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home:diseases:addisons [01.06.2019] – [Notes and comments] sallieqhome:diseases:addisons [01.18.2019] – [hyperkalemia] sallieq
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 [[http://www.mayoclinic.org/diseases-conditions/addisons-disease/home/ovc-20155636|Addison's disease -overview by Mayo Clinic Staff]] [[http://www.mayoclinic.org/diseases-conditions/addisons-disease/home/ovc-20155636|Addison's disease -overview by Mayo Clinic Staff]]
  
-===== hyperkalemia =====+==== Evidence of infection ==== 
 + 
 + The adrenal crisis had been precipitated by influenza virus type B infection.(({{pubmed>long:26240101}})) 
 +==== hyperkalemia ====
  
 Those with a tendency to high potassium levels would be helped by our home made 'Jigsaw water'. Read the details in [[home:othertreatments:sodium_bicarbonate|sodium bicarbonate]] Those with a tendency to high potassium levels would be helped by our home made 'Jigsaw water'. Read the details in [[home:othertreatments:sodium_bicarbonate|sodium bicarbonate]]
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-===== Evidence of infectious cause =====+===== Delay in diagnosis ===== 
 + 
 +Addison's Disease: A Diagnostic Dilemma. (({{pubmed>long:28919626}}))   
 + 
 +Addison's disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison's disease.(({{pubmed>long:23633816}}))   
 + 
 + 
 + A LONG FOLLOW-UP STUDY ON 143 PATIENTS.(({{pubmed>long:30608902}})) 
 + 
 + 
 + In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon.(({{pubmed>long:000}})) 
 + 
 + 
 +(({{pubmed>long:30562824}})) 
 + 
  
 ===== Recent research ===== ===== Recent research =====
  
- Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis.   (({{pubmed>long:30562824}})) +Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with primary adrenal insufficiency (PAIis still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis.   (({{pubmed>long:30562824}})) 
  
 Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases.    (({{pubmed>long:2433003}}))  Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases.    (({{pubmed>long:2433003}})) 
  
  
-The most common causes of PAI are autoimmune adrenalitis (Addison's disease), infectious diseases, adrenalectomy, neoplasia, medications, and various rare genetic syndromes and inborn errors of metabolism that typically present in childhood although late-onset presentations are becoming increasingly recognized.   (({{pubmed>long:29956047}})) +The most common causes of PAI are autoimmune adrenalitis (Addison's disease), infectious diseases, adrenalectomy, neoplasia, medications, and various rare genetic syndromes and inborn errors of metabolism that typically present in childhood although late-onset presentations are becoming increasingly recognized.   (({{pubmed>long:29956047}})) Fady Hannah-Shmouni and Constantine A. Stratakis : An overview of inborn errors of metabolism manifesting with primary adrenal insufficiency
      
 Main presenting symptoms of Addison's disease such as fatigue, anorexia, vomiting and convulsion often mimics central nervous system (CNS) infections.  (({{pubmed>long:28919626}}))  Main presenting symptoms of Addison's disease such as fatigue, anorexia, vomiting and convulsion often mimics central nervous system (CNS) infections.  (({{pubmed>long:28919626}})) 
  
-New-onset autoimmune Addison's disease should be considered as a potentially reversible condition in some patients. Future studies of immunomodulation in autoimmune Addison's disease may be warranted.   (({{pubmed>long:99999999}})) +New-onset autoimmune Addison's disease should be considered as a potentially reversible condition in some patients. Future studies of immunomodulation in autoimmune Addison's disease may be warranted.   (({{pubmed>long:22767640}}))  
 + 
 +The prevalence of the metabolic syndrome in patients with AM was 35.71% after a period of treatment longer than 15 years. (({{pubmed>long:30627312}}))  
 ===== Patient's reports ===== ===== Patient's reports =====
  
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-Sample PubMed cite(({{pubmed>long:18200565}}))+
  
  
home/diseases/addisons.txt · Last modified: 09.14.2022 by 127.0.0.1
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