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home:diseases:addisons [01.11.2019]
sallieq [Recent research]
home:diseases:addisons [01.18.2019]
sallieq [Delay in diagnosis]
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 [[http://​www.mayoclinic.org/​diseases-conditions/​addisons-disease/​home/​ovc-20155636|Addison'​s disease -overview by Mayo Clinic Staff]] [[http://​www.mayoclinic.org/​diseases-conditions/​addisons-disease/​home/​ovc-20155636|Addison'​s disease -overview by Mayo Clinic Staff]]
  
-===== hyperkalemia ​=====+==== Evidence of infection ​==== 
 + 
 + The adrenal crisis had been precipitated by influenza virus type B infection.(({{pubmed>​long:​26240101}})) 
 +==== hyperkalemia ​====
  
 Those with a tendency to high potassium levels would be helped by our home made '​Jigsaw water'​. Read the details in [[home:​othertreatments:​sodium_bicarbonate|sodium bicarbonate]] Those with a tendency to high potassium levels would be helped by our home made '​Jigsaw water'​. Read the details in [[home:​othertreatments:​sodium_bicarbonate|sodium bicarbonate]]
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-===== Evidence of infectious cause =====+===== delay in Diagnosis ​===== 
 + 
 +Addison'​s Disease: A Diagnostic Dilemma. (({{pubmed>​long:​28919626}})) ​  
 + 
 +Addison'​s disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison'​s disease.(({{pubmed>​long:​23633816}})) ​  
 + 
 + 
 + A LONG FOLLOW-UP STUDY ON 143 PATIENTS.(({{pubmed>​long:​30608902}})) 
 + 
 + 
 +<​blockquote>​ In addition to the common "​classical"​ causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants,​ drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. 
 + 
 + 
 +PAI is frequently not considered resulting in a delayed diagnosis. Successful therapy is mainly based on adequate patient education as a cornerstone in the prevention and management of adrenal crisis. (({{pubmed>​long:​30562824}}))</​blockquote>​ 
 + 
  
 ===== Recent research ===== ===== Recent research =====
  
- Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with primary adrenal insufficiency (PAI) is still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "​classical"​ causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants,​ drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis. ​  ​(({{pubmed>​long:​30562824}})) ​+Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with primary adrenal insufficiency (PAI) is still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "​classical"​ causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants,​ drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis. ​  ​(({{pubmed>​long:​30562824}})) ​
  
 Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases. ​   (({{pubmed>​long:​2433003}})) ​ Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases. ​   (({{pubmed>​long:​2433003}})) ​
  
  
-The most common causes of PAI are autoimmune adrenalitis (Addison'​s disease), infectious diseases, adrenalectomy,​ neoplasia, medications,​ and various rare genetic syndromes and inborn errors of metabolism that typically present in childhood although late-onset presentations are becoming increasingly recognized. ​  ​(({{pubmed>​long:​29956047}})) ​+The most common causes of PAI are autoimmune adrenalitis (Addison'​s disease), infectious diseases, adrenalectomy,​ neoplasia, medications,​ and various rare genetic syndromes and inborn errors of metabolism that typically present in childhood although late-onset presentations are becoming increasingly recognized. ​  ​(({{pubmed>​long:​29956047}})) ​Fady Hannah-Shmouni and Constantine A. Stratakis : An overview of inborn errors of metabolism manifesting with primary adrenal insufficiency
   ​   ​
 Main presenting symptoms of Addison'​s disease such as fatigue, anorexia, vomiting and convulsion often mimics central nervous system (CNS) infections. ​ (({{pubmed>​long:​28919626}})) ​ Main presenting symptoms of Addison'​s disease such as fatigue, anorexia, vomiting and convulsion often mimics central nervous system (CNS) infections. ​ (({{pubmed>​long:​28919626}})) ​
  
-New-onset autoimmune Addison'​s disease should be considered as a potentially reversible condition in some patients. Future studies of immunomodulation in autoimmune Addison'​s disease may be warranted. ​  ​(({{pubmed>​long:​99999999}})) +New-onset autoimmune Addison'​s disease should be considered as a potentially reversible condition in some patients. Future studies of immunomodulation in autoimmune Addison'​s disease may be warranted. ​  ​(({{pubmed>​long:​22767640}}))  
 + 
 +The prevalence of the metabolic syndrome in patients with AM was 35.71% after a period of treatment longer than 15 years. (({{pubmed>​long:​30627312}}))  ​
 ===== Patient'​s reports ===== ===== Patient'​s reports =====
  
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-Sample PubMed cite(({{pubmed>​long:​18200565}}))+
  
  
home/diseases/addisons.txt · Last modified: 02.11.2019 by sallieq
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