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home:diseases:cancer [06.12.2018]
sallieq [Microbial interaction and disease]
home:diseases:cancer [05.16.2019] (current)
sallieq [Other Immune Suppressants]
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 Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure. Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure.
 +
 +It may be particularly important for MP patients with cancer in the family to avoid caffeine as far as possible.
 +
 +"It is difficult to assess the practical significance of phagocytic suppression,​ but our previous work (unpublished) has shown that cancer cells can suppress phagocytosis in a similar manner. If this is the case, caffeine may be aiding in the suppression of immune response in the tumor microenvironment." ​ (({{pubmed>​long:​27022462}}))
 +
 +
 +
  
 =====Evidence of infectious cause===== =====Evidence of infectious cause=====
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   * **liver cancer** – It is "well established"​ that chronic infections with hepatitis B and C viruses (HBV, HCV) represent major risk factors for HCC.(({{pubmed>​long:​10710202}}))   * **liver cancer** – It is "well established"​ that chronic infections with hepatitis B and C viruses (HBV, HCV) represent major risk factors for HCC.(({{pubmed>​long:​10710202}}))
   * **lung cancer** – According to a 2011 meta-analysis,​ patients exposed to //C. pneumoniae//​ infection had a 48% greater risk for lung cancer risk, relative to those not exposed.(({{pubmed>​long:​21194924}}))   * **lung cancer** – According to a 2011 meta-analysis,​ patients exposed to //C. pneumoniae//​ infection had a 48% greater risk for lung cancer risk, relative to those not exposed.(({{pubmed>​long:​21194924}}))
-  * **prostate cancer** – In a 2005 culture-based study, Cohen found that //​Propionibacterium acnes// in 35% of prostate samples of 34 consecutive patients tested.(({{pubmed>​long:​15879794}})) ​+  * **prostate cancer** – In a 2005 culture-based study, Cohen found that //​Propionibacterium acnes// in 35% of prostate samples of 34 consecutive patients tested.(({{pubmed>​long:​15879794}})) 
 +  * **Table of cancers** with associated agents. [[https://​bmccancer.biomedcentral.com/​track/​pdf/​10.1186/​s12885-017-3234-4|Infections and Cancer]]
  
  
 With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. ​ (({{pubmed>​long:​27470177}})) With the recent advent of high throughput sequencing studies, we can expect additional insights into how diseases like cancer are associated with shifts in microbial communities. ​ (({{pubmed>​long:​27470177}}))
  
 +==== see also M P Study Site ====
 +
 +[[https://​www.marshallprotocol.com/​forum39/​16259.html|Study shows mechanism for Microbiome to cause Cancer]]
 +
 +===== Innate immunity =====
 +
 +<​blockquote>​Macrophages are immune cells just like T and B cells, but differ in that they can eat cells that are not supposed to be in the body. In fact, they are the most prominent immune cell found in cancer, but unfortunately,​ most are often convinced to help cancer grow and spread. Cancer cells frequently stop macrophages from attacking them by expressing CD47, a "​don'​t eat me" signal. Researchers now say that merely blocking inhibitory signals like CD47 is not always sufficient to convince macrophages to attack cancer. Instead, two signals are required. First, they need a signal to activate them—such as a toll-like receptor agonist. After that, a second signal—such as a CD47 inhibitor—can lower the threshold needed to wage battle on the cancer.</​blockquote>​
 +
 +
 +"It turns out macrophages need to be primed before they can go to work, which explains why solid tumors may resist treatment with CD47 inhibitors alone," ​  ​(({{pubmed>​long:​30664738}})) ​
 +
 +Increasing evidence supports the occurrence of an intriguing link between tumor onset and development with the microenvironment in which cancer cells are embedded. In this context, a critical role of CD73, in calibrating the duration, magnitude and composition of adenosine signaling in cancer development and progression,​ has been identified. ​ (({{pubmed>​long:​24958495}}))
 +
 +The Vitamin D3 analogue calcipotriol suppresses CpG-activated TLR9-MyD88 signalling in murine plasmacytoid dendritic cells (({{pubmed>​long: ​   29392742}})) ​
  
 +{{tag> ​ }}
 =====Vitamin D metabolism===== =====Vitamin D metabolism=====
  
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   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>​long:​20720256}})) ​   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>​long:​20720256}})) ​
  
-<html+ 
-<!--+ 
 +==== Are There Concerns About V.D Supplement ? ==== 
 + 
 +There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. 
 + 
 +  * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. 
 +  *  
 +  * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers.  
 + 
 + 
 +The Vitamin D3 analogue calcipotriol suppresses CpG-activated TLR9-MyD88 signalling in murine plasmacytoid dendritic cells (({{pubmed>long:​29392742}})) ​ 
 + 
 +Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis. (({{pubmed>​long:​30718230}}))  
 + 
 +2014  a Cochrane meta-analysis that included 18 randomized clinical trials comparing vitamin D administration versus no intervention in healthy population found no difference regarding cancer incidence. ​ In randomised controlled trials, relative risks for all cause mortality were 0.89 (0.80 to 0.99) for vitamin D3 supplementation and 1.04 (0.97 to 1.11) for vitamin D2 supplementation. The effects observed for vitamin D3 supplementation remained unchanged when grouped by various characteristics. However, for vitamin D2 supplementation,​ increased risks of mortality were observed in studies with lower intervention doses and shorter average intervention periods. ​ (({{pubmed>​long: ​   24690623}})) 
 ====1,​25-dihydroxyvitamin D ==== ====1,​25-dihydroxyvitamin D ====
  
 Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>​long:​8989244}})) As the level of 1,25-D falls, the level of the innate immune system'​s ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis. Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>​long:​8989244}})) As the level of 1,25-D falls, the level of the innate immune system'​s ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis.
---> + 
-</html>+[[https://​autoimmunityresearch.org/​hormones.pdf|Hormonal changes result from change in 1,25 dihydroxyvitamin-D]] 
 + 
 +==== Other Immune Suppressants ==== 
 + 
 + 
 +Women with hereditary cancer predispositions should put their smartphones,​ tablets, and laptops into air-plane mode at all times when not in use.   ​(({{pubmed>long:    29456806}})) 
 + 
 +Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma. ​  ​(({{pubmed>long:    24193082}}))  
 + 
 +This compound has antiproliferative and antimigratory effects in squamous cell carcinoma, glioblastoma,​ and breast cancer cell lines (({{pubmed>​long: ​   31025400}})) 
 + 
 +Several researchers have highlighted a possible link between glioma and human cytomegalovirus (HCMV). ​ (({{pubmed>​long:​30888562}}))  
 + 
 +[[https://​sacramento.cbslocal.com/​2019/​03/​25/​ripon-cell-tower-school-removal-cancer/​|Cell tower removed after 4 students get cancers]] 
 + 
 +[[https://​prepforthat.com/​portland-blocking-5g-networks-over-health-risks/​|Officials Attempt To Block 5G Network Installation Over Health Risks]] 
 + 
 + 
 + 
 +  
  
 ===== Single species vs. communities of microbes ===== ===== Single species vs. communities of microbes =====
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 Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}})) Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}}))
  
-A number of types of chronic infection have been observed to be associated with cancers in some studies, but without an identified specific bacterial pathogen. Examples are chronic ulcers and osteomyelitis ​sinus tracts (squamous cell carcinoma), chronic urinary tract infections (UTIs) (bladder cancer), and chronic prostatitis (prostate cancer).(({{pubmed>​long:​20930075}}))+A number of types of chronic infection have been observed to be associated with cancers in some studies, but without an identified specific bacterial pathogen. Examples are chronic ulcers and osteomylitis, ​sinus tracts (squamous cell carcinoma), chronic urinary tract infections (UTIs) (bladder cancer), and chronic prostatitis (prostate cancer).(({{pubmed>​long:​20930075}}))
  
 The Marshall Pathogenesis is at complete odds with Koch's postulates, suggesting that it is not one species but entire communities of microbes that are responsible for many cancers. The process by which a person accumulates microbes responsible for disease is known as “successive infection.” In successive infection, an infectious cascade of pathogens progressively slow the immune response and allow for subsequent infections to proliferate,​ resulting in dysbiosis (microbial imbalances). According to this model, a single microbe may not need to be present in all cases of disease in order to be implicated in it. The Marshall Pathogenesis is at complete odds with Koch's postulates, suggesting that it is not one species but entire communities of microbes that are responsible for many cancers. The process by which a person accumulates microbes responsible for disease is known as “successive infection.” In successive infection, an infectious cascade of pathogens progressively slow the immune response and allow for subsequent infections to proliferate,​ resulting in dysbiosis (microbial imbalances). According to this model, a single microbe may not need to be present in all cases of disease in order to be implicated in it.
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 During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha),​ and chemokines that attract more phagocytes and other cells of the immune system to the site of infection to amplify the inflammatory response. These cells respond through physiological processes mediated by the cellular enzymes NADPH oxidase, superoxide dismutase (SOD), myeloperoxidase,​ and nitric oxide synthase (NOS). ​ During a normal response to infection, inflammation is created as a means for the host to combat invading pathogens. Inflammation is first initiated by the recruitment of phagocytes to the site of infection. The phagocytes recruited to the site of infection also secrete proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha),​ and chemokines that attract more phagocytes and other cells of the immune system to the site of infection to amplify the inflammatory response. These cells respond through physiological processes mediated by the cellular enzymes NADPH oxidase, superoxide dismutase (SOD), myeloperoxidase,​ and nitric oxide synthase (NOS). ​
  
-The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite,​ may damage DNA, proteins, and cell membranes and indirectly induce cell repair. Areas of tissue injury and inflammation trigger regenerative cell division from tissue and marrow-derived stem cells. Increased cell division may lead to point mutations, deletions, or translocations as damaged DNA escapes the repair system; the aberrant DNA is then propagated by subsequent cell division. This can result in disordered cell differentiation and, ultimately, oncogenesis. Hence, chronic inflammation,​ caused by microbes, instigates a cycle of cell damage, repair, and compensatory proliferation that promotes the development of cancer cells.(({{pubmed>​long:​21088404}}))+The result is the release of reactive oxygen and nitrogen oxide species (ROS and RNOS) to kill potential pathogens. The free radicals and secondary products derived from them, such as secondary amines, HNO2, N2O3, and peroxynitrite,​ may damage DNA, proteins, and cell membranes and indirectly induce cell repair. Areas of tissue injury and inflammation trigger regenerative cell division from tissue and marrow-derived stem cells. Increased cell division may lead to point mutations, deletions, or translocations as damaged DNA escapes the repair system; the aberrant DNA is then propagated by subsequent cell division. This can result in disordered cell differentiation and, ultimately, oncogenesis. Hence, chronic inflammation,​ caused by microbes, instigates a cycle of cell damage, repair, and compensatory proliferation that promotes the development of cancer cells
 + 
 +<​blockquote>​ 
 +Advanced stage follicular lymphoma (FL) is incurable by conventional therapies...... ​ until  intranodal injections of low-dose rituximab (5 mg), immature autologous dendritic cells, and granulocyte-macrophage colony-stimulating factor at the same lymphoma node.(({{pubmed>​long:​25293773}}))</​blockquote>​
  
  
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 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​ According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​
  
-Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells."​ (({{pubmed>​long:​28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells" (({{pubmed>​long:​27115170}}))  ​+Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells."​ (({{pubmed>​long:​28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells"(({{pubmed>​long:​27115170}}))  ​
  
 For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //​Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>​long:​16566840}})) ​ For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //​Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>​long:​16566840}})) ​
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 {{section>:​home:​alternate:​genetic_predisposition#​cancer&​noheader&​firstseconly}} {{section>:​home:​alternate:​genetic_predisposition#​cancer&​noheader&​firstseconly}}
 +
 + <​blockquote>​These findings suggest that pro-tumorigenic entotic engulfment activity is associated with mutant p53 expression, and the two combined are a key factor in genomic instability (({{pubmed>​long:​30076358}}))</​blockquote> ​
 +
 +
 +
 +
 +
 +
 +
  
  
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-=====Marshall Protocol as a treatment for cancer?​=====+===== Marshall Protocol as a treatment for cancer? =====
  
 The MP uses olmesartan to activate the VDR, a nuclear receptor which is downregulated in cancer. While the MP appears to be a sensible preventive, it is not suitable for treating active metastasis. The MP uses olmesartan to activate the VDR, a nuclear receptor which is downregulated in cancer. While the MP appears to be a sensible preventive, it is not suitable for treating active metastasis.
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 </​blockquote>​ </​blockquote>​
  
 +
 +==== Research ====
 +
 +This result provides a new idea on the anti-tumor mechanism of olmesartan, which may be used as a novel therapeutic target of cervical cancer. ​ (({{pubmed>​long:​28304186}}))
 ====Safety of olmesartan==== ====Safety of olmesartan====
 <​mainarticle>​ [[home:​protocol:​olmesartan:​safety|Safety of olmesartan (Benicar)]] </​article>​ <​mainarticle>​ [[home:​protocol:​olmesartan:​safety|Safety of olmesartan (Benicar)]] </​article>​
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 Note also that the primary ARBs being evaluated, candesartan and telmisartan,​ have significantly different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists. Note also that the primary ARBs being evaluated, candesartan and telmisartan,​ have significantly different actions than olmesartan. According to the //in silico// emulations of Dr. Marshall, they are VDR antagonists.
 +
 +==== Risk ====
 +
 +<​blockquote>​analyses found no evidence that cancer risk increased with increasing duration of ARB exposure (RR increase per year=0.99)
 +
 +CONCLUSION: ​ In this large nationwide cohort, use of ARBs was not significantly associated with increased risk of incident cancer overall or of lung cancer. ​ (({{pubmed>​long:​21482967}}))</​blockquote>​
 +
 +
 +    ​
 +
  
 =====Other treatments===== =====Other treatments=====
  
-====Vitamin D======== 
-<​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​ 
  
-{{section>​:home:​pathogenesis:​vitamind:​cancer#​vitamin_D_and_cancer&​noheader&​firstseconly}}+[[http://​cancerres.aacrjournals.org/​content/​69/​6/​2260.short|Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases]]
  
 ====Chemotherapy and radiation==== ====Chemotherapy and radiation====
  
-Chemotherapy is aggressively immunosuppressive,​ and will allow a patient'​s bacterial load to return, by shutting down your immune system. For example, hepatitis infections(({{pubmed>​long:​21472116}})) ​as is pneumocystis pneumonia have been known to become reactivated during chemotherapy.(({{pubmed>​long:​17458875}})) ​+Chemotherapy is aggressively immunosuppressive,​ and will allow a patient'​s bacterial load to return, by shutting down your immune system. For example, hepatitis infections(({{pubmed>​long:​21472116}})); also pneumocystis pneumonia have been known to become reactivated during chemotherapy.(({{pubmed>​long:​17458875}})) ​ 
 +==== Treatment for acute active Cancers====
  
  
 +[[https://​www.nature.com/​articles/​nrc3298|Evolutionary dynamics of carcinogenesis and why targeted therapy does not work]]
  
 +[[http://​cancerres.aacrjournals.org/​content/​69/​11/​4894.short|Adaptive Therapy]]
  
 +==== Toll-like receptor 9 (TLR9) agonists ====
 +
 +The activity and safety of these novel anticancer agents are being explored in a wide range of tumor types as part of a variety of therapeutic strategies with the goal of harnessing the immune response to fight cancer. ​ (({{pubmed>​long:​18176597}})) ​
 +
 +Activation of Toll-Like Receptor 9 by DNA from Different Bacterial Species ​  ​(({{pubmed>​long:​16428738}})) ​
 ====Vaccines==== ====Vaccines====
  
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 //**Gene**, MarshallProtocol.com//</​blockquote> ​ //**Gene**, MarshallProtocol.com//</​blockquote> ​
 +==== Vitamin D====
 +<​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​
 +
 +{{section>:​home:​pathogenesis:​vitamind:​cancer#​vitamin_D_and_cancer&​noheader&​firstseconly}}
 +
 +
 +=== Vitamin E ===
 +
 +
 +Vitamin E supplementation and the risk of heart failure in women.
 +(({{pubmed>​long: ​   22438520}}))
 +
 +Supplementation with vitamin E did not result in any significant improvements in prognostic or functional indexes of heart failure or in the quality of life of patients with advanced heart failure.(({{pubmed>​long: ​   11157316}}))
 +
 +Canolol was found to counteract the fibrotic effects of vitamin E + CoQ10 on cardiac fibrosis in the context of a high-fat diet enriched with RSO. This effect occurred through a restoration of cardiac Ag2R-1b mRNA expression and decreased ischemia.(({{pubmed>​long: ​   29456586}}))
 +
 +
  
  
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 //​**Debra**,​ MarshallProtocol.com//​ //​**Debra**,​ MarshallProtocol.com//​
 </​blockquote>​ </​blockquote>​
- 
- 
  
  
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 </​blockquote>​ </​blockquote>​
  
-<​blockquote>​ I found breast cancer in 1990, had a lumpectomy and follow up mastectomy with lymph node removal, as the cancer had begun to spread there. Similarly spreading, but in different organs, killed my mother at a slightly later stage of life. She had not sought treatment until too late. I have no doubt that prompt surgery and follow up radiotherapy and tamoxifen saved my life.  At that period there were no alternatives or understanding of the microbiome.+<​blockquote>​__Proliferating breast cancer__  
 +I found breast cancer in 1990, had a lumpectomy and follow up mastectomy with lymph node removal, as the cancer had begun to spread there. Similarly spreading, but in different organs, killed my mother at a slightly later stage of life. She had not sought treatment until too late. I have no doubt that prompt surgery and follow up radiotherapy and tamoxifen saved my life.  At that period there were no alternatives or understanding of the microbiome.
  
 Interestingly,​ I also developed a pre-cancerous site on my skin.  This was removed in day surgery. ​ Something appeared years later, about the size of a 5 cent piece close to the scar of the first. I was not alarmed, but watched it for any sign of change and reported to my doctor who was prescribing my Olmesartan according to the Marshall Protocol. She duly sent me to the skin specialist, who adopted a wait and see approach. (//There would have been complications in skin surgery on that arm because of the lymphoedema developed due to air travel after the lymph node removal//). After a couple of visits he took fine detail pictures of the changing blemish. One of these days I would like to go back and ask for these pictures, as a year later, the cancer had completely gone.  ​ Interestingly,​ I also developed a pre-cancerous site on my skin.  This was removed in day surgery. ​ Something appeared years later, about the size of a 5 cent piece close to the scar of the first. I was not alarmed, but watched it for any sign of change and reported to my doctor who was prescribing my Olmesartan according to the Marshall Protocol. She duly sent me to the skin specialist, who adopted a wait and see approach. (//There would have been complications in skin surgery on that arm because of the lymphoedema developed due to air travel after the lymph node removal//). After a couple of visits he took fine detail pictures of the changing blemish. One of these days I would like to go back and ask for these pictures, as a year later, the cancer had completely gone.  ​
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 </​blockquote>​ </​blockquote>​
  
 +
 +===== Recent research =====
 +
 +Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. ​ (({{pubmed>​long:​30104241}})) ​
 +
 +{{section>:​home:​pathogenesis:​innate_immunity#​recent_research_into_valuable_proteins&​noheader}}
 + 
 +Discovery of novel nonsteroidal VDR agonists with novel diarylmethane skeleton for the treatment of breast cancer. (({{pubmed>​long:​30579121}})) ​
 +
 +Olmesartan and Bay11-7082 inhibit the MCF-7 cells growth indicating RAS and NF-kappaB pathway blockade lead to cytotoxicity and apoptosis induction against tumour cells. So ARBs and NF-kappaB pathway inhibitors could be considered as anticancer drugs in future. ​ (({{pubmed>​long:​26138656}}))
 +
 +In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required. ​ (({{pubmed>​long:​29105106}}))
 +
 +miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. ​ (({{pubmed>​long: ​   28304186}}))
 +
 +Therapeutic potentials of SCFA receptors [section 7 in   ​(({{pubmed>​long:​27113407}})) ]
 +Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis,​ central nervous system and cardiovascular health.
 +
 +
 +
 +Vitamin D and immune cells stimulate bone marrow disease (({{pubmed>​long:​30718230}})) ​
  
 =====Read more===== =====Read more=====
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   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
-  * [[http://​www.foodsmatter.com/​es/​health_risks/​articles/​goldsworthy-biological-effects-04-12.pdf|biological effects]]+  ​* [[https://​www.amjmed.com/​article/​S0002-9343(15)00509-4/​pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]] 
 +  ​* [[http://​www.foodsmatter.com/​es/​health_risks/​articles/​goldsworthy-biological-effects-04-12.pdf|biological effects ​of non-ionising electromagnetic fields]]
   * [[http://​bioinitiative.org/​report/​wp-content/​uploads/​pdfs/​sec01_2012_summary_for_public.pdf|Bioinitiative Report]]   * [[http://​bioinitiative.org/​report/​wp-content/​uploads/​pdfs/​sec01_2012_summary_for_public.pdf|Bioinitiative Report]]
  
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 +
 +  (({{pubmed>​long:​000}})) ​
 +
 +  (({{pubmed>​long:​000}})) ​
 New Evidence Links Virus to Brain Cancer - http://​www.med.wisc.edu/​news-events/​news/​new-evidence-links-virus-to-brain-cancer/​32922 New Evidence Links Virus to Brain Cancer - http://​www.med.wisc.edu/​news-events/​news/​new-evidence-links-virus-to-brain-cancer/​32922
  
home/diseases/cancer.1528776849.txt.gz · Last modified: 06.12.2018 by sallieq
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