Marshall Protocol Knowledge Base - home:special

Children and the Marshall Protocol

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.26.2018		current
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	====== Children and the Marshall Protocol ======		====== Children and the Marshall Protocol ======

-	Children with a range of [[home:diseases\|diseases and conditions]] can be treated with the Marshall Protocol (MP). There are more than a dozen in the study cohort who are doing well, and others who are being treated by family physicians, not regularly reporting. Benicar is [[http://www.prnewswire.com/news-releases/fda-approves-benicarr-for-the-treatment-of-high-blood-pressure-in-children-and-adolescents-aged-6-16-84104997.html\|approved by the FDA]] for use in children and adolescents 6 to 16 years of age.	+	Children with a range of [[home:diseases\|diseases and conditions]] can be treated with the Marshall Protocol (MP). There are more than a dozen in the study cohort who are doing well, and others who are being treated by family physicians, not regularly reporting. Benicar is [[https://www.prnewswire.com/news-releases/fda-approves-benicarr-for-the-treatment-of-high-blood-pressure-in-children-and-adolescents-aged-6-16-84104997.html\|approved by the FDA]] for use in children and adolescents 6 to 16 years of age.


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	===== Safety =====		===== Safety =====

-	When considering any treatment plan, the physician (and the patient) should weigh the risks versus the benefits. When compared to other protocols or medications that sick children are customarily given for Th1 inflammatory disease, the decision to go with the MP is usually self-evident. Physicians can find support for managing a child by posting in the [[http://www.marshallprotocol.com/forum17/\|MP Health Professionals Forum]]. Physicians may also directly contact Prof. Marshall by phone.	+	When considering any treatment plan, the physician (and the patient) should weigh the risks versus the benefits. When compared to other protocols or medications that sick children are customarily given for Th1 inflammatory disease, the decision to go with the MP is usually self-evident. Physicians can find support for managing a child by posting in the [[https://www.marshallprotocol.com/forum17/\|MP Health Professionals Forum]]. Physicians may also directly contact Prof. Marshall by phone.


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	The olmesartan (Benicar) dosage for a child should be considered on an individual basis, case by case. A simple weight ratio is often not helpful, as the distribution volume for the drug varies greatly with disease severity, even for people of a similar weight. A physician needs to consider symptoms, lab work and the level of 1,25-D when deciding on the optimal dosing for a child. More seriously ill children often need the same dose of Benicar as do some of the adults.		The olmesartan (Benicar) dosage for a child should be considered on an individual basis, case by case. A simple weight ratio is often not helpful, as the distribution volume for the drug varies greatly with disease severity, even for people of a similar weight. A physician needs to consider symptoms, lab work and the level of 1,25-D when deciding on the optimal dosing for a child. More seriously ill children often need the same dose of Benicar as do some of the adults.

-	Daiichi Sankyo, Inc. [[http://www.prnewswire.com/news-releases/fda-approves-benicarr-for-the-treatment-of-high-blood-pressure-in-children-and-adolescents-aged-6-16-84104997.html\|announced in 2010]] that the U.S. Food and Drug Administration (FDA) has approved the Benicar for use in children and adolescents 6 to 16 years of age. Benicar was originally approved in 2002 for the treatment of hypertension in adults. The FDA has set no dose at which Olmesartan is considered unsafe, in children or in adults.	+	Daiichi Sankyo, Inc. [[https://www.prnewswire.com/news-releases/fda-approves-benicarr-for-the-treatment-of-high-blood-pressure-in-children-and-adolescents-aged-6-16-84104997.html\|announced in 2010]] that the U.S. Food and Drug Administration (FDA) has approved the Benicar for use in children and adolescents 6 to 16 years of age. Benicar was originally approved in 2002 for the treatment of hypertension in adults. The FDA has set no dose at which Olmesartan is considered unsafe, in children or in adults.


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	autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)		autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)

-	Read the [[http://bacteriality.com/2008/03/15/interview18/\|interview]]	+	Read the [[https://bacteriality.com/2008/03/15/interview18/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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	<div class="patientinterviewboxr">		<div class="patientinterviewboxr">

-	{{tag> special Special_issues}}	+	{{tag>special children Special_issues}}
	<div class="patientinterviewimage"></html>{{:home:patients:robyn.gif?nolink\|}}<html></div>		<div class="patientinterviewimage"></html>{{:home:patients:robyn.gif?nolink\|}}<html></div>
	<div class="patientinterviewtext">		<div class="patientinterviewtext">
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	Lyme, myoclonus		Lyme, myoclonus

-	Read the [[http://bacteriality.com/2007/10/28/interview6/\|interview]]	+	Read the [[https://bacteriality.com/2007/10/28/interview6/\|interview]]

	<html></div></div>		<html></div></div>
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	</blockquote>		</blockquote>

-	===== References =====	+	===== References =====</nodisp>

Working with a dentist

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Disability

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.13.2019		current
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	==== Websites ====		==== Websites ====

-	* [[http://www.socialsecurity.gov\|Social Security General Information]] (includes information about receiving benefits while working)	+	* [[https://www.socialsecurity.gov\|Social Security General Information]] (includes information about receiving benefits while working)
-	* [[http://www.ssa.gov/disability/professionals/bluebook/AdultListings.htm\|Social Security Listing of Impairments]]	+	* [[https://www.ssa.gov/disability/professionals/bluebook/AdultListings.htm\|Social Security Listing of Impairments]]
-	* [[http://disabilityblogger.blogspot.com/\|Social Security Disability SSI Blog]]	+	* [[https://disabilityblogger.blogspot.com/\|Social Security Disability SSI Blog]]
	*		*
-	* [[http://www.dol.gov/odep/\|U.S. Department of Labor information about employment opportunities for the disabled]]	+	* [[https://www.dol.gov/odep/\|U.S. Department of Labor information about employment opportunities for the disabled]]

	==== Books ====		==== Books ====
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	{{tag>special_issues special}}		{{tag>special_issues special}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====
-	broken links * [[http://www.disabilityblogger.blogspot.com/2006/04/questions-about-applying-for-social.html\|Questions about applying for Social Security Disability or SSI]]	+	//broken links//
		+	[[https://www.disabilityblogger.blogspot.com/2006/04/questions-about-applying-for-social.html\|Questions about applying for Social Security Disability or SSI]]

-		+	* [[https://janweb.icdi.wvu.edu/index.htm\|The Job Accommodation Network ]]is a service provided by the U.S. Department of Labor's Office of Disability Employment Policy (ODEP). JAN's mission is to facilitate the employment and retention of workers with disabilities by providing employers, employment providers, people with disabilities, their family members and other interested parties with information on job accommodations, entrepreneurship, and related subjects.
-		+
-	* [[http://janweb.icdi.wvu.edu/index.htm\|The Job Accommodation Network ]]is a service provided by the U.S. Department of Labor's Office of Disability Employment Policy (ODEP). JAN's mission is to facilitate the employment and retention of workers with disabilities by providing employers, employment providers, people with disabilities, their family members and other interested parties with information on job accommodations, entrepreneurship, and related subjects.	+



	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum37/3355.html#p29849 s291	+	* https://www.marshallprotocol.com/forum37/3355.html#p29849 s291
-	* http://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=92380#p92380 s293	+	* https://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=92380#p92380 s293
-	* http://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=92408#p92408 s294	+	* https://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=92408#p92408 s294
-	* http://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=133650#p133650 s295	+	* https://www.marshallprotocol.com/view_topic.php?id=3355&forum_id=37&jump_to=133650#p133650 s295
	*		*
	===== References =====		===== References =====
		+	</nodisp>

Hospitals and emergencies - For Patients

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.19.2018		current
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	* You have the right to know the identity, professional status and professional credentials of health care personnel, as well as the name of the health care practitioner primarily responsible for your care while you are hospitalized.		* You have the right to know the identity, professional status and professional credentials of health care personnel, as well as the name of the health care practitioner primarily responsible for your care while you are hospitalized.
	* You have the right to receive an explanation regarding your diagnosis, treatment, medical procedures, and prognosis (what to expect) in terms you can understand. When it is not medically advisable to provide this information to you, it should be relayed to appropriate family members or your designated decision-maker.		* You have the right to receive an explanation regarding your diagnosis, treatment, medical procedures, and prognosis (what to expect) in terms you can understand. When it is not medically advisable to provide this information to you, it should be relayed to appropriate family members or your designated decision-maker.
-	* Know your rights under the [[http://www.hhs.gov/ocr/hipaa/\|Health Insurance Portability and Accountability Act]] (HIPAA), a federal law. Find out who is allowed to have access to your confidential medical information and how to get that information for your own use.	+	* Know your rights under the [[https://www.hhs.gov/ocr/hipaa/\|Health Insurance Portability and Accountability Act]] (HIPAA), a federal law. Find out who is allowed to have access to your confidential medical information and how to get that information for your own use.
	* You have the right to voice concerns or complaints regarding your experience as a patient. You are entitled to information about the mechanism for the initiation, review, and resolution of any complaints or concerns. If necessary, contact the customer advocate, hospital ombudsman or social worker for help.		* You have the right to voice concerns or complaints regarding your experience as a patient. You are entitled to information about the mechanism for the initiation, review, and resolution of any complaints or concerns. If necessary, contact the customer advocate, hospital ombudsman or social worker for help.

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	* [[home:symptoms:neurological:managing\|Mental and neurological symptoms]]		* [[home:symptoms:neurological:managing\|Mental and neurological symptoms]]

-	{{tag>Special_issues}}	+	{{tag>Special_issues special }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=82253#p82253	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=82253#p82253
-	* http://www.marshallprotocol.com/view_topic.php?id=4661&forum_id=37&jump_to=140139#p140139	+	* https://www.marshallprotocol.com/view_topic.php?id=4661&forum_id=37&jump_to=140139#p140139
-	* http://www.marshallprotocol.com/forum18/12026.html	+	* https://www.marshallprotocol.com/forum18/12026.html


-	===== References =====	+	===== References =====</nodisp>

Kidneys at Work

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.19.2018		current
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	Episode 1: Overview		Episode 1: Overview

-	The chemistry of the blood must be carefully controlled. Major players in this control are the kidneys which remove unwanted and harmful metabolites and foreign molecules from the blood and regulate the concentrations of the blood's electrolytes. Kidney: [[http://www.urology-textbook.com/anatomy.html\|Anatomy]], [[http://www.urology-textbook.com/index-urology-r.html\|Renal Artery, Vein and Nerves]] – To effect this function kidneys receive about 20% of the blood flow. They filter about 10% of this with each passage at a normal rate of about 120ml/minute. Filtration is effected by nephrons of which there may be about 1 million, per kidney at birth, though the number can vary more than tenfold. The filtration is dependent on the number of functional nephrons and declines as they are lost to damage and disease. Nephrons contain a glomerulus where filtration occurs with the filtrate fed into a tubular structure were re-absorption occurs (including 99% of the sodium and water) before the urine is passed into a collecting duct. The collecting ducts join together to ultimately form the ureter which passes the urine down to the bladder. Kidney: Histology of the [[http://www.urology-textbook.com/kidney-nephron.html\|Nephron and Glomerulus]]	+	The chemistry of the blood must be carefully controlled. Major players in this control are the kidneys which remove unwanted and harmful metabolites and foreign molecules from the blood and regulate the concentrations of the blood's electrolytes. Kidney: [[https://www.urology-textbook.com/anatomy.html\|Anatomy]], [[https://www.urology-textbook.com/index-urology-r.html\|Renal Artery, Vein and Nerves]] – To effect this function kidneys receive about 20% of the blood flow. They filter about 10% of this with each passage at a normal rate of about 120ml/minute. Filtration is effected by nephrons of which there may be about 1 million, per kidney at birth, though the number can vary more than tenfold. The filtration is dependent on the number of functional nephrons and declines as they are lost to damage and disease. Nephrons contain a glomerulus where filtration occurs with the filtrate fed into a tubular structure were re-absorption occurs (including 99% of the sodium and water) before the urine is passed into a collecting duct. The collecting ducts join together to ultimately form the ureter which passes the urine down to the bladder. Kidney: Histology of the [[https://www.urology-textbook.com/kidney-nephron.html\|Nephron and Glomerulus]]


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-	The nephron consists of a capsule enclosing the glomerulus and feeding the filtrate into the tubular structure. Kidney: Histology of Renal Tubules – http://www.urology-textbook.com The tubular structure contains four segments, each of which may be considered to have sub-segments. In order from the capsule the four segments are:	+	The nephron consists of a capsule enclosing the glomerulus and feeding the filtrate into the tubular structure. Kidney: Histology of Renal Tubules – https://www.urology-textbook.com The tubular structure contains four segments, each of which may be considered to have sub-segments. In order from the capsule the four segments are:


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-	Importantly, the convolutions of the Distal Convoluted Tubule take it past the entrance to the capsule where it contacts the juxtaglomerular apparatus which regulates the function of the nephron by action on the afferent and efferent arterioles. With the aid of the juxtaglomerular apparatus, each individual nephron has the possibility to change the filtration performance in the glomerulus, depending on the urine analysis in its distal tubule. The tubule then continues into the collecting duct which joins with ducts from other tubules to ultimately form the ureter to carry urine to the bladder. Kidney: Physiology of the Glomerular Filtration Rate – http://www.urology-textbook.com	+	Importantly, the convolutions of the Distal Convoluted Tubule take it past the entrance to the capsule where it contacts the juxtaglomerular apparatus which regulates the function of the nephron by action on the afferent and efferent arterioles. With the aid of the juxtaglomerular apparatus, each individual nephron has the possibility to change the filtration performance in the glomerulus, depending on the urine analysis in its distal tubule. The tubule then continues into the collecting duct which joins with ducts from other tubules to ultimately form the ureter to carry urine to the bladder. Kidney: Physiology of the Glomerular Filtration Rate – https://www.urology-textbook.com

	There is a connecting tubule (CNT) which joins the distal convoluted tubule into a collecting duct.		There is a connecting tubule (CNT) which joins the distal convoluted tubule into a collecting duct.
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-	The following is largely abstracted from this [[http://www.urology-textbook.com/kidney-tubular-reabsorption.html\|Urology-textbook]]	+	The following is largely abstracted from this [[https://www.urology-textbook.com/kidney-tubular-reabsorption.html\|Urology-textbook]]


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-	The following is largely abstracted from further down the page in this [[http://www.urology-textbook.com/kidney-tubular-reabsorption.html\|Urology-textbook]]	+	The following is largely abstracted from further down the page in this [[https://www.urology-textbook.com/kidney-tubular-reabsorption.html\|Urology-textbook]]


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	{{tag>kidneys}}		{{tag>kidneys}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


-	===== References =====	+




		+	===== References =====
		+	</nodisp>

Working with an optometrist

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.12.2018		current
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	Anyone who has recently had uveitis should discuss the risks of contact lens use quite carefully with an ophthalmologist who has advanced training in treating uveitis.		Anyone who has recently had uveitis should discuss the risks of contact lens use quite carefully with an ophthalmologist who has advanced training in treating uveitis.

-	{{tag>eyes specialists Special_issues}}	+	{{tag>eyes specialists Special_issues special }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Probably should all be in eye care, of which working with an optometrist is a part....but I do not see an eye care topic anywhere now. --- //Joe Trunk 2008/11/29 19:50//		* Probably should all be in eye care, of which working with an optometrist is a part....but I do not see an eye care topic anywhere now. --- //Joe Trunk 2008/11/29 19:50//

-	===== References =====	+	===== References =====</nodisp>

Pregnancy, fertility, and menopause

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Smoking tobacco

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Surgery

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.12.2019		current
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	Continuing MP medications along with most other antibiotics administered in conjunction with surgery may result in a strong immune system reaction. MP patients may not want to combine the suffering after a procedure with immunopathology.		Continuing MP medications along with most other antibiotics administered in conjunction with surgery may result in a strong immune system reaction. MP patients may not want to combine the suffering after a procedure with immunopathology.

-	It is preferable to consult with hospital staff and negotiate use of compatible ABx if at all possible in order to improve surgical outcome. [[http://anesthesiology.pubs.asahq.org/Article.aspx?articleid=2318959\|Continuing Olmesartan reduces surgical risk]]	+	It is preferable to consult with hospital staff and negotiate use of compatible ABx if at all possible in order to improve surgical outcome. [[https://anesthesiology.pubs.asahq.org/Article.aspx?articleid=2318959\|Continuing Olmesartan reduces surgical risk]]
		+
		+	So if a patient must take an antibiotic, Ceftin, Biaxin or fluoroquinolones are recommended, as they minimize the possibility of unstable immunopathology. Use of these does not preclude an MP patient from continuing with olmesartan.

	MP patients who do not discontinue MP medications before surgery should use their knowledge of what adjustment of MP medications works for them to dampen immune system reactions prior to, and during recovery from the procedure.		MP patients who do not discontinue MP medications before surgery should use their knowledge of what adjustment of MP medications works for them to dampen immune system reactions prior to, and during recovery from the procedure.
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	{{tag>surgery specialists Special_issues special }}		{{tag>surgery specialists Special_issues special }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1125.html#p8885 f176	+	* https://www.marshallprotocol.com/forum32/1125.html#p8885 f176
	*		*
	*		*
	*		*
-	===== References =====	+	===== References =====</nodisp>

Tattoos

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.12.2018		current
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	<relatedarticle> [[home:pathogenesis:transmission\|Transmission of bacteria and onset of chronic disease]] </article>		<relatedarticle> [[home:pathogenesis:transmission\|Transmission of bacteria and onset of chronic disease]] </article>
-
-


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	As with all injected substances, there is a small risk of introducing these pathogens during the process of tattooing.		As with all injected substances, there is a small risk of introducing these pathogens during the process of tattooing.
-

	[{{ :home:special:nf1.gif\|Lupus vulgaris over a tattoo mark. Lupus vulgaris is caused by tuberculosis. While tuberculosis is widely accepted as an infectious disease, it is notable that chronic inflammatory diseases of "unknown" origin can also show cutaneous disease-specific lesions following a tattoo. This suggests a common, if not species-specific, pathology.}}]		[{{ :home:special:nf1.gif\|Lupus vulgaris over a tattoo mark. Lupus vulgaris is caused by tuberculosis. While tuberculosis is widely accepted as an infectious disease, it is notable that chronic inflammatory diseases of "unknown" origin can also show cutaneous disease-specific lesions following a tattoo. This suggests a common, if not species-specific, pathology.}}]


-	Researchers have documented that diseases such as lupus vulgaris (painful skin lesions caused by //M. tuberculosis// bacteria) can be induced by a tattoo procedure.(({{pubmed>long:12941097}})) Tuberculosis, of course, is unquestionably a bacterial illness.	+	Researchers have documented that diseases such as lupus vulgaris (painful skin lesions caused by //M. tuberculosis// bacteria) can be induced by a tattoo procedure.(({{pmid>long:12941097}})) Tuberculosis, of course, is unquestionably a bacterial illness.

-	But the literature also contains multiple reports of sarcoidosis patients – a disease of supposedly unknown origin – also developing skin lesions within tattoos. According to one researcher, this is "a well-recognized occurrence in patients with sarcoidosis."(({{pubmed>long:16027303}})) Ali reviews dozens of cases in which granuloma have formed, more often than not, years after the application of a tattoo.(({{pubmed>long:18258148}})) More than one case report describes how a patient developed sarcoidal granulomas in only one pigment of a tattoo(({{pubmed>long:18258148}})) – which suggests that the needle corresponding to that pigment was infected.	+	But the literature also contains multiple reports of sarcoidosis patients – a disease of supposedly unknown origin – also developing skin lesions within tattoos. According to one researcher, this is "a well-recognized occurrence in patients with sarcoidosis."(({{pmid>long:16027303}})) Ali reviews dozens of cases in which granuloma have formed, more often than not, years after the application of a tattoo.(({{pmid>long:18258148}})) More than one case report describes how a patient developed sarcoidal granulomas in only one pigment of a tattoo(({{pmid>long:18258148}})) – which suggests that the needle corresponding to that pigment was infected.

	There are a number of explanations for how a tattoo could cause this reaction, but the most logical one is that tattoo needles introduce new pathogens into the skin. For one, the fact that sarcoid granuloma appear years after the application of a tattoo corresponds nicely with the length of time it takes for bacteria to grow.		There are a number of explanations for how a tattoo could cause this reaction, but the most logical one is that tattoo needles introduce new pathogens into the skin. For one, the fact that sarcoid granuloma appear years after the application of a tattoo corresponds nicely with the length of time it takes for bacteria to grow.


		+	{{tag>Transmission_of_Disease Special_issues special }}

-		+	<nodisp>
-	{{tag>Transmission_of_Disease Special_issues}}	+
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=1081&forum_id=32&jump_to=157636#p157636 f63	+	* https://www.marshallprotocol.com/view_topic.php?id=1081&forum_id=32&jump_to=157636#p157636 f63
	*		*
	*		*
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	===== References=====		===== References=====
		+	</nodisp>

Ticks, what to do when bitten

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Donation of blood, bone marrow, organs or other tissues

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Vaccines and TB tests

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.12.2018		current
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	The use of tetracyclines, especially the MP antibiotic [[home:mp:minocycline\|minocycline]], during tooth development (the second half of pregnancy, infancy, and childhood up to the age of eight years) may cause permanent discoloration of the teeth (yellow/gray/brown).		The use of tetracyclines, especially the MP antibiotic [[home:mp:minocycline\|minocycline]], during tooth development (the second half of pregnancy, infancy, and childhood up to the age of eight years) may cause permanent discoloration of the teeth (yellow/gray/brown).

-	In older children and adults, temporary discoloration of teeth occurs infrequently(({{pubmed>long:15485524}})) and not in doses recommended by the MP.	+	In older children and adults, temporary discoloration of teeth occurs infrequently(({{pmid>long:15485524}})) and not in doses recommended by the MP.


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	These recommendations apply to many dental procedures, including teeth cleaning and extractions. Patients with congenital heart disease can have complicated circumstances and should consult with their cardiologists.		These recommendations apply to many dental procedures, including teeth cleaning and extractions. Patients with congenital heart disease can have complicated circumstances and should consult with their cardiologists.

-	The American Heart Association [[http://www.eurekalert.org/pub_releases/2007-04/aha-mpd041907.php\|press release]] explains the rationale behind the recommendations. Among other reasons, they mention "allergic reactions" to antibiotics. This may be an example of the [[home:protocol:immunopathology\|immunopathological response]].	+	The American Heart Association [[https://www.eurekalert.org/pub_releases/2007-04/aha-mpd041907.php\|press release]] explains the rationale behind the recommendations. Among other reasons, they mention "allergic reactions" to antibiotics. This may be an example of the [[home:protocol:immunopathology\|immunopathological response]].
	==== Choice of antibiotic ====		==== Choice of antibiotic ====
	If a dentist wants an MP patient to take an antibiotic prior to a procedure, the MP patient should ask the dentist if the MP antibiotics that the patient is currently taking would suffice.		If a dentist wants an MP patient to take an antibiotic prior to a procedure, the MP patient should ask the dentist if the MP antibiotics that the patient is currently taking would suffice.
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	MP patients should not take prophylactic [[home:mp:clindamycin\|clindamycin]] unless they have taken it before with [[home:mp:olmesartan:response\|olmesartan]] and know how they might react to it.		MP patients should not take prophylactic [[home:mp:clindamycin\|clindamycin]] unless they have taken it before with [[home:mp:olmesartan:response\|olmesartan]] and know how they might react to it.

-	Moxifloxacin (Avelox), a [[home:othertreatments:antibacterials:takingnonmpantibiotics\|fluoroquinolone]], is safe to take with olmesartan – and, at least according to one study, may be more effective than other antibiotics traditionally used by dentists.(({{pubmed>long:16940094}})) MP patients should read the information on other [[home:othertreatments:antibacterials:takingnonmpantibiotics\|non-MP antibiotics]] before agreeing to take anything else. An MP patient could also ask the dentist if the work can be postponed until the patient has progressed further on the MP. This will give teeth a chance to heal and avoid the need to stop the MP in the early stages when the patient is still learning to manage the MP medication or stabilizing symptoms. Also, when one's bacterial load is lower, an antibiotic challenge will be less of a threat.	+	Moxifloxacin (Avelox), a [[home:othertreatments:antibacterials:takingnonmpantibiotics\|fluoroquinolone]], is safe to take with olmesartan – and, at least according to one study, may be more effective than other antibiotics traditionally used by dentists.(({{pmid>long:16940094}})) MP patients should read the information on other [[home:othertreatments:antibacterials:takingnonmpantibiotics\|non-MP antibiotics]] before agreeing to take anything else. An MP patient could also ask the dentist if the work can be postponed until the patient has progressed further on the MP. This will give teeth a chance to heal and avoid the need to stop the MP in the early stages when the patient is still learning to manage the MP medication or stabilizing symptoms. Also, when one's bacterial load is lower, an antibiotic challenge will be less of a threat.


-	{{tag>dentist periodontal_disease specialists Special_issues}}	+	{{tag>dentist periodontal_disease specialists Special_issues special }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=51152#p51152 s167	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=51152#p51152 s167
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=39535#p39535 s163	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=39535#p39535 s163
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120204#p120204 s173	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120204#p120204 s173
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120199#p120199 s172	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120199#p120199 s172
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=42976#p42976 s164	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=42976#p42976 s164

	* Citations needed within. --- //Joe Trunk 2008/12/01 18:31//		* Citations needed within. --- //Joe Trunk 2008/12/01 18:31//
	* need to discuss how tonsillectomies tend to be ineffective --- //Paul Albert 11.05.2010//		* need to discuss how tonsillectomies tend to be ineffective --- //Paul Albert 11.05.2010//

-	===== References =====	+	===== References =====</nodisp>

10.12.2018		current
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	===== MP may restore fertility =====		===== MP may restore fertility =====

-	For 60 years, doctors have believed women were born with all the eggs they'll ever have. Recently Harvard scientists are challenging that dogma, saying they've discovered the ovaries of young women harbor very rare stem cells capable of producing new eggs.(({{pubmed>long:22844256}})) This work suggests that formation of oocytes is driven by the biochemical environment, as is all stem cell activity.	+	For 60 years, doctors have believed women were born with all the eggs they'll ever have. Recently Harvard scientists are challenging that dogma, saying they've discovered the ovaries of young women harbor very rare stem cells capable of producing new eggs.(({{pmid>long:22844256}})) This work suggests that formation of oocytes is driven by the biochemical environment, as is all stem cell activity.

	The MP is a curative therapy. As the MP resolves inflammation, this healing will likely restore sexual capability and fertility. Any or all aspects of the MP, including avoiding vitamin D and sunlight/bright lights, may contribute to hormonal changes which lead to restoration of health and fertility in men or women.		The MP is a curative therapy. As the MP resolves inflammation, this healing will likely restore sexual capability and fertility. Any or all aspects of the MP, including avoiding vitamin D and sunlight/bright lights, may contribute to hormonal changes which lead to restoration of health and fertility in men or women.
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-	[{{ :home:pathogenesis:microbiota:gestationalage.gif\|Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery. This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[http://www.ncbi.nlm.nih.gov/pubmed/18725970\|DiGulio et al.]]}}]	+	[{{ :home:pathogenesis:microbiota:gestationalage.gif\|Newer cultivation techniques have associated bacterial count in a pregnant woman's amniotic fluid with age at delivery. This data strongly suggests a causative role for pathogenic bacteria in premature delivery. Source: [[https://www.ncbi.nlm.nih.gov/pubmed/18725970\|DiGulio et al.]]}}]


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	Microbes play an important factor in whether a woman will carry a pregnancy to term.		Microbes play an important factor in whether a woman will carry a pregnancy to term.

-	Using molecular tools to quantify bacterial count in pregnant women's amniotic fluid, DiGiulio //et al.// showed that the number of bacterial sequences found was inversely correlated with length of pregnancy.(({{pubmed>long:18725970}}))	+	Using molecular tools to quantify bacterial count in pregnant women's amniotic fluid, DiGiulio //et al.// showed that the number of bacterial sequences found was inversely correlated with length of pregnancy.(({{pmid>long:18725970}}))

-	Also underscoring the importance of microbes in premature delivery is a 2010 paper showing that the injection of lipopolysaccharides (endotoxins) could create a mouse model for preterm labor.(({{pubmed>long:19995880}})) The release of endotoxins are well known byproducts of the immunopathological response, which is generated when gram-negative bacteria are destroyed.	+	Also underscoring the importance of microbes in premature delivery is a 2010 paper showing that the injection of lipopolysaccharides (endotoxins) could create a mouse model for preterm labor.(({{pmid>long:19995880}})) The release of endotoxins are well known byproducts of the immunopathological response, which is generated when gram-negative bacteria are destroyed.

-	In recent years, the incidence of preterm deliveries has increased in the U.S. The National Center for Health Statistics (Centers for Disease Control and Prevention) has reported a 20% increase (from 10.6% to 12.7%) in the percentage of preterm deliveries during the years 1990–2005.(({{pubmed>long:18772340}}))	+	In recent years, the incidence of preterm deliveries has increased in the U.S. The National Center for Health Statistics (Centers for Disease Control and Prevention) has reported a 20% increase (from 10.6% to 12.7%) in the percentage of preterm deliveries during the years 1990–2005.(({{pmid>long:18772340}}))
	==== Sarcoidosis ====		==== Sarcoidosis ====
	The following describes some of the effects of sarcoidosis on pregnancy:		The following describes some of the effects of sarcoidosis on pregnancy:

-	* Women with sarcoidosis report feeling better when they are pregnant. Sarcoidosis involves a Th1-activated immune system response. The NF-kappaB/IkappaB signaling pathway is down-regulated in T cells in pregnancy, shifting the immune system away from Th1 and toward a Th2 immune response.(({{pubmed>long:15034076}})) There are other factors to consider, especially vitamin D and sunlight exposure. These play a role in activation of NF-kappaB and the Th1 immune response.	+	* Women with sarcoidosis report feeling better when they are pregnant. Sarcoidosis involves a Th1-activated immune system response. The NF-kappaB/IkappaB signaling pathway is down-regulated in T cells in pregnancy, shifting the immune system away from Th1 and toward a Th2 immune response.(({{pmid>long:15034076}})) There are other factors to consider, especially vitamin D and sunlight exposure. These play a role in activation of NF-kappaB and the Th1 immune response.
-	* Pregnancy in women with sarcoidosis usually goes to term with no problems. Pregnant women diagnosed with sarcoidosis need to be aware, however, that some of the drug therapies (methotrexate, anti-malarials, Thalidomide, etc.) normally used for sarcoidosis are contraindicated in pregnancy. (({{pubmed>long:10637902}}))	+	* Pregnancy in women with sarcoidosis usually goes to term with no problems. Pregnant women diagnosed with sarcoidosis need to be aware, however, that some of the drug therapies (methotrexate, anti-malarials, Thalidomide, etc.) normally used for sarcoidosis are contraindicated in pregnancy. (({{pmid>long:10637902}}))
-	* Oral corticosteroids increase the risk of cleft palate.(({{pubmed>long:11091360}}))	+	* Oral corticosteroids increase the risk of cleft palate.(({{pmid>long:11091360}}))
	* Regarding cesarian section versus vaginal delivery, consider that sarcoidosis inflammation is known to have an affinity for scar tissue.		* Regarding cesarian section versus vaginal delivery, consider that sarcoidosis inflammation is known to have an affinity for scar tissue.

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	===== Risk of pre-term birth for expectant mothers taking multivitamins =====		===== Risk of pre-term birth for expectant mothers taking multivitamins =====

-	Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pubmed>long:20353456}}))	+	Regular multivitamin-mineral supplement use during pregnancy, in a developed country setting, is not associated with size at birth. However, a 2010 study of British women found that daily multivitamin use in the third trimester was associated with preterm birth.(({{pmid>long:20353456}}))


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-	Santiago //et al.// collected swabs of vaginal microflora from 17 women over the course of two consecutive menstrual cycles. Researchers noted a rise in Gram positive cocci during menses.(({{pubmed>long:22140538}}))	+	Santiago //et al.// collected swabs of vaginal microflora from 17 women over the course of two consecutive menstrual cycles. Researchers noted a rise in Gram positive cocci during menses.(({{pmid>long:22140538}}))
	===== Patients experiences =====		===== Patients experiences =====

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	{{topic>presentations tutorials papers abstracts book_chapters +pregnancy}}		{{topic>presentations tutorials papers abstracts book_chapters +pregnancy}}

-	{{tag>Special_issues pregnancy}}	+	{{tag>Special_issues special pregnancy}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/2362.html f24	+	* https://www.marshallprotocol.com/forum32/2362.html f24
-	* http://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=37167#p37167 s39	+	* https://www.marshallprotocol.com/view_topic.php?id=3094&forum_id=37&jump_to=37167#p37167 s39


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	PMID: 19939856</blockquote>		PMID: 19939856</blockquote>

-	===== References =====	+	===== References =====</nodisp>

10.12.2018		current
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	Smoking has been called "the single most preventable risk of disease" but the underlying disease process by which smoking is said to cause death and disease is not well-defined. However, there are several areas of study which point to the role of pathogens and modulation of the immune response in the diseases caused by smoking:		Smoking has been called "the single most preventable risk of disease" but the underlying disease process by which smoking is said to cause death and disease is not well-defined. However, there are several areas of study which point to the role of pathogens and modulation of the immune response in the diseases caused by smoking:
-	* Pathogens have been detected in cigarettes.(({{pubmed>long:20064769}}))	+	* Pathogens have been detected in cigarettes.(({{pmid>long:20064769}}))
-	* Smoking has been shown to contribute to delayed apoptosis of immune cells as well as decrease production of antimicrobial peptides. Some evidence has emerged that smoking offers sick people symptomatic relief – through immunosuppression,(({{pubmed>long:9610683}})) an anti-inflammatory effect,(({{pubmed>long:12033743}})) or any number of other possible mechanisms.	+	* Smoking has been shown to contribute to delayed apoptosis of immune cells as well as decrease production of antimicrobial peptides. Some evidence has emerged that smoking offers sick people symptomatic relief – through immunosuppression,(({{pmid>long:9610683}})) an anti-inflammatory effect,(({{pmid>long:12033743}})) or any number of other possible mechanisms.
-	* Sick people are less likely to quit smoking, which may artificially inflate estimate of the harmful effect of tobacco. For example, schizophrenic patients, have reported that they smoked "primarily for sedative effects and control of negative symptoms of schizophrenia."(({{pubmed>long:12132630}})) Symptomatic relief may also explain why people with mental illness are twice as likely to smoke than people without a mental illness.(({{pubmed>long:12132630}}))	+	* Sick people are less likely to quit smoking, which may artificially inflate estimate of the harmful effect of tobacco. For example, schizophrenic patients, have reported that they smoked "primarily for sedative effects and control of negative symptoms of schizophrenia."(({{pmid>long:12132630}})) Symptomatic relief may also explain why people with mental illness are twice as likely to smoke than people without a mental illness.(({{pmid>long:12132630}}))


	===== "The single most preventable risk of disease" =====		===== "The single most preventable risk of disease" =====

-	The World Health Organization estimates that tobacco caused 5.4 million deaths in 2004(([[http://www.who.int/entity/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf\|WHO global burden of disease report 2008]])) and 100 million deaths over the course of the 20th century.(([[http://www.who.int/entity/tobacco/mpower/mpower_report_prevalence_data_2008.pdf\|WHO Report on the Global Tobacco Epidemic, 2008]])) Similarly, the United States Centers for Disease Control and Prevention describes tobacco use as "the single most important preventable risk to human health in developed countries and an important cause of premature death worldwide."(([[http://www.cdc.gov/tobacco/quit_smoking/you_can_quit/nicotine.htm\|Nicotine: A Powerful Addiction]], Centers for Disease Control and Prevention))	+	The World Health Organization estimates that tobacco caused 5.4 million deaths in 2004(([[https://www.who.int/entity/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf\|WHO global burden of disease report 2008]])) and 100 million deaths over the course of the 20th century.(([[https://www.who.int/entity/tobacco/mpower/mpower_report_prevalence_data_2008.pdf\|WHO Report on the Global Tobacco Epidemic, 2008]])) Similarly, the United States Centers for Disease Control and Prevention describes tobacco use as "the single most important preventable risk to human health in developed countries and an important cause of premature death worldwide."(([[https://www.cdc.gov/tobacco/quit_smoking/you_can_quit/nicotine.htm\|Nicotine: A Powerful Addiction]], Centers for Disease Control and Prevention))


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-	Compounds in cigarettes have been said to be carcinogenic. As discussed in [[home:publications:proal_autoimmunity_2010\|Amy Proal's presentation at the 2010 International Congress on Autoimmunity]], Sapkota //et al.// identified fifteen different classes of bacteria and a broad range of pathogenic organisms in five commonly smoked cigarettes tested.(({{pubmed>long:20064769}})) That said, the underlying disease process by which smoking is said to cause death is not well-defined.	+	Compounds in cigarettes have been said to be carcinogenic. As discussed in [[home:publications:proal_autoimmunity_2010\|Amy Proal's presentation at the 2010 International Congress on Autoimmunity]], Sapkota //et al.// identified fifteen different classes of bacteria and a broad range of pathogenic organisms in five commonly smoked cigarettes tested.(({{pmid>long:20064769}})) That said, the underlying disease process by which smoking is said to cause death is not well-defined.


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	===== Smoking is immunosuppressive =====		===== Smoking is immunosuppressive =====

-	* Smoking and prolonged stress decrease production of antimicrobial peptides – Smoking and prolonged stress have been linked to increased susceptibility to bacterial infection. A 2010 study appearing in //Cell Host and Microbe// shows that this may be caused by a decrease in antimicrobial peptide (AmP) activity as a result of increased stimulation of a neuroendocrine signalling pathway.(({{pubmed>long:20413096}})) Radek //et al.// showed that when nicotinic acetylcholine receptors (nAChRs) were stimulated, mice had decreased AmP production and were increasingly susceptible to the pathogens methicillin-resistant //Staphylococcus aureus// and Group A //Streptococcus// infections.	+	* Smoking and prolonged stress decrease production of antimicrobial peptides – Smoking and prolonged stress have been linked to increased susceptibility to bacterial infection. A 2010 study appearing in //Cell Host and Microbe// shows that this may be caused by a decrease in antimicrobial peptide (AmP) activity as a result of increased stimulation of a neuroendocrine signalling pathway.(({{pmid>long:20413096}})) Radek //et al.// showed that when nicotinic acetylcholine receptors (nAChRs) were stimulated, mice had decreased AmP production and were increasingly susceptible to the pathogens methicillin-resistant //Staphylococcus aureus// and Group A //Streptococcus// infections.
-	* Nicotine interferes with apoptosis – According to a 2007 review, nicotine acts on immune cells. Although nicotine itself is usually not referred to as a carcinogen, there is ongoing debate whether nicotine functions as a "tumor enhancer." By binding to nicotinic acetylcholine receptors, nicotine deregulates essential biological processes like angiogenesis, apoptosis, and cell-mediated immunity.(({{pubmed>long:17846896}})) Delayed apoptosis – that is, the inability of cells to self-destruct – is one of the hallmarks of chronic inflammatory disease. It is well-documented that microbes induce delayed apoptosis in order to gain a survival advantage.	+	* Nicotine interferes with apoptosis – According to a 2007 review, nicotine acts on immune cells. Although nicotine itself is usually not referred to as a carcinogen, there is ongoing debate whether nicotine functions as a "tumor enhancer." By binding to nicotinic acetylcholine receptors, nicotine deregulates essential biological processes like angiogenesis, apoptosis, and cell-mediated immunity.(({{pmid>long:17846896}})) Delayed apoptosis – that is, the inability of cells to self-destruct – is one of the hallmarks of chronic inflammatory disease. It is well-documented that microbes induce delayed apoptosis in order to gain a survival advantage.


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	Though tobacco undoubtedly has some role in death and disease, the validity of these conclusions may not be as strong as some researchers have argued. Because conducting randomized controlled trials of tobacco users will likely never be conducted for ethical reasons, conclusions about tobacco must rely on certain statistical assumptions. Epidemiological studies of tobacco use multivariate analysis to control for any number of factors associated with likelihood of disease: education, age, ethnicity, income, gender, etc.		Though tobacco undoubtedly has some role in death and disease, the validity of these conclusions may not be as strong as some researchers have argued. Because conducting randomized controlled trials of tobacco users will likely never be conducted for ethical reasons, conclusions about tobacco must rely on certain statistical assumptions. Epidemiological studies of tobacco use multivariate analysis to control for any number of factors associated with likelihood of disease: education, age, ethnicity, income, gender, etc.

-	These types of studies assume that after controlling for all these key factors, people who smoke are statistically identical to people who don't smoke. But, epidemiological models may not fully account for the fact that people who are ill (or, especially people who are more likely to become ill) are more inclined to begin smoking, and more disinclined to discontinue smoking. Some evidence has emerged that smoking offers sick people symptomatic relief – through immunosuppression,(({{pubmed>long:9610683}})) an anti-inflammatory effect,(({{pubmed>long:12033743}})) or any number of other possible mechanisms.	+	These types of studies assume that after controlling for all these key factors, people who smoke are statistically identical to people who don't smoke. But, epidemiological models may not fully account for the fact that people who are ill (or, especially people who are more likely to become ill) are more inclined to begin smoking, and more disinclined to discontinue smoking. Some evidence has emerged that smoking offers sick people symptomatic relief – through immunosuppression,(({{pmid>long:9610683}})) an anti-inflammatory effect,(({{pmid>long:12033743}})) or any number of other possible mechanisms.

-	Schizophrenic patients, for example, have reported that they smoked "primarily for sedative effects and control of negative symptoms of schizophrenia."(({{pubmed>long:12132630}})) Symptomatic relief may also explain why people with mental illness are twice as likely to smoke than people without a mental illness.(({{pubmed>long:12132630}})) This effect may also be true for diseases which don't have a clear mental component.	+	Schizophrenic patients, for example, have reported that they smoked "primarily for sedative effects and control of negative symptoms of schizophrenia."(({{pmid>long:12132630}})) Symptomatic relief may also explain why people with mental illness are twice as likely to smoke than people without a mental illness.(({{pmid>long:12132630}})) This effect may also be true for diseases which don't have a clear mental component.

	If people smoke for symptomatic relief, there is a possible epidemiological paradox. As the health risks associated with smoking become more well-known, the less likely any given person is to smoke because of any reason but symptomatic relief. Under these circumstances, we would expect that the association between disease and smoking to //increase// in societies that begin to exert pressures (social, governmental, economic, etc.) against smoking.		If people smoke for symptomatic relief, there is a possible epidemiological paradox. As the health risks associated with smoking become more well-known, the less likely any given person is to smoke because of any reason but symptomatic relief. Under these circumstances, we would expect that the association between disease and smoking to //increase// in societies that begin to exert pressures (social, governmental, economic, etc.) against smoking.
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	===== Smoking and Chlamydia pneumoniae =====		===== Smoking and Chlamydia pneumoniae =====

-	Smoking, an independent risk factor for cardiovascular disease, has also been shown to be an independent risk factor for //C. pneumoniae// seropositivity. It has also been suggested that an exacerbation of //C. pneumoniae// infection through smoking cigarettes may increase the potential for a systemic infection and therefore increase the chance for development of atherosclerosis.(({{pubmed>long:10839723}}))	+	Smoking, an independent risk factor for cardiovascular disease, has also been shown to be an independent risk factor for //C. pneumoniae// seropositivity. It has also been suggested that an exacerbation of //C. pneumoniae// infection through smoking cigarettes may increase the potential for a systemic infection and therefore increase the chance for development of atherosclerosis.(({{pmid>long:10839723}}))

	===== Alternatives to smoking =====		===== Alternatives to smoking =====

-	Certain pharmaceutical preparations such as Nicorette gum contain nicotine for the treatment of tobacco dependence. Because as discussed above, nicotine appears to interfere with immune function,(({{pubmed>long:20413096}})) such smoking alternatives may impair patients' progress on the Marshall Protocol and are therefore contraindicated.	+	Certain pharmaceutical preparations such as Nicorette gum contain nicotine for the treatment of tobacco dependence. Because as discussed above, nicotine appears to interfere with immune function,(({{pmid>long:20413096}})) such smoking alternatives may impair patients' progress on the Marshall Protocol and are therefore contraindicated.


-	{{tag>Special_issues}}	+	{{tag>Special_issues special }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	Toxicol Sci. 2009 May;109(1):50-8. Epub 2009 Feb 25.		Toxicol Sci. 2009 May;109(1):50-8. Epub 2009 Feb 25.
-	The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.(({{pubmed>long:19244278}}))	+	The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.(({{pmid>long:19244278}}))

	Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.		Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M.
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	</blockquote>		</blockquote>

-	===== References =====	+	===== References =====</nodisp>

11.08.2019		current
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	Marshall Protocol (MP) patients who develop a bulls-eye rash after a tick bite or who think a tick bite has put them at risk for Lyme disease should ask their physician about taking 100mg of minocycline twice daily for 30 days.		Marshall Protocol (MP) patients who develop a bulls-eye rash after a tick bite or who think a tick bite has put them at risk for Lyme disease should ask their physician about taking 100mg of minocycline twice daily for 30 days.

-	Ticks are an efficient [[https://medical-dictionary.thefreedictionary.com/vector\|vector]] of diseases. (({{pubmed>long:26707835}}))	+	Ticks are an efficient [[https://medical-dictionary.thefreedictionary.com/vector\|vector]] of diseases. (({{pmid>long:26707835}}))

	==== Keeping ticks away ====		==== Keeping ticks away ====

-	The mixture of creeping thyme and citronella containing 1.5% of each showed higher repellency (91%) than individual essential oils at the concentration of 3%. (({{pubmed>long: 28645519}}))	+	The mixture of creeping thyme and citronella containing 1.5% of each showed higher repellency (91%) than individual essential oils at the concentration of 3%. (({{pmid>long: 28645519}}))

	In tick country carry a device to freeze any tick which attaches itself (ask your pharmacy for it). This kills the tick so it does not transfer amy more fluid into you. Once dead, you may brush the tick off. This is much safer than an attempt to twist the tick off.		In tick country carry a device to freeze any tick which attaches itself (ask your pharmacy for it). This kills the tick so it does not transfer amy more fluid into you. Once dead, you may brush the tick off. This is much safer than an attempt to twist the tick off.
	===== Treatment for MP patients =====		===== Treatment for MP patients =====

-	* For patients taking less than 100mg of minocycline – Continue olmesartan (Benicar). Ask physician about taking 100mg of minocycline twice daily for 10 days.(({{pubmed>long:12729432}})) (Note that in this case minocycline is dosed more frequently than it is typically used during the MP. This is due to the fact that the drug is being used to target an acute rather than a chronic infection.)	+	* For patients taking less than 100mg of minocycline – Continue olmesartan (Benicar). Ask physician about taking 100mg of minocycline twice daily for 10 days.(({{pmid>long:12729432}})) (Note that in this case minocycline is dosed more frequently than it is typically used during the MP. This is due to the fact that the drug is being used to target an acute rather than a chronic infection.)
	* For patients taking 100mg of minocycline but not a three antibiotic combination – Continue olmesartan. Ask physician about taking 100mg of minocycline twice daily for 30 days. To reduce any kind of immunosuppressive effect, these patients may wish to reduce although not eliminate any other MP antibiotics being taken.		* For patients taking 100mg of minocycline but not a three antibiotic combination – Continue olmesartan. Ask physician about taking 100mg of minocycline twice daily for 30 days. To reduce any kind of immunosuppressive effect, these patients may wish to reduce although not eliminate any other MP antibiotics being taken.
	* For patients who have progressed to Phase Three – Patients who are taking three or more antibiotics may opt to continue this effective treatment for killing many bacteria.		* For patients who have progressed to Phase Three – Patients who are taking three or more antibiotics may opt to continue this effective treatment for killing many bacteria.
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	===== Tick removal instructions =====		===== Tick removal instructions =====

-	Here is [[http://www.otom.com/\|information on a tick remover device.]]	+	Here is [[https://www.otom.com/\|information on a tick remover device.]]

-	Here are [[http://www.mydr.com.au/first-aid-self-care/tick-removal\|new instructions]] on how to remove a tick.	+	Better are [[https://www.mydr.com.au/first-aid-self-care/tick-removal\|new instructions]] on how to remove a tick.

-	Here is another set of [[http://vetmedicine.about.com/c/ht/00/07/How_Remove_Tick0962935143.htm\|tips on tick removal]].	+	Here is another set of [[https://vetmedicine.about.com/c/ht/00/07/How_Remove_Tick0962935143.htm\|tips on tick removal]].

-	The U.S. Centers for Disease Control and Prevention's website [[http://www.cdc.gov/ncidod/dvbid/lyme/ld_tickremoval.htm\|information on tick removal]] is surprisingly brief and reassuring. Perhaps this reflects their official stance the borreliosis/Lyme disease is not a big problem in the United States.	+	The U.S. Centers for Disease Control and Prevention's website [[https://www.cdc.gov/ncidod/dvbid/lyme/ld_tickremoval.htm\|information on tick removal]] is surprisingly brief and reassuring. Perhaps this reflects their official stance the borreliosis/Lyme disease is not a big problem in the United States.

	The general consensus seems to be to //not// use heat to try to make the tick come out. There is no agreement on the technique that works best and whether or not it is vital to ensure the head is removed.		The general consensus seems to be to //not// use heat to try to make the tick come out. There is no agreement on the technique that works best and whether or not it is vital to ensure the head is removed.
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	===== Additional information =====		===== Additional information =====

-	Human Tick-Borne Diseases in Australia. (({{pubmed>long:30746341}}))	+	Human Tick-Borne Diseases in Australia. (({{pmid>long:30746341}}))
	<blockquote>Six ticks, including Amblyomma triguttatum, Bothriocroton hydrosauri, Haemaphysalis novaeguineae, Ixodes cornuatus, Ixodes holocyclus, and Ixodes tasmani may transmit Coxiella burnetii, Rickettsia australis, Rickettsia honei, or Rickettsia honei subsp. marmionii.		<blockquote>Six ticks, including Amblyomma triguttatum, Bothriocroton hydrosauri, Haemaphysalis novaeguineae, Ixodes cornuatus, Ixodes holocyclus, and Ixodes tasmani may transmit Coxiella burnetii, Rickettsia australis, Rickettsia honei, or Rickettsia honei subsp. marmionii.

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	These pathogens include Anaplasma spp., Bartonella spp., Burkholderia spp., Francisella spp., Dera Ghazi Khan virus (DGKV), tick-borne encephalitis virus (TBEV), Lake Clarendon virus (LCV), Saumarez Reef virus (SREV), Upolu virus (UPOV), or Vinegar Hill virus (VINHV).</blockquote>		These pathogens include Anaplasma spp., Bartonella spp., Burkholderia spp., Francisella spp., Dera Ghazi Khan virus (DGKV), tick-borne encephalitis virus (TBEV), Lake Clarendon virus (LCV), Saumarez Reef virus (SREV), Upolu virus (UPOV), or Vinegar Hill virus (VINHV).</blockquote>

-	It has recently been demonstrated that saliva from Rhipicephalus sanguineus ticks contains adenosine (ADO) and prostaglandin E2 (PGE2), two non-protein molecules that have significant immunomodulatory properties. (({{pubmed>long:28693553}}))	+	It has recently been demonstrated that saliva from Rhipicephalus sanguineus ticks contains adenosine (ADO) and prostaglandin E2 (PGE2), two non-protein molecules that have significant immunomodulatory properties. (({{pmid>long:28693553}}))

-	* [[http://www.medscape.org/viewarticle/453519\|10 Days of Doxycycline Sufficient for Early Lyme Disease]] – Medscape article (free registration required)	+	* [[https://www.medscape.org/viewarticle/453519\|10 Days of Doxycycline Sufficient for Early Lyme Disease]] – Medscape article (free registration required)

	{{tag>Lyme_disease Special_issues special }}		{{tag>Lyme_disease Special_issues special }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=30954#p30954 s218	+	* https://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=30954#p30954 s218
-	* http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=46252#p46252 s242	+	* https://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=46252#p46252 s242
	*		*
	* Instructions for MP patients need tech clarification to set forth two categories of MP patients - 1) those who should take 100mg of mino twice a day (with Benicar? discontinue any other MP antibiotics?), and 2) those who should do nothing different than continue with their regular MP antibiotics. --- //Joe Trunk 2008/11/28 23:34//		* Instructions for MP patients need tech clarification to set forth two categories of MP patients - 1) those who should take 100mg of mino twice a day (with Benicar? discontinue any other MP antibiotics?), and 2) those who should do nothing different than continue with their regular MP antibiotics. --- //Joe Trunk 2008/11/28 23:34//
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-	===== References =====	+	===== References =====</nodisp>

10.19.2018		current
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	Even when blood is filtered, pathogens may pass between donor and recipient. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. //Cell Wall Deficient Forms: Stealth Pathogens//. CRC Press. Boca Raton, FL.))		Even when blood is filtered, pathogens may pass between donor and recipient. At an average of around 0.01 microns in diameter, L-form bacteria are small enough to pass through even the finest of filters.((Mattman, L. 2000. //Cell Wall Deficient Forms: Stealth Pathogens//. CRC Press. Boca Raton, FL.))

-	According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pubmed>long:12172448}})) The U.S. Food and Drug Administration (FDA) has a history of enforcing its restriction on the distribution of blood from sarcoidosis patients. In the FDA took action against the American Red Cross because blood was collected from a donor/donors who had been diagnosed with sarcoidois.	+	According to one study, patients who receive a donor organ from a sarcoidosis patient develop the disease, and clean organs transplanted into sarcoidosis patients become infected.(({{pmid>long:12172448}})) The U.S. Food and Drug Administration (FDA) has a history of enforcing its restriction on the distribution of blood from sarcoidosis patients. In the FDA took action against the American Red Cross because blood was collected from a donor/donors who had been diagnosed with sarcoidois.

	All blood banks may not have strict regulations against donations from people with so-called autoimmune diseases or Th1 inflammation, but given the known bacterial etiology, Marshall Protocol (MP) patients are advised not to donate blood, bone marrow, organs or other tissues.		All blood banks may not have strict regulations against donations from people with so-called autoimmune diseases or Th1 inflammation, but given the known bacterial etiology, Marshall Protocol (MP) patients are advised not to donate blood, bone marrow, organs or other tissues.
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	* A letter in CHEST online advocates the removal of phagocytic cells from blood being transfused.		* A letter in CHEST online advocates the removal of phagocytic cells from blood being transfused.
-	* Sarcoidosis has been transmitted to organ recipients from organ donors. (({{pubmed>long:12002380}}))	+	* Sarcoidosis has been transmitted to organ recipients from organ donors. (({{pmid>long:12002380}}))
-	* Lancet published this case report in 1990 of sarcoidosis after a heart transplant. (({{pubmed>long:1979389}}))	+	* Lancet published this case report in 1990 of sarcoidosis after a heart transplant. (({{pmid>long:1979389}}))
-	* Sarcoidosis has been reported to have been transmitted in bone marrow and stem cells. (({{pubmed>long:7951107}}))	+	* Sarcoidosis has been reported to have been transmitted in bone marrow and stem cells. (({{pmid>long:7951107}}))
-	* Granulomatous pneumonitis followed bone marrow transplantation. (({{pubmed>long:11607780}}))	+	* Granulomatous pneumonitis followed bone marrow transplantation. (({{pmid>long:11607780}}))
-	* Pulmonary sarcoidosis following stem cell transplantation: is it more than a chance occurrence? (({{pubmed>long:15302757}}))	+	* Pulmonary sarcoidosis following stem cell transplantation: is it more than a chance occurrence? (({{pmid>long:15302757}}))
-	* Cutaneous sarcoidosis in blood donation venepuncture sites. (({{pubmed>long:4646848}}))	+	* Cutaneous sarcoidosis in blood donation venepuncture sites. (({{pmid>long:4646848}}))

-	{{tag>Special_issues}}	+	{{tag>Special_issues special}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	//removed//....The FDA website and [[http://www.fda.gov/bbs/topics/ENFORCE/ENF00520.html\|this FDA enforcement report]] state that in 1997	+	//removed//....The FDA website and [[https://www.fda.gov/bbs/topics/ENFORCE/ENF00520.html\|this FDA enforcement report]] state that in 1997
-	//AND// [[http://www.chestjournal.org/cgi/eletters/127/5/1722\|This letter]] in CHEST	+	//AND// [[https://www.chestjournal.org/cgi/eletters/127/5/1722\|This letter]] in CHEST

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/4174.html f245-7	+	* https://www.marshallprotocol.com/forum32/4174.html f245-7
-	* http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=41360#p41360 s239	+	* https://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=41360#p41360 s239
-	* http://www.marshallprotocol.com/forum37/1153.html s359	+	* https://www.marshallprotocol.com/forum37/1153.html s359
	* couldn't verify Trevor's statement that the Red Cross doesn't allow donations from sarc patients so I deleted it		* couldn't verify Trevor's statement that the Red Cross doesn't allow donations from sarc patients so I deleted it

-	===== References =====	+	===== References =====</nodisp>

10.26.2018		current
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	Marshall Protocol (MP) patients should work with their doctors to examine the costs and benefits of taking any kind of injectable preparation which contains substances synthesized from organisms.		Marshall Protocol (MP) patients should work with their doctors to examine the costs and benefits of taking any kind of injectable preparation which contains substances synthesized from organisms.

-	Flu vaccines may be important to prevent acute infections, the acquisition of which can substantially set back progress on the MP or be life-threatening. Influenza vaccination is associated with a 50% reduction in the incidence of sudden cardiac death, acute myocardial infarction (heart attack), and ischemic stroke. Both heart attack and stroke have their peak incidence in winter months, which correspond to the time of year when cases of influenza also peak.(({{pubmed>long:12573201}}))	+	Flu vaccines may be important to prevent acute infections, the acquisition of which can substantially set back progress on the MP or be life-threatening. Influenza vaccination is associated with a 50% reduction in the incidence of sudden cardiac death, acute myocardial infarction (heart attack), and ischemic stroke. Both heart attack and stroke have their peak incidence in winter months, which correspond to the time of year when cases of influenza also peak.(({{pmid>long:12573201}}))

	//Patients should follow their doctors' advice regarding the immunizations they feel are essential.//		//Patients should follow their doctors' advice regarding the immunizations they feel are essential.//
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	==== Evidence for vaccine involvement in chronic disease ====		==== Evidence for vaccine involvement in chronic disease ====

-	* Guillain-Barre outbreak in 1976 – It is widely accepted that the influenza vaccine was responsible for the outbreak of Guillain-Barre syndrome in the United States in the seventies.(({{pubmed>long:17560693}})) In fact, in 1976, the national swine influenza vaccination program in the United States was temporarily suspended.(({{pubmed>long:19033158}}))	+	* Guillain-Barre outbreak in 1976 – It is widely accepted that the influenza vaccine was responsible for the outbreak of Guillain-Barre syndrome in the United States in the seventies.(({{pmid>long:17560693}})) In fact, in 1976, the national swine influenza vaccination program in the United States was temporarily suspended.(({{pmid>long:19033158}}))

	<blockquote>An unexplained increase in the risk of Guillain-Barre syndrome (GBS) occurred among recipients of the swine influenza vaccine in 1976-1977. Guillain-Barre syndrome remains the most frequent neurological condition reported after influenza vaccination to the Vaccine Adverse Events Reporting System (VAERS) since its inception in 1990.		<blockquote>An unexplained increase in the risk of Guillain-Barre syndrome (GBS) occurred among recipients of the swine influenza vaccine in 1976-1977. Guillain-Barre syndrome remains the most frequent neurological condition reported after influenza vaccination to the Vaccine Adverse Events Reporting System (VAERS) since its inception in 1990.

-	//Penina Haber, et al.// (({{pubmed>long:15562126}}))</blockquote>	+	//Penina Haber, et al.// (({{pmid>long:15562126}}))</blockquote>


-	* Bell's palsy – A 2004 paper found that incidence of Bell's palsy was higher following administration of flu vaccine between 1991 and 2001.(({{pubmed>long:15317028}})) Other papers appear to have confirmed this.(({{pubmed>long:14985487}})) This vaccine appears not to be in use.	+	* Bell's palsy – A 2004 paper found that incidence of Bell's palsy was higher following administration of flu vaccine between 1991 and 2001.(({{pmid>long:15317028}})) Other papers appear to have confirmed this.(({{pmid>long:14985487}})) This vaccine appears not to be in use.
-	* Simian virus 40 (SV40) in polio vaccine – Some have argued that large numbers of the U.S. population were infected with a contaminated batch of simian virus 40, a virus linked to mesotheliomia, an otherwise rare form of cancer.(({{pubmed>long:8183577}})) (({{pubmed>long:12459734}})) (({{pubmed>long:11205211}}))	+	* Simian virus 40 (SV40) in polio vaccine – Some have argued that large numbers of the U.S. population were infected with a contaminated batch of simian virus 40, a virus linked to mesotheliomia, an otherwise rare form of cancer.(({{pmid>long:8183577}})) (({{pmid>long:12459734}})) (({{pmid>long:11205211}}))
-	* Clinical trial for AIDS vaccine – A [[http://www.reuters.com/article/healthNews/idUSN1362317620071113?feedType=RSS&feedName=healthNews\|2007 international trial]] for an AIDS vaccine had to be abruptly discontinued when scientists realized that the vaccine somehow raised the risk of infection. The researchers administering the trial stressed that the vaccine could not itself cause the infection. Although it was not mentioned in the news story about the incident, one plausible hypothesis is that the vaccines were infected with bacteria.	+	* Clinical trial for AIDS vaccine – A [[https://www.reuters.com/article/healthNews/idUSN1362317620071113?feedType=RSS&feedName=healthNews\|2007 international trial]] for an AIDS vaccine had to be abruptly discontinued when scientists realized that the vaccine somehow raised the risk of infection. The researchers administering the trial stressed that the vaccine could not itself cause the infection. Although it was not mentioned in the news story about the incident, one plausible hypothesis is that the vaccines were infected with bacteria.
	==== Evidence against vaccine involvement in chronic disease ====		==== Evidence against vaccine involvement in chronic disease ====

-	With perhaps an occasional exception,(({{pubmed>long:17656395}})) the vast majority of studies and reviews have found no apparent link between vaccinations and autism, the disease that has been most recently tied to the onset of chronic disease.(({{pubmed>long:17928818}})) (({{pubmed>long:17168158}}))	+	With perhaps an occasional exception,(({{pmid>long:17656395}})) the vast majority of studies and reviews have found no apparent link between vaccinations and autism, the disease that has been most recently tied to the onset of chronic disease.(({{pmid>long:17928818}})) (({{pmid>long:17168158}}))

	<blockquote>		<blockquote>
	A suggested association between certain childhood vaccines and autism has been one of the most contentious vaccine safety controversies in recent years. Despite compelling scientific evidence against a causal association, many parents and parent advocacy groups continue to suspect that vaccines, particularly measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines (TCVs), can cause autism.		A suggested association between certain childhood vaccines and autism has been one of the most contentious vaccine safety controversies in recent years. Despite compelling scientific evidence against a causal association, many parents and parent advocacy groups continue to suspect that vaccines, particularly measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines (TCVs), can cause autism.

-	//Frank DeStefano// (({{pubmed>long:17928818}})) </blockquote>	+	//Frank DeStefano// (({{pmid>long:17928818}})) </blockquote>

-	Andrew Wakefield authored a widely publicized study linking the measles, mumps and rubella (MMR) vaccine with autism.(([[http://www.bmj.com/rapid-response/2011/11/02/wakefield%E2%80%99s-lancet-paper-vindicated-%E2%80%93-yet-again\|Multiple studies have since confirmed the correlation after initially being decried as fraudulant.]]))(([[https://www.ebcala.org/areas-of-law/vaccine-law/co-author-of-lancet-mmr-autism-study-exonerated-on-all-charges-of-professional-misconduct\|Legal exoneration has also been given.]]))	+	Andrew Wakefield authored a widely publicized study linking the measles, mumps and rubella (MMR) vaccine with autism.(([[https://www.bmj.com/rapid-response/2011/11/02/wakefield%E2%80%99s-lancet-paper-vindicated-%E2%80%93-yet-again\|Multiple studies have since confirmed the correlation after initially being decried as fraudulant.]]))(([[https://www.ebcala.org/areas-of-law/vaccine-law/co-author-of-lancet-mmr-autism-study-exonerated-on-all-charges-of-professional-misconduct\|Legal exoneration has also been given.]]))

	==== Cause for concern? ====		==== Cause for concern? ====

-	That the vaccine additives thimerosal and mercury cause autism appears to have been thoroughly discredited.(({{pubmed>long:19200293}}))	+	That the vaccine additives thimerosal and mercury cause autism appears to have been thoroughly discredited.(({{pmid>long:19200293}}))

	What is less certain is how effective current purification and/or filtration processes for injectable medicines are at removing viruses, L-form bacteria, and mycoplasma. One cause for concern is that L-form bacteria have been largely ignored by medicine. Researchers who do not think L-forms are present in disease would not think sub-microscopic bacteria are present in vaccines.		What is less certain is how effective current purification and/or filtration processes for injectable medicines are at removing viruses, L-form bacteria, and mycoplasma. One cause for concern is that L-form bacteria have been largely ignored by medicine. Researchers who do not think L-forms are present in disease would not think sub-microscopic bacteria are present in vaccines.

-	Technology for purifying vaccines is beyond the scope of the Knowledge Base. It should be noted, however, that pathogenic bacterial forms so small they cannot be detected by an optical microscope – 0.015 microns – have been identified and photographed by researchers such as Dr. Emil Wirostko.(({{pubmed>long:2923094}}))	+	Technology for purifying vaccines is beyond the scope of the Knowledge Base. It should be noted, however, that pathogenic bacterial forms so small they cannot be detected by an optical microscope – 0.015 microns – have been identified and photographed by researchers such as Dr. Emil Wirostko.(({{pmid>long:2923094}}))

	One researcher tested vaccines used in the first gulf war and concluded they had mycoplasma contamination.((Nicolson GL, Nass M, Nicolson NL. Anthrax vaccine: controversy over safety and efficacy. //Antimicrobics and Infectious Disease Newsletter// 2000;18:1-6.))		One researcher tested vaccines used in the first gulf war and concluded they had mycoplasma contamination.((Nicolson GL, Nass M, Nicolson NL. Anthrax vaccine: controversy over safety and efficacy. //Antimicrobics and Infectious Disease Newsletter// 2000;18:1-6.))
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	<html><!--		<html><!--
-	However, if filters are being used, it should be noted that the smallest commercially available filters are 0.1 - 0.2 microns,(({{pubmed>long:8140710}})) (({{pubmed>long:2801045}})) --></html>	+	However, if filters are being used, it should be noted that the smallest commercially available filters are 0.1 - 0.2 microns,(({{pmid>long:8140710}})) (({{pmid>long:2801045}})) --></html>

	===== Risk in receiving flu vaccine or pneumovax =====		===== Risk in receiving flu vaccine or pneumovax =====
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	* Is your risk of exposure to germs excessive?		* Is your risk of exposure to germs excessive?
	* Do you want to take the chance of making your Th1 inflammation worse by possibly acquiring a new batch of pleomorphic bacteria that are so small they slipped through the vaccine filters?		* Do you want to take the chance of making your Th1 inflammation worse by possibly acquiring a new batch of pleomorphic bacteria that are so small they slipped through the vaccine filters?
		+	* Do you suffer from excessive reactivity, e.g. celiac inability to ingest wheat?
		+
		+	One young man (not on the Marshall Protocol) reported anaphylaxis after a recent influenza shot.

	MP patients should talk with their health care practitioners about the risk/benefit ratio regarding the flu v or pneumovax. The benefits of the flu vaccine and pneumovax do not outweigh the risk for most MP patients with chronic inflammatory disease, but patients who are in a high-risk category should consider receiving these vaccines.		MP patients should talk with their health care practitioners about the risk/benefit ratio regarding the flu v or pneumovax. The benefits of the flu vaccine and pneumovax do not outweigh the risk for most MP patients with chronic inflammatory disease, but patients who are in a high-risk category should consider receiving these vaccines.
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	===== Tetanus vaccine =====		===== Tetanus vaccine =====

-	Adult MP patients who decide to receive the [[http://www.vaccineinformation.org/tetanus/qandavax.asp\|tetanus vaccine]] should request the tetanus/diptheria (Td) injection. They should avoid the tetanus/diptheria/pertussis (Tdap) injection, because it would be more challenging to the immune system, and adults do not usually need the pertussis protection.	+	Adult MP patients who decide to receive the [[https://www.vaccineinformation.org/tetanus/qandavax.asp\|tetanus vaccine]] should request the tetanus/diptheria (Td) injection. They should avoid the tetanus/diptheria/pertussis (Tdap) injection, because it would be more challenging to the immune system, and adults do not usually need the pertussis protection.

	Any adverse reaction an individual may have had to tetanus immunization in the past was likely due to the pertussis or diptheria component. Although rarely given, an injection of just tetanus toxoid (TT) every five years can be administered as an alternative. This would prevent needing Td or Tdap after an injury.		Any adverse reaction an individual may have had to tetanus immunization in the past was likely due to the pertussis or diptheria component. Although rarely given, an injection of just tetanus toxoid (TT) every five years can be administered as an alternative. This would prevent needing Td or Tdap after an injury.
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	===== Read more =====		===== Read more =====

-	* [[http://www.theatlantic.com/issues/2000/02/002bookchin.htm\|The Virus and the vaccine]] – 2000 article appearing in //Atlantic Monthly// about the virus SV40 which has been associated with a number of rare human cancers	+	* [[https://www.theatlantic.com/issues/2000/02/002bookchin.htm\|The Virus and the vaccine]] – 2000 article appearing in //Atlantic Monthly// about the virus SV40 which has been associated with a number of rare human cancers


	{{tag>Special_issues special }}		{{tag>Special_issues special }}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1081.html f60-2	+	* https://www.marshallprotocol.com/forum32/1081.html f60-2
-	* http://www.marshallprotocol.com/view_topic.php?id=10120&forum_id=32&jump_to=118988#p118988 f129	+	* https://www.marshallprotocol.com/view_topic.php?id=10120&forum_id=32&jump_to=118988#p118988 f129
-	* http://www.marshallprotocol.com/view_topic.php?id=3634&forum_id=32&jump_to=118228#p118228 f71	+	* https://www.marshallprotocol.com/view_topic.php?id=3634&forum_id=32&jump_to=118228#p118228 f71

-	* Latest Cochrane review findings: "There is not enough evidence to decide whether routine vaccination to prevent influenza in healthy adults is effective", source: http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001269/frame.html	+	* Latest Cochrane review findings: "There is not enough evidence to decide whether routine vaccination to prevent influenza in healthy adults is effective", source: https://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001269/frame.html


	This article may have some interesting data except for the fact that they seem to misunderstand autoantibodies:		This article may have some interesting data except for the fact that they seem to misunderstand autoantibodies:

-	<blockquote>Agmon-Levin, N., Z. Paz, et al. (2009). "Vaccines and autoimmunity." Nat Rev Rheumatol 5(11): 648-652.(({{pubmed>long:19865091}}))	+	<blockquote>Agmon-Levin, N., Z. Paz, et al. (2009). "Vaccines and autoimmunity." Nat Rev Rheumatol 5(11): 648-652.(({{pmid>long:19865091}}))


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	<blockquote>J Trop Pediatr. 2009 Nov 4. [Epub ahead of print]		<blockquote>J Trop Pediatr. 2009 Nov 4. [Epub ahead of print]
-	Effect of Season of Inoculation on Immune Response to Rubella Vaccine in Children.(({{pubmed>long:19889749}}))	+	Effect of Season of Inoculation on Immune Response to Rubella Vaccine in Children.(({{pmid>long:19889749}}))

	Linder N, Abudi Y, Abdalla W, Badir M, Amitai Y, Samuels J, Mendelson E, Levy I.		Linder N, Abudi Y, Abdalla W, Badir M, Amitai Y, Samuels J, Mendelson E, Levy I.
Line 152:		Line 156:
	PMID: 19889749</blockquote>		PMID: 19889749</blockquote>

-	===== References =====	+	===== References =====</nodisp>