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home:diseases:aging [12.06.2018] – [Aging (senescence)] sallieqhome:diseases:aging [01.12.2019] – [Read more] sallieq
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 Aging deeply affects (or is affected by!) the human microbiota's homeostasis with the host's immune system:(({{pubmed>long: 20498852}})) (({{pubmed>long:22283774}})) Aging deeply affects (or is affected by!) the human microbiota's homeostasis with the host's immune system:(({{pubmed>long: 20498852}})) (({{pubmed>long:22283774}}))
-  * **macrophage function** – Macrophages, which act as "pathogen sensors", lose the ability to initiate an inflammatory response as people age.(({{pubmed>long:15268749}})) Microbes use a variety of methods to infect macrophages. For example, //Neisseria meningitidis// prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.(({{pubmed>long:16369030}}))+
   * **autoimmune** – As people age, their risk for developing an "autoimmune" condition also increases.(({{pubmed>long:1822969}})) The article on [[home:alternate:autoimmunity|autoimmune conditions]] discusses why so-called “autoantibodies” are merely antibodies generated in response to pathogenic bacterial cells that have been destroyed as a result of an active immune response.   * **autoimmune** – As people age, their risk for developing an "autoimmune" condition also increases.(({{pubmed>long:1822969}})) The article on [[home:alternate:autoimmunity|autoimmune conditions]] discusses why so-called “autoantibodies” are merely antibodies generated in response to pathogenic bacterial cells that have been destroyed as a result of an active immune response.
 +  * **macrophage function** – Macrophages, which act as "pathogen sensors", lose the ability to initiate an inflammatory response as people age.(({{pubmed>long:15268749}})) Microbes use a variety of methods to infect macrophages. For example, //Neisseria meningitidis// prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.(({{pubmed>long:16369030}}))
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 +<blockquote>This theory is based on the fact that genes affecting host organism longevity are represented by subpopulations: genes of host eukaryotic cells, commensal microbiota, and non-living genetic elements. ........... we propose that lifespan and aging are defined by the accumulation of alterations over all genes of macroorganism and microbiome and the non-living genetic elements associated with them. (({{pubmed>long:29978435}}))  </blockquote>
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 Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest.  Could the chronic inflammation associated with aging be caused by pathogens? Given the crudeness of tools now used to measure microbes and the ubiquity of the human microbiota, this seems like a reasonable if not inevitable conclusion as the early studies have begun to suggest. 
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 //**E. Cevenini**//(({{pubmed>long:20388071}}))</blockquote> //**E. Cevenini**//(({{pubmed>long:20388071}}))</blockquote>
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   * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http://www.eurekalert.org/pub_releases/2012-06/tes-dtl062212.php|2012 study]] found that declining testosterone levels are not an inevitable part of the aging process, as many people think. Men who had declines in testosterone were more likely to be those who became obese, had stopped smoking or were depressed at either clinic visit.   * **Declining testosterone levels in men not part of normal aging, study finds** – A [[http://www.eurekalert.org/pub_releases/2012-06/tes-dtl062212.php|2012 study]] found that declining testosterone levels are not an inevitable part of the aging process, as many people think. Men who had declines in testosterone were more likely to be those who became obese, had stopped smoking or were depressed at either clinic visit.
 +  * [[https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-3-12/comments|We have a lot to learn about 'diseases of the aging']]
  
  
home/diseases/aging.txt · Last modified: 09.14.2022 by 127.0.0.1
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