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home:diseases:anxiety [01.26.2020] – [Research into various drug effects] sallieqhome:diseases:anxiety [09.14.2022] (current) – external edit 127.0.0.1
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-Finally there's certain evidence that olmesartan (Benicar) may be useful against stress disorders. A National Institutes of Health paper says an important stress hormone, ANGII, and by extension stress disorders, could be managed by the use of ARBs, of which olmesartan  is one.(({{pubmed>long:17514587}}))+Finally there's certain evidence that olmesartan (Benicar) may be useful against stress disorders. A National Institutes of Health paper says an important stress hormone, ANGII, and by extension stress disorders, could be managed by the use of ARBs, of which olmesartan  is one.(({{pmid>long:17514587}}))
  
  
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 autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS) autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)
  
-Read the [[http://bacteriality.com/2008/03/15/interview18/|interview]]+Read the [[https://bacteriality.com/2008/03/15/interview18/|interview]]
  
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 <blockquote>Infection and inflammation lead to changes in mood and cognition. Although the "classic" sickness behavior syndrome, involving fatigue, social withdrawal, and loss of appetites are most familiar, other emotional responses accompany immune activation, including anxiety. Recent studies have shown that gastrointestinal bacterial infections lead to enhanced anxiety-like behavior in mice. The bacteria-induced signal is most likely carried by vagal sensory neurons, and occurs early on (within 6h) during the infection. These signals induce evidence of activation in brain regions that integrate viscerosensory information with mood, and potentiate activation in brain regions established as key players in fear and anxiety.  <blockquote>Infection and inflammation lead to changes in mood and cognition. Although the "classic" sickness behavior syndrome, involving fatigue, social withdrawal, and loss of appetites are most familiar, other emotional responses accompany immune activation, including anxiety. Recent studies have shown that gastrointestinal bacterial infections lead to enhanced anxiety-like behavior in mice. The bacteria-induced signal is most likely carried by vagal sensory neurons, and occurs early on (within 6h) during the infection. These signals induce evidence of activation in brain regions that integrate viscerosensory information with mood, and potentiate activation in brain regions established as key players in fear and anxiety. 
  
-//**L.E. Goehler** et al.//(({{pubmed>long:17428636}}))</blockquote>+//**L.E. Goehler** et al.//(({{pmid>long:17428636}}))</blockquote>
  
-Further, Neufeld //et al.// showed that germ-free mice exhibited reduced anxiety-like behavior as well as significant neurochemical changes in the brain compared to specific-pathogen-free mice. (({{pubmed>long:21054680}}))+Further, Neufeld //et al.// showed that germ-free mice exhibited reduced anxiety-like behavior as well as significant neurochemical changes in the brain compared to specific-pathogen-free mice. (({{pmid>long:21054680}}))
  
  
  
-The frequency with which patients of certain Th1 diseases also experience anxiety(({{pubmed>long:8818377}})) (({{pubmed>long:18774427}})) (({{pubmed>long:18774427}})) (({{pubmed>long:9361174}})) (({{pubmed>long:15569892}})) (({{pubmed>long:7883407}})) (({{pubmed>long:9707157}})) (({{pubmed>long:12011605}})) (({{pubmed>long:11391746}})) may also suggest a single underlying cause.+The frequency with which patients of certain Th1 diseases also experience anxiety(({{pmid>long:8818377}})) (({{pmid>long:18774427}})) (({{pmid>long:18774427}})) (({{pmid>long:9361174}})) (({{pmid>long:15569892}})) (({{pmid>long:7883407}})) (({{pmid>long:9707157}})) (({{pmid>long:12011605}})) (({{pmid>long:11391746}})) may also suggest a single underlying cause.
  
  
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 {{tag>diseases symptoms neurological}} {{tag>diseases symptoms neurological}}
  
 +Findings suggest that a low dose of THC produces subjective stress-relieving effects in line with those commonly reported among cannabis users, but that higher doses may non-specifically increase negative mood. (({{pmid>long:28599212}}))   [[https://www.sciencedirect.com/science/article/abs/pii/S037687161730220X?via%3Dihub|effects of delta-9-THC on responses to the Trier Social Stress Test (TSST)]] 
  
- findings suggest that a low dose of THC produces subjective stress-relieving effects in line with those commonly reported among cannabis users, but that higher doses may non-specifically increase negative mood.  [[https://www.sciencedirect.com/science/article/abs/pii/S037687161730220X?via%3Dihub|effects of delta-9-THC on responses to the Trier Social Stress Test (TSST)Link]]+Baseline symptoms of depression (but not anxiety or stress) appeared to be exacerbated across time/tracked sessions. [[https://www.sciencedirect.com/science/article/pii/S0165032718303100?via%3Dihub|Journal of Affective Disorders]]  (({{pmid>long:29656267}})) 
  
-baseline symptoms of depression (but not anxiety or stress) appeared to be exacerbated across time/tracked sessions. [[https://www.sciencedirect.com/science/article/pii/S0165032718303100?via%3Dihub|  Science Direct]]  (({{pubmed>long:29656267}}))  +Perhaps most well-studied is the role the CeA plays in unconditioned and conditioned fear generation (Ciocchi et al., 2010, Li et al., 2013, Tye et al., 2011), fear extinction, and conditioned inhibition (Amano et al., 2010), as well as conditioned orienting responses to emotionally salient stimuli (El-Amamy and Holland, 2007, Groshek et al., 2005).  [[https://www.cell.com/neuron/fulltext/S0896-6273(14)00017-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627314000178%3Fshowall%3Dtrue|The central amygdala Link]]  (({{pmid>long:24607231}}))
- +
-Perhaps most well-studied is the role the CeA plays in unconditioned and conditioned fear generation (Ciocchi et al., 2010, Li et al., 2013, Tye et al., 2011), fear extinction, and conditioned inhibition (Amano et al., 2010), as well as conditioned orienting responses to emotionally salient stimuli (El-Amamy and Holland, 2007, Groshek et al., 2005).  [[https://www.cell.com/neuron/fulltext/S0896-6273(14)00017-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627314000178%3Fshowall%3Dtrue|The central amygdala Link]]  (({{pubmed>long:24607231}}))+
  
 the mechanisms by which stress increases amygdala-dmPFC synaptic strength and generates anxiety-like behaviors are not well understood. Here, we show that the mouse basolateral amygdala (BLA)-prelimbic prefrontal cortex (plPFC) circuit is engaged by stress and activation of this pathway in anxiogenic. [[https://www.cell.com/neuron/pdf/S0896-6273(19)31090-6.pdf|Functional coupling between the amygdala and the dorsomedial prefrontal cortex Link]] the mechanisms by which stress increases amygdala-dmPFC synaptic strength and generates anxiety-like behaviors are not well understood. Here, we show that the mouse basolateral amygdala (BLA)-prelimbic prefrontal cortex (plPFC) circuit is engaged by stress and activation of this pathway in anxiogenic. [[https://www.cell.com/neuron/pdf/S0896-6273(19)31090-6.pdf|Functional coupling between the amygdala and the dorsomedial prefrontal cortex Link]]
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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   * Legacy content     * Legacy content  
-    * http://www.marshallprotocol.com/view_topic.php?id=2696&forum_id=32&jump_to=45601#p23751 f102 +    * https://www.marshallprotocol.com/view_topic.php?id=2696&forum_id=32&jump_to=45601#p23751 f102 
-    * http://www.marshallprotocol.com/forum32/7148.html f248 +    * https://www.marshallprotocol.com/forum32/7148.html f248 
-    * http://www.marshallprotocol.com/view_topic.php?id=4243&forum_id=37&jump_to=41630#p41630 s62+    * https://www.marshallprotocol.com/view_topic.php?id=4243&forum_id=37&jump_to=41630#p41630 s62
  
  
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 Bacteria’s presence or absence affected how the mice used certain brain chemicals and genes involved in brain development. Taken together, the results indicate that intestinal bacteria somehow shape the brain and make mice more anxious — or cautious, depending how you look at it, Pettersson says. Bacteria’s presence or absence affected how the mice used certain brain chemicals and genes involved in brain development. Taken together, the results indicate that intestinal bacteria somehow shape the brain and make mice more anxious — or cautious, depending how you look at it, Pettersson says.
 </blockquote> </blockquote>
-===== References =====+===== References =====</nodisp> 
home/diseases/anxiety.1580076811.txt.gz · Last modified: 01.26.2020 by sallieq
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