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home:diseases:addisons [01.15.2019] – [Recent research] sallieqhome:diseases:addisons [02.11.2019] – [Notes and comments] sallieq
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 [[http://www.mayoclinic.org/diseases-conditions/addisons-disease/home/ovc-20155636|Addison's disease -overview by Mayo Clinic Staff]] [[http://www.mayoclinic.org/diseases-conditions/addisons-disease/home/ovc-20155636|Addison's disease -overview by Mayo Clinic Staff]]
  
-===== hyperkalemia =====+==== Evidence of infection ==== 
 + 
 + The adrenal crisis had been precipitated by influenza virus type B infection.(({{pubmed>long:26240101}})) 
 +==== hyperkalemia ====
  
 Those with a tendency to high potassium levels would be helped by our home made 'Jigsaw water'. Read the details in [[home:othertreatments:sodium_bicarbonate|sodium bicarbonate]] Those with a tendency to high potassium levels would be helped by our home made 'Jigsaw water'. Read the details in [[home:othertreatments:sodium_bicarbonate|sodium bicarbonate]]
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-===== Evidence of infectious cause =====+===== delay in Diagnosis ===== 
 + 
 +Addison's Disease: A Diagnostic Dilemma. (({{pubmed>long:28919626}}))   
 + 
 +Addison's disease is a rare endocrinal disorder, with several oral and systemic manifestations. A variety of pathological processes may cause Addison's disease.(({{pubmed>long:23633816}}))   
 + 
 + 
 + A LONG FOLLOW-UP STUDY ON 143 PATIENTS.(({{pubmed>long:30608902}})) 
 + 
 + 
 +<blockquote> In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. 
 + 
 + 
 +PAI is frequently not considered resulting in a delayed diagnosis. Successful therapy is mainly based on adequate patient education as a cornerstone in the prevention and management of adrenal crisis. (({{pubmed>long:30562824}}))</blockquote> 
 + 
  
 ===== Recent research ===== ===== Recent research =====
  
- Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with primary adrenal insufficiency (PAI) is still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis.   (({{pubmed>long:30562824}})) +Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with primary adrenal insufficiency (PAI) is still increased and the health-related quality of life (HRQoL) is often reduced. PAI is a rare disease but recent data report an increasing prevalence. In addition to the common "classical" causes of PAI like autoimmune, infectious, neoplastic and genetic disorders, other iatrogenic conditions - mostly pharmacological side effects (e. g., adrenal haemorrhage associated with anticoagulants, drugs affecting glucocorticoid synthesis, action or metabolism and some of the novel anti-cancer checkpoint inhibitors) are contributing factors to this phenomenon. Due to the rarity of the disease and often non-specific symptoms at least in the early stages, PAI is frequently not considered resulting in a delayed diagnosis.   (({{pubmed>long:30562824}})) 
  
 Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases.    (({{pubmed>long:2433003}}))  Acute adrenal crisis is a life-threatening condition that requires immediate treatment. Standard replacement therapy consists of multiple daily doses of hydrocortisone or cortisone acetate combined with fludrocortisone. Annual follow-up by an endocrinologist is recommended with the focus on optimization of replacement therapy and detection of new autoimmune diseases.    (({{pubmed>long:2433003}})) 
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-Sample PubMed cite(({{pubmed>long:18200565}})) 
  
  
-{{tag>Diseases arrange}}+ 
 +{{tag>Diseases }}
  
  
  
 ===== Notes and comments ===== ===== Notes and comments =====
 +
 +  (({{pubmed>long:000}}))
  
  
home/diseases/addisons.txt · Last modified: 09.14.2022 by 127.0.0.1
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