Marshall Protocol Knowledge Base - home:symptoms

Managing cardiac symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Managing dental and periodontal symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.07.2019		current
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	As the article on [[home:diseases:periodontal\|periodontal disease and gingivitis]] explains, these diseases are widely accepted as caused by a polymicrobial infection. Like all symptoms of inflammatory disease, dental pain and inflammation may temporarily increase during periods of immunopathology. These symptoms can be managed using the [[home:mp:managing_immunopathology\|typical strategies for managing immunopathology]], and should resolve through the course of the Marshall Protocol (MP).		As the article on [[home:diseases:periodontal\|periodontal disease and gingivitis]] explains, these diseases are widely accepted as caused by a polymicrobial infection. Like all symptoms of inflammatory disease, dental pain and inflammation may temporarily increase during periods of immunopathology. These symptoms can be managed using the [[home:mp:managing_immunopathology\|typical strategies for managing immunopathology]], and should resolve through the course of the Marshall Protocol (MP).

-	Dental problems seem to be particularly common among patients with Th1 disease. High levels of 1,25-D, which is common in such patients, can cause the teeth to be resorbed into the blood,(({{pubmed>long:10782361}})) (({{pubmed>long:10363752}})) a process which increases vulnerability to bacteria. Also, decreased production of saliva, a symptom of inflammation, can make teeth more susceptible to the mix of pathogens present in the mouth that decay teeth.	+	Dental problems seem to be particularly common among patients with Th1 disease. High levels of 1,25-D, which is common in such patients, can cause the teeth to be resorbed into the blood,(({{pmid>long:10782361}})) (({{pmid>long:10363752}})) a process which increases vulnerability to bacteria. Also, decreased production of saliva, a symptom of inflammation, can make teeth more susceptible to the mix of pathogens present in the mouth that decay teeth.

	<blockquote>You can expect some aggravation of symptoms especially if you have had any infected tooth requiring a root canal or deep filling. Once started on minocycline, the gum inflammation and infection will improve. The tooth pain can wax and wane throughout the ramping up phase of the antibiotics but tend to be transient.		<blockquote>You can expect some aggravation of symptoms especially if you have had any infected tooth requiring a root canal or deep filling. Once started on minocycline, the gum inflammation and infection will improve. The tooth pain can wax and wane throughout the ramping up phase of the antibiotics but tend to be transient.
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	===== Halitosis (bad breath) =====		===== Halitosis (bad breath) =====

-	[[http://bacteriality.com/2008/05/01/breath/\|Several studies]] have confirmed that most cases of halitosis, also known as bad breath, are caused by bacteria. One environmental study of patients with and without halitosis found that 32 species including 13 noncultivable species were found only in subjects with halitosis. //Solobacterium moorei// was present in all subjects with halitosis but not in any control subjects.(({{pubmed>long:17670880}}))	+	[[https://bacteriality.com/2008/05/01/breath/\|Several studies]] have confirmed that most cases of halitosis, also known as bad breath, are caused by bacteria. One environmental study of patients with and without halitosis found that 32 species including 13 noncultivable species were found only in subjects with halitosis. //Solobacterium moorei// was present in all subjects with halitosis but not in any control subjects.(({{pmid>long:17670880}}))

	Patients suffering from halitosis can use one of the [[home:othertreatments:mouthwash\|mouthwashes]] recommended for MP patients.		Patients suffering from halitosis can use one of the [[home:othertreatments:mouthwash\|mouthwashes]] recommended for MP patients.

-	<blockquote>Appl Environ Microbiol. 2010 May;76(9):2806-14. Epub 2010 Mar 12.	+	<blockquote>
-	Relationship between oral malodor and the global composition of indigenous bacterial populations in saliva.	+	Oral malodor develops mostly from the metabolic activities of indigenous bacterial populations within the oral cavity, but whether healthy or oral malodor-related patterns of the global bacterial composition exist remains unclear. In this study, the bacterial compositions in the saliva of 240 subjects complaining of oral malodor were divided into groups based on terminal-restriction fragment length polymorphism (T-RFLP) profiles using hierarchical cluster analysis, and the patterns of the microbial community composition of those exhibiting higher and lower malodor were explored. Four types of bacterial community compositions were detected (clusters I, II, III, and IV).
		+
		+	Two parameters for measuring oral malodor intensity (the concentration of volatile sulfur compounds in mouth air and the organoleptic score) were noticeably lower in cluster I than in the other clusters.

-	Takeshita T, Suzuki N, Nakano Y, Shimazaki Y, Yoneda M, Hirofuji T, Yamashita Y.	+	Using multivariate analysis, the differences in the levels of oral malodor were significant after adjustment for potential confounding factors such as total bacterial count, mean periodontal pocket depth, and tongue coating score (P < 0.001). Among the four clusters with different proportions of indigenous members, the T-RFLP profiles of cluster I were implicated as the bacterial populations with higher proportions of Streptococcus, Granulicatella, Rothia, and Treponema species than those of the other clusters. These results clearly correlate the global composition of indigenous bacterial populations with the severity of oral malodor. (({{pmid>long:20228112}}))
-	Section of Preventive Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Higashi-ku, Fukuoka, Japan.	+
-	Abstract	+
-	Oral malodor develops mostly from the metabolic activities of indigenous bacterial populations within the oral cavity, but whether healthy or oral malodor-related patterns of the global bacterial composition exist remains unclear. In this study, the bacterial compositions in the saliva of 240 subjects complaining of oral malodor were divided into groups based on terminal-restriction fragment length polymorphism (T-RFLP) profiles using hierarchical cluster analysis, and the patterns of the microbial community composition of those exhibiting higher and lower malodor were explored. Four types of bacterial community compositions were detected (clusters I, II, III, and IV). Two parameters for measuring oral malodor intensity (the concentration of volatile sulfur compounds in mouth air and the organoleptic score) were noticeably lower in cluster I than in the other clusters. Using multivariate analysis, the differences in the levels of oral malodor were significant after adjustment for potential confounding factors such as total bacterial count, mean periodontal pocket depth, and tongue coating score (P < 0.001). Among the four clusters with different proportions of indigenous members, the T-RFLP profiles of cluster I were implicated as the bacterial populations with higher proportions of Streptococcus, Granulicatella, Rothia, and Treponema species than those of the other clusters. These results clearly correlate the global composition of indigenous bacterial populations with the severity of oral malodor. (({{pubmed>long:20228112}}))	+
	</blockquote>		</blockquote>

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	The use of tetracyclines, especially the MP antibiotic [[home:mp:minocycline\|minocycline]] during tooth development, which occurs during the second half of pregnancy, infancy, and childhood up to the age of eight years, may cause permanent discoloration of the teeth (yellow/gray/brown). However, teeth staining can happen in adults as well.		The use of tetracyclines, especially the MP antibiotic [[home:mp:minocycline\|minocycline]] during tooth development, which occurs during the second half of pregnancy, infancy, and childhood up to the age of eight years, may cause permanent discoloration of the teeth (yellow/gray/brown). However, teeth staining can happen in adults as well.

-	This adverse reaction is more common during long-term use of the drug, but it has been observed following repeated short-term courses. Use of minocycline is generally avoided in children under age eight for that reason. In some situations, the benefits of using minocycline may outweight the risk of cosmetic changes in the teeth. The risk is probably less when the doses are low, and it does not appear that all children develop tooth staining. Enamel hypoplasia (poor development) has also been reported.(({{pubmed>long:11089368}}))	+	This adverse reaction is more common during long-term use of the drug, but it has been observed following repeated short-term courses. Use of minocycline is generally avoided in children under age eight for that reason. In some situations, the benefits of using minocycline may outweight the risk of cosmetic changes in the teeth. The risk is probably less when the doses are low, and it does not appear that all children develop tooth staining. Enamel hypoplasia (poor development) has also been reported.(({{pmid>long:11089368}}))

-	In some situations, the benefits of using minocycline may outweigh the risk of cosmetic changes in the teeth. The risk is probably less when the doses are low, and it does not appear that all children develop tooth staining.(({{pubmed>long:15215140}}))	+	In some situations, the benefits of using minocycline may outweigh the risk of cosmetic changes in the teeth. The risk is probably less when the doses are low, and it does not appear that all children develop tooth staining.(({{pmid>long:15215140}}))

-	In older children and adults, temporary discoloration of teeth occurs infrequently(({{pubmed>long:15485524}})) and not in doses recommended by the MP. The MP uses [[home:mp:antibiotic_dosing\|low doses of minocycline]] that are only a fraction of what is typically used for other treatments.	+	In older children and adults, temporary discoloration of teeth occurs infrequently(({{pmid>long:15485524}})) and not in doses recommended by the MP. The MP uses [[home:mp:antibiotic_dosing\|low doses of minocycline]] that are only a fraction of what is typically used for other treatments.

	The staining is actually of the plaque and tartar (hardened plaque) and so may be removed with efficient cleaning or by a dental hygienist. MP patients may notice greater plaque and tartar build-up while on the MP.		The staining is actually of the plaque and tartar (hardened plaque) and so may be removed with efficient cleaning or by a dental hygienist. MP patients may notice greater plaque and tartar build-up while on the MP.
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-	<blockquote>[[http://jennifer.hubpages.com/hub/Make_Your_Own_and_Save_-_Toothpaste_and_Mouthwash\|Here]] are some recipes at this link for homemade toothpaste and mouthwash that incorporate baking soda and hydrogen peroxide.	+	<blockquote>[[https://jennifer.hubpages.com/hub/Make_Your_Own_and_Save_-_Toothpaste_and_Mouthwash\|Here]] are some recipes at this link for homemade toothpaste and mouthwash that incorporate baking soda and hydrogen peroxide.

	//MarshallProtocol.com//</blockquote>		//MarshallProtocol.com//</blockquote>
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	===== Temporomandibular joint (TMJ) pain =====		===== Temporomandibular joint (TMJ) pain =====

-	[[http://www.nidcr.nih.gov/OralHealth/Topics/TMJ/TMJDisorders.htm\|Temporomandibular joint and muscle disorders]], commonly called "TMJ," are a group of conditions that cause pain and dysfunction in the jaw joint and the muscles that control jaw movement.	+	[[https://www.nidcr.nih.gov/OralHealth/Topics/TMJ/TMJDisorders.htm\|Temporomandibular joint and muscle disorders]], commonly called "TMJ," are a group of conditions that cause pain and dysfunction in the jaw joint and the muscles that control jaw movement.

	One of the first symptoms of TMJ will be that the jaw isn't working properly. Patients may be able to barely open and close their mouth, and their upper and lower bite no longer align as they once did. The teeth may no longer touch. There may be an odd clicking sound when they move their jaw.		One of the first symptoms of TMJ will be that the jaw isn't working properly. Patients may be able to barely open and close their mouth, and their upper and lower bite no longer align as they once did. The teeth may no longer touch. There may be an odd clicking sound when they move their jaw.
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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=37813#p37813 s157	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=37813#p37813 s157
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38553#p38553 s160	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38553#p38553 s160
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38552#p38552 s159	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38552#p38552 s159
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38659#p38659 s162	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38659#p38659 s162
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=87584#p87584 s169	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=87584#p87584 s169
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120195#p120195 s170	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=120195#p120195 s170
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38551#p38551 s158	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38551#p38551 s158
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=76795#p76795 s168	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=76795#p76795 s168
-	* http://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38656#p38656 s161	+	* https://www.marshallprotocol.com/view_topic.php?id=4221&forum_id=37&jump_to=38656#p38656 s161

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-	===== References =====	+	===== References =====</nodisp>

Ear symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
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	====== Ear symptoms ======		====== Ear symptoms ======

-	A number of chronic ear complaints appear to be the result of microbes. For example, biofilm bacteria play a well-defined role in otitis media.(({{pubmed>long:16835426}}))	+	A number of chronic ear complaints appear to be the result of microbes. For example, biofilm bacteria play a well-defined role in otitis media.(({{pmid>long:16835426}}))

	As evidenced by patient and physician reports, the Marshall Protocol seems to target a range of ear conditions. However, immunopathology due to treatment can cause temporary increases in ear-related symptoms. As always, one's first measure should be to slow the immune system response to see if it provides relief. If not, there are safe measures you can take to palliate these intolerable symptoms.		As evidenced by patient and physician reports, the Marshall Protocol seems to target a range of ear conditions. However, immunopathology due to treatment can cause temporary increases in ear-related symptoms. As always, one's first measure should be to slow the immune system response to see if it provides relief. If not, there are safe measures you can take to palliate these intolerable symptoms.
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	===== Cerumen (ear wax) =====		===== Cerumen (ear wax) =====

-	Patients for whom excess ear wax is a problem, may wish to try [[http://www.similasanusa.com/products-ear-wax-relief.cfm\|Similasan Ear Wax Relief]], available over the counter.	+	Patients for whom excess ear wax is a problem, may wish to try [[https://www.similasanusa.com/products-ear-wax-relief.cfm\|Similasan Ear Wax Relief]], available over the counter.


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	===== Heartbeat heard in ears =====		===== Heartbeat heard in ears =====

-	The "heartbeat" you hear in your ear is called [[http://www.dizziness-and-balance.com/disorders/hearing/tinnitus.htm\|pulsitile tinnitus]]. Pulsatile tinnitus is usually due to a small blood vessel that is coupled by fluid to your ear drum. It is usually nothing serious and also untreatable. This should resolve with the MP.	+	The "heartbeat" you hear in your ear is called [[https://www.dizziness-and-balance.com/disorders/hearing/tinnitus.htm\|pulsitile tinnitus]]. Pulsatile tinnitus is usually due to a small blood vessel that is coupled by fluid to your ear drum. It is usually nothing serious and also untreatable. This should resolve with the MP.
		+
		+	===== EMF =====
		+
		+	Tinnitis may also be associated with exposure to electromagnetic radiation.


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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/6649.html f260	+	* https://www.marshallprotocol.com/forum32/6649.html f260
-	* http://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=82158#p82158 f213	+	* https://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=82158#p82158 f213
-	* http://www.marshallprotocol.com/forum32/7102.html#p72538 f210	+	* https://www.marshallprotocol.com/forum32/7102.html#p72538 f210
-	* http://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=82155#p82155 f212	+	* https://www.marshallprotocol.com/view_topic.php?id=7102&forum_id=32&jump_to=82155#p82155 f212
-	* http://www.marshallprotocol.com/view_topic.php?id=10901&forum_id=32&jump_to=131913#p131913 f119	+	* https://www.marshallprotocol.com/view_topic.php?id=10901&forum_id=32&jump_to=131913#p131913 f119
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		+	===== References =====</nodisp>

-	===== References =====

Managing eye symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.15.2018		current
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	* dry eye – Many people with “dry eye” find that their eyes water but still feel dry. This occurs because the eye has two different tear ducts. Unfortunately, the ducts that produce tears necessary to maintain normal moisture in the eyes are often blocked or reduced by inflammation. Although the tears produced by the eye’s other ducts attempt to make up for loss of moisture, they do not have the same lubricating properties and simply cause the eye to water.		* dry eye – Many people with “dry eye” find that their eyes water but still feel dry. This occurs because the eye has two different tear ducts. Unfortunately, the ducts that produce tears necessary to maintain normal moisture in the eyes are often blocked or reduced by inflammation. Although the tears produced by the eye’s other ducts attempt to make up for loss of moisture, they do not have the same lubricating properties and simply cause the eye to water.
	* floaters – Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent. There is no physical possibility that floaters are microbes.		* floaters – Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent. There is no physical possibility that floaters are microbes.
-	* ocular migraine – During migraine processes, changes also may take place in blood flow to the area of the brain responsible for vision (visual cortex or occipital lobe). Resulting [[http://www.allaboutvision.com/conditions/ocular-migraine.htm\|ophthalmic or ocular migraines]] commonly can produce visual symptoms even without a headache. Ocular migraines generally are considered harmless. They are typically painless, cause no permanent visual or brain damage, and usually do not require treatment. Nevertheless, patients should always consult their eye doctor when they have unusual vision symptoms, because it's possible that you have another condition requiring treatment, such as a [[http://www.allaboutvision.com/conditions/retinadetach.htm\|retinal detachment]], which should be checked out immediately.	+	* ocular migraine – During migraine processes, changes also may take place in blood flow to the area of the brain responsible for vision (visual cortex or occipital lobe). Resulting [[https://www.allaboutvision.com/conditions/ocular-migraine.htm\|ophthalmic or ocular migraines]] commonly can produce visual symptoms even without a headache. Ocular migraines generally are considered harmless. They are typically painless, cause no permanent visual or brain damage, and usually do not require treatment. Nevertheless, patients should always consult their eye doctor when they have unusual vision symptoms, because it's possible that you have another condition requiring treatment, such as a [[https://www.allaboutvision.com/conditions/retinadetach.htm\|retinal detachment]], which should be checked out immediately.
-	* photopsia – [[http://www.retinalphysician.com/article.aspx?article=101095\|Photopsia]] is an affection of the eye, in which the patient perceives luminous rays, flashes, coruscations, etc. Photopsia can be due to inflammation irritating the outer retina or photoreceptors. These perceive only light, so any stimulation will be perceived as light. But there are other, more serious causes including: retinal detachment, TIA, posterior vitreous detachment, and even migraines (with or without headache).	+	* photopsia – [[https://www.retinalphysician.com/article.aspx?article=101095\|Photopsia]] is an affection of the eye, in which the patient perceives luminous rays, flashes, coruscations, etc. Photopsia can be due to inflammation irritating the outer retina or photoreceptors. These perceive only light, so any stimulation will be perceived as light. But there are other, more serious causes including: retinal detachment, TIA, posterior vitreous detachment, and even migraines (with or without headache).
-	* vasculitis (visibly red conjunctiva) – Normally the [[http://medical-dictionary.thefreedictionary.com/conjunctiva\|conjunctiva]] is clear white. Visibly red veins of the eye is a sign of vasculitis (inflammation of the veins) and is common in chronic disease. Because it is in the eye, it is very obvious and disconcerting. But it is also common in the skin, small varicose veins, easy bruising; in the gut, microscopic blood loss and in hidden areas. Because immunopathology entails the release of cytokines and apoptosis (cell death) of infected cells caused by innate immune activation, this does occur prior to treatment as the bacteria as part of their life cycle will manifest in more typical forms causing immune identification and response.	+	* vasculitis (visibly red conjunctiva) – Normally the [[https://medical-dictionary.thefreedictionary.com/conjunctiva\|conjunctiva]] is clear white. Visibly red veins of the eye is a sign of vasculitis (inflammation of the veins) and is common in chronic disease. Because it is in the eye, it is very obvious and disconcerting. But it is also common in the skin, small varicose veins, easy bruising; in the gut, microscopic blood loss and in hidden areas. Because immunopathology entails the release of cytokines and apoptosis (cell death) of infected cells caused by innate immune activation, this does occur prior to treatment as the bacteria as part of their life cycle will manifest in more typical forms causing immune identification and response.


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	The MP is designed so that patients can minimize the chance of eye damage due to increased inflammation by maintaining a tight olmesartan blockade. Altering the dose and scheduling of antibiotics will manage the severity of the immunopathology by slowing the rate at which bacteria are destroyed and thus reduce the chance of eye inflammation. In addition, a variety of eye medications and drops are available to treat eye inflammation and dry eye.		The MP is designed so that patients can minimize the chance of eye damage due to increased inflammation by maintaining a tight olmesartan blockade. Altering the dose and scheduling of antibiotics will manage the severity of the immunopathology by slowing the rate at which bacteria are destroyed and thus reduce the chance of eye inflammation. In addition, a variety of eye medications and drops are available to treat eye inflammation and dry eye.

-	* Ganfort – Prescription eye drops lower the pressure in the eye by decreasing the fluid produced and helping the flow of fluid out of the eye chamber. Although GANFORT® PF 0.3/5 eye drops help control your condition, it does not cure it.	+
	* Optive – Non-prescription eye lubricant, which is a safer option than Restasis.		* Optive – Non-prescription eye lubricant, which is a safer option than Restasis.
	* cyclosporine (Restasis) – A corticosteroid. Generally contraindicated for MP patients, however, less immunosuppressive than prednisolone.		* cyclosporine (Restasis) – A corticosteroid. Generally contraindicated for MP patients, however, less immunosuppressive than prednisolone.
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	* prednisolone (Prednisone, Pred Mild, Pred Forte) – A corticosteroid. Generally contraindicated for MP patients. More immunosuppressive than cyclosporine.		* prednisolone (Prednisone, Pred Mild, Pred Forte) – A corticosteroid. Generally contraindicated for MP patients. More immunosuppressive than cyclosporine.
	* terramycin – An antibacterial eye ointment.		* terramycin – An antibacterial eye ointment.
		+	* Ganfort – Prescription eye drops which lower the pressure in the eye by decreasing the fluid produced and helping the flow of fluid out of the eye chamber. Although GANFORT® PF 0.3/5 eye drops help control your condition, it does not cure it.
	* [[home:othertreatments:chemotherapy#methotrexate\|Methotrexate]] – Contraindicated.		* [[home:othertreatments:chemotherapy#methotrexate\|Methotrexate]] – Contraindicated.

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	Patients should work with their doctor or ophthalmologist to limit their use of substances which affect the proper functioning of the immune system. Patients' doctors who believe they need immunosuppressant eye drops to temorarily control inflammation may use the drugs while on the MP.		Patients should work with their doctor or ophthalmologist to limit their use of substances which affect the proper functioning of the immune system. Patients' doctors who believe they need immunosuppressant eye drops to temorarily control inflammation may use the drugs while on the MP.

-	Be advised that use of steroids delays resolution of original disease symptoms while on the MP, and can have serious side effects. These side effects include glaucoma,(({{pubmed>long:5953285}})) cataracts,(({{pubmed>long:16905028}})) ocular hypertension,(({{pubmed>long: 1559550}})) [[home:othertreatments:corticosteroids#side_effects_of_corticosteroid_therapy\|various other side effects]], (({{pubmed>long:11820911}})) as well as increase in ocular pressure.	+	Be advised that use of steroids delays resolution of original disease symptoms while on the MP, and can have serious side effects. These side effects include glaucoma,(({{pmid>long:5953285}})) cataracts,(({{pmid>long:16905028}})) ocular hypertension,(({{pmid>long: 1559550}})) [[home:othertreatments:corticosteroids#side_effects_of_corticosteroid_therapy\|various other side effects]], (({{pmid>long:11820911}})) as well as increase in ocular pressure.

	<blockquote>		<blockquote>
	Although newer corticosteroids with lesser pressure elevating characteristics have been developed, corticosteroid-induced ocular hypertension and glaucoma continue to be significant risks of local and systemic administration.		Although newer corticosteroids with lesser pressure elevating characteristics have been developed, corticosteroid-induced ocular hypertension and glaucoma continue to be significant risks of local and systemic administration.

-	//McGhee et al.//(({{pubmed>long:11820911}})) </blockquote>	+	//McGhee et al.//(({{pmid>long:11820911}})) </blockquote>

	When possible, physicians should try weaning their patients from immunosuppressive eye drops. Try going down one drop a day, and then dropping down one drop every other day. Patients are more likely to be successful weaning from prednisone when they wean very slowly.		When possible, physicians should try weaning their patients from immunosuppressive eye drops. Try going down one drop a day, and then dropping down one drop every other day. Patients are more likely to be successful weaning from prednisone when they wean very slowly.
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	==== TNF-alpha inhibitors ====		==== TNF-alpha inhibitors ====

-	Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pubmed>long:16331857}})) TNF-alpha inhibitors, also known as TNF blockers, anti-TNF drugs or TNF-alpha antagonists, are drugs which interfere with the body's production of TNF-alpha.(({{pubmed>long: 18387510}})) Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects such as increase risk of serious infection such as mycobacterial infection.(({{pubmed>long:16705109}})) (({{pubmed>long:12614731}}))	+	Tumor necrosis factor-alpha or TNF-alpha is a cytokine critical for effective immune surveillance.(({{pmid>long:16331857}})) TNF-alpha inhibitors, also known as TNF blockers, anti-TNF drugs or TNF-alpha antagonists, are drugs which interfere with the body's production of TNF-alpha.(({{pmid>long: 18387510}})) Anti-TNF drugs are expensive, ineffective at treating chronic disease and have a number of adverse effects such as increase risk of serious infection such as mycobacterial infection.(({{pmid>long:16705109}})) (({{pmid>long:12614731}}))


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	==== Punctal plugs ====		==== Punctal plugs ====

-	A [[http://encyclopedia.thefreedictionary.com/Punctal+plugs\|punctal plug]] is a small medical device that is inserted into the tear duct (puncta) of an eye to block the duct. Patients should always make sure their hands are clean when touching their eyes.	+	A [[https://encyclopedia.thefreedictionary.com/Punctal+plugs\|punctal plug]] is a small medical device that is inserted into the tear duct (puncta) of an eye to block the duct. Patients should always make sure their hands are clean when touching their eyes.


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	===== References =====	+	===== References =====</nodisp>

Food intolerances

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

10.19.2018		current
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	//Shadowzone, MarshallProtocol.com//		//Shadowzone, MarshallProtocol.com//
	</blockquote>		</blockquote>
		+
		+	Some report symptom improvement when removing nightshades from their diet.
		+

	{{tag>gastrointestinal symptoms}}		{{tag>gastrointestinal symptoms}}
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 71:		Line 75:

	This should provide a start with a link to the book "Nightshade free Pain free" and also perhaps also		This should provide a start with a link to the book "Nightshade free Pain free" and also perhaps also
-	http://www.noarthritis.com/research.htm	+	https://www.noarthritis.com/research.htm
-	and http://www.anaturalway.com/Foods%20that%20Cripple.html</blockquote>	+	and https://www.anaturalway.com/Foods%20that%20Cripple.html</blockquote></nodisp>

Gastrointestinal symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.21.2018		current
Line 60:		Line 60:
	{{tag>gastrointestinal symptoms }}		{{tag>gastrointestinal symptoms }}

		+	==== Further researxh ====

		+	Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely. (({{pmid>long:25023670}}))

		+	In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. (({{pmid>long:25947920}}))

		+
		+
		+
		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	===== References =====	+	===== References =====</nodisp>

Gray hair

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.07.2019		current
Line 3:		Line 3:
	===== Introduction =====		===== Introduction =====

-	Hair graying, also known as achromotrichia, is the most obvious sign of aging in humans. Change in hair color occurs when melanin ceases to be produced in the hair root and new hairs grow in without pigment. The stem cells at the base of hair follicles produce melanocytes, the cells that produce and store pigment in hair and skin. The death of the melanocyte stem cells causes the onset of graying.(({{pubmed>long:15618488}}))	+	Hair graying, also known as achromotrichia, is the most obvious sign of aging in humans. Change in hair color occurs when melanin ceases to be produced in the hair root and new hairs grow in without pigment. The stem cells at the base of hair follicles produce melanocytes, the cells that produce and store pigment in hair and skin. The death of the melanocyte stem cells causes the onset of graying.(({{pmid>long:15618488}}))

	Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone).		Hair loss and hair color loss is very common in Th1 disease (it is made even worse by medications such as prednisone).


-	For most researchers at least, the mechanisms which ultimately drive the process are largely unknown,(({{pubmed>long:15618488}})) However, there is reason to believe that the decline in melanin production by melanocyte stem cells may be due to an inflammatory process driven by the Th1 pathogens.	+	For most researchers at least, the mechanisms which ultimately drive the process are largely unknown,(({{pmid>long:15618488}})) However, there is reason to believe that the decline in melanin production by melanocyte stem cells may be due to an inflammatory process driven by the Th1 pathogens.

	One important factor in understanding why hair turns gray may prove to be activity to the Vitamin D Receptor (VDR), a receptor which is responsible for mounting an immune response to pathogenic bacteria. One of the many genes the Receptor transcribes is for hair follicles.		One important factor in understanding why hair turns gray may prove to be activity to the Vitamin D Receptor (VDR), a receptor which is responsible for mounting an immune response to pathogenic bacteria. One of the many genes the Receptor transcribes is for hair follicles.
Line 14:		Line 14:
	<blockquote>VDR expression in the epidermal component of the hair follicle, the keratinocyte, is critical for maintenance of the hair cycle.		<blockquote>VDR expression in the epidermal component of the hair follicle, the keratinocyte, is critical for maintenance of the hair cycle.

-	//Kristi Skorija, et al.// (({{pubmed>long:15591533}}))	+	//Kristi Skorija, et al.// (({{pmid>long:15591533}}))
	</blockquote>		</blockquote>

Line 22:		Line 22:

	* [[home:pathogenesis:th1spectrum\|Comorbidities with other inflammatory conditions]] – According to observational studies, patients suffering from known inflammatory diseases are somewhat more likely to get gray hair and vise-versa. This suggests some kind of shared pathology.		* [[home:pathogenesis:th1spectrum\|Comorbidities with other inflammatory conditions]] – According to observational studies, patients suffering from known inflammatory diseases are somewhat more likely to get gray hair and vise-versa. This suggests some kind of shared pathology.
-	* Heart attack (myocardial infarction) – After statistical adjustment for possible confounders, one research team found a correlation between graying of the hair, facial wrinkling, and frontoparietal baldness and crown-top baldness and myocardial infarction in men.(({{pubmed>long:7484729}})) The relative risk was greater for men with completely gray hair as compared to men with moderately gray hair. Men who had completely gray hair had approximately double the risk of heart attack as compared to men with no gray hair. A similar although weaker and not statistically significant trend was seen in women.	+	* Heart attack: (myocardial infarction) – After statistical adjustment for possible confounders, one research team found a correlation between graying of the hair, facial wrinkling, and frontoparietal baldness and crown-top baldness and myocardial infarction in men.(({{pmid>long:7484729}})) The relative risk was greater for men with completely gray hair as compared to men with moderately gray hair. Men who had completely gray hair had approximately double the risk of heart attack as compared to men with no gray hair. A similar although weaker and not statistically significant trend was seen in women.
-	* Vitilligo – Patients with vitiligo frequently have premature gray hair.(({{pubmed>long:7633817}})) Vitilligo, a common autoimmune condition in which patients lose skin pigment, is often treated with immunosuppressive measures such as phototherapy.(({{pubmed>long:17524129}}))	+	* Vitilligo – Patients with vitiligo frequently have premature gray hair.(({{pmid>long:7633817}})) Vitilligo, a common autoimmune condition in which patients lose skin pigment, is often treated with immunosuppressive measures such as phototherapy.(({{pmid>long:17524129}}))
	===== Patients experiences =====		===== Patients experiences =====

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	I have very little gray hair and the new hair that is growing in is black rather than gray.		I have very little gray hair and the new hair that is growing in is black rather than gray.

-	//Sue Andorn,// [[http://bacteriality.com/2007/09/22/interview3/\|Bacteriality interview]]	+	//Sue Andorn,// [[https://bacteriality.com/2007/09/22/interview3/\|Bacteriality interview]]
	</blockquote>		</blockquote>

Line 54:		Line 54:
	{{tag>symptoms arrange}}		{{tag>symptoms arrange}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 80:		Line 81:

	-Also, have a “symptom” to take off my list, which I never had put on the list since I thought it was normal. Last month when it was time to do the roots of my hair to cover grey, I couldn't see any grey. I thought I was losing my ability to see color. Great. So, I finally had someone else look at it for me, and they could not see any grey either! Also, the non-grey roots which had become increasingly dark the past few years, were close to my normal blonde color, they were a dirty blonde, I could barely tell the difference from them and the color I've been using. I am keeping my eyes open for the next time around, need to double check and see if it happens again! ~CFSgirl		-Also, have a “symptom” to take off my list, which I never had put on the list since I thought it was normal. Last month when it was time to do the roots of my hair to cover grey, I couldn't see any grey. I thought I was losing my ability to see color. Great. So, I finally had someone else look at it for me, and they could not see any grey either! Also, the non-grey roots which had become increasingly dark the past few years, were close to my normal blonde color, they were a dirty blonde, I could barely tell the difference from them and the color I've been using. I am keeping my eyes open for the next time around, need to double check and see if it happens again! ~CFSgirl
-	===== References =====	+	===== References =====</nodisp>

Swollen lymph glands

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

02.06.2019		current
Line 8:		Line 8:
	Lymph nodes play a criticial role in removing bacteria, abnormal cells and other matter as part of the immune system reaction to invasion by pathogens.		Lymph nodes play a criticial role in removing bacteria, abnormal cells and other matter as part of the immune system reaction to invasion by pathogens.

-	Lymphadenopathy (enlarged, swollen, or tender lymph nodes) is usually a sign of infection and is quite common in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and sarcoidosis. The [[http://en.wikipedia.org/wiki/Lymphadenopathy\|\|Wikipedia article on lymphadenopathy]] covers the range of causes. Note the distinction between infection and "autoimmune" disease, one which according to the Marshall Pathogenesis, is trivial.	+	Lymphadenopathy (enlarged, swollen, or tender lymph nodes) is usually a sign of infection and is quite common in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and sarcoidosis. The [[https://en.wikipedia.org/wiki/Lymphadenopathy\|\|Wikipedia article on lymphadenopathy]] covers the range of causes. Note the distinction between infection and "autoimmune" disease, one which according to the Marshall Pathogenesis, is trivial.

-	Lymphadenopathy can occur anywhere there are [[http://www.nhlcyberfamily.org/nodes.htm\|lymph nodes]]. Lymphadenopathy can often be detected by low-tech means: visually or by touch. Lymph nodes deep in the groin or beneath the ribs in the chest can be monitored with imaging such as chest x-ray, CT or PET scan.	+	Lymphadenopathy can occur anywhere there are [[https://www.nhlcyberfamily.org/nodes.htm\|lymph nodes]]. Lymphadenopathy can often be detected by low-tech means: visually or by touch. Lymph nodes deep in the groin or beneath the ribs in the chest can be monitored with imaging such as chest x-ray, CT or PET scan.

	Treating chronic disease with the Marshall Protocol means that symptoms usually get worse before they get better, due to immunopathology. It is common for lymph nodes to increase in size, tenderness, and/or number as part of the immunopathology of recovery. This is evident when palpated or visible lymph nodes wax and wane with antibiotic administration. As the MP treats the underlying cause of sarcoidosis and lymphadenopathy, it may take many months for lymph nodes to return to normal size (reported to be 1 cm or less).		Treating chronic disease with the Marshall Protocol means that symptoms usually get worse before they get better, due to immunopathology. It is common for lymph nodes to increase in size, tenderness, and/or number as part of the immunopathology of recovery. This is evident when palpated or visible lymph nodes wax and wane with antibiotic administration. As the MP treats the underlying cause of sarcoidosis and lymphadenopathy, it may take many months for lymph nodes to return to normal size (reported to be 1 cm or less).
Line 20:		Line 20:
	In the case of sarcoidosis, most patients with lymphadenopathy had tests which ruled out lymphoma (cancer) before they were diagnosed with that illness.		In the case of sarcoidosis, most patients with lymphadenopathy had tests which ruled out lymphoma (cancer) before they were diagnosed with that illness.

-	Patients and doctors who do not understand the nature of immunopathology that occurs during the Marshall Protocol may become alarmed when lymph nodes increase in size or do not decrease. Doctors may want to reassure themselves or the patient by doing additional biopsies to, once again, rule out lympoma. However, this invasive procedure is rarely necessary. Since lymphoma develops very slowly, a "watch and wait" tactic is more appropriate. [[home:mp:managing_immunopathology\|Slowing down immunopathology]] or, if necessary, taking a break from the Protocol can also be done if anyone needs immediate reassurance that inflammation is responsible for emergent or increase lymphadenopathy while on the MP.	+	Patients and doctors who do not understand the nature of immunopathology that occurs during the Marshall Protocol may become alarmed when lymph nodes increase in size or do not decrease. Doctors may want to reassure themselves or the patient by doing additional biopsies to, once again, rule out lymphoma. However, this invasive procedure is rarely necessary. Since lymphoma develops very slowly, a "watch and wait" tactic is more appropriate. [[home:mp:managing_immunopathology\|Slowing down immunopathology]] or, if necessary, taking a break from the Protocol can also be done if anyone needs immediate reassurance that inflammation is responsible for emergent or increased lymphadenopathy while on the MP.


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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


		+	</nodisp>

Muscle and bone symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.16.2019		current
Line 11:		Line 11:


-	In the context of muscle aging, it is important to remember that it is not just a decline in muscle mass which contributes to the deterioration of muscle function. Other factors underpinning muscle quality come into play, including muscle composition, aerobic capacity and metabolism, fatty infiltration, insulin resistance, fibrosis and neural activation. Genetic, developmental, endocrine and lifestyle factors, such as physical activity, smoking and poor diet have dual effects on both muscle and bone mass in later life and these will be reviewed here. (({{pubmed>long:25820482}}))	+	In the context of muscle aging, it is important to remember that it is not just a decline in muscle mass which contributes to the deterioration of muscle function. Other factors underpinning muscle quality come into play, including muscle composition, aerobic capacity and metabolism, fatty infiltration, insulin resistance, fibrosis and neural activation. Genetic, developmental, endocrine and lifestyle factors, such as physical activity, smoking and poor diet have dual effects on both muscle and bone mass in later life and these will be reviewed here. (({{pmid>long:25820482}}))

-	Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups (({{pubmed>long:23702032}}))	+	Muscle wasting occurs in a variety of conditions, including both genetic diseases, such as muscular dystrophies, and acquired disorders, ranging from muscle disuse to cancer cachexia, from heart failure to aging sarcopenia. In most of these conditions, the loss of muscle tissue is not homogeneous, but involves specific muscle groups (({{pmid>long:23702032}}))


-	Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. (({{pubmed>long:30639055}}))	+	Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. (({{pmid>long:30639055}}))

-	Age related changes of the motor excitabilities and central and peripheral muscle strength. The middle-aged group had lower MVC and twitch force of quadriceps, but not VA, than young group. No between group differences were found in fatigue indexes. (({{pubmed>long:30640164}}))	+	Age related changes of the motor excitabilities and central and peripheral muscle strength. The middle-aged group had lower MVC and twitch force of quadriceps, but not VA, than young group. No between group differences were found in fatigue indexes. (({{pmid>long:30640164}}))

	Active pharmaceuticals continue to be identified in dietary supplements....		Active pharmaceuticals continue to be identified in dietary supplements....
-	The drug ingredients in these dietary supplements have the potential to cause serious adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other pharmaceuticals within the supplement. (({{pubmed>long:30646238}}))	+	The drug ingredients in these dietary supplements have the potential to cause serious adverse health effects owing to accidental misuse, overuse, or interaction with other medications, underlying health conditions, or other pharmaceuticals within the supplement. (({{pmid>long:30646238}}))

	===== Connective tissue =====		===== Connective tissue =====
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	Trigger thumbs are like trigger fingers–they literally get stuck in a certain position. This comes from inflammation involving the tendon. In my case, my thumbs started to feel “strange” and weak. They sometimes tingled and/or ached. When I would bend them after several months of the above, I would feel a snap or a pop. Finally, one became fixed in a bent position and the other in a straight position. The swelling and pain intensified throughout this time in my thumbs and the surrounding area in my palm.</blockquote>		Trigger thumbs are like trigger fingers–they literally get stuck in a certain position. This comes from inflammation involving the tendon. In my case, my thumbs started to feel “strange” and weak. They sometimes tingled and/or ached. When I would bend them after several months of the above, I would feel a snap or a pop. Finally, one became fixed in a bent position and the other in a straight position. The swelling and pain intensified throughout this time in my thumbs and the surrounding area in my palm.</blockquote>

		+	==== Poor digestion ====
		+
		+	can cause muscle wasting, among other symptoms. Some people find that prolonged use of Olmesartan can affect absorption of nutrients. Consult your doctor about sufficiency of protein in blood circulation.
	==== Issues in pain management ====		==== Issues in pain management ====

Line 40:		Line 43:
	===== Vitamin D and activity =====		===== Vitamin D and activity =====

-	Findings suggest that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density. There were no differences between the effects of higher and lower doses of vitamin D. There is little justification to use vitamin D supplements to maintain or improve musculoskeletal health. This conclusion should be reflected in clinical guidelines. (({{pubmed>long:30293909}}))	+	Findings suggest that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density. There were no differences between the effects of higher and lower doses of vitamin D. There is little justification to use vitamin D supplements to maintain or improve musculoskeletal health. This conclusion should be reflected in clinical guidelines. (({{pmid>long:30293909}}))

	===== Member posts =====		===== Member posts =====
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	//replaced out of order in out of view section//		//replaced out of order in out of view section//
-	Family Practice.com. New realities in pain management issues. Available at: http://www.familypractice.com/lectures/pain2/lecture_ mccarberg_text_frame.htm\Familypractice. Accessed on April 21, 2003. Family Practice.com. New realities in pain management issues. Available at: http://www.familypractice.com/ lectures/pain2/lecture_marcus_text_frame.htm\Familypractice. Accessed on April 21, 2003. Medscape. Barriers to effective pain management. Available at: http://www.medscape.com/viewarticle/405853_3\Medscape. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Regulatory systems and pain management. Available at: http://www.medsch.wisc.edu/painpolicy/eguide2000/text_version/appendix_b.html\Medsch. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Are intractable pain treatment acts what we need? Available at: http://www.medsch.wisc.edu/ painpolicy/eguide2000/text_version/ appendix_d.html\Medsch. Accessed on April 21, 2003. DrugTopics.com. Pain management regulation. Available at: http://www.drugtopics.com/be_core/ content/ journals/d/data/2003/0407/show_article.jsp?filename=dce04a2003.html\Drugtopics. Accessed on April 21, 2003. RxList. Description of diclofenac and misoprostol. Available at: http://www.rxlist.com/cgi/generic2/ arthrotec.htm\Rxlist. Accessed on April 21, 2003. Doctor’s Guide. FDA approves once-daily Avinza (extended release morphine) for chronic, moderate-to-severe pain (March 21, 2001). Available at: http://www.docguide.com/ news/content.nsf/news/ 8525697700573E1885256B830048A246+ avinza&hl=en&ie=UTF-8\Docguide. Accessed on April 21, 2003. RxList. Description of levetiracetam. Available at: http://www.rxlist.com/cgi/generic3/keppra.htm]Rxlist. Accessed on April 21, 2003. National Institute on Drug Abuse. Pain and opiophobia. Available at: http://www.nida.nih.gov/ResearchReports/Prescription/ Prescription6a.html\Nida. Accessed on April 21, 2003. Fujimoto D. Regulatory issues in pain management. Clin Geriatr Med. 2001;17:537-551. Available at: http://www.partnersagainstpain.com/ html/profed/profed.htm\Partnersagainstpain. Accessed April 21, 2003. “Millions of people suffer needlessly from agonizing pain because physicians have been reluctant to use ‘high-risk’ opioids” Crain & Shen 2000	+	Family Practice.com. New realities in pain management issues. Available at: https://www.familypractice.com/lectures/pain2/lecture_ mccarberg_text_frame.htm\Familypractice. Accessed on April 21, 2003. Family Practice.com. New realities in pain management issues. Available at: https://www.familypractice.com/ lectures/pain2/lecture_marcus_text_frame.htm\Familypractice. Accessed on April 21, 2003. Medscape. Barriers to effective pain management. Available at: https://www.medscape.com/viewarticle/405853_3\Medscape. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Regulatory systems and pain management. Available at: https://www.medsch.wisc.edu/painpolicy/eguide2000/text_version/appendix_b.html\Medsch. Accessed on April 21, 2003. Pain and Policies Study Group, University of Wisconsin. Are intractable pain treatment acts what we need? Available at: https://www.medsch.wisc.edu/ painpolicy/eguide2000/text_version/ appendix_d.html\Medsch. Accessed on April 21, 2003. DrugTopics.com. Pain management regulation. Available at: https://www.drugtopics.com/be_core/ content/ journals/d/data/2003/0407/show_article.jsp?filename=dce04a2003.html\Drugtopics. Accessed on April 21, 2003. RxList. Description of diclofenac and misoprostol. Available at: https://www.rxlist.com/cgi/generic2/ arthrotec.htm\Rxlist. Accessed on April 21, 2003. Doctor’s Guide. FDA approves once-daily Avinza (extended release morphine) for chronic, moderate-to-severe pain (March 21, 2001). Available at: https://www.docguide.com/ news/content.nsf/news/ 8525697700573E1885256B830048A246+ avinza&hl=en&ie=UTF-8\Docguide. Accessed on April 21, 2003. RxList. Description of levetiracetam. Available at: https://www.rxlist.com/cgi/generic3/keppra.htm]Rxlist. Accessed on April 21, 2003. National Institute on Drug Abuse. Pain and opiophobia. Available at: https://www.nida.nih.gov/ResearchReports/Prescription/ Prescription6a.html\Nida. Accessed on April 21, 2003. Fujimoto D. Regulatory issues in pain management. Clin Geriatr Med. 2001;17:537-551. Available at: https://www.partnersagainstpain.com/ html/profed/profed.htm\Partnersagainstpain. Accessed April 21, 2003. “Millions of people suffer needlessly from agonizing pain because physicians have been reluctant to use ‘high-risk’ opioids” Crain & Shen 2000

	s90:		s90:
Line 666:		Line 670:


-	===== References =====	+	===== References =====</nodisp>

Managing symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

Nosebleeds

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

01.03.2012		current
Line 18:		Line 18:
	- One's doctor may want to check your coagulation time if nosebleed repeats.		- One's doctor may want to check your coagulation time if nosebleed repeats.

-	This [[http://emedicine.medscape.com/article/764719-overview#a11\|Medscape article]] gives physicians advice on how to treat a nosebleed.	+	This [[https://emedicine.medscape.com/article/764719-overview#a11\|Medscape article]] gives physicians advice on how to treat a nosebleed.


Line 28:		Line 28:
	* Do not pick your nose.		* Do not pick your nose.
	* Increase the humidity of your home.		* Increase the humidity of your home.
-	* Do not take aspirin, vitamin E or essential fatty acids or any other OTC medications that might thin your blood.	+	* Do not take aspirin, Gingko biloba, vitamin E or essential fatty acids or any other OTC medications that might thin your blood.
	* Vitamin K may be needed if a patient is deficient (deficiency in adults is rare).		* Vitamin K may be needed if a patient is deficient (deficiency in adults is rare).

	{{tag>symptoms}}		{{tag>symptoms}}
-	===== Notes and comments =====	+	<nodisp>
		+	===== Notes and comments =====</nodisp>

Other symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

07.05.2019		current
Line 40:		Line 40:


-	2015 Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. (({{pubmed>long:25828845}}))	+	Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. (({{pmid>long:25828845}}))

-	2014 Anti-inflammatory strategies in cartilage repair. (({{pubmed>long:24846478}}))	+	Anti-inflammatory strategies in cartilage repair. (({{pmid>long:24846478}}))

-	2013 Tissue engineering for articular cartilage repair--the state of the art.	+	Tissue engineering for articular cartilage repair--the state of the art.
-	(({{pubmed>long:23636950}}))	+	(({{pmid>long:23636950}}))

-	2017 Effectiveness of chitosan scaffold in skin, bone and cartilage healing. (({{pubmed>long:28684351}}))	+	Effectiveness of chitosan scaffold in skin, bone and cartilage healing. (({{pmid>long:28684351}}))

-	2015 Role of platelet-rich plasma in articular cartilage injury and disease. (({{pubmed>long:25068847}}))	+	Role of platelet-rich plasma in articular cartilage injury and disease. (({{pmid>long:25068847}}))

-	2016 Role of the Subchondral Bone in Articular Cartilage Degeneration and Repair. (({{pubmed>long:26990714}}))	+	Role of the Subchondral Bone in Articular Cartilage Degeneration and Repair. (({{pmid>long:26990714}}))

-	Cartilage repair across germ layer origins. (({{pubmed>long:27789004}}))	+	Cartilage repair across germ layer origins. (({{pmid>long:27789004}}))

-	Smart Polymeric Hydrogels for Cartilage Tissue Engineering: A Review on the Chemistry and Biological Functions. (({{pubmed>long:27775329 }}))	+	Smart Polymeric Hydrogels for Cartilage Tissue Engineering: A Review on the Chemistry and Biological Functions. (({{pmid>long:27775329}}))

-	Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. (({{pubmed>long:26867787}}))	+	Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair. (({{pmid>long:26867787}}))

-	Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. (({{pubmed>long:25210707 }}))	+	Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. (({{pmid>long:25210707 }}))

-	Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect. (({{pubmed>long:30538463}}))	+	Mechanism research on a bioactive resveratrol- PLA-gelatin porous nano-scaffold in promoting the repair of cartilage defect. (({{pmid>long:30538463}}))

	=== Remodelling ===		=== Remodelling ===
Line 201:		Line 201:
	{{tag>symptoms }}		{{tag>symptoms }}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

Line 278:		Line 279:
	The sTfR test should be considered for anemic patients whose differential diagnosis includes iron deficiency and anemia of inflammatory disease. Transferrin receptor values are elevated in iron deficiency anemia (IDA), and in chronic hemolytic anemias.		The sTfR test should be considered for anemic patients whose differential diagnosis includes iron deficiency and anemia of inflammatory disease. Transferrin receptor values are elevated in iron deficiency anemia (IDA), and in chronic hemolytic anemias.

-	Source: http://www.med.yale.edu/labmed/labnews/jan1999c1.jpg	+	Source: https://www.med.yale.edu/labmed/labnews/jan1999c1.jpg

	According to this reference:		According to this reference:
Line 339:		Line 340:

	Iron supplements		Iron supplements
-	Do not take iron supplements in an effort to increase hemoglobin and and hematocrit. Iron will only help the CWD bacteria multiply. Increasing iron in your diet would also be counterproductive. This article from the CDC's Emerging and Infectious Diseases explains how microbes sequester iron from the host: “Iron Loading and Disease Surveillance” // http://www.cdc.gov/ncidod/EID/vol5no3/weinberg.htm //	+	Do not take iron supplements in an effort to increase hemoglobin and and hematocrit. Iron will only help the CWD bacteria multiply. Increasing iron in your diet would also be counterproductive. This article from the CDC's Emerging and Infectious Diseases explains how microbes sequester iron from the host: “Iron Loading and Disease Surveillance” // https://www.cdc.gov/ncidod/EID/vol5no3/weinberg.htm //

	Transferrin saturation		Transferrin saturation
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	--------------------------------------------------------------------------------		--------------------------------------------------------------------------------

-	Generated from this source: http://www.marshallprotocol.com/forum32/3479.html#p31115	+	Generated from this source: https://www.marshallprotocol.com/forum32/3479.html#p31115
	WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.		WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.
	Migration code: F252		Migration code: F252
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	Lowcarbezine mailing list		Lowcarbezine mailing list
	Lowcarbezine@holdthetoast.com		Lowcarbezine@holdthetoast.com
-	http://www.ericschmitz.com/mailman/listinfo/lowcarbezine	+	https://www.ericschmitz.com/mailman/listinfo/lowcarbezine

	____________________		____________________
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-	Generated from this source: http://www.marshallprotocol.com/view_topic.php?id=2495&forum_id=32&jump_to=45233#p45233	+	Generated from this source: https://www.marshallprotocol.com/view_topic.php?id=2495&forum_id=32&jump_to=45233#p45233
	WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.		WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.
	Migration code: F228		Migration code: F228
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-	Generated from this source: http://www.marshallprotocol.com/forum32/2495.html#p68205	+	Generated from this source: https://www.marshallprotocol.com/forum32/2495.html#p68205
	WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.		WARNING: THIS PAGE PROVIDES TEXT FROM THE LEGACY SITE AND MAY NOT HAVE BEEN REVIEWED RECENTLY.
	Migration code: F232		Migration code: F232
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	Hair growth is closely related to the VDR and 1,25-D.		Hair growth is closely related to the VDR and 1,25-D.

-	http://mend.endojournals.org/cgi/content/abstract/me.2004-0415v1	+	https://mend.endojournals.org/cgi/content/abstract/me.2004-0415v1

	This article makes a close connection between alopecia and psoriasis, which the MP has been determined to resolve.		This article makes a close connection between alopecia and psoriasis, which the MP has been determined to resolve.
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-	===== References =====	+	===== References =====</nodisp>

Pain

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

12.22.2018		current
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	====== Pain ======		====== Pain ======

-	Pain is a common symptom in chronic inflammatory diseases. About 30% of the population of the United States suffers from acute or chronic pain, often of unknown cause.(({{pubmed>long:21900506}})) Any part of the body may be affected by inflammation resulting in pain. Lymph nodes are located all over the body and are prime suspects to swell and produce pain from immunopathology in chronic inflammatory diseases.	+	Pain is a common symptom in chronic inflammatory diseases. About 30% of the population of the United States suffers from acute or chronic pain, often of unknown cause.(({{pmid>long:21900506}})) Any part of the body may be affected by inflammation resulting in pain. Lymph nodes are located all over the body and are prime suspects to swell and produce pain from immunopathology in chronic inflammatory diseases.

	When pain has been chronic and severe, it is not unusual for inflammatory symptoms to be indicative of both longstanding and ongoing inflammation and immunopathology. For purposes of pain control, it is not necessary to differentiate. Adjusting the Marshall Protocol (MP) medications is the best way to manage immunopathology including pain. If a patient's intolerable pain is not managed by adjustment of the MP medications, he or she should work with their doctor to use palliative methods for relief.		When pain has been chronic and severe, it is not unusual for inflammatory symptoms to be indicative of both longstanding and ongoing inflammation and immunopathology. For purposes of pain control, it is not necessary to differentiate. Adjusting the Marshall Protocol (MP) medications is the best way to manage immunopathology including pain. If a patient's intolerable pain is not managed by adjustment of the MP medications, he or she should work with their doctor to use palliative methods for relief.
		+
		+	Cytokines, Inflammation and Pain (({{pmid>long:17426506}}))

	===== Management of pain =====		===== Management of pain =====
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-	Studies have shown that people in hospitals given adequate pain control tend to heal faster and are able to be discharged sooner than those who are not given adequate pain medications.(({{pubmed>long:17667496}})) The physiologic consequences of uncontrolled pain are myriad, and should not be overlooked.	+	Studies have shown that people in hospitals given adequate pain control tend to heal faster and are able to be discharged sooner than those who are not given adequate pain medications.(({{pmid>long:17667496}})) The physiologic consequences of uncontrolled pain are myriad, and should not be overlooked.

-	For many patients, the level of pain is truly incapacitating and these patients have to have pain control just to be able to get through the day.(({{pubmed>long:17578977}})) The "tough it out" mentality can backfire for times when the pain simply becomes too much. For these patients, choosing to use [[home:othertreatments:pain_medication\|pain medication]] is the realistic and inevitable choice.	+	For many patients, the level of pain is truly incapacitating and these patients have to have pain control just to be able to get through the day.(({{pmid>long:17578977}})) The "tough it out" mentality can backfire for times when the pain simply becomes too much. For these patients, choosing to use [[home:othertreatments:pain_medication\|pain medication]] is the realistic and inevitable choice.


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	* managing [[home:diseases:anxiety\|anxiety and stress]]		* managing [[home:diseases:anxiety\|anxiety and stress]]
-	* [[http://www.orthop.washington.edu/?q=patient-care/articles/arthritis/exercise-and-arthritis.html\|range of motion exercises]] – provided by University of Washington Orthopaedics and Sports Medicine; contains videos for movements exercises covering a range of body parts	+	* [[https://www.orthop.washington.edu/?q=patient-care/articles/arthritis/exercise-and-arthritis.html\|range of motion exercises]] – provided by University of Washington Orthopaedics and Sports Medicine; contains videos for movements exercises covering a range of body parts
-	* [[http://www.orthop.washington.edu/?q=patient-care/articles/arthritis/water-exercises.html\|water exercises]] – provided by University of Washington Orthopaedics and Sports Medicine; contains videos for movements exercises covering a range of body parts	+	* [[https://www.orthop.washington.edu/?q=patient-care/articles/arthritis/water-exercises.html\|water exercises]] – provided by University of Washington Orthopaedics and Sports Medicine; contains videos for movements exercises covering a range of body parts
	* [[home:othertreatments:tens\|TENS (Transcutaneous Electrical Nerve Stimulation)]] – battery-powered unit which sends electrical impulses through electrodes placed on or near the painful site		* [[home:othertreatments:tens\|TENS (Transcutaneous Electrical Nerve Stimulation)]] – battery-powered unit which sends electrical impulses through electrodes placed on or near the painful site
	* [[home:special:surgery\|elective surgery]] – MP patients are advised to postpone elective surgery as long as possible. Many MP patients discover they no longer need surgery once the inflammation is resolved.		* [[home:special:surgery\|elective surgery]] – MP patients are advised to postpone elective surgery as long as possible. Many MP patients discover they no longer need surgery once the inflammation is resolved.
	* [[home:othertreatments:trigger\|trigger point therapy]]		* [[home:othertreatments:trigger\|trigger point therapy]]
	* visualization techniques		* visualization techniques
-	* marijuana – Marijuana has been used by some patients with chronic pain such as ALS.(({{pubmed>long:11467101}})) Legality of use varies widely by jurisdiction. Please follow all relevant laws.	+	* marijuana – Marijuana has been used by some patients with chronic pain such as ALS.(({{pmid>long:11467101}})) Legality of use varies widely by jurisdiction. Please follow all relevant laws.
	* [[home:lifestyle:exercise\|physical activity and exercise]] – may increase tissue perfusion		* [[home:lifestyle:exercise\|physical activity and exercise]] – may increase tissue perfusion
	* adequate rest – fatigue always worsens pain		* adequate rest – fatigue always worsens pain
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	==== Coccyx pain ====		==== Coccyx pain ====

-	A special cushion called a [[http://www.amazon.com/s/ref=nb_ss_hpc?url=search-alias%3Dhpc&field-keywords=tush+cush&x=0&y=0\|tush cush]] can be used to control coccyx immunopathology.	+	A special cushion called a [[https://www.amazon.com/s/ref=nb_ss_hpc?url=search-alias%3Dhpc&field-keywords=tush+cush&x=0&y=0\|tush cush]] can be used to control coccyx immunopathology.

	Immunopathology can result in increased inflammation in the back, which can be painful. It may be affecting either nerves or muscles, but immunopathology is temporary. It gives you a good idea of where all the problems are.		Immunopathology can result in increased inflammation in the back, which can be painful. It may be affecting either nerves or muscles, but immunopathology is temporary. It gives you a good idea of where all the problems are.
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-	Different researchers have successfully used ARBs – of which olmesartan (Benicar) is one – to treat migraines and headaches.(({{pubmed>long:12681087}}))(({{pubmed>long:12503978}})) For patients on the Marshall Protocol (MP), the institution of the olmesartan (Benicar) blockade is enough to resolve migraines.	+	Different researchers have successfully used ARBs – of which olmesartan (Benicar) is one – to treat migraines and headaches.(({{pmid>long:12681087}}))(({{pmid>long:12503978}})) For patients on the Marshall Protocol (MP), the institution of the olmesartan (Benicar) blockade is enough to resolve migraines.

	==== Flank pain ====		==== Flank pain ====
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	neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement		neurosarcoidosis, systemic sarcoidosis; spasticity, myasthenia, CNS dysfunction, joint pain, pulmonary, splenic and cardiac involvement

-	Read the [[http://bacteriality.com/2008/03/02/interview17/\|interview]]	+	Read the [[https://bacteriality.com/2008/03/02/interview17/\|interview]]

	<html></div></div></html>		<html></div></div></html>
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-	<blockquote>Earlier this week Opa visited his doctor and asked for buprenorphine. He had brought a printout of the [[http://www.painphysicianjournal.com/2009/may/2009;12;679-684.pdf\|pain physician article]] with him. Doc prescribed him the sublingual form.	+	<blockquote>Earlier this week Opa visited his doctor and asked for buprenorphine. He had brought a printout of the [[https://www.painphysicianjournal.com/2009/may/2009;12;679-684.pdf\|pain physician article]] with him. Doc prescribed him the sublingual form.

	Opa already confirmed that the new pain medication helps to contol his acute pain during IP surges.		Opa already confirmed that the new pain medication helps to contol his acute pain during IP surges.
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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	* s105		* s105

-	This condition is important enough for our members who suffer from pain control issues, that I would like to see at least a sentence with a reference to something like this: http://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia ... Paul, can you take care of this? --- //Joyful 08.27.2010//	+	This condition is important enough for our members who suffer from pain control issues, that I would like to see at least a sentence with a reference to something like this: https://en.wikipedia.org/wiki/Opioid-induced_hyperalgesia ... Paul, can you take care of this? --- //Joyful 08.27.2010//


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	For me, the electrical shocks preceded healing.</blockquote>		For me, the electrical shocks preceded healing.</blockquote>

-	===== References =====	+	===== References =====</nodisp>

Respiratory symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

03.16.2017		current
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	==== Nasal irrigation and neti pots ====		==== Nasal irrigation and neti pots ====

-	[[http://www.marshallprotocol.com/view_topic.php?id=14552&forum_id=11\|Several patients]] on the Marshall Protocol site have been advocating (and using with good results) neti pots for sinus and other nasal issues. But, there have been reports of [[http://vitals.msnbc.msn.com/_news/2011/12/16/9503070-brain-eating-amoeba-kills-2-via-neti-pots\|deaths]] resulting from using tap water in neti pots. Instead, patients considering nasal irrigation should use distilled or other purified (boiled) water.	+	Several patients on the Marshall Protocol site have been advocating (and using with good results) neti pots for sinus and other nasal issues. But, there have been reports of [[https://vitals.msnbc.msn.com/_news/2011/12/16/9503070-brain-eating-amoeba-kills-2-via-neti-pots\|deaths]] resulting from using tap water in neti pots. Instead, patients considering nasal irrigation should use distilled or other purified (boiled) water.


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-	* dextromethorphan (Robitussin, Vicks, etc.) – Dextromethorphan, the active ingredient in cough medicines, such as Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, and others may be modestly effective in decreasing cough in adults.(({{pubmed>long:19874728}}))	+	* dextromethorphan (Robitussin, Vicks, etc.) – Dextromethorphan, the active ingredient in cough medicines, such as Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, and others may be modestly effective in decreasing cough in adults.(({{pmid>long:19874728}}))
-	* theobromine – Theobromine, also known as xantheose, is a bitter alkaloid of the cacao plant, found in chocolate, as well as in a number of other foods, including the leaves of the tea plant. A 2004 study published by Imperial College London concluded that theobromine has an antitussive cough-reducing effect superior to codeine by suppressing vagus nerve activity.(({{pubmed>long:15548587}})) In the study, theobromine significantly increased the capsaicin concentration required to induce coughs when compared with a placebo.(({{pubmed>long:15548587}})) It is possible to get an effective dose from 50g of dark chocolate, which contain 2-10 times more cocao than milk chocolate.	+	* theobromine – Theobromine, also known as xantheose, is a bitter alkaloid of the cacao plant, found in chocolate, as well as in a number of other foods, including the leaves of the tea plant. A 2004 study published by Imperial College London concluded that theobromine has an antitussive cough-reducing effect superior to codeine by suppressing vagus nerve activity.(({{pmid>long:15548587}})) In the study, theobromine significantly increased the capsaicin concentration required to induce coughs when compared with a placebo.(({{pmid>long:15548587}})) It is possible to get an effective dose from 50g of dark chocolate, which contain 2-10 times more cocao than milk chocolate.
-	* codeine – Codeine is an opioid (narcotic) that acts on the vagus nerve to suppress coughing. It is available only by prescription in many states. However, other states permit pharmacists to sell cough remedies containing codeine without a prescription if the customer signs for it. Because codeine is an opioid, some people fear it may be addicting. In reality, addiction is uncommon. Codeine can be helpful at bedtime because of its slight sedative effect. While codeine was once viewed as the gold standard in cough suppressants, the evidence to support this is weak, with a recent placebo-controlled trial finding that codeine was no better than placebo.(({{pubmed>long:17218808}}))	+	* codeine – Codeine is an opioid (narcotic) that acts on the vagus nerve to suppress coughing. It is available only by prescription in many states. However, other states permit pharmacists to sell cough remedies containing codeine without a prescription if the customer signs for it. Because codeine is an opioid, some people fear it may be addicting. In reality, addiction is uncommon. Codeine can be helpful at bedtime because of its slight sedative effect. While codeine was once viewed as the gold standard in cough suppressants, the evidence to support this is weak, with a recent placebo-controlled trial finding that codeine was no better than placebo.(({{pmid>long:17218808}}))

	==== Inhalers ====		==== Inhalers ====
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	* [[home:othertreatments:antidepressants\|anti-anxiety agents]] – A medication for anxiety may calm respiratory symptoms.		* [[home:othertreatments:antidepressants\|anti-anxiety agents]] – A medication for anxiety may calm respiratory symptoms.
	* throat lozenges (cough drops) – Cough drops are a good way to occasionally soothe an irritated throat. Expensive medicine-flavored cough drops are not any better than inexpensive candy-flavored ones or hard candy. Most cough drops have no effect on the cough-producing mechanism. If nasal congestion prevents air passage, over the counter decongestants can also be used, but should be used judiciously.		* throat lozenges (cough drops) – Cough drops are a good way to occasionally soothe an irritated throat. Expensive medicine-flavored cough drops are not any better than inexpensive candy-flavored ones or hard candy. Most cough drops have no effect on the cough-producing mechanism. If nasal congestion prevents air passage, over the counter decongestants can also be used, but should be used judiciously.
-	* zinc lozenges – Zinc lozenges are touted to prevent viruses from multiplying in the throat, but there is no scientific proof of this.(({{pubmed>long:10796643}}))	+	* zinc lozenges – Zinc lozenges are touted to prevent viruses from multiplying in the throat, but there is no scientific proof of this.(({{pmid>long:10796643}}))
	* vitamin C (ascorbic acid) - Ascorbates promote the transcription of inflammation and, therefore, high levels of vitamin C, such as the kind one might get from a supplement, may prove to affect the immune system in a way that is counterproductive. Because Vitamin C affects the immune system in yet-unknown ways, supplementation is contraindicated.		* vitamin C (ascorbic acid) - Ascorbates promote the transcription of inflammation and, therefore, high levels of vitamin C, such as the kind one might get from a supplement, may prove to affect the immune system in a way that is counterproductive. Because Vitamin C affects the immune system in yet-unknown ways, supplementation is contraindicated.

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	An incentive spirometer is a medical device used to help patients improve the functioning of their lungs. If your activity level is low and you are unable to tolerate mild exercise, use of this device to expand pulmonary tissues may excercise the lungs to promote a more even bacterial kill during the process of recovery. The patient breathes in from the device as slowly and as deeply as possible. An indicator provides a gauge of how well the patient's lung or lungs are functioning, by indicating sustained inhalation vacuum. The patient is generally asked to do many repetitions a day while measuring his or her progress by way of the gauge.		An incentive spirometer is a medical device used to help patients improve the functioning of their lungs. If your activity level is low and you are unable to tolerate mild exercise, use of this device to expand pulmonary tissues may excercise the lungs to promote a more even bacterial kill during the process of recovery. The patient breathes in from the device as slowly and as deeply as possible. An indicator provides a gauge of how well the patient's lung or lungs are functioning, by indicating sustained inhalation vacuum. The patient is generally asked to do many repetitions a day while measuring his or her progress by way of the gauge.

-	Incentive spirometers are [[http://www.google.com/search?aq=f&sourceid=chrome&ie=UTF-8&q=Incentive+inspirometer#q=Incentive+spirometer&num=10&hl=en&safe=off&pwst=1&prmd=ivs&source=univ&tbs=shop:1&tbo=u&ei=4O_nTOH0DcWBlAeUh_ykDA&sa=X&oi=product_result_group&ct=title&resnum=3&ved=0CEMQrQQwAg&biw=1027&bih=859&fp=5d2312cccd08d213\|widely available]] for purchase.	+	Incentive spirometers are [[https://www.google.com/search?aq=f&sourceid=chrome&ie=UTF-8&q=Incentive+inspirometer#q=Incentive+spirometer&num=10&hl=en&safe=off&pwst=1&prmd=ivs&source=univ&tbs=shop:1&tbo=u&ei=4O_nTOH0DcWBlAeUh_ykDA&sa=X&oi=product_result_group&ct=title&resnum=3&ved=0CEMQrQQwAg&biw=1027&bih=859&fp=5d2312cccd08d213\|widely available]] for purchase.


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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/view_topic.php?id=4175&forum_id=23&jump_to=83450#p83450 f22	+	* https://www.marshallprotocol.com/view_topic.php?id=4175&forum_id=23&jump_to=83450#p83450 f22
-	* http://www.marshallprotocol.com/view_topic.php?id=10124&forum_id=32&jump_to=119000#p119000 f128	+	* https://www.marshallprotocol.com/view_topic.php?id=10124&forum_id=32&jump_to=119000#p119000 f128


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	PMID: 19831405		PMID: 19831405
-	===== References =====	+	===== References =====</nodisp>

Skin conditions

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

09.19.2012		current
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	===== Skin microbiome =====		===== Skin microbiome =====

-	A decade ago, Chiller //et al.// concluded, “The skin is a poor media for bacteria given the large number of inherent defense mechanisms.”(({{pubmed>long:11924823}})) This assessment was undermined seven years later by Fierer //et al//.’s work, which found that the average human palm harbors at least 150 bacterial species – an order of magnitude greater than previous estimates.(({{pubmed>long:19004758}})) A 2009 //Science// study expanded on this understanding of microbial diversity in skin, showing that forearms and underarms, though located just a short distance apart, are as “ecologically dissimilar as rainforests are to deserts.”(({{pubmed>long:19478181}})) Trillions of bacteria, fungi, viruses, archaea, and small arthropods colonize the skin surface, collectively comprising the skin microbiome.(({{pubmed>long:22189793}})) One prominent researcher [[http://news.bbc.co.uk/1/hi/health/6333137.stm\|called]] human skin a "virtual zoo of bacteria."(({{pubmed>long:17293459}}))	+	A decade ago, Chiller //et al.// concluded, “The skin is a poor media for bacteria given the large number of inherent defense mechanisms.”(({{pmid>long:11924823}})) This assessment was undermined seven years later by Fierer //et al//.’s work, which found that the average human palm harbors at least 150 bacterial species – an order of magnitude greater than previous estimates.(({{pmid>long:19004758}})) A 2009 //Science// study expanded on this understanding of microbial diversity in skin, showing that forearms and underarms, though located just a short distance apart, are as “ecologically dissimilar as rainforests are to deserts.”(({{pmid>long:19478181}})) Trillions of bacteria, fungi, viruses, archaea, and small arthropods colonize the skin surface, collectively comprising the skin microbiome.(({{pmid>long:22189793}})) One prominent researcher [[https://news.bbc.co.uk/1/hi/health/6333137.stm\|called]] human skin a "virtual zoo of bacteria."(({{pmid>long:17293459}}))

-	Novel insights are being revealed about the extent to which skin microbiota affects health. For example, odors produced by skin microbiota are attractive to mosquitoes as shown by //in vitro// studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans.(({{pubmed>long:20840217}}))	+	Novel insights are being revealed about the extent to which skin microbiota affects health. For example, odors produced by skin microbiota are attractive to mosquitoes as shown by //in vitro// studies, and variation in bacterial species on the human skin may explain the variation in mosquito attraction between humans.(({{pmid>long:20840217}}))


	===== Immune response and skin disease =====		===== Immune response and skin disease =====

-	In human skin antimicrobial peptide (AMP) are produced mainly by keratinocytes, neutrophils, sebocytes or sweat glands and are either expressed constantly or after an inflammatory stimulus.(({{pubmed>long:18782030}})) As Schittek //et al.// explain, in several human skin diseasess, there is an inverse correlation between severity of the disease and the level of AMP production. Skin lesions of patients with atopic dermatitis show a diminished expression of the beta-defensins and the cathelicidin LL-37 (both of which are strongly expressed by the Vitamin D Receptor). Furthermore, these patients have a reduced amount of the AMP dermcidin in their sweat which correlates with an impaired innate defense of human skin //in vivo//. In addition, decreased levels of AMPs are associated with burns and chronic wounds. In contrast, overexpression of AMPs can lead to increased protection against skin infections as seen in patients with psoriasis and rosacea, inflammatory skin-diseases which rarely result in superinfection. In other skin diseases, e.g. in patients with acne vulgaris, increased levels of AMPs are often found in inflamed or infected skin areas indicating a role of these peptides in the protection from infection. These data indicate that AMPs have a therapeutical potential as topical anti-infectives in several skin diseases.(({{pubmed>long:18782030}}))	+	In human skin antimicrobial peptide (AMP) are produced mainly by keratinocytes, neutrophils, sebocytes or sweat glands and are either expressed constantly or after an inflammatory stimulus.(({{pmid>long:18782030}})) As Schittek //et al.// explain, in several human skin diseases, there is an inverse correlation between severity of the disease and the level of AMP production. Skin lesions of patients with atopic dermatitis show a diminished expression of the beta-defensins and the cathelicidin LL-37 (both of which are strongly expressed by the Vitamin D Receptor). Furthermore, these patients have a reduced amount of the AMP dermcidin in their sweat which correlates with an impaired innate defense of human skin //in vivo//. In addition, decreased levels of AMPs are associated with burns and chronic wounds. In contrast, overexpression of AMPs can lead to increased protection against skin infections as seen in patients with psoriasis and rosacea, inflammatory skin-diseases which rarely result in superinfection. In other skin diseases, e.g. in patients with acne vulgaris, increased levels of AMPs are often found in inflamed or infected skin areas indicating a role of these peptides in the protection from infection. These data indicate that AMPs have a therapeutical potential as topical anti-infectives in several skin diseases.(({{pmid>long:18782030}}))


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	<blockquote>Topical steroid creams are available OTC and may be needed to relieve intolerable itching. Use them sparingly. If intolerable itching is not helped by OTC steroid cream, talk to your doctor about a prescription strength topical corticosteroid preparation and use it sparingly.		<blockquote>Topical steroid creams are available OTC and may be needed to relieve intolerable itching. Use them sparingly. If intolerable itching is not helped by OTC steroid cream, talk to your doctor about a prescription strength topical corticosteroid preparation and use it sparingly.

-	All topical corticosteroids are absorbed through the skin and enter the circulation. See for example this report of a person who lost their femoral head joint (hip) due to steroidal cream being applied to the face.(({{pubmed>long:11289593}}))	+	All topical corticosteroids are absorbed through the skin and enter the circulation. See for example this report of a person who lost their femoral head joint (hip) due to steroidal cream being applied to the face.(({{pmid>long:11289593}}))

	All steroids are bad in high dose – they differ only in their efficacy vs dose characteristics. So if you have to use them, then please do it very sparingly. Additionally, any skin that you apply the creams to will not be doing any healing, as the steroid will heavily suppress the immune system in the region it is applied.		All steroids are bad in high dose – they differ only in their efficacy vs dose characteristics. So if you have to use them, then please do it very sparingly. Additionally, any skin that you apply the creams to will not be doing any healing, as the steroid will heavily suppress the immune system in the region it is applied.
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	For years, I have been using 100% pure glycerin (from a drug store or health food store). This is the part of many of the best moisturizers that really does the most effective moisturizing. I then add about 1/3 to Â½ part water and it makes a nice soothing moisturizer.		For years, I have been using 100% pure glycerin (from a drug store or health food store). This is the part of many of the best moisturizers that really does the most effective moisturizing. I then add about 1/3 to Â½ part water and it makes a nice soothing moisturizer.

-	Another place with good products for the sensitive is Special Foods (visit the [[http://www.specialfoods.com\|web site]] and click on products or call 703-644-0991), which has a line of lip balms and lotions that only use beeswax, combined with a variety of oils. Their lip balm is still the only kind I can use and you can't believe how valuable it has been to me over the years (my lips used to become cracked and bleed etc.. using every other product, until I discovered this).	+	Another place with good products for the sensitive is Special Foods (visit the [[https://www.specialfoods.com\|web site]] and click on products or call 703-644-0991), which has a line of lip balms and lotions that only use beeswax, combined with a variety of oils. Their lip balm is still the only kind I can use and you can't believe how valuable it has been to me over the years (my lips used to become cracked and bleed etc.. using every other product, until I discovered this).

	For a lotion, they may be rather expensive and perhaps there would be other options for hypoallergenic lotions at a health food store if you want to order it (try needs.com), or just using a hypoallergenic vegetable oil? You could try more than one option. Also, in case you might have become sensitive to the soap you are using, there is a pure glycerin unscented soap at the health food store that I like called Clearly Natural glycerin soap.		For a lotion, they may be rather expensive and perhaps there would be other options for hypoallergenic lotions at a health food store if you want to order it (try needs.com), or just using a hypoallergenic vegetable oil? You could try more than one option. Also, in case you might have become sensitive to the soap you are using, there is a pure glycerin unscented soap at the health food store that I like called Clearly Natural glycerin soap.
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	<blockquote>		<blockquote>
-	[[http://www.aubrey-organics.com/\|Aubrey Organics]] had some shampoos that I could use in place of soap, and at one point I was tolerating Kirk's Coco Castille bar soap.	+	[[https://www.aubrey-organics.com/\|Aubrey Organics]] had some shampoos that I could use in place of soap, and at one point I was tolerating Kirk's Coco Castille bar soap.

	//P.B., MarshallProtocol.com//</blockquote>		//P.B., MarshallProtocol.com//</blockquote>
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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

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	PMID: 17073677		PMID: 17073677
	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>

Urinary symptoms

anonymous@undisclosed.example.com (Anonymous) — Wed, 14 Sep 2022 20:53:47 +0000

06.04.2017		current
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	In the event of a cardiac emergency, call 911, chew a 325mg uncoated aspirin, and lie down so your heart doesn't have to work so hard. If you think you might pass out, try forcing yourself to cough deeply. It changes the pressure in your chest and can have the same effect as the thump given in CPR. Follow your instincts. If you think you need to see a doctor, call an ambulance. A cardiac emergency should not go to the hospital in a car.... you might need help on the way.		In the event of a cardiac emergency, call 911, chew a 325mg uncoated aspirin, and lie down so your heart doesn't have to work so hard. If you think you might pass out, try forcing yourself to cough deeply. It changes the pressure in your chest and can have the same effect as the thump given in CPR. Follow your instincts. If you think you need to see a doctor, call an ambulance. A cardiac emergency should not go to the hospital in a car.... you might need help on the way.

-	If someone goes into cardiac arrest, note that the American Heart Association [[http://handsonlycpr.org/\|recommends CPR]] without the mouth-to-mouth breathing: call 911 and then push hard and fast on the person's chest until help comes.	+	If someone goes into cardiac arrest, note that the American Heart Association [[https://handsonlycpr.org/\|recommends CPR]] without the mouth-to-mouth breathing: call 911 and then push hard and fast on the person's chest until help comes.


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-	Note that cardiac immunopathology may mimic myocardial infarction. If the cytokines are released into muscle tissue, for example cardiac muscle, they can weaken that muscle.(({{pubmed>long:12729323}})) (({{pubmed>long:12380936}})) This causes something mimicking myocardial infarction (heart attack), and it may be more common than most physicians suspect. It is believe there has yet to be such a case mimicking myocardial infarction, as the release of cytokines on the MP is controlled, and the level set by the patient.	+	Note that cardiac immunopathology may mimic myocardial infarction. If the cytokines are released into muscle tissue, for example cardiac muscle, they can weaken that muscle.(({{pmid>long:12729323}})) (({{pmid>long:12380936}})) This causes something mimicking myocardial infarction (heart attack), and it may be more common than most physicians suspect. It is believe there has yet to be such a case mimicking myocardial infarction, as the release of cytokines on the MP is controlled, and the level set by the patient.


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	The Marshall Protocol has been designed to reduce the chance of tachycardia. Taking a cardiac medication (like a beta-blocker which slows the heart), as a preventative, usually isn't necessary, nor does it appear to be necessary in acute emergencies:		The Marshall Protocol has been designed to reduce the chance of tachycardia. Taking a cardiac medication (like a beta-blocker which slows the heart), as a preventative, usually isn't necessary, nor does it appear to be necessary in acute emergencies:

-	<blockquote>Studies show that the early administration of beta-blockers to heart attack victims does not save lives, and occasionally causes dangerous heart failure. While two studies support the use of beta-blockers after heart attack, there are 26 studies that found no survival benefit to administering beta-blockers early on. Moreover, in 2005, the largest, best study of the drugs showed that beta-blockers in the vulnerable, early hours of heart attacks did not save lives, but did cause a definite increase in heart failure.(({{pubmed>long:16271643}}))	+	<blockquote>Studies show that the early administration of beta-blockers to heart attack victims does not save lives, and occasionally causes dangerous heart failure. While two studies support the use of beta-blockers after heart attack, there are 26 studies that found no survival benefit to administering beta-blockers early on. Moreover, in 2005, the largest, best study of the drugs showed that beta-blockers in the vulnerable, early hours of heart attacks did not save lives, but did cause a definite increase in heart failure.(({{pmid>long:16271643}}))

	Remarkably, the medical community has continued to strongly recommend immediate beta-blocker treatment. Why? Because according to the theory of the straining heart, the treatment makes sense. It should work, even though it doesn’t. Ideology trumps evidence.		Remarkably, the medical community has continued to strongly recommend immediate beta-blocker treatment. Why? Because according to the theory of the straining heart, the treatment makes sense. It should work, even though it doesn’t. Ideology trumps evidence.

-	//David H. Newman, M.D//, [[http://well.blogs.nytimes.com/2009/04/02/the-ideology-of-health-care/\|NYTimes.com]]</blockquote>	+	//David H. Newman, M.D//, [[https://well.blogs.nytimes.com/2009/04/02/the-ideology-of-health-care/\|NYTimes.com]]</blockquote>


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		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====

-	--- //Sallie Q 06.04.2017// adding uTube on smart meter effect	+

	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/1420.html#p11542 f4	+	* https://www.marshallprotocol.com/forum32/1420.html#p11542 f4
-	* http://www.marshallprotocol.com/forum32/1420.html#p55416 f5	+	* https://www.marshallprotocol.com/forum32/1420.html#p55416 f5
-	* http://www.medscape.com/index/section_1989_0 s85	+	* https://www.medscape.com/index/section_1989_0 s85
-	* http://www.marshallprotocol.com/view_topic.php?id=1420&forum_id=32&jump_to=119110#p119110 f8	+	* https://www.marshallprotocol.com/view_topic.php?id=1420&forum_id=32&jump_to=119110#p119110 f8
-	* http://www.marshallprotocol.com/view_topic.php?id=1420&forum_id=32&jump_to=71794#p71794 f6	+	* https://www.marshallprotocol.com/view_topic.php?id=1420&forum_id=32&jump_to=71794#p71794 f6
-	* http://www.marshallprotocol.com/view_topic.php?id=4304&forum_id=37&jump_to=42219#p42219 s76	+	* https://www.marshallprotocol.com/view_topic.php?id=4304&forum_id=37&jump_to=42219#p42219 s76


-	===== References =====	+	===== References =====</nodisp>

03.22.2017		current
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	===== Urine is not sterile =====		===== Urine is not sterile =====

-	While urine within the urinary tract has been traditionally regarded as "sterile", this assumption relies on culture-based methods, which capture a small fraction of microbial richness. A 2011 pyrosequencing study looked at 16S rDNA amplicons of eight culture-negative healthy female urine specimens.(({{pubmed>long:22047020}})) The study found significant diversity, with the predominant genera detected being //Lactobacillus, Prevotella// and //Gardnerella//. Notably, a significant amount of sequences belonging to bacteria with a known pathogenic potential was observed.	+	While urine within the urinary tract has been traditionally regarded as "sterile", this assumption relies on culture-based methods, which capture a small fraction of microbial richness. A 2011 pyrosequencing study looked at 16S rDNA amplicons of eight culture-negative healthy female urine specimens.(({{pmid>long:22047020}})) The study found significant diversity, with the predominant genera detected being //Lactobacillus, Prevotella// and //Gardnerella//. Notably, a significant amount of sequences belonging to bacteria with a known pathogenic potential was observed.


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	The medical term for bladder or urinary tract infection (UTI) is cystitis, which literally means inflammation of the urinary bladder. A UTI is often caused by an acute bacterial infection. UTIs can occur in any part of the urinary tract including the kidneys, ureters, urethra and bladder. UTIs are more common in women because a woman's shorter urethra provides easier access for bacteria, but men are also susceptible.		The medical term for bladder or urinary tract infection (UTI) is cystitis, which literally means inflammation of the urinary bladder. A UTI is often caused by an acute bacterial infection. UTIs can occur in any part of the urinary tract including the kidneys, ureters, urethra and bladder. UTIs are more common in women because a woman's shorter urethra provides easier access for bacteria, but men are also susceptible.

-	[{{ :home:pathogenesis:microbiota:uti.jpg?450\|Scanning electron images of the surface of a mouse bladder infected with urinary tract infection show large intracellular communities of biofilm bacteria inside pods. Uninfected bladders appeared smooth, but infected bladders [[http://www.ncbi.nlm.nih.gov/pubmed/12843396\|had bumps]] all over them. “It was spectacular!” senior author S.J. Hultgren recalled in the accompanying //Science// article. "They looked like fried eggs on the surface of the bladder.”}}]	+	[{{ :home:pathogenesis:microbiota:uti.jpg?450\|Scanning electron images of the surface of a mouse bladder infected with urinary tract infection show large intracellular communities of biofilm bacteria inside pods. Uninfected bladders appeared smooth, but infected bladders [[https://www.ncbi.nlm.nih.gov/pubmed/12843396\|had bumps]] all over them. “It was spectacular!” senior author S.J. Hultgren recalled in the accompanying //Science// article. "They looked like fried eggs on the surface of the bladder.”}}]


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	<relatedarticle> [[home:othertreatments:antibacterials\|Non-MP antibacterials]] </article>		<relatedarticle> [[home:othertreatments:antibacterials\|Non-MP antibacterials]] </article>

-	If a urinalysis is positive for bacteria and one's doctors wants to use an antibiotic other than minocycline, ask him or her to consider Ceftin, Biaxin or a fluoroquinolone, which will not interfere with immunopathology.	+	If a urinalysis is positive for bacteria and one's doctor wants to use an antibiotic other than minocycline, ask him or her to consider Ceftin, Biaxin or a fluoroquinolone, which will not interfere with immunopathology.

	Other strategies for managing a UTI include:		Other strategies for managing a UTI include:
	* Standard measures for managing immunopathology – Try slowing the immune system reaction to see if symptoms of cystitis are relieved.		* Standard measures for managing immunopathology – Try slowing the immune system reaction to see if symptoms of cystitis are relieved.
-	* Cranberries and cranberry drinks/supplements – A substance in cranberries may help clear bacteria from the urinary tract by preventing bacteria from sticking to mucosal surfaces lining the bladder and gut.(({{pubmed>long:17694340}})) The recommended dosing for prophylaxis of urinary tract infection is based on a recent positive randomized controlled trial that used one tablet of concentrated cranberry extract (300 to 400 mg) twice daily, or 8 oz of pure unsweetened cranberry juice three times daily. Note that pure unsweetened cranberry juice can be added to clear diet soda (e.g. Diet 7-Up) to make a more palatable drink. To be effective in preventing UTIs, cranberry must be taken without interruption in order to maintain its physical presence in the bladder.	+	* Cranberries and cranberry drinks/supplements – A substance in cranberries may help clear bacteria from the urinary tract by preventing bacteria from sticking to mucosal surfaces lining the bladder and gut.(({{pmid>long:17694340}})) The recommended dosing for prophylaxis of urinary tract infection is based on a recent positive randomized controlled trial that used one tablet of concentrated cranberry extract (300 to 400 mg) twice daily, or 8 oz of pure unsweetened cranberry juice three times daily. Note that pure unsweetened cranberry juice can be added to clear diet soda (e.g. Diet 7-Up) to make a more palatable drink. To be effective in preventing UTIs, cranberry must be taken without interruption in order to maintain its physical presence in the bladder.
	* //Avoid consumption of sugars especially D-mannose.// Sugars contribute to the growth of pathogenic bacteria.		* //Avoid consumption of sugars especially D-mannose.// Sugars contribute to the growth of pathogenic bacteria.

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	==== If the urinalysis is negative ====		==== If the urinalysis is negative ====

-	* Symptoms of UTI may be due to immunopathology – The release of endotoxins and cytokine storm that follows bacterial die-off can mimic symptoms of cystitis. Marshall Protocol patients with cystitis whose urinalysis does not reveal a bladder infection may be experiencing immunopathology. Genital irritation may be due to [[http://www.seekwellness.com/incontinence/pelvic-pain-vulvodynia.htm\|vulvodynia]]. This may or not be related to an alteration in the pH of urine. If this is the case, a medical exam is suggested.	+	* Symptoms of UTI may be due to immunopathology – The release of endotoxins and cytokine storm that follows bacterial die-off can mimic symptoms of cystitis. Marshall Protocol patients with cystitis whose urinalysis does not reveal a bladder infection may be experiencing immunopathology. Genital irritation may be due to [[https://www.seekwellness.com/incontinence/pelvic-pain-vulvodynia.htm\|vulvodynia]]. This may or not be related to an alteration in the pH of urine. If this is the case, a medical exam is suggested.
-	* Symptoms of UTI may be due to a subclinical infection – One study found that a large fraction of fastidious and anaerobic bacteria (22.43%) was not detected under culture conditions but only by using PCR, a genomic sequencing technique which is more rigorous at identifying bacteria.(({{pubmed>long:18336452}})) If this is the case the MP is still a patient's best option for ridding him or herself of the conditions which originally caused this problem.	+	* Symptoms of UTI may be due to a subclinical infection – One study found that a large fraction of fastidious and anaerobic bacteria (22.43%) was not detected under culture conditions but only by using PCR, a genomic sequencing technique which is more rigorous at identifying bacteria.(({{pmid>long:18336452}})) If this is the case the MP is still a patient's best option for ridding him or herself of the conditions which originally caused this problem.

	Note that excessive urination, known as polyuria, may be due to subclinical kidney inflammation.		Note that excessive urination, known as polyuria, may be due to subclinical kidney inflammation.
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	===== Bacterial vaginosis =====		===== Bacterial vaginosis =====

-	Bacterial vaginosis is a common syndrome associated with numerous adverse health outcomes in women. According to a 2012 study using broad-range PCR , the community of vaginal bacteria detected in subjects with BV was much more taxon rich and diverse than in subjects without BV.(({{pubmed>long:18487399}})) //Actinobacteria// and //Bacteroidetes// were strongly associated with BV.	+	Bacterial vaginosis is a common syndrome associated with numerous adverse health outcomes in women. According to a 2012 study using broad-range PCR , the community of vaginal bacteria detected in subjects with BV was much more taxon rich and diverse than in subjects without BV.(({{pmid>long:18487399}})) //Actinobacteria// and //Bacteroidetes// were strongly associated with BV.


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	{{tag>symptoms}}		{{tag>symptoms}}

		+	<nodisp>
	===== Notes and comments =====		===== Notes and comments =====


	* Legacy content		* Legacy content
-	* http://www.marshallprotocol.com/forum32/7836.html f203	+	* https://www.marshallprotocol.com/forum32/7836.html f203
-	* http://www.marshallprotocol.com/forum32/5841.html f267	+	* https://www.marshallprotocol.com/forum32/5841.html f267

	<blockquote>Antibiotics Can Help Improve Overactive Bladder Print This Email this		<blockquote>Antibiotics Can Help Improve Overactive Bladder Print This Email this
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	"We have looked at over 65,000 culture samples and have not found any increased risk of antibiotic resistance," he said. "A Darwinian understanding of the underlying pathophysiology would lead us to expect very low levels of antibiotic resistance. For resistance to occur, bacterial replication is required to allow for variation and the influence of selection pressure. But in OAB, there is evidence that the bacteria are relatively dormant, and replication is low, so the chances of developing resistance in the offending pathogens are very low and our data confirm this."		"We have looked at over 65,000 culture samples and have not found any increased risk of antibiotic resistance," he said. "A Darwinian understanding of the underlying pathophysiology would lead us to expect very low levels of antibiotic resistance. For resistance to occur, bacterial replication is required to allow for variation and the influence of selection pressure. But in OAB, there is evidence that the bacteria are relatively dormant, and replication is low, so the chances of developing resistance in the offending pathogens are very low and our data confirm this."
	</blockquote>		</blockquote>
-	===== References =====	+	===== References =====</nodisp>