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home:diseases:cancer [06.12.2018]
sallieq [Microbial interaction and disease]
home:diseases:cancer [09.06.2018] (current)
sallieq [Are There Concerns About Over-supplementing with Vitamin D?]
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   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>​long:​20720256}})) ​   * **cancer mortality** – A 2010 longitudinal study found that both high and low concentrations of plasma 25(OH)D were associated with elevated risks of overall and cancer mortality, and low concentrations are associated with cardiovascular mortality.(({{pubmed>​long:​20720256}})) ​
  
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 +==== Are There Concerns About Over-supplementing with Vitamin D? ==== 
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 +There is a common misconception that vitamin D supplementation is safe at any reasonable level, or that if some is good, more may be better. 
 + 
 +  * It is clear that vitamin D intakes and serum 25(OH)D must be very high—perhaps 200-400 ng/mL—to cause the classic toxicity of marked hypercalcemia and kidney and liver damage. 
 +  *  
 +  * However, emerging observational data suggest that adverse outcomes may occur at much lower levels, such as in the 50-75 ng/mL range. These suspected adverse outcomes appear to include increases in all-cause mortality and increases in the rate of heart disease and some cancers.  
 + 
 + 
 ====1,​25-dihydroxyvitamin D ==== ====1,​25-dihydroxyvitamin D ====
  
 Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>​long:​8989244}})) As the level of 1,25-D falls, the level of the innate immune system'​s ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis. Mawer //et al.// reported that 1,25-D is such a sensitive indicator of the immune response that it can even be used to determine prognosis in breast cancer with bone metastasis.(({{pubmed>​long:​8989244}})) As the level of 1,25-D falls, the level of the innate immune system'​s ability to mount an immune response also falls, and the prognosis becomes less favorable. This seems to indicate that it might be possible to use the level of 1,25-D as one means of suggesting whether or not breast cancer treatment is effective if doctors know how to interpet the results. But, one should note that the patients in the above study had bone metastasis.
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 ===== Single species vs. communities of microbes ===== ===== Single species vs. communities of microbes =====
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 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​ According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​
  
-Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells."​ (({{pubmed>​long:​28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells" (({{pubmed>​long:​27115170}}))  ​+Natural killer cells "are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells."​ (({{pubmed>​long:​28236750}})) and  "are able to recognize and trigger cell death in tumors by detecting receptor expression abnormalities in transformed cells"(({{pubmed>​long:​27115170}}))  ​
  
 For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //​Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>​long:​16566840}})) ​ For example, //H. pylori// can cause gastric cancer or MALT lymphoma in some individuals. In contrast, exposure to //H. pylori// appears to reduce the risk of esophageal cancer in others. //​Salmonella typhi// infection has been associated with the development of gallbladder cancer; however //S. typhi// has been associated with positive outcomes for melanoma, colon and bladder cancers.(({{pubmed>​long:​16566840}})) ​
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   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
 +  * [[https://​www.amjmed.com/​article/​S0002-9343(15)00509-4/​pdf|Questions About Vitamin D for Primary Care Practice: Input From an NIH Conference]]
   * [[http://​www.foodsmatter.com/​es/​health_risks/​articles/​goldsworthy-biological-effects-04-12.pdf|biological effects]]   * [[http://​www.foodsmatter.com/​es/​health_risks/​articles/​goldsworthy-biological-effects-04-12.pdf|biological effects]]
   * [[http://​bioinitiative.org/​report/​wp-content/​uploads/​pdfs/​sec01_2012_summary_for_public.pdf|Bioinitiative Report]]   * [[http://​bioinitiative.org/​report/​wp-content/​uploads/​pdfs/​sec01_2012_summary_for_public.pdf|Bioinitiative Report]]
home/diseases/cancer.1528776849.txt.gz · Last modified: 06.12.2018 by sallieq
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