.A. Willrich// (({{pmid>long:19530969}}))
	</blockquote>		</blockquote>

Line 76:		Line 76:
	===== Immunopathological effects of statins? =====		===== Immunopathological effects of statins? =====

-	According to the reports from the statin trials, all of which have been sponsored by the drug companies, side effects are mild and rare, but underreporting is prevalent. According to drug companies, muscular symptoms occur in less than one percent of patients taking statins, however researchers independent of drug companies have found the frequency to be 64%(({{pubmed>long:16386629}})) and 75%.(({{pubmed>long:16873939}})) In the IDEAL trial, almost 90% of participants in both groups had side effects, and in almost half of them they were recorded as serious.(({{pubmed>long:16740566}})) The following adverse effects for statins have been noted in the medical literature:	+	According to the reports from the statin trials, all of which have been sponsored by the drug companies, side effects are mild and rare, but underreporting is prevalent. According to drug companies, muscular symptoms occur in less than one percent of patients taking statins, however researchers independent of drug companies have found the frequency to be 64%(({{pmid>long:16386629}})) and 75%.(({{pmid>long:16873939}})) In the IDEAL trial, almost 90% of participants in both groups had side effects, and in almost half of them they were recorded as serious.(({{pmid>long:16740566}})) The following adverse effects for statins have been noted in the medical literature:
-	* increased incidence of lupus and pneumonia(({{pubmed>long:11936540}})) – Note the similarity between "statin-induced lupus" and "[[home:mp:allergies\|minocycline-induced lupus]]."(({{pubmed>long:17366961}}))	+	* increased incidence of lupus and pneumonia(({{pmid>long:11936540}})) – Note the similarity between "statin-induced lupus" and "[[home:mp:allergies\|minocycline-induced lupus]]."(({{pmid>long:17366961}}))
	* dyspnea (pain while breathing) – Those with pulmonary involvement such as sarcoidosis patients sometimes confuse their disease symptoms with the side effects of statins.		* dyspnea (pain while breathing) – Those with pulmonary involvement such as sarcoidosis patients sometimes confuse their disease symptoms with the side effects of statins.
-	* muscle pain(({{pubmed>long:12622602}})) (({{pubmed>long:15006590}}))	+	* muscle pain(({{pmid>long:12622602}})) (({{pmid>long:15006590}}))
-	* renal dysfunction — Statins appear to be able to cause proteinuria through tubular inhibition of active transport of small molecular weight proteins.(({{pubmed>long:15339975}})) (({{pubmed>long:15073451}}))	+	* renal dysfunction — Statins appear to be able to cause proteinuria through tubular inhibition of active transport of small molecular weight proteins.(({{pmid>long:15339975}})) (({{pmid>long:15073451}}))
-	* tendon complications(({{pubmed>long:17599460}}))	+	* tendon complications(({{pmid>long:17599460}}))
-	* cognitive dysfunction – A 2008 survey of statin patients found that 75% experienced cognitive dysfunction determined to be probably or definitely related to statin therapy. Of 143 patients who reported stopping statin therapy, 90% reported improvement in cognitive problems, sometimes within days of statin discontinuation with a median time to recovery of 2.5 weeks. In some patients, a diagnosis of dementia or Alzheimer's disease reportedly was reversed. Severity of cognitive problems were clearly related to statin potency.(({{pubmed>long:19558254}}))	+	* cognitive dysfunction – A 2008 survey of statin patients found that 75% experienced cognitive dysfunction determined to be probably or definitely related to statin therapy. Of 143 patients who reported stopping statin therapy, 90% reported improvement in cognitive problems, sometimes within days of statin discontinuation with a median time to recovery of 2.5 weeks. In some patients, a diagnosis of dementia or Alzheimer's disease reportedly was reversed. Severity of cognitive problems were clearly related to statin potency.(({{pmid>long:19558254}}))
-	* fatigue – Almost half of participants in a 2012 study reported a significant increase in fatigue while taking statins.(({{pubmed>long:22688574}}))	+	* fatigue – Almost half of participants in a 2012 study reported a significant increase in fatigue while taking statins.(({{pmid>long:22688574}}))


-	As discussed in the previous section, it may be that their effect on nuclear receptors explain how some statins increase patients' disease symptoms. Indeed, a 2009 //Pathology// paper described antimicrobial activity of atorvastatin and rosuvastatin.(({{pubmed>long:20001351}})) Some of the observed side effects of statins may be immunopathological in nature. One study reports both bactericidal and inflammatory response changes in macrophage activity from simvastatin. (({{pubmed>long:19892847}})) It is possible that statins have similar immune-activating properties to the main drug for the Marshall Protocol, olmesartan, which causes an increase in disease symptoms following bacterial death.	+	As discussed in the previous section, it may be that their effect on nuclear receptors explain how some statins increase patients' disease symptoms. Indeed, a 2009 //Pathology// paper described antimicrobial activity of atorvastatin and rosuvastatin.(({{pmid>long:20001351}})) Some of the observed side effects of statins may be immunopathological in nature. One study reports both bactericidal and inflammatory response changes in macrophage activity from simvastatin. (({{pmid>long:19892847}})) It is possible that statins have similar immune-activating properties to the main drug for the Marshall Protocol, olmesartan, which causes an increase in disease symptoms following bacterial death.

-	However, olmesartan has several advantages over the statins including a [[home:protocol:olmesartan:safety\|superior safety profile]],(({{pubmed>long:11361048}})) demonstrated ability to decrease plaque formation,(({{pubmed>long:19124398}})) and renoprotective properties.(({{pubmed>long:17130263}}))	+	However, olmesartan has several advantages over the statins including a [[home:protocol:olmesartan:safety\|superior safety profile]],(({{pmid>long:11361048}})) demonstrated ability to decrease plaque formation,(({{pmid>long:19124398}})) and renoprotective properties.(({{pmid>long:17130263}}))

-	In any case, researchers tend not to study or discuss what may be statins' primary mechanism of action: its effect on immune function. Nor, is their an earnest exploration of how modulating immune activity against chronic microbes(({{pubmed>long:11036910}})) affects the course of human disease.	+	In any case, researchers tend not to study or discuss what may be statins' primary mechanism of action: its effect on immune function. Nor, is their an earnest exploration of how modulating immune activity against chronic microbes(({{pmid>long:11036910}})) affects the course of human disease.
	===== Contraindications of statins =====		===== Contraindications of statins =====

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	===== Statins are over-prescribed =====		===== Statins are over-prescribed =====

-	For adults aged between 30 and 80 years old who already have occlusive vascular disease, statins confer a total and cardiovascular mortality benefit and are not controversial. However, 75% of patients who take statins are not in this category.(({{pubmed>long:17240267}}))	+	For adults aged between 30 and 80 years old who already have occlusive vascular disease, statins confer a total and cardiovascular mortality benefit and are not controversial. However, 75% of patients who take statins are not in this category.(({{pmid>long:17240267}}))

-	For patients who are healthy, there is marginal evidence that statins prevent heart attacks or strokes.(({{pubmed>long:17240267}})) One meta-analysis (which was itself compromised almost entirely of industry-funded studies) showed that in healthy patients, there was only a 0.6% reduction in mortality. In other words, physicians would need to treat between 100 and 450 patients with a statin for more than four years to prevent one death.(({{pubmed>long:19841451}}))	+	For patients who are healthy, there is marginal evidence that statins prevent heart attacks or strokes.(({{pmid>long:17240267}})) One meta-analysis (which was itself compromised almost entirely of industry-funded studies) showed that in healthy patients, there was only a 0.6% reduction in mortality. In other words, physicians would need to treat between 100 and 450 patients with a statin for more than four years to prevent one death.(({{pmid>long:19841451}}))

	Certainly, one of the motivations to demonstrate statins' value as a preventative therapy is financial. The best-selling drug in the world is Lipitor (atorvastatin), which is manufactured by Pfizer.		Certainly, one of the motivations to demonstrate statins' value as a preventative therapy is financial. The best-selling drug in the world is Lipitor (atorvastatin), which is manufactured by Pfizer.
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-	//John Abramson, M.D., [[http://www.boston.com/yourlife/health/blog/2007/01/statins_overpre_1.html\|Harvard Medical School]]//	+	//John Abramson, M.D., [[https://www.boston.com/yourlife/health/blog/2007/01/statins_overpre_1.html\|Harvard Medical School]]//
	</blockquote>		</blockquote>

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	===== Vitamin D =====		===== Vitamin D =====

-	A 2012 randomized, placebo-controlled trial gave 120 adults with levels of 25-D below 20 ng/mL and elevated risk for cardiovascular disease either 50,000 IU of vitamin D3 weekly for 8 weeks or placebo. The study found a significant and undesired increase in LDL cholesterol.(({{pubmed>long:22947589}}))	+	A 2012 randomized, placebo-controlled trial gave 120 adults with levels of 25-D below 20 ng/mL and elevated risk for cardiovascular disease either 50,000 IU of vitamin D3 weekly for 8 weeks or placebo. The study found a significant and undesired increase in LDL cholesterol.(({{pmid>long:22947589}}))


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	===== Read more =====		===== Read more =====

-	* [[http://www.fathead-movie.com/index.php/2011/01/20/bad-news-for-statins-is-good-news/\|Bad News For Statins Is Good News]] – blog post explaining how evidence does not support the use of statins in patients without cardiovascular disease	+	* [[https://www.fathead-movie.com/index.php/2011/01/20/bad-news-for-statins-is-good-news/\|Bad News For Statins Is Good News]] – blog post explaining how evidence does not support the use of statins in patients without cardiovascular disease
-	* [[http://www.joimr.org/JOIMR_Vol7_No1_Dec2009.pdf\|JOIMR Editorial December 2009]]	+	* [[https://www.joimr.org/JOIMR_Vol7_No1_Dec2009.pdf\|Jeff Cable:Adverse Events of Statins]]


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	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	del broke * [[http://www.youtube.com/watch?v=rDVf-00w5gk\|The Heart of the Matter]] - excellent documentary with interviews of experienced cardiologists explaining the evidence against the cholesterol hypothesis.	+	del broke * [[https://www.youtube.com/watch?v=rDVf-00w5gk\|The Heart of the Matter]] - excellent documentary with interviews of experienced cardiologists explaining the evidence against the cholesterol hypothesis.


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1198.html#p84709	+	* https://www.marshallprotocol.com/forum32/1198.html#p84709
-	* http://www.marshallprotocol.com/view_topic.php?id=1198&forum_id=32&jump_to=84711#p84711	+	* https://www.marshallprotocol.com/view_topic.php?id=1198&forum_id=32&jump_to=84711#p84711
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=66100#p66100	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=66100#p66100
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=66100#p66100	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=66100#p66100
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=45902#p45902	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=45902#p45902


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	PMID: 21075355		PMID: 21075355

-	http://www.eurekalert.org/pub_releases/2010-11/uoc--csb111210.php	+	https://www.eurekalert.org/pub_releases/2010-11/uoc--csb111210.php

-	http://news.oneindia.in/2010/11/18/cholesterollowering-statins-killbacteria.html	+	https://news.oneindia.in/2010/11/18/cholesterollowering-statins-killbacteria.html
	</blockquote>		</blockquote>

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	© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.		© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
	PMID: 22432744</blockquote>		PMID: 22432744</blockquote>
-	===== References ======	+	===== References ======</nodisp>

Steroid inhalers

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

04.02.2010		current
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	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT	+

	* Legacy content		* Legacy content
-	*	+	* </nodisp>

Stimulants

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
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	There is no evidence that caffeine is helpful to the recovery trajectory of MP patients. Caffeine may be problematic for the following reasons:		There is no evidence that caffeine is helpful to the recovery trajectory of MP patients. Caffeine may be problematic for the following reasons:
-	* University of Iowa scientists [[http://www.physorg.com/news/2011-06-caffeine-consuming-bacterium.html\|have identified]] four different bacteria that actually can live on caffeine including //Pseudomonas putida CBB5//. The team identified the gene sequence that enables the bacterium to break down the caffeine compound in nature.	+	* University of Iowa scientists [[https://www.physorg.com/news/2011-06-caffeine-consuming-bacterium.html\|have identified]] four different bacteria that actually can live on caffeine including //Pseudomonas putida CBB5//. The team identified the gene sequence that enables the bacterium to break down the caffeine compound in nature.
-	* Caffeine can substantially contribute to bone loss.(({{pubmed>long:17223552}})) (({{pubmed>long:11684540}}))	+	* Caffeine can substantially contribute to bone loss.(({{pmid>long:17223552}})) (({{pmid>long:11684540}}))
	* Finally, caffeine is said to act on the cAMP and PKA pathway, and therefore it is likely to have negative effects on VDR homeostasis and on recovery.		* Finally, caffeine is said to act on the cAMP and PKA pathway, and therefore it is likely to have negative effects on VDR homeostasis and on recovery.

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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	NYTimes		NYTimes
-	- Read more -	+	- Read more - removed

-	* [[http://mobile.nytimes.com/article?a=904506\|Children's A.D.D. Drugs Don't Work Long-Term]]	+	* [[https://mobile.nytimes.com/article?a=904506\|Children's A.D.D. Drugs Don't Work Long-Term]]
	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=151745#p151745	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=151745#p151745
-	* http://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=37026#p37026	+	* https://www.marshallprotocol.com/view_topic.php?id=842&forum_id=2&jump_to=37026#p37026
-	* http://www.marshallprotocol.com/forum37/1491.html#p12231	+	* https://www.marshallprotocol.com/forum37/1491.html#p12231
		+
		+	===== References =====</nodisp>

-	===== References =====

Sunshine/light exposure as therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.26.2018		current
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	Contrary to popular belief, epidemiological research points to an //increase// in suicide across countries during the beginning of the summer months when people tend to get more light exposure.		Contrary to popular belief, epidemiological research points to an //increase// in suicide across countries during the beginning of the summer months when people tend to get more light exposure.

-	Light exposure does nothing to resolve underlying disease state and can actually delay progress for Marshall Protocol (MP) patients. Certainly prolonged light exposure has been shown to increase skin melanoma – the World Health Organization now categorizes tanning beds under the highest cancer risk category.(({{pubmed>long:19655431}}))	+	Light exposure does nothing to resolve underlying disease state and can actually delay progress for Marshall Protocol (MP) patients. Certainly prolonged light exposure has been shown to increase skin melanoma – the World Health Organization now categorizes tanning beds under the highest cancer risk category.(({{pmid>long:19655431}}))

	MP patients who have completed the treatment have been able to attest to the fact that sunshine is not necessary for good health or happiness.		MP patients who have completed the treatment have been able to attest to the fact that sunshine is not necessary for good health or happiness.
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	===== Sunshine and suicide =====		===== Sunshine and suicide =====

-	In spite of a widespread belief that the peak occurs in late autumn and early winter,(({{pubmed>long:17688099}})) a positive correlation between sunlight and suicide has been demonstrated by several researchers.	+	In spite of a widespread belief that the peak occurs in late autumn and early winter,(({{pmid>long:17688099}})) a positive correlation between sunlight and suicide has been demonstrated by several researchers.

	<blockquote>We found a remarkably consistent pattern of seasonality with peak incidence around June in the northern hemisphere and December in the southern hemisphere. Moreover, there was a positive association between the seasonal amplitude of suicide (measured by relative risk) and total sunshine in the corresponding country. These findings indicate that sunshine may have a triggering effect on suicide....		<blockquote>We found a remarkably consistent pattern of seasonality with peak incidence around June in the northern hemisphere and December in the southern hemisphere. Moreover, there was a positive association between the seasonal amplitude of suicide (measured by relative risk) and total sunshine in the corresponding country. These findings indicate that sunshine may have a triggering effect on suicide....

-	//Eleni Petridou, et al// (({{pubmed>long:11805594}}))</blockquote>	+	//Eleni Petridou, et al// (({{pmid>long:11805594}}))</blockquote>

	Petridou's work is striking, because it identifies an effect for all 20 countries studied:		Petridou's work is striking, because it identifies an effect for all 20 countries studied:
Line 26:		Line 26:

	Increased summer incidence of suicide has also been identified in other countries including		Increased summer incidence of suicide has also been identified in other countries including
-	Finland,(({{pubmed>long:9718233}}))	+	Finland,(({{pmid>long:9718233}}))
-	Norway,(({{pubmed>long:12103450}}))	+	Norway,(({{pmid>long:12103450}}))
-	Belgium,(({{pubmed>long:8352350}}))	+	Belgium,(({{pmid>long:8352350}}))
-	France,(({{pubmed>long:2960714}}))	+	France,(({{pmid>long:2960714}}))
-	Italy,(({{pubmed>long:9241572}}))	+	Italy,(({{pmid>long:9241572}}))
-	Japan,(({{pubmed>long:15575348}}))	+	Japan,(({{pmid>long:15575348}}))
-	USA,(({{pubmed>long:2326139}}))	+	USA,(({{pmid>long:2326139}}))
-	Lithuania,(({{pubmed>long:16504069}}))	+	Lithuania,(({{pmid>long:16504069}}))
-	Switzerland,(({{pubmed>long:16234425}}))	+	Switzerland,(({{pmid>long:16234425}}))
-	Chile,(({{pubmed>long:10030056}})) and	+	Chile,(({{pmid>long:10030056}})) and
-	South Africa.(({{pubmed>long:9061800}}))	+	South Africa.(({{pmid>long:9061800}}))

	In many, if not all, of these studies the increased incidence of suicide was shown to be independent of an increase in homicide.		In many, if not all, of these studies the increased incidence of suicide was shown to be independent of an increase in homicide.
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-	Phototherapy suppresses immunity which can lead to the progression of other infections such as human papilloma virus (HPV). A 2010 study used a nested polymerase chain reaction, to analyze skin biopsies taken a from 20 psoriasis patients under phototherapy (UVB) and 20 untreated psoriatic patients. The authors were able to detect viruses in 60% of the treatment but in none of the controls.(({{pubmed>long:20415738}}))	+	Phototherapy suppresses immunity which can lead to the progression of other infections such as human papilloma virus (HPV). A 2010 study used a nested polymerase chain reaction, to analyze skin biopsies taken a from 20 psoriasis patients under phototherapy (UVB) and 20 untreated psoriatic patients. The authors were able to detect viruses in 60% of the treatment but in none of the controls.(({{pmid>long:20415738}}))

-	A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pubmed>long:21375518}}))	+	1,25(OH)2D3 resulted in suppression of proinflammatory cytokine response in vitro
		+	First, we carried out LPS and Pam3Cys stimulation on PBMC with the addition of 100 nM 1,25(OH)2D3. After 24 h, IL-6 secretion was reduced by 53% and 29% upon Pam3Cys and LPS stimulation, respectively, in the cells treated with 1,25(OH)2D3 (Fig. 1a). A significant drop in TNF-α production by 17% (Pam3Cys stimulation) and 35% (LPS stimulation) was also observed with 1,25(OH)2D3 at 24 h. Having demonstrated that 1,25(OH)2D3 had the capacity to modulated IL-6 and TNF-α response in vitro, and with the understanding that physiological vitamin D3 levels in the body may vary through the seasons, we validate these observations in vivo in a cohort of healthy volunteers.(({{pmid>long:21323660}}))

-	Certain support for this study comes from a 2011 Australian paper that found that 8 week old mice given a single exposure of ultraviolet radiation had suppressed immunity.(({{pubmed>long:21243005}}))	+	A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pmid>long:21375518}}))

-	[[http://www.nejm.org/doi/full/10.1056/NEJMicm1104059\|Unilateral Dermatoheliosis]]	+	Certain support for this study comes from a 2011 Australian paper that found that 8 week old mice given a single exposure of ultraviolet radiation had suppressed immunity.(({{pmid>long:21243005}}))
		+
		+	[[https://www.nejm.org/doi/full/10.1056/NEJMicm1104059\|Unilateral Dermatoheliosis]]


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	This phenomenon can be observed among different patient populations.		This phenomenon can be observed among different patient populations.

-	In recent years, researchers have begun to describe people addicted to tanning, at least according to criteria set out by the Diagnostic and Statistical Manual for substance-related disorders.(({{pubmed>long:19152511}})) One research team calls the addiction "UV light substance-related disorder."(({{pubmed>long:17257709}})) A 2010 study suggests individuals who have used indoor tanning facilities may meet criteria for addiction, and may also be more prone to anxiety symptoms and substance use.(({{pubmed>long:20404230}})) Among 229 study participants (students at a northeastern U.S. college) who had used indoor tanning facilities, the average number of visits during a given year was 23. A total of 90 (39.3 percent) met criteria for tanning addiction on one measure and 70 (30.6 percent) met criteria on the other measure. Students who did meet these criteria were more likely to report symptoms of anxiety and use of alcohol, marijuana and other substances than those who did not meet these criteria.	+	In recent years, researchers have begun to describe people addicted to tanning, at least according to criteria set out by the Diagnostic and Statistical Manual for substance-related disorders.(({{pmid>long:19152511}})) One research team calls the addiction "UV light substance-related disorder."(({{pmid>long:17257709}})) A 2010 study suggests individuals who have used indoor tanning facilities may meet criteria for addiction, and may also be more prone to anxiety symptoms and substance use.(({{pmid>long:20404230}})) Among 229 study participants (students at a northeastern U.S. college) who had used indoor tanning facilities, the average number of visits during a given year was 23. A total of 90 (39.3 percent) met criteria for tanning addiction on one measure and 70 (30.6 percent) met criteria on the other measure. Students who did meet these criteria were more likely to report symptoms of anxiety and use of alcohol, marijuana and other substances than those who did not meet these criteria.

	<blockquote>If associations between affective factors and indoor tanning behavior are replicated, results suggest that treating an underlying mood disorder may be a necessary step in reducing skin cancer risk among those who frequently tan indoors. Researchers have hypothesized that those who tan regularly year round may require more intensive intervention efforts, such as motivational interviewing, relative to those who tan periodically in response to mood changes or special events.		<blockquote>If associations between affective factors and indoor tanning behavior are replicated, results suggest that treating an underlying mood disorder may be a necessary step in reducing skin cancer risk among those who frequently tan indoors. Researchers have hypothesized that those who tan regularly year round may require more intensive intervention efforts, such as motivational interviewing, relative to those who tan periodically in response to mood changes or special events.

-	//Catherine E. Mosher, Ph.D. and Sharon Danoff-Burg, Ph.D.//(({{pubmed>long:20404230}}))	+	//Catherine E. Mosher, Ph.D. and Sharon Danoff-Burg, Ph.D.//(({{pmid>long:20404230}}))
	</blockquote>		</blockquote>

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-	* [[http://www.truenudists.com/forum/viewthread.php?id=1480&post=15509\|"Why Am I Sick?" (Nudist Forum)]] - a number of devoted nudists complain about their symptoms of inflammatory disease	+	* [[https://www.truenudists.com/forum/viewthread.php?id=1480&post=15509\|"Why Am I Sick?" (Nudist Forum)]] - a number of devoted nudists complain about their symptoms of inflammatory disease
-	* [[http://news.nationalgeographic.com/news/2009/05/090508-sunlight-suicide.html\|Too Much Sunshine Spurs Suicides in Arctic, Study Says]] – review of a 2009 //BMC Psychiatry// article,((Björkstén. [[http://www.biomedcentral.com/content/pdf/1471-244x-9-20.pdf\|Accentuation of suicides but not homicides with rising latitudes of Greenland in the sunny months]]. //BMC Psychiatry//; 2009. )) which showed that suicide was much more common among Greenland residents in the summer than the winter months	+	* [[https://news.nationalgeographic.com/news/2009/05/090508-sunlight-suicide.html\|Too Much Sunshine Spurs Suicides in Arctic, Study Says]] – review of a 2009 //BMC Psychiatry// article,((Björkstén. [[https://www.biomedcentral.com/content/pdf/1471-244x-9-20.pdf\|Accentuation of suicides but not homicides with rising latitudes of Greenland in the sunny months]]. //BMC Psychiatry//; 2009. )) which showed that suicide was much more common among Greenland residents in the summer than the winter months
-	* [[http://www.rt.com/news/russia-muslim-sect-satarov-213/\|Children born and living without sunlight]] – In 2012, it was learned that 27 children had been living underground as members of a Muslim sect. Many had lived there for their entire lives and had never seen daylight. The conditions of these children was pronounced as "satisfactory" by pediatricians	+	* [[https://www.rt.com/news/russia-muslim-sect-satarov-213/\|Children born and living without sunlight]] – In 2012, it was learned that 27 children had been living underground as members of a Muslim sect. Many had lived there for their entire lives and had never seen daylight. The conditions of these children was pronounced as "satisfactory" by pediatricians

	{{tag> }}		{{tag> }}
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=5035&forum_id=32&jump_to=75781#p75781 f242	+	* https://www.marshallprotocol.com/view_topic.php?id=5035&forum_id=32&jump_to=75781#p75781 f242
	* e72		* e72
	* f347		* f347
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	</blockquote>		</blockquote>

-	<blockquote>http://www.tgdaily.com/trendwatch-brief/57832-are-tanning-bed-addicts-like-junkies	+	<blockquote>https://www.tgdaily.com/trendwatch-brief/57832-are-tanning-bed-addicts-like-junkies

	So the next question is whether Vitamin D is addictive. I wonder how many years it will be until somebody studies that :)		So the next question is whether Vitamin D is addictive. I wonder how many years it will be until somebody studies that :)
Line 136:		Line 140:
	..Trevor..		..Trevor..

-	http://www.sciencedaily.com/releases/2010/03/100303162854.htm	+	https://www.sciencedaily.com/releases/2010/03/100303162854.htm

	</blockquote>		</blockquote>
Line 142:		Line 146:

	<blockquote>Med Hypotheses. 2001 Nov;57(5):609-11.		<blockquote>Med Hypotheses. 2001 Nov;57(5):609-11.
-	Role of endogenous opioids in the effects of light on mood and behavior.(({{pubmed>long:11735320}}))	+	Role of endogenous opioids in the effects of light on mood and behavior.(({{pmid>long:11735320}}))
	Sher L.		Sher L.
	drleosher@aol.com		drleosher@aol.com
Line 168:		Line 172:

	<blockquote>		<blockquote>
-	http://www.sciencedaily.com/releases/2011/03/110309073938.htm	+	https://www.sciencedaily.com/releases/2011/03/110309073938.htm

	Sunlight Can Influence the Breakdown of Medicines in the Body		Sunlight Can Influence the Breakdown of Medicines in the Body
Line 189:		Line 193:
	From: Dr Trevor Marshall		From: Dr Trevor Marshall
	Date: 2011-03-13 11:37:08		Date: 2011-03-13 11:37:08
-	Reply: http://marshallprotocol.com/reply.php?topic_id=11829	+	Reply: https://marshallprotocol.com/reply.php?topic_id=11829

	Very interesting. They are still assuming that the seasonal changes in Vit D are due to sun exposure during each season, and not to changes in some other metabolite as seasons fluctuate (body temperature, for example).		Very interesting. They are still assuming that the seasonal changes in Vit D are due to sun exposure during each season, and not to changes in some other metabolite as seasons fluctuate (body temperature, for example).
Line 223:		Line 227:
	CONCLUSION: This first study of the distribution of myositis phenotypes and UV radiation exposure in the US showed that UV radiation may modulate the clinical and immunologic expression of autoimmune disease in women. Further investigation of the mechanisms by which these effects are produced may provide insights into pathogenesis and suggest therapeutic or preventative strategies.		CONCLUSION: This first study of the distribution of myositis phenotypes and UV radiation exposure in the US showed that UV radiation may modulate the clinical and immunologic expression of autoimmune disease in women. Further investigation of the mechanisms by which these effects are produced may provide insights into pathogenesis and suggest therapeutic or preventative strategies.
	PMID: 19644877</blockquote>		PMID: 19644877</blockquote>
-	===== References =====	+	===== References ===== </nodisp>

TENS (transcutaneous electrical nerve stimulation)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

08.25.2017		current
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	TENS and AL-TENS [acupuncture-like TENS] are shown to be effective in pain control over placebo in this review. Heterogeneity of the included studies was observed, which might be due to the different study designs and outcomes used. More well designed studies with a standardized protocol and adequate number of participants are needed to conclude the effectiveness of TENS in the treatment of OA of the knee.		TENS and AL-TENS [acupuncture-like TENS] are shown to be effective in pain control over placebo in this review. Heterogeneity of the included studies was observed, which might be due to the different study designs and outcomes used. More well designed studies with a standardized protocol and adequate number of participants are needed to conclude the effectiveness of TENS in the treatment of OA of the knee.

-	//Manathip Osiri et al.//(({{pubmed>long:11034768}})) </blockquote>	+	//Manathip Osiri et al.//(({{pmid>long:11034768}})) </blockquote>


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	I too have the arm/rotator cuff problem and have found the TENS unit very helpful for the pain. If you have insurance coverage, you should give it a try. My provider paid to rent one per month to see if it helps. I use an Epix XL, my husband just got an Epix VT for his back.		I too have the arm/rotator cuff problem and have found the TENS unit very helpful for the pain. If you have insurance coverage, you should give it a try. My provider paid to rent one per month to see if it helps. I use an Epix XL, my husband just got an Epix VT for his back.

-	My husband's physical therapist recommended this one to purchase saying it was as good as the more expensive one that the insurance company paid for: [[http://www.alimed.com/ProductDetail.asp?style=78804&fprd=BioStim+INF+Digital+Interferential+Stimulator&oid1=&oid2=&print=Y\|BioStim, Alimed]]. You need a doctor's prescription which I'm sure wouldn't be hard to get. The physical therapist thought it was around $140 but at this website it says $299. I don't know if you can shop for price somewhere else. But I use mine a lot and it would be worth the price. It's drug free pain relief.	+	My husband's physical therapist recommended this one to purchase saying it was as good as the more expensive one that the insurance company paid for: [[https://www.alimed.com/ProductDetail.asp?style=78804&fprd=BioStim+INF+Digital+Interferential+Stimulator&oid1=&oid2=&print=Y\|BioStim, Alimed]]. You need a doctor's prescription which I'm sure wouldn't be hard to get. The physical therapist thought it was around $140 but at this website it says $299. I don't know if you can shop for price somewhere else. But I use mine a lot and it would be worth the price. It's drug free pain relief.

	//MrsKeeper, MarshallProtocol.com// </blockquote>		//MrsKeeper, MarshallProtocol.com// </blockquote>
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	===== Read more =====		===== Read more =====

-	* [[http://www.amazon.com/exec/obidos/tg/detail/-/B000XHNBLU/ref=pd_luc_mri?_encoding=UTF8&m=ATVPDKIKX0DER&v=glance\|Prosepra Electronic Pulse Massager / TENS]] - a low cost unit, no rotary control, available from several suppliers	+	* [[https://www.amazon.com/exec/obidos/tg/detail/-/B000XHNBLU/ref=pd_luc_mri?_encoding=UTF8&m=ATVPDKIKX0DER&v=glance\|Prosepra Electronic Pulse Massager / TENS]] - a low cost unit, no rotary control, available from several suppliers
-	* [[http://www.spine-health.com/treatment/pain-management/transcutaneous-electrical-nerve-stimulators-tens\|Types of TENS units]]	+	* [[https://www.spine-health.com/treatment/pain-management/transcutaneous-electrical-nerve-stimulators-tens\|Types of TENS units]]
-	* [[http://www.drugs.com/cg/how-to-use-a-tens-unit.html\|How to use a TENS unit]]	+	* [[https://www.drugs.com/cg/how-to-use-a-tens-unit.html\|How to use a TENS unit]]


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=39933#p39933 s91	+	* https://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=39933#p39933 s91
		+	* store closed [[https://www.masters.com.au/what_TENS.htm\|What is TENS?]]
	* move acupuncture to its own article?		* move acupuncture to its own article?

-	=====References=====	+	=====References=====</nodisp>

Thyroid hormone and mineral supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.18.2020		current
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	===== Research =====		===== Research =====

-	Microbiota and Thyroid Interaction in Health and Disease(({{pubmed>long:31257166}}))	+	Mineral requirements

-	This article provides an update on the role of the essential trace element selenium(({{pubmed>long:26313901}}))	+	Microbiota and Thyroid Interaction in Health and Disease(({{pmid>long:31257166}}))

-	Selenium and iodine are essential for thyroid hormone synthesis and function. (({{pubmed>long:26088475}}))	+	This article provides an update on the role of the essential trace element selenium(({{pmid>long:26313901}}))

-	<blockquote>Although iodine remains the major nutrient required for the functioning of the thyroid gland, other dietary components play important roles in clinical thyroidology-these include selenium, l-carnitine, myo-inositol, melatonin, and resveratrol-some of which have antioxidant properties</blockquote>(({{pubmed>long: 31540254}}))	+	Selenium and iodine are essential for thyroid hormone synthesis and function. (({{pmid>long:26088475}}))
		+
		+	<blockquote>Although iodine remains the major nutrient required for the functioning of the thyroid gland, other dietary components play important roles in clinical thyroidology-these include selenium, l-carnitine, myo-inositol, melatonin, and resveratrol-some of which have antioxidant properties</blockquote>(({{pmid>long: 31540254}}))


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	===== Read more =====		===== Read more =====

-	* [[http://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf\|biological effects]]	+	* [[https://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf\|biological effects]]

	{{tag>supplements}}		{{tag>supplements}}
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4479&forum_id=37&jump_to=59298#p59298	+	* https://www.marshallprotocol.com/view_topic.php?id=4479&forum_id=37&jump_to=59298#p59298
-	* http://www.marshallprotocol.com/view_topic.php?id=6333&forum_id=11	+	* https://www.marshallprotocol.com/view_topic.php?id=6333&forum_id=11
		+
		+	=====References=====</nodisp>

-	=====References=====

Trigger point therapy

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	====== Trigger point therapy ======		====== Trigger point therapy ======

-	Trigger points are described as hyperirritable spots in skeletal muscle that are associated with palpable nodules in taut bands of muscle fibers. Trigger point researchers believe that palpable nodules are small contraction knots and a common cause of pain. Compression of a trigger point may elicit local tenderness, pain elsewhere, or local twitch response.	+	Trigger points are described as hyper-irritable spots in skeletal muscle that are associated with palpable nodules in taut bands of muscle fibers. Trigger point researchers believe that palpable nodules are small contraction knots and a common cause of pain. Compression of a trigger point may elicit local tenderness, pain elsewhere, or local twitch response.


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	* //The trigger point therapy workbook: your self-treatment guide for pain relief, second edition// – self-help book designed to help the layperson to treat themselves for painful trigger points with massage		* //The trigger point therapy workbook: your self-treatment guide for pain relief, second edition// – self-help book designed to help the layperson to treat themselves for painful trigger points with massage
-	* [[http://www.triggerpointbook.com/\|selections available from author's website]]	+	* [[https://www.triggerpointbook.com/\|selections available from author's website]]
-	* [[http://www.amazon.com/gp/product/1572243759\|book available on Amazon.com]]	+	* [[https://www.amazon.com/gp/product/1572243759\|book available on Amazon.com]]
-	* //[[http://www.amazon.com/Travell-Simons-Myofascial-Pain-Dysfunction/dp/0683307711/ref=sr_1_1?ie=UTF8&s=books&qid=1242767525&sr=1-1\|Travell & Simons' myofascial pain and dysfunction: the trigger point therapy workbook]]// – a two-volume manual	+	* //[[https://www.amazon.com/Travell-Simons-Myofascial-Pain-Dysfunction/dp/0683307711/ref=sr_1_1?ie=UTF8&s=books&qid=1242767525&sr=1-1\|Travell & Simons' myofascial pain and dysfunction: the trigger point therapy workbook]]// – a two-volume manual


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=75446#p75446 s102	+	* https://www.marshallprotocol.com/view_topic.php?id=4446&forum_id=37&jump_to=75446#p75446 s102
	*		*
-	=====References=====	+	=====References=====</nodisp>

Vitamin and mineral supplementation

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Whey protein

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	{{tag>non-MP_therapies proteins}}		{{tag>non-MP_therapies proteins}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1078.html	+	* https://www.marshallprotocol.com/forum32/1078.html
		+
		+	=====References=====</nodisp>

02.07.2019		current
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	* escitalopram (Cipralex, Esipram, Lexapro, Seroplex)		* escitalopram (Cipralex, Esipram, Lexapro, Seroplex)
	* fluoxetine (Actan, Fluxene, Lorien, Lovan, Prozac, Tuneluz)		* fluoxetine (Actan, Fluxene, Lorien, Lovan, Prozac, Tuneluz)
-	* fluphenazine (Modecate, Prolixin Decanoate, Dapotum D, Anatensol, Fludecate, Sinqualone Deconoate, Dapotum Injektion, Flunanthate, Moditen Enanthate Injection, Sinqualone Enanthate, Prolixin, Permitil, Dapotum, Lyogen, Moditen, Omca, Sediten, Selecten, Sevinol, Sinqualone, Trancin) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pubmed>long:20382888}}))	+	* fluphenazine (Modecate, Prolixin Decanoate, Dapotum D, Anatensol, Fludecate, Sinqualone Deconoate, Dapotum Injektion, Flunanthate, Moditen Enanthate Injection, Sinqualone Enanthate, Prolixin, Permitil, Dapotum, Lyogen, Moditen, Omca, Sediten, Selecten, Sevinol, Sinqualone, Trancin) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pmid>long:20382888}}))
	* nortriptyline (Aventyl, Norpress, Pamelor)		* nortriptyline (Aventyl, Norpress, Pamelor)
	* paroxetine (Aropax, Paxil, Paxil CR, Paxxet, Pexeva, Sereupin, Seroxat)		* paroxetine (Aropax, Paxil, Paxil CR, Paxxet, Pexeva, Sereupin, Seroxat)
	* S-Adenosyl-L-Methionine (SAM-e)		* S-Adenosyl-L-Methionine (SAM-e)
-	* sertraline (Eleva, Lustral, Sertra, Xydep, Zoloft) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pubmed>long:20382888}}))	+	* sertraline (Eleva, Lustral, Sertra, Xydep, Zoloft) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pmid>long:20382888}}))
	* St. John's wort – contains about a dozen compounds of potential pharmacological activity. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor, among other mechanisms. The activation of PXR would give immunosupression similar to minocycline. Contraindicated.		* St. John's wort – contains about a dozen compounds of potential pharmacological activity. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor, among other mechanisms. The activation of PXR would give immunosupression similar to minocycline. Contraindicated.
	* trazodone (APO-Trazodone, Desyrel, Donaren)		* trazodone (APO-Trazodone, Desyrel, Donaren)
-	* trifluoperazine (Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pubmed>long:20382888}}))	+	* trifluoperazine (Eskazinyl, Eskazine, Jatroneural, Modalina, Stelazine, Terfluzine, Trifluoperaz, Triftazin) – shown to be "a direct inhibitor of the innate immune signaling pathway"(({{pmid>long:20382888}}))
	* venlafaxine (Effexor, Effexor XR, PMS-Venlafaxine XR, Venlafaxine XR)		* venlafaxine (Effexor, Effexor XR, PMS-Venlafaxine XR, Venlafaxine XR)

		+	<blockquote>I became increasingly more and more irritable and angry on St. John's Wort, and I kept raising the dose, trying to compensate. When I finally got up to the maximum dose after about 9 months on it, and figured out it was the St. John's Wort that was responsible for my anger and irritability, I stopped it cold turkey. And ended up in a psychiatric ward two days later from being suicidal, with very disjointed and slow thinking processes, and a lot of confusion/brain fog and severe depression.

		+
		+	//L.J.//</blockquote>


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	According to published reports, lithium affects the immune system profoundly.		According to published reports, lithium affects the immune system profoundly.

-	Lithium has some antiviral effects. A 2000 study stated that the drug has been shown to have antiviral effects in experimental and clinical conditions, particularly against herpes viruses.(({{pubmed>long:11071016}})) However, the antidepressant's immunosuppressive effects may be dominant over its anti-infective impact. Lithium may exacerbate autoimmune conditions such as thyroiditis or rarely Graves' disease.(({{pubmed>long:19942149}})) The common clinical side effects of the drug are goitre (swelling in the thyroid gland) in up to 40% and hypothyroidism in about 20%.	+	Lithium has some antiviral effects. A 2000 study stated that the drug has been shown to have antiviral effects in experimental and clinical conditions, particularly against herpes viruses.(({{pmid>long:11071016}})) However, the antidepressant's immunosuppressive effects may be dominant over its anti-infective impact. Lithium may exacerbate autoimmune conditions such as thyroiditis or rarely Graves' disease.(({{pmid>long:19942149}})) The common clinical side effects of the drug are goitre (swelling in the thyroid gland) in up to 40% and hypothyroidism in about 20%.

	Patients or physicians contemplating the Marshall Protocol should work out a plan with their doctor to wean lithium prior to beginning minocycline.		Patients or physicians contemplating the Marshall Protocol should work out a plan with their doctor to wean lithium prior to beginning minocycline.
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	===== Efficacy =====		===== Efficacy =====

-	As described in a [[http://www.medscape.com/viewarticle/727323\|Medscape article]], a 2010 review of four meta-analyses of efficacy trials submitted to the US Food and Drug Administration (FDA) suggests that antidepressants are only "marginally efficacious" compared with placebo and "document profound publication bias that inflates their apparent efficacy."(({{pubmed>long:20616621}}))	+	As described in a [[https://www.medscape.com/viewarticle/727323\|Medscape article]], a 2010 review of four meta-analyses of efficacy trials submitted to the US Food and Drug Administration (FDA) suggests that antidepressants are only "marginally efficacious" compared with placebo and "document profound publication bias that inflates their apparent efficacy."(({{pmid>long:20616621}}))

	In addition, when the researchers also analyzed the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, "the largest antidepressant effectiveness trial ever conducted," they found that "the effectiveness of antidepressant therapies was probably even lower than the modest one reported...with an apparent progressively increasing dropout rate across each study phase.		In addition, when the researchers also analyzed the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, "the largest antidepressant effectiveness trial ever conducted," they found that "the effectiveness of antidepressant therapies was probably even lower than the modest one reported...with an apparent progressively increasing dropout rate across each study phase.
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	* atherosclerosis – Antidepressants may boost mood at the expense of accelerated atherosclerosis for middle-age men, according to an observational study of more than 500 twins who had served in the Vietnam War.((Shah AJ, et al "Association of antidepressant medications with carotid intima media thickness in middle aged veteran twins" ACC 2011.))		* atherosclerosis – Antidepressants may boost mood at the expense of accelerated atherosclerosis for middle-age men, according to an observational study of more than 500 twins who had served in the Vietnam War.((Shah AJ, et al "Association of antidepressant medications with carotid intima media thickness in middle aged veteran twins" ACC 2011.))
-	* obesity – According to a 2009 //JAMA// article, subjects treated with antipsychotics became overweight or obese in as little as 12 weeks.(({{pubmed>long:19861668}})) A team led by Dr. Christoph Correll of Zucker Hillside Hospital and the Feinstein Institute for Medical Research in New York studied 272 children and teens aged 4 to 19 with bipolar disorder, schizophrenia and disruptive or aggressive behavior spectrum disorders.(({{pubmed>long:20586697}})) After roughly 11 weeks, those who took Zyprexa gained an average of 18.7 pounds (8.5 kg), those on Seroquel gained 13.4 pounds (6.1 kg), those on Risperdal gained 11.7 pounds (3.5 kg) and those on Abilify gained 9.7 pounds (4.4 kg). "The weight gain is dramatic, rapid and pervasive," Correll [[http://www.reuters.com/article/idUSTRE59Q4Q920091028\|said]] in a telephone interview.	+	* obesity – According to a 2009 //JAMA// article, subjects treated with antipsychotics became overweight or obese in as little as 12 weeks.(({{pmid>long:19861668}})) A team led by Dr. Christoph Correll of Zucker Hillside Hospital and the Feinstein Institute for Medical Research in New York studied 272 children and teens aged 4 to 19 with bipolar disorder, schizophrenia and disruptive or aggressive behavior spectrum disorders.(({{pmid>long:20586697}})) After roughly 11 weeks, those who took Zyprexa gained an average of 18.7 pounds (8.5 kg), those on Seroquel gained 13.4 pounds (6.1 kg), those on Risperdal gained 11.7 pounds (3.5 kg) and those on Abilify gained 9.7 pounds (4.4 kg). "The weight gain is dramatic, rapid and pervasive," Correll [[https://www.reuters.com/article/idUSTRE59Q4Q920091028\|said]] in a telephone interview.
-	* risk of autism – A case control study, which looked at medical records of California mothers, found that expectant mothers who took an antidepressant medication increased their risk of delivering a child with autism spectrum disorder (ASD).(({{pubmed>long:21727247}})) The 2011 analysis suggested that exposure to a selective serotonin reuptake inhibitor, particularly during the first trimester, //may// somewhat increase the risk of ASD.	+	* risk of autism – A case control study, which looked at medical records of California mothers, found that expectant mothers who took an antidepressant medication increased their risk of delivering a child with autism spectrum disorder (ASD).(({{pmid>long:21727247}})) The 2011 analysis suggested that exposure to a selective serotonin reuptake inhibitor, particularly during the first trimester, //may// somewhat increase the risk of ASD.


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	===== Read more =====		===== Read more =====

-	* [[http://www.nybooks.com/articles/archives/2011/jun/23/epidemic-mental-illness-why/\|The Epidemic of Mental Illness: Why?]] – In an essay in //The New York Review of Books//, Marcia Angell, former editor in chief of //The New England Journal of Medicine//, favorably entertains the premise that “psychoactive drugs are useless."	+	* [[https://www.nybooks.com/articles/archives/2011/jun/23/epidemic-mental-illness-why/\|The Epidemic of Mental Illness: Why?]] – In an essay in //The New York Review of Books//, Marcia Angell, former editor in chief of //The New England Journal of Medicine//, favorably entertains the premise that “psychoactive drugs are useless."
-	* Fluoxetine inhibits coxsackie virus replication – A 2012 study showed that Prozac reduced the synthesis of viral RNA and protein.(({{pubmed>long:22751539}}))	+	* Fluoxetine inhibits coxsackie virus replication – A 2012 study showed that Prozac reduced the synthesis of viral RNA and protein.(({{pmid>long:22751539}}))


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	broken [[http://www.marshallprotocol.com/reply.php?topic_id=14385\|St. John's wort]]	+	broken [[https://www.marshallprotocol.com/reply.php?topic_id=14385\|St. John's wort]]

-	Canadian judge rules SSRI antidepressants like Prozac can cause children to commit murder ... http://www.naturalnews.com/034433_SSRI_drugs_children_murder.html	+	Canadian judge rules SSRI antidepressants like Prozac can cause children to commit murder ... https://www.naturalnews.com/034433_SSRI_drugs_children_murder.html

	Broad Review of FDA Trials Suggests Antidepressants Only Marginally Better than Placebo		Broad Review of FDA Trials Suggests Antidepressants Only Marginally Better than Placebo

-	http://www.medscape.com/viewarticle/727323	+	https://www.medscape.com/viewarticle/727323


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=2696&forum_id=32&jump_to=73551#p73551 f104	+	* https://www.marshallprotocol.com/view_topic.php?id=2696&forum_id=32&jump_to=73551#p73551 f104
	*		*
	*		*
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-	* [[http://www.reuters.com/article/idUSTRE6A059M20101101\|Teenager recovery from depression often fleeting]] - full text [[http://archpsyc.ama-assn.org/cgi/content/full/archgenpsychiatry.2010.150\|here]]	+	* [[https://www.reuters.com/article/idUSTRE6A059M20101101\|Teenager recovery from depression often fleeting]] - full text [[https://archpsyc.ama-assn.org/cgi/content/full/archgenpsychiatry.2010.150\|here]]


	<blockquote>From: Dr Trevor MarshallDate: 2011-02-09 20:37:05		<blockquote>From: Dr Trevor MarshallDate: 2011-02-09 20:37:05
-	Reply: http://www.marshallprotocol.com/reply.php?topic_id=14045	+	Reply: https://www.marshallprotocol.com/reply.php?topic_id=14045

	Even a short time on antipsychotics may increase the risk of heart disease:		Even a short time on antipsychotics may increase the risk of heart disease:

-	http://www.reuters.com/article/2011/02/09/us-antipsychotics-heart-idUSTRE71871020110209	+	https://www.reuters.com/article/2011/02/09/us-antipsychotics-heart-idUSTRE71871020110209

-	http://archpsyc.ama-assn.org/cgi/content/abstract/archgenpsychiatry.2011.2v1	+	https://archpsyc.ama-assn.org/cgi/content/abstract/archgenpsychiatry.2011.2v1
	Foley and her team looked at 25 previous studies that had tracked risk factors for heart disease in patients taking older or newer antipsychotics. These included high blood pressure, cholesterol levels, and body weight.		Foley and her team looked at 25 previous studies that had tracked risk factors for heart disease in patients taking older or newer antipsychotics. These included high blood pressure, cholesterol levels, and body weight.
	They found that across all the studies, six to seven of every 10 people on antipsychotics were overweight after six months. Before taking the drugs, only about four of every 10 were overweight, the same as in the general population.		They found that across all the studies, six to seven of every 10 people on antipsychotics were overweight after six months. Before taking the drugs, only about four of every 10 were overweight, the same as in the general population.
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	"In addition to the physical contact, it surprised us to find that these immune cells also have machinery to take up serotonin and to secrete it in an excitatory manner," Ahern said. "The point behind this transmission is not entirely clear, but it appears to be an additional way of stimulating a T cell response."		"In addition to the physical contact, it surprised us to find that these immune cells also have machinery to take up serotonin and to secrete it in an excitatory manner," Ahern said. "The point behind this transmission is not entirely clear, but it appears to be an additional way of stimulating a T cell response."
	Drugs that block serotonin reuptake "likely change some of the parameters of T-cell activation, but we don't know yet if it enhances or inhibits the total immune response," Ahern said. "But it is something that should be explored because we really have no idea what SSRIs are doing to people's immune systems."</blockquote>		Drugs that block serotonin reuptake "likely change some of the parameters of T-cell activation, but we don't know yet if it enhances or inhibits the total immune response," Ahern said. "But it is something that should be explored because we really have no idea what SSRIs are doing to people's immune systems."</blockquote>
-	===== References =====	+	===== References =====</nodisp>

08.29.2012		current
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-	Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance and is required for proper proliferation and function of natural killer cells, T cells, B cells, macrophages, and dendritic cells.(({{pubmed>long:16331857}})) Anti-TNF drugs, also known as TNF blockers, are drugs which interfere with the body's production of TNF-alpha.(({{pubmed>long: 18387510}}))	+	Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance and is required for proper proliferation and function of natural killer cells, T cells, B cells, macrophages, and dendritic cells.(({{pmid>long:16331857}})) Anti-TNF drugs, also known as TNF blockers, are drugs which interfere with the body's production of TNF-alpha.(({{pmid>long: 18387510}}))

	Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects. Also, anti-TNF inhibitors can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.		Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects. Also, anti-TNF inhibitors can make a patient feel temporarily less symptomatic, because they reduce immunopathology, the bacterial die-off reaction.
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	During immunopathology, cytokines, are elevated. Although cytokines are usually associated with an inflammatory process, it has been demonstrated that TNF, interleukin-6 (IL-6) and IL-8 are involved in the immunopathological reaction, each peaking at different times throughout the response: TNF elevates first, shortly after antibiotic administration, followed by IL-6 at the onset of symptoms and finally IL-8.		During immunopathology, cytokines, are elevated. Although cytokines are usually associated with an inflammatory process, it has been demonstrated that TNF, interleukin-6 (IL-6) and IL-8 are involved in the immunopathological reaction, each peaking at different times throughout the response: TNF elevates first, shortly after antibiotic administration, followed by IL-6 at the onset of symptoms and finally IL-8.

-	The release of cytokines appears to be essential for recovery after an infection. One study found that the cytokine TNF-alpha is necessary for the proper expression of acquired specific resistance following infection with //Mycobacterium tuberculosis//.(({{pubmed>long:18544042}})) (({{pubmed>long:12852719}})) (({{pubmed>long:15216471}})) Another effect of the use of TNF blockers is to break or reduce the formation of granuloma, one of the body's mechanisms to control bacterial pathogens.(({{pubmed>long:16322600}}))	+	The release of cytokines appears to be essential for recovery after an infection. One study found that the cytokine TNF-alpha is necessary for the proper expression of acquired specific resistance following infection with //Mycobacterium tuberculosis//.(({{pmid>long:18544042}})) (({{pmid>long:12852719}})) (({{pmid>long:15216471}})) Another effect of the use of TNF blockers is to break or reduce the formation of granuloma, one of the body's mechanisms to control bacterial pathogens.(({{pmid>long:16322600}}))

	For these reasons among others, TNF-alpha inhibitors, drugs which suppress the cytokine, are contraindicated for MP patients.		For these reasons among others, TNF-alpha inhibitors, drugs which suppress the cytokine, are contraindicated for MP patients.
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	===== Increased risk of infection =====		===== Increased risk of infection =====

-	One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 2.0 times higher risk for serious infections.(({{pubmed>long:16705109}})) The study's authors concluded that these side effects were dose-dependent.	+	One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 2.0 times higher risk for serious infections.(({{pmid>long:16705109}})) The study's authors concluded that these side effects were dose-dependent.


-	[[http://www.fda.gov/medwatch/SAFETY/2001/remicadeTB_deardoc.pdf\|According to Centocor]], the company which manufactures Remicade, patients taking the drug put themselves at increased risk for opportunistic infection.	+	[[https://google2.fda.gov/search?q=cache:8wrRnr956OEJ:www.accessdata.fda.gov/drugsatfda_docs/label/2002/inflcen062802lb.pdf+TNF-blocking+agents&client=FDAgov&output=xml_no_dtd&proxystylesheet=FDAgov&site=FDAgov&ie=UTF-8&access=p&oe=UTF-8\|According to Centocor]], the company which manufactures Remicade, patients taking the drug put themselves at increased risk for opportunistic infection.

	<blockquote>Serious infections, including sepsis and pneumonia, have been reported in patients receiving TNF-blocking agents. Some of these infections have been fatal.		<blockquote>Serious infections, including sepsis and pneumonia, have been reported in patients receiving TNF-blocking agents. Some of these infections have been fatal.

-	//U.S. Food and Drug Administration//, [[http://www.fda.gov/MedWatch/safety/2006/Oct_PIs/Remicade_PI.pdf\|2006 statement]]</blockquote>	+	//U.S. Food and Drug Administration//, [[https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/inflcen111099lb.pdf\|page 6 : Warnings]]</blockquote>

-	//M. tuberculosis// is one such infection.(({{pubmed>long:19565495}}))	+	//M. tuberculosis// is one such infection.(({{pmid>long:19565495}}))

	<blockquote>Cases of active tuberculosis have been reported worldwide with the use of therapeutic agents that inhibit tumour necrosis factor (TNF) alpha. TNF-alpha has a central role in mycobacterial infection and disease. Accordingly, progression of recently acquired tuberculosis infection or reactivation of remotely acquired infection //should be expected// with the use of anti-TNF agents.		<blockquote>Cases of active tuberculosis have been reported worldwide with the use of therapeutic agents that inhibit tumour necrosis factor (TNF) alpha. TNF-alpha has a central role in mycobacterial infection and disease. Accordingly, progression of recently acquired tuberculosis infection or reactivation of remotely acquired infection //should be expected// with the use of anti-TNF agents.

-	//Michael A. Gardam, et al.// (({{pubmed>long:12614731}}))</blockquote>	+	//Michael A. Gardam, et al.// (({{pmid>long:12614731}}))</blockquote>

-	To reduce the likelihood of contracting or exacerbating tuberculosis, prospective patients are routinely tested for infection via a skin test. However, as some researchers have noted, TB skin tests on patients treated with immunosupressants, which are routinely used on rheumatoid arthritis patients, are not reliable, because they result in false negatives.(({{pubmed>long:12614731}}))	+	To reduce the likelihood of contracting or exacerbating tuberculosis, prospective patients are routinely tested for infection via a skin test. However, as some researchers have noted, TB skin tests on patients treated with immunosupressants, which are routinely used on rheumatoid arthritis patients, are not reliable, because they result in false negatives.(({{pmid>long:12614731}}))

-	"Exaggerated //Borreliosis// infections" have been noted(({{pubmed>long:20184613}})) as have been fatal fungal infections. In 2008, the FDA [[http://www.fda.gov/CDER/drug/InfoSheets/HCP/TNF_blockersHCP.htm\|ordered stronger warnings]] on Enbrel, Remicade, Humira and Cimzia due to increased risk of fungal infections.	+	"Exaggerated //Borreliosis// infections" have been noted(({{pmid>long:20184613}})) as have been fatal fungal infections. In 2008, the FDA ordered stronger warnings on Enbrel, Remicade, Humira and Cimzia due to increased risk of fungal infections.

	Researchers have also observed reactivation of latent viral infections, namely hepatitis B in patients who are chronic carriers of the virus.		Researchers have also observed reactivation of latent viral infections, namely hepatitis B in patients who are chronic carriers of the virus.

-	For these reasons, physicians are [[http://www.fda.gov/medwatch/SAFETY/2004/Remicade_12-22-04_PI.pdf\|strongly advised]] by the FDA not to prescribe TNF blockers to patients who suffer from active or latent infections and to discontinue therapy in the event of serious infection. Yet, this advisory is strikingly incomplete. In fact, all patients who suffer from diseases for which an anti-TNF agent could possibly indicated suffer from a chronic bacterial infection, a fact which underscores the importance of not taking such drugs.	+	For these reasons, physicians are [[https://www.fda.gov/medwatch/SAFETY/2004/Remicade_12-22-04_PI.pdf\|strongly advised]] by the FDA not to prescribe TNF blockers to patients who suffer from active or latent infections and to discontinue therapy in the event of serious infection. Yet, this advisory is strikingly incomplete. In fact, all patients who suffer from diseases for which an anti-TNF agent could possibly indicated suffer from a chronic bacterial infection, a fact which underscores the importance of not taking such drugs.

	===== Other adverse effects ======		===== Other adverse effects ======

-	* Allergic reaction – Some patients report an allergic response to Remicade. One possible reason may be that the [[http://cancerweb.ncl.ac.uk/cgi-bin/omd?chimeric+molecule\|chimeric monoclonal]] antibody in Remicade is part human, part mouse. Exposed to purely mouse (murine) antibodies, human immune systems naturally develop human antibodies to the foreign mouse proteins, a process which can trigger an allergic-like response.	+	* Allergic reaction – Some patients report an allergic response to Remicade. One possible reason may be that the [[https://cancerweb.ncl.ac.uk/cgi-bin/omd?chimeric+molecule\|chimeric monoclonal]] antibody in Remicade is part human, part mouse. Exposed to purely mouse (murine) antibodies, human immune systems naturally develop human antibodies to the foreign mouse proteins, a process which can trigger an allergic-like response.
	* Congestive heart failure – Exacerbation of CHF is a major side effect of Remicade use in patients with moderate to severe CHF. This is especially problematic in that many sarcoidosis patients do not know that they have cardiac involvement.		* Congestive heart failure – Exacerbation of CHF is a major side effect of Remicade use in patients with moderate to severe CHF. This is especially problematic in that many sarcoidosis patients do not know that they have cardiac involvement.
-	* Liver problems – [[http://www.fda.gov/medwatch/SAFETY/2004/Remicade_12-22-04_PI.pdf\|According to the FDA]], patients taking Remicade can (but rarely) experience severe hepatic reactions including acute liver failure, jaundice, hepatitis and cholestasis.	+	* Liver problems – [[https://www.fda.gov/medwatch/SAFETY/2004/Remicade_12-22-04_PI.pdf\|According to the FDA]], patients taking Remicade can (but rarely) experience severe hepatic reactions including acute liver failure, jaundice, hepatitis and cholestasis.
-	* Skin problems – In one prospective trial, 25% of patients on TNF-alpha-blocking therapy suffered from a dermatological condition that led them to visit a skin specialist. In a control group of patients who were not undergoing TNF-alpha blocking therapy and had less severe disease only 13% visited a dermatologist during the same period of time.(({{pubmed>long:15899052}}))	+	* Skin problems – In one prospective trial, 25% of patients on TNF-alpha-blocking therapy suffered from a dermatological condition that led them to visit a skin specialist. In a control group of patients who were not undergoing TNF-alpha blocking therapy and had less severe disease only 13% visited a dermatologist during the same period of time.(({{pmid>long:15899052}}))
-	* Cancer – One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 3.3 times higher risk for "malignancies."(({{pubmed>long:16705109}})) The study's authors concluded that these side effects were dose-dependent. Since then, the FDA has issued [[http://www.fda.gov/CDER/drug/early_comm/TNF_blockers.htm\|an early communication]] about an ongoing investigation of approximately 30 reports of cancer in children and young adults. More recently, a study of over 20,000 US military veterans show that nonmelanoma skin cancer risk is about one third higher for patients with rheumatoid arthritis treated with TNF inhibitors than for similar patients treated with nonbiologic disease-modifying antirheumatic drugs (DMARDs).(({{pubmed>long:21415022}}))	+	* Cancer – One recent systematic review of the adverse effects of anti-TNF therapies as they were used in rheumatoid arthritis concluded that patients taking the drugs are at 3.3 times higher risk for "malignancies."(({{pmid>long:16705109}})) The study's authors concluded that these side effects were dose-dependent. Since then, the FDA has issued [[https://www.fda.gov/CDER/drug/early_comm/TNF_blockers.htm\|an early communication]] about an ongoing investigation of approximately 30 reports of cancer in children and young adults. More recently, a study of over 20,000 US military veterans show that nonmelanoma skin cancer risk is about one third higher for patients with rheumatoid arthritis treated with TNF inhibitors than for similar patients treated with nonbiologic disease-modifying antirheumatic drugs (DMARDs).(({{pmid>long:21415022}}))


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	Considering that Abbott’s Humira was the company’s best-selling product in 2007 with over $3 billion in sales, and Remicade also topped Schering-Plough’s portfolio with sales of $1.65 billion, there is minimal hope that such companies will be willing to embrace a true understanding of how their drugs foster the development of chronic disease.		Considering that Abbott’s Humira was the company’s best-selling product in 2007 with over $3 billion in sales, and Remicade also topped Schering-Plough’s portfolio with sales of $1.65 billion, there is minimal hope that such companies will be willing to embrace a true understanding of how their drugs foster the development of chronic disease.

-	Insurance coverage and baseline cost of anti-TNF drugs varies, but patients in the United States and Canada [[http://www.healingwell.com/community/default.aspx?f=38&m=1043934\|have reported]] being charged $4,600 or more for a single treatment of Remicade. According to one estimate, $1,000 of the $4,600 goes to pay the prescribing physician's clinical group.	+	Insurance coverage and baseline cost of anti-TNF drugs varies, but patients in the United States and Canada [[https://www.healingwell.com/community/default.aspx?f=38&m=1043934\|have reported]] being charged $4,600 or more for a single treatment of Remicade. According to one estimate, $1,000 of the $4,600 goes to pay the prescribing physician's clinical group.

-	One citizen watchdog group, the New Jersey Citizen Action (NJCA), [[http://www.prescriptionaccess.org/docs/remicade.pdf\|filed a lawsuit]] to stop Remicade from being promoted by promising doctors windfall profits when they prescribe the drug.	+	One citizen watchdog group, the New Jersey Citizen Action (NJCA), [[https://www.prescriptionaccess.org/docs/remicade.pdf\|filed a lawsuit]] to stop Remicade from being promoted by promising doctors windfall profits when they prescribe the drug.


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	{{tag> }}		{{tag> }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=28080#p28080 s32	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=28080#p28080 s32
-	===== References =====	+	===== References =====</nodisp>

10.24.2010		current
Line 3:		Line 3:


-	<relatedarticle> [[home:diseases\|Osteoporosis and osteopenia]] </article>	+	<relatedarticle> [[home:diseases:osteoporosis_osteopenia\|Osteoporosis and osteopenia]] </article>

	A variety of medications including the bisphosphonates have been touted to conserve or increase bone mass. These drugs have a number of side effects and are known or suspected to interfere with proper immune function.		A variety of medications including the bisphosphonates have been touted to conserve or increase bone mass. These drugs have a number of side effects and are known or suspected to interfere with proper immune function.
Line 10:		Line 10:
	Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digesting of bone by osteoclasts.		Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digesting of bone by osteoclasts.

-	The bisphosphonate has a variety of side effects:(({{pubmed>long:19371818}}))	+	The bisphosphonate has a variety of side effects:(({{pmid>long:19371818}}))
-	* chronic musculoskeletal pain(({{pubmed>long:17627083}}))	+	* chronic musculoskeletal pain(({{pmid>long:17627083}}))
-	* atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pubmed>long:8114238}}))	+	* atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pmid>long:8114238}}))
-	* calcium deposition in the soft tissues(({{pubmed>long: 14523647}}))	+	* calcium deposition in the soft tissues(({{pmid>long: 14523647}}))
	* osteonecrosis of the jaw, i.e. bone death		* osteonecrosis of the jaw, i.e. bone death
	* reduced organ function, e.g. renal dysfunction or failure		* reduced organ function, e.g. renal dysfunction or failure
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	* calcitonin (Miacalcin nasal spray) – A synthetic hormone with unknown effects on the immune system		* calcitonin (Miacalcin nasal spray) – A synthetic hormone with unknown effects on the immune system
-	* raloxifene (Evista) – An oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention ofosteoporosis in postmenopausal women. In a 2006 study published in //New England Journal of Medicine//, raloxifene produced significantly more strokes and blood clots than the placebo.(({{pubmed>long: 16837676}}))	+	* raloxifene (Evista) – An oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention ofosteoporosis in postmenopausal women. In a 2006 study published in //New England Journal of Medicine//, raloxifene produced significantly more strokes and blood clots than the placebo.(({{pmid>long: 16837676}}))
	* teriparatide (Forteo) – A hormonal injection of parathyroid hormone, a hormone secreted by the parathyroid gland that regulates calcium in the body. Parathyroid hormone controls many other hormones, and may cause deposition of calcium into soft tissues.		* teriparatide (Forteo) – A hormonal injection of parathyroid hormone, a hormone secreted by the parathyroid gland that regulates calcium in the body. Parathyroid hormone controls many other hormones, and may cause deposition of calcium into soft tissues.


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	EDIT


-	===== References =====	+	FDA Alert - Oral Bisphosphonates: Ongoing Safety Review - https://bit.ly/9EfpXY
		+
		+	===== References ===== </nodisp>

07.25.2019		current
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-	Patients who have spent time in an area of heavy metal contamination are advised to avoid such areas in future. An early patient who had worked continuously with heavy metal contamination in presence of volatile solvents, found recovery on MP was limited. Anyone in a similar position should test blood levels of those contaminants. If chelation is deemed necessary, it may be better to do this before MP rather than after.	+	Patients who have spent time in an area of heavy metal contamination are advised to avoid such areas in future. An early patient who had worked continuously with heavy metal contamination in presence of volatile solvents, found recovery on MP was limited. //Anyone in a similar position should test blood levels of those contaminants. If chelation is deemed necessary, it may be better to do this before MP rather than after.//

	Small amounts of heavy metals are excreted naturally. see below		Small amounts of heavy metals are excreted naturally. see below
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-	[[http://www.naturalstandard.com\|Natural Standard]], an evidence-based database for integrative medicine recently concluded (access requires a subscription) there are no studies on detoxification which qualify for listing in its online resource.	+	[[https://www.naturalstandard.com\|Natural Standard]], an evidence-based database for integrative medicine recently concluded (access requires a subscription) there are no studies on detoxification which qualify for listing in its online resource.


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	broken [[http://www.naturalstandard.com/monographs/monoframeset.asp?monograph=/monographs/alternativemodalities/detoxificationtherapy.asp%3Fprintversion%3Dtrue\|recently concluded]]	+	broken [[https://www.naturalstandard.com/monographs/monoframeset.asp?monograph=/monographs/alternativemodalities/detoxificationtherapy.asp%3Fprintversion%3Dtrue\|recently concluded]]

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/3472.html f315	+	* https://www.marshallprotocol.com/forum32/3472.html f315
-	* http://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=62387#p62387 f31	+	* https://www.marshallprotocol.com/view_topic.php?id=1078&forum_id=32&jump_to=62387#p62387 f31
-	* http://www.marshallprotocol.com/view_topic.php?id=3391&forum_id=37&jump_to=31002#p31002 s189	+	* https://www.marshallprotocol.com/view_topic.php?id=3391&forum_id=37&jump_to=31002#p31002 s189
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=43403#p43403 s165	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=43403#p43403 s165
-	* http://www.marshallprotocol.com/view_topic.php?id=9619&forum_id=32&jump_to=110274#p110274 f131	+	* https://www.marshallprotocol.com/view_topic.php?id=9619&forum_id=32&jump_to=110274#p110274 f131
-	* http://www.marshallprotocol.com/view_topic.php?id=9619&forum_id=32&jump_to=110274#p110274 f131	+	* https://www.marshallprotocol.com/view_topic.php?id=9619&forum_id=32&jump_to=110274#p110274 f131
	*		*
	*		*

-	===== References =====	+	===== References =====</nodisp>

12.31.2018		current
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	===== Introduction =====		===== Introduction =====

-	Frankincense and myrrh essential oils have been used in combination since 1500 BC; however, no antimicrobial investigations have been undertaken to confirm their effect in combination. This study validates the enhanced efficacy when used in combination against a selection of pathogens. (({{pubmed>long:22288378}}))	+	Frankincense and myrrh essential oils have been used in combination since 1500 BC; however, no antimicrobial investigations have been undertaken to confirm their effect in combination. This study validates the enhanced efficacy when used in combination against a selection of pathogens. (({{pmid>long:22288378}}))

	===== Some findings =====		===== Some findings =====


-	All fractions of frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines. Potency of essential oil-suppressed tumor cell viability may be associated with the greater abundance of high molecular weight compounds in Fractions III and IV. Although chemical component(s) responsible for tumor cell cytotoxicity remains undefined, crude essential oil prepared from hydrodistillation of Boswellia sacra gum resins might be a useful alternative therapeutic agent for treating patients with pancreatic adenocarcinoma, an aggressive cancer with poor prognosis.(({{pubmed>long:23237355}}))	+	All fractions of frankincense essential oil from Boswellia sacra are capable of suppressing viability and inducing apoptosis of a panel of human pancreatic cancer cell lines. Potency of essential oil-suppressed tumor cell viability may be associated with the greater abundance of high molecular weight compounds in Fractions III and IV. Although chemical component(s) responsible for tumor cell cytotoxicity remains undefined, crude essential oil prepared from hydrodistillation of Boswellia sacra gum resins might be a useful alternative therapeutic agent for treating patients with pancreatic adenocarcinoma, an aggressive cancer with poor prognosis.(({{pmid>long:23237355}}))

-	FREO (frankincense essential oil) exhibited robust anti-proliferative activity in skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1. We also studied its effect in regulating genome-wide gene expression. FREO robustly modulated global gene expression. Furthermore, Ingenuity® Pathway Analysis showed that FREO affected many important signaling pathways that are closely related to inflammation, immune response, and tissue remodeling. This study provides the first evidence of the biological activities of FREO in human dermal fibroblasts. (({{pubmed>long:29450138}}))	+	FREO (frankincense essential oil) exhibited robust anti-proliferative activity in skin cells. It also significantly inhibited collagen III, interferon gamma-induced protein 10, and intracellular cell adhesion molecule 1. We also studied its effect in regulating genome-wide gene expression. FREO robustly modulated global gene expression. Furthermore, Ingenuity® Pathway Analysis showed that FREO affected many important signaling pathways that are closely related to inflammation, immune response, and tissue remodeling. This study provides the first evidence of the biological activities of FREO in human dermal fibroblasts. (({{pmid>long:29450138}}))

-	Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (({{pubmed>long:22171782}}))	+	Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (({{pmid>long:22171782}}))

	==== Bladder cancer ====		==== Bladder cancer ====

-	Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability. (({{pubmed>long:19296830}}))	+	Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability. (({{pmid>long:19296830}}))


	Human bladder cancer J82 cells were more sensitive to the pro-apoptotic effects of frankincense essential oil than the immortalized normal bladder UROtsa cells. In contrast, sandalwood essential oil exhibited a similar potency in suppressing the viability of both J82 and UROtsa cells. Although frankincense and sandalwood essential oils activated common pathways such as inflammatory interleukins (IL-6 signaling), each essential oil had a unique molecular action on the bladder cancer cells.		Human bladder cancer J82 cells were more sensitive to the pro-apoptotic effects of frankincense essential oil than the immortalized normal bladder UROtsa cells. In contrast, sandalwood essential oil exhibited a similar potency in suppressing the viability of both J82 and UROtsa cells. Although frankincense and sandalwood essential oils activated common pathways such as inflammatory interleukins (IL-6 signaling), each essential oil had a unique molecular action on the bladder cancer cells.

-	Conclusion: The effects of frankincense and sandalwood essential oils on J82 cells and UROtsa cells involved different mechanisms leading to cancer cell death. While frankincense essential oil elicited selective cancer cell death via NRF-2-mediated oxidative stress, sandalwood essential oil induced non-selective cell death via DNA damage and cell cycle arrest. (({{pubmed>long:25006348}}))	+	Conclusion: The effects of frankincense and sandalwood essential oils on J82 cells and UROtsa cells involved different mechanisms leading to cancer cell death. While frankincense essential oil elicited selective cancer cell death via NRF-2-mediated oxidative stress, sandalwood essential oil induced non-selective cell death via DNA damage and cell cycle arrest. (({{pmid>long:25006348}}))


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	The oil was found to contain monoterpenes (13.1%), sesquiterpenes (1%), and diterpenes (42.5%)		The oil was found to contain monoterpenes (13.1%), sesquiterpenes (1%), and diterpenes (42.5%)
-	Biologically, the oil exhibited a strong immunostimulant activity (90% lymphocyte transformation) when assessed by a lymphocyte proliferation assay. (({{pubmed>long:12710734}}))	+	Biologically, the oil exhibited a strong immunostimulant activity (90% lymphocyte transformation) when assessed by a lymphocyte proliferation assay. (({{pmid>long:12710734}}))

-	The dominant compounds of B. carteri EO were α-pinene (38.41%) and myrcene (15.21%), while C. myrrha EO was characterized by high content of furanoeudesma-1,3-diene (17.65%), followed by curzerene (12.97%), β-elemene (12.70%), and germacrene B (12.15%). Burn incense fume and soot had α-pinene (68.6%) and incensole (28.6%) as the most dominant compounds, respectively. In vitro antimicrobial assays demonstrated high bacterial and fungal sensitivity to the liquid and vapour phases of EOs, and burn incense fume. (({{pubmed>long:29530608}}))	+	The dominant compounds of B. carteri EO were α-pinene (38.41%) and myrcene (15.21%), while C. myrrha EO was characterized by high content of furanoeudesma-1,3-diene (17.65%), followed by curzerene (12.97%), β-elemene (12.70%), and germacrene B (12.15%). Burn incense fume and soot had α-pinene (68.6%) and incensole (28.6%) as the most dominant compounds, respectively. In vitro antimicrobial assays demonstrated high bacterial and fungal sensitivity to the liquid and vapour phases of EOs, and burn incense fume. (({{pmid>long:29530608}}))


-	In this study, we assessed the possible effects of frankincense, pine needle and geranium essential oils on cell viability, proliferation, migration and invasion as well as the possible mechanisms. MCF-7 cells were treated with oils, and associations with BC were investigated. In the present study, we clearly revealed that frankincense, pine needle and geranium essential oils suppressed cell viability, proliferation, migration and invasion in human BC MCF-7 cells. Further data demonstrated that frankincense, pine needle and geranium essential oils induced apoptosis, but did not affect cell cycle progression. Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. In addition, these 3 essential oils modulated the activity of the AMPK/mTOR signaling pathway. (({{pubmed>long:29115548}}))	+	In this study, we assessed the possible effects of frankincense, pine needle and geranium essential oils on cell viability, proliferation, migration and invasion as well as the possible mechanisms. MCF-7 cells were treated with oils, and associations with BC were investigated. In the present study, we clearly revealed that frankincense, pine needle and geranium essential oils suppressed cell viability, proliferation, migration and invasion in human BC MCF-7 cells. Further data demonstrated that frankincense, pine needle and geranium essential oils induced apoptosis, but did not affect cell cycle progression. Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. In addition, these 3 essential oils modulated the activity of the AMPK/mTOR signaling pathway. (({{pmid>long:29115548}}))

-	The present study aimed to solubilize the antineoplastic agent, mitomycin C (MMC), in two nanoemulsions (NEs) consisting of different essential oils (ginger (Gi) and frankincense (Fr)) in order to examine their anticancer activities on the HeLa cervical cancer cells and MCF-7 breast cancer cells. (({{pubmed>long:30119267}}))	+	The present study aimed to solubilize the antineoplastic agent, mitomycin C (MMC), in two nanoemulsions (NEs) consisting of different essential oils (ginger (Gi) and frankincense (Fr)) in order to examine their anticancer activities on the HeLa cervical cancer cells and MCF-7 breast cancer cells. (({{pmid>long:30119267}}))

-	Using gas chromatography-mass spectrometry (GC-MS), 76 and 99 components were identified in the myrrh and frankincense essential oils, respectively, with the most abundant components, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl- and n-Octylacetate, accounting for 12.01 and 34.66%, respectively. The effects of the two essential oils, independently and as a mixture, on five tumor cell lines, MCF-7, HS-1, HepG2, HeLa and A549, were investigated using the MTT assay. The results indicated that the MCF-7 and HS-1 cell lines showed increased sensitivity to the myrrh and frankincense essential oils compared with the remaining cell lines. In addition, the anticancer effects of myrrh were markedly increased compared with those of frankincense, however, no significant synergistic effects were identified. (({{pubmed>long:24137478}}))	+	Using gas chromatography-mass spectrometry (GC-MS), 76 and 99 components were identified in the myrrh and frankincense essential oils, respectively, with the most abundant components, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl- and n-Octylacetate, accounting for 12.01 and 34.66%, respectively. The effects of the two essential oils, independently and as a mixture, on five tumor cell lines, MCF-7, HS-1, HepG2, HeLa and A549, were investigated using the MTT assay. The results indicated that the MCF-7 and HS-1 cell lines showed increased sensitivity to the myrrh and frankincense essential oils compared with the remaining cell lines. In addition, the anticancer effects of myrrh were markedly increased compared with those of frankincense, however, no significant synergistic effects were identified. (({{pmid>long:24137478}}))


	===== A patient's fatigue =====		===== A patient's fatigue =====

-	Fatigue experienced by patients diagnosed with cancer can be debilitating and can be challenging to manage. The use of supportive therapies such as essential oils is gaining popularity among patients diagnosed with cancer. This article describes one patient's experience using frankincense (Boswellia carterii) essential oil to help in the management of her fatigue. The topical application of the frankincense helped to take her fatigue from being barely able to lift her head to being able to do some basic activities of daily living.(({{pubmed>long:29642127}}))	+	Fatigue experienced by patients diagnosed with cancer can be debilitating and can be challenging to manage. The use of supportive therapies such as essential oils is gaining popularity among patients diagnosed with cancer. This article describes one patient's experience using frankincense (Boswellia carterii) essential oil to help in the management of her fatigue. The topical application of the frankincense helped to take her fatigue from being barely able to lift her head to being able to do some basic activities of daily living.(({{pmid>long:29642127}}))

	===== Biofilm =====		===== Biofilm =====

-	Boswellia spp. essential oils represent an interesting source of anti-microbial agents in the development of new strategies to prevent and treat biofilms. (({{pubmed>long:19146534}}))	+	Boswellia spp. essential oils represent an interesting source of anti-microbial agents in the development of new strategies to prevent and treat biofilms. (({{pmid>long:19146534}}))

	===== A southern hemisphere essential oil =====		===== A southern hemisphere essential oil =====

-	The major aromatic components of the essential leaf oil of the New Zealand lemonwood tree Pittosporum eugenioides are octyl acetate (33%), terpinen-4-ol (13%), decanol (6%) and (Z)-hex-3-enol (5%). These products are responsible for the characteristic Citrus-like aroma which is detected when the leaves are crushed, a phenomenon which provided the species with its common name. The major component of the oil, octyl acetate is also an abundant component of the essential oils of Heracleum and Boswellia species. (({{pubmed>long:15018048}}))	+	The major aromatic components of the essential leaf oil of the New Zealand lemonwood tree Pittosporum eugenioides are octyl acetate (33%), terpinen-4-ol (13%), decanol (6%) and (Z)-hex-3-enol (5%). These products are responsible for the characteristic Citrus-like aroma which is detected when the leaves are crushed, a phenomenon which provided the species with its common name. The major component of the oil, octyl acetate is also an abundant component of the essential oils of Heracleum and Boswellia species. (({{pmid>long:15018048}}))


	{{tag>non-MP_therapies}}		{{tag>non-MP_therapies}}

-	<note>Dear MPKB Reader: You have arrived at one of the articles that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we are still working on. Thanks for your patience.</note>

		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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		+	</nodisp>

09.01.2019		current
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	* hydrocodone-acetaminophen (Lortab, Norco, Percocet, Vicodin, Xodol) - Generally reported OK		* hydrocodone-acetaminophen (Lortab, Norco, Percocet, Vicodin, Xodol) - Generally reported OK
	* ibuprofen (Motrin, Advil) – of Motrin and Advil, Advil is preferred: Motrin has two times the additives a Motrin – 18 versus 9 – and the additives are some very difficult substances for the body to break down; //see NSAIDs//		* ibuprofen (Motrin, Advil) – of Motrin and Advil, Advil is preferred: Motrin has two times the additives a Motrin – 18 versus 9 – and the additives are some very difficult substances for the body to break down; //see NSAIDs//
-	* ketamine – An anesthetic drug commonly used in Lyme disease and chronic fatigue syndrome. Reports suggested that Ketamine doesn't work very well at palliation, and it loses efficacy quickly as the months go by. Also, Ketamine may damage bladder function.(({{pubmed>long:21684556}}))	+	* ketamine – An anesthetic drug commonly used in Lyme disease and chronic fatigue syndrome. Reports suggested that Ketamine doesn't work very well at palliation, and it loses efficacy quickly as the months go by. Also, Ketamine may damage bladder function.(({{pmid>long:21684556}}))
-	* morphine – avoid if possible - shown to be immunosuppressive in a study(({{pubmed>long:9208156}}))	+	* morphine – avoid if possible - shown to be immunosuppressive in a study(({{pmid>long:9208156}}))
-	* naltrexone – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone would certainly appear to affect the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.	+	* naltrexone – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone appears to negatively impact the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.


-	Ultra-low dose naltrexone enhances cannabinoid-induced antinociception. (({{pubmed>long:16286810}}))	+	Ultra-low dose naltrexone enhances cannabinoid-induced antinociception. (({{pmid>long:16286810}}))

	Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone.		Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone.

-	<blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[http://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773\|thread on CureMyTh1.org]] where these issues were briefly discussed.	+	<blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[https://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773\|thread on CureMyTh1.org]] where these issues were briefly discussed.

	LDN is special because it is a very low dose drug, and it must therefore be targeted tightly towards whatever it affects. Science is still not completely sure what LDN does, which is why there is this myth about it helping the immune system. However, it doesn't seem to get in the way of olmesartan, especially at low doses.		LDN is special because it is a very low dose drug, and it must therefore be targeted tightly towards whatever it affects. Science is still not completely sure what LDN does, which is why there is this myth about it helping the immune system. However, it doesn't seem to get in the way of olmesartan, especially at low doses.
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	//Trevor Marshall, PhD// </blockquote>		//Trevor Marshall, PhD// </blockquote>

-	Opioids do suppress the immune system,(({{pubmed>long:8947928}})) so it is important not to use them more than necessary. Patients should work with their physician to find an appropriate dose.	+	Opioids do suppress the immune system,(({{pmid>long:8947928}})) so it is important not to use them more than necessary. Patients should work with their physician to find an appropriate dose.
	==== NSAIDs ====		==== NSAIDs ====

	Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications.		Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications.

-	NSAIDS and COX-2 inhibitors can inhibit antibody production in human cells, thus lowering host defense.(({{pubmed>long:19345936}})) NSAIDs can also increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used. A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.(({{pubmed>long:20031832}}))	+	NSAIDS and COX-2 inhibitors can inhibit antibody production in human cells, thus lowering host defense.(({{pmid>long:19345936}})) NSAIDs can also increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used. A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.(({{pmid>long:20031832}}))


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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-	[[http://www.diagnosisms.com/2011/04/29/what-is-the-ms-hug/\|Excellent article re: "the MS Hug"]]	+	[[https://www.diagnosisms.com/2011/04/29/what-is-the-ms-hug/\|Excellent article re: "the MS Hug"]]

-	More than 20 studies, including a large analysis of data on more than 200,000 children, have produced results that link acetaminophen use to an increased risk of asthma. http://nyti.ms/u9ZxHZ	+	More than 20 studies, including a large analysis of data on more than 200,000 children, have produced results that link acetaminophen use to an increased risk of asthma. https://nyti.ms/u9ZxHZ


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	Common pain relief medications may influence cancer growth:		Common pain relief medications may influence cancer growth:
-	http://news.uchicago.edu/news.php?asset_id=1780	+	https://news.uchicago.edu/news.php?asset_id=1780

	<blockquote>NSAIDs actually inhibit immune tolerance/suppression. Prostanoids are highly immuno-suppressive, in particular PGE2, which is also associated with pain perception, fever and tissue healing. NSAIDs inhibit the cyclo-oxygenases and in this manner limit the conversion of arachidonic acid into PGE2. Thus, NSAIDs can alleviate pain and fever but can also lead to further joint destruction, for example.		<blockquote>NSAIDs actually inhibit immune tolerance/suppression. Prostanoids are highly immuno-suppressive, in particular PGE2, which is also associated with pain perception, fever and tissue healing. NSAIDs inhibit the cyclo-oxygenases and in this manner limit the conversion of arachidonic acid into PGE2. Thus, NSAIDs can alleviate pain and fever but can also lead to further joint destruction, for example.
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	Hope you feel better soon....:)		Hope you feel better soon....:)

-	I also found a post here: http://www.marshallprotocol.com/view_topic.php?id=12488&forum_id=35&highlight=robaxin	+	I also found a post here: https://www.marshallprotocol.com/view_topic.php?id=12488&forum_id=35&highlight=robaxin

	When searching methocarbamol and muscle relaxant I found many posts about MP'ers taking a muscle relaxant. I don't recall finding any info on the MPKB site. It would be helpful to have info about muscle relaxants added to the MPKB site if not already there.		When searching methocarbamol and muscle relaxant I found many posts about MP'ers taking a muscle relaxant. I don't recall finding any info on the MPKB site. It would be helpful to have info about muscle relaxants added to the MPKB site if not already there.
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-	===== References =====	+	===== References =====</nodisp>

07.05.2020		current
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	With a couple of exceptions, it is unnecessary for most Marshall Protocol (MP) patients to supplement with vitamins or minerals. A balanced diet of [[home:food:real_foods\|whole foods]] usually offers a person all the nutrients needed for good health. While nutritional supplements including multivitamins are wildly popular, there is no solid evidence that they contribute to long-term health, reduce symptoms, or cure chronic disease.		With a couple of exceptions, it is unnecessary for most Marshall Protocol (MP) patients to supplement with vitamins or minerals. A balanced diet of [[home:food:real_foods\|whole foods]] usually offers a person all the nutrients needed for good health. While nutritional supplements including multivitamins are wildly popular, there is no solid evidence that they contribute to long-term health, reduce symptoms, or cure chronic disease.

-	Patients who are concerned that their diet is less than ideal should study the [[http://en.wikipedia.org/wiki/Reference_Daily_Intake\|Reference Daily Intake]] (RDI) values of the standard nutrients against their diet to determine if they are deficient. Patients should not consume more nutrients than what is recommended than the RDI. Note that both vitamin D and supplemented (not naturally occurring) folic acid are contraindicated.	+	Patients who are concerned that their diet is less than ideal should study the [[https://en.wikipedia.org/wiki/Reference_Daily_Intake\|Reference Daily Intake]] (RDI) values of the standard nutrients against their diet to determine if they are deficient. Patients should not consume more nutrients than what is recommended than the RDI. Note that both vitamin D and supplemented (not naturally occurring) folic acid are contraindicated.

	Multivitamins and B-complex vitamins can be purchased without vitamin D but they contain folic acid. In order to avoid added vitamin D and folic acid and or potentially immunomodulatory herbs, take each of the vitamins and minerals needed, if any, separately.		Multivitamins and B-complex vitamins can be purchased without vitamin D but they contain folic acid. In order to avoid added vitamin D and folic acid and or potentially immunomodulatory herbs, take each of the vitamins and minerals needed, if any, separately.
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	"angiotensin 2 receptor antagonists can result in an increased urinary excretion of zinc with subsequent systemic zinc deficiency" therefore those on Olmesartan may be excreting Zinc.		"angiotensin 2 receptor antagonists can result in an increased urinary excretion of zinc with subsequent systemic zinc deficiency" therefore those on Olmesartan may be excreting Zinc.

-	see Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions -a systematic review of zinc and antihypertensive therapy. Int J Clin Pract2013;67(8):717-25. doi: 10.1111/ijcp.12040 [published Online First: 2013/01/03	+	//see// Braun LA, Rosenfeldt F. Pharmaco-nutrient interactions -a systematic review of zinc and antihypertensive therapy. Int J Clin Pract2013;67(8):717-25. doi: 10.1111/ijcp.12040 [published Online First: 2013/01/03
	==== Food sources ====		==== Food sources ====

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	===== No evidence of a therapeutic benefit =====		===== No evidence of a therapeutic benefit =====

-	According to a 2009 study, approximately 33% of US adults use multivitamin/multimineral supplements (another 50% use dietary supplements).(({{pubmed>long:18235127}}))	+	According to a 2009 study, approximately 33% of US adults use multivitamin/multimineral supplements (another 50% use dietary supplements).(({{pmid>long:18235127}}))

	Long-term studies on the use of multivitamins show that the pills tend not to protect against disease:		Long-term studies on the use of multivitamins show that the pills tend not to protect against disease:
-	* Supplements don't prevent infections in the elderly – A 2005 //BMJ// study said that there was "conflicting data" in their systematic review in the use of multivitamins and mineral supplements in preventing infections in elderly people.(({{pubmed>long:15805125}})) However, in [[http://www.bmj.com/content/331/7509/142.full\|an erratum]], the authors retroactively excluded three studies from their analysis and said there was "no benefit."	+	* Supplements don't prevent infections in the elderly – A 2005 //BMJ// study said that there was "conflicting data" in their systematic review in the use of multivitamins and mineral supplements in preventing infections in elderly people.(({{pmid>long:15805125}})) However, in [[https://www.bmj.com/content/331/7509/142.full\|an erratum]], the authors retroactively excluded three studies from their analysis and said there was "no benefit."
-	* Children who end up taking vitamins in the United States today don't actually need them - A 2009 //Archives of Pediatrics and Adolescent Medicine// found that about one-third of American children ages 2 to 17 had used a vitamin or mineral supplement within the previous month, but that most of them did not need to supplement their diet.(({{pubmed>long:19188647}}))	+	* Children who end up taking vitamins in the United States today don't actually need them - A 2009 //Archives of Pediatrics and Adolescent Medicine// found that about one-third of American children ages 2 to 17 had used a vitamin or mineral supplement within the previous month, but that most of them did not need to supplement their diet.(({{pmid>long:19188647}}))
-	* Increased risk of pre-term birth – Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pubmed>long:20353456}}))	+	* Increased risk of pre-term birth – Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pmid>long:20353456}}))


	==== Cancer ====		==== Cancer ====

-	Use of vitamin and mineral supplements among cancer survivors is widespread. In studies combining different cancer sites, 64% to 81% of survivors reported using any vitamin or mineral supplements and 26% to 77% reported using any multivitamins.(({{pubmed>long:18235127}})) However:	+	Use of vitamin and mineral supplements among cancer survivors is widespread. In studies combining different cancer sites, 64% to 81% of survivors reported using any vitamin or mineral supplements and 26% to 77% reported using any multivitamins.(({{pmid>long:18235127}})) However:
-	* Multivitamins don't protect against cancer – A study of more than 160,000 post-menopausal women, published in the //Archives of Internal Medicine// found that multivitamins did not prevent cancer, heart attacks, or strokes and did not reduce overall mortality.(({{pubmed>long:19204221}}))	+	* Multivitamins don't protect against cancer – A study of more than 160,000 post-menopausal women, published in the //Archives of Internal Medicine// found that multivitamins did not prevent cancer, heart attacks, or strokes and did not reduce overall mortality.(({{pmid>long:19204221}}))
-	* Multivitamins may increase breast cancer – A large prospective study of 35,329 cancer-free women found that multivitamin use was associated with a moderate but statistically significant increased risk of breast cancer (breast cancer survivors reported the highest use of multivitamins among cancer survivors(({{pubmed>long:18235127}}))) after an average follow-up of 9.5 years.(({{pubmed>long:20335555}})) After adjustment for breast cancer risk factors, women who used multivitamins had a 19% higher risk of breast cancer than those who did not use multivitamins.	+	* Multivitamins may increase breast cancer – A large prospective study of 35,329 cancer-free women found that multivitamin use was associated with a moderate but statistically significant increased risk of breast cancer (breast cancer survivors reported the highest use of multivitamins among cancer survivors(({{pmid>long:18235127}}))) after an average follow-up of 9.5 years.(({{pmid>long:20335555}})) After adjustment for breast cancer risk factors, women who used multivitamins had a 19% higher risk of breast cancer than those who did not use multivitamins.
-	* Vitamins don't protect against lung cancer – A 2008 prospective cohort of 77,721 men and women found that supplemental multivitamins, vitamin C, vitamin E, and folate were not associated with a decreased risk of lung cancer. Supplemental vitamin E was associated with a small increased risk.(({{pubmed>long:17989343}}))	+	* Vitamins don't protect against lung cancer – A 2008 prospective cohort of 77,721 men and women found that supplemental multivitamins, vitamin C, vitamin E, and folate were not associated with a decreased risk of lung cancer. Supplemental vitamin E was associated with a small increased risk.(({{pmid>long:17989343}}))


	==== Cardiovascular issues ====		==== Cardiovascular issues ====

-	Vitamin D supplementation is ineffective in improving cardiovascular health among various patient populations, including in the presence or absence of vitamin D deficiency. (({{pubmed>long:28229054}}))	+	Vitamin D supplementation is ineffective in improving cardiovascular health among various patient populations, including in the presence or absence of vitamin D deficiency. (({{pmid>long:28229054}}))


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	<relatedarticle> [[home:food:folic\|Folic acid and folate]]</article>		<relatedarticle> [[home:food:folic\|Folic acid and folate]]</article>

-	In a 2010 randomized controlled trial appearing in //JAMA//, the effect of high-dose vitamin B (folic acid, vitamin B6 and vitamin B12) on diabetics was studied. In the trial, those receiving the B vitamins had significantly greater worsening of kidney function, measured as GFR. (Glomerular filtration rate is the test used to measure the level of kidney function.) The participants also had twice as many heart and stroke incidents.(({{pubmed>long:20424250}}))	+	In a 2010 randomized controlled trial appearing in //JAMA//, the effect of high-dose vitamin B (folic acid, vitamin B6 and vitamin B12) on diabetics was studied. In the trial, those receiving the B vitamins had significantly greater worsening of kidney function, measured as GFR. (Glomerular filtration rate is the test used to measure the level of kidney function.) The participants also had twice as many heart and stroke incidents.(({{pmid>long:20424250}}))


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	===== Read more =====		===== Read more =====

-	* [[http://www.slate.com/id/2240688/\|The Vita Myth: Do supplements really do any good?]]	+	* [[https://www.slate.com/id/2240688/\|The Vita Myth: Do supplements really do any good?]]
-	* [[http://www.nytimes.com/2009/02/03/health/03vitamins.html\|Children Who Take Vitamins Often Don’t Need Them]]	+	* [[https://www.nytimes.com/2009/02/03/health/03vitamins.html\|Children Who Take Vitamins Often Don’t Need Them]]
-	* [[http://www.slate.com/id/2234004/\|Megavitamins: the vitamin business thrived through the recession. Why?]]	+	* [[https://www.slate.com/id/2234004/\|Megavitamins: the vitamin business thrived through the recession. Why?]]


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	Vitamin B therapy dangerous for millions of diabetics with kidney disease		Vitamin B therapy dangerous for millions of diabetics with kidney disease
-	http://www.eurekalert.org/pub_releases/2010-04/uowo-vbt042210.php	+	https://www.eurekalert.org/pub_releases/2010-04/uowo-vbt042210.php

	Dr. David Spence of Western's Robarts Research Institute and his colleagues began their study of people with kidney disease, anticipating that people who received high dose vitamin B therapy (folic acid, vitamin B6 and vitamin B12) could see improved kidney function and fewer heart attacks and stroke, compared with those on placebos.		Dr. David Spence of Western's Robarts Research Institute and his colleagues began their study of people with kidney disease, anticipating that people who received high dose vitamin B therapy (folic acid, vitamin B6 and vitamin B12) could see improved kidney function and fewer heart attacks and stroke, compared with those on placebos.
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	<blockquote>B-vitamins and diabetic nephropathy		<blockquote>B-vitamins and diabetic nephropathy
-	http://www.medscape.com/viewarticle/731177	+	https://www.medscape.com/viewarticle/731177
-	http://www.ncbi.nlm.nih.gov/pubmed/8143940</blockquote>	+	https://www.ncbi.nlm.nih.gov/pubmed/8143940</blockquote>

	Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults. (({{pubmed 27509187}}))		Oral cholecalciferol 3000 IU/day does not affect arterial stiffness or blood pressure after 16 weeks of treatment in healthy normotensive adults. (({{pubmed 27509187}}))
-	=====References=====	+	=====References=====</nodisp>