Methotrexate (MTX)

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:53 +0000

09.16.2017		current
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	[{{ :home:othertreatments:antibacterials:ecoli-dhfr-mtx_small.jpeg\|Methotrexate complexed with E.coli DHFR}}]		[{{ :home:othertreatments:antibacterials:ecoli-dhfr-mtx_small.jpeg\|Methotrexate complexed with E.coli DHFR}}]

-	Methotrexate and trimethoprim are very similar drugs. The both act on [[http://en.wikipedia.org/wiki/DHFR\|Dihydrofolate Reductase (DHFR)]]. To the right is methotrexate complexed with //E. coli// DHFR.	+	Methotrexate and trimethoprim are very similar drugs. The both act on [[https://en.wikipedia.org/wiki/DHFR\|Dihydrofolate Reductase (DHFR)]]. To the right is methotrexate complexed with //E. coli// DHFR.

	Both trimethoprim and MTX have a very high affinity for the Bacterial DHFR, while Trimethoprim has a lower affinity for human DHFR than MTX. You would need a very large dose of Trimethoprim in a human being to equal the DHFR effects of a typical rheumatologic MTX dosing regime.		Both trimethoprim and MTX have a very high affinity for the Bacterial DHFR, while Trimethoprim has a lower affinity for human DHFR than MTX. You would need a very large dose of Trimethoprim in a human being to equal the DHFR effects of a typical rheumatologic MTX dosing regime.

-	//Inter alia//, DHFR catalyzes THFR, an essential step in the production of [[http://en.wikipedia.org/wiki/Purine\|purines]], [[http://en.wikipedia.org/wiki/Thymidine_monophosphate\|thymidine monophosphate]], and some amino acids.	+	//Inter alia//, DHFR catalyzes THFR, an essential step in the production of [[https://en.wikipedia.org/wiki/Purine\|purines]], [[https://en.wikipedia.org/wiki/Thymidine_monophosphate\|thymidine monophosphate]], and some amino acids.

	MTX therefore inhibits the synthesis of DNA and proteins, and this is the action typically attributed to it in a therapeutic environment. However, purines are very active compounds and form the basis of many human metabolites. I would note that a purine-like imidazole ring is part of the olmesartan molecule.		MTX therefore inhibits the synthesis of DNA and proteins, and this is the action typically attributed to it in a therapeutic environment. However, purines are very active compounds and form the basis of many human metabolites. I would note that a purine-like imidazole ring is part of the olmesartan molecule.
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	It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation.		It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation.

-	However, for hepatitis patients currently using methotrexate, withdrawal may carry serious risks. Therefore [[http://www.hss.edu/professional-conditions_methotrexate-contraindicated-in-rheumatoid-arthritis-hepatitis-b-c.asp\|methotrexate is now considered contraindicated for hepatitis patients]].	+	However, for hepatitis patients currently using methotrexate, withdrawal may carry serious risks. Therefore [[https://www.hss.edu/professional-conditions_methotrexate-contraindicated-in-rheumatoid-arthritis-hepatitis-b-c.asp\|methotrexate is now considered contraindicated for hepatitis patients]].



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Methotrexate (MTX)