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home:diseases:cancer [04.07.2019]
sallieq [Read more]
home:diseases:cancer [07.11.2019] (current)
sallieq [Recent research]
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 ======Cancer====== ======Cancer======
  
-According to a 2006 estimate, 18% of the global cancer burden is attributable to infectious agents, but almost every indication is that this figure is far too conservative.(({{pubmed>​long:​20930075}})) Researchers confined by the logic of Koch's postulates have looked for a single microbe causing a single disease. Evidence ​is accumulating, however, that it is communities of microbes that are responsible for cancer. According to the Marshall Pathogenesis,​ chronic microbes persist, in large part, by dysregulating the Vitamin D Receptor (VDR), a key nuclear receptor with a well-characterized role in both the innate immune response and metastasis suppression. Indeed one of the hallmarks of cancer is a disruption in the vitamin D endocrine system including high 1,25-D and slowed activity of the receptor. As they progressively multiply through a process known as successive infection, microbes elicit an inflammatory response, a response which has been shown to increase over time the risk of metastasis. ​+According to a 2006 estimate, 18% of the global cancer burden is attributable to infectious agents, but almost every indication is that this figure is far too conservative.(({{pubmed>​long:​20930075}})) Researchers confined by the logic of Koch's postulates have looked for a single microbe causing a single disease. Evidence ​suggests, however, that it is communities of microbes that are responsible for cancer. According to the Marshall Pathogenesis,​ chronic microbes persist, in large part, by dysregulating the Vitamin D Receptor (VDR), a key nuclear receptor with a well-characterized role in both the innate immune response and metastasis suppression. Indeed one of the hallmarks of cancer is a disruption in the vitamin D endocrine system including high 1,25-D and slowed activity of the receptor. As they progressively multiply through a process known as successive infection, microbes elicit an inflammatory response, a response which has been shown to increase over time the risk of metastasis. ​
  
 Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure. Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure.
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   * **liver cancer** – It is "well established"​ that chronic infections with hepatitis B and C viruses (HBV, HCV) represent major risk factors for HCC.(({{pubmed>​long:​10710202}}))   * **liver cancer** – It is "well established"​ that chronic infections with hepatitis B and C viruses (HBV, HCV) represent major risk factors for HCC.(({{pubmed>​long:​10710202}}))
   * **lung cancer** – According to a 2011 meta-analysis,​ patients exposed to //C. pneumoniae//​ infection had a 48% greater risk for lung cancer risk, relative to those not exposed.(({{pubmed>​long:​21194924}}))   * **lung cancer** – According to a 2011 meta-analysis,​ patients exposed to //C. pneumoniae//​ infection had a 48% greater risk for lung cancer risk, relative to those not exposed.(({{pubmed>​long:​21194924}}))
-  * **prostate cancer** – In a 2005 culture-based study, Cohen found that //​Propionibacterium acnes// in 35% of prostate samples of 34 consecutive patients tested.(({{pubmed>​long:​15879794}})) ​+  * **prostate cancer** – In a 2005 culture-based study, Cohen found that //​Propionibacterium acnes// in 35% of prostate samples of 34 consecutive patients tested.(({{pubmed>​long:​15879794}})) 
 +  * **Table of cancers** with associated agents. [[https://​bmccancer.biomedcentral.com/​track/​pdf/​10.1186/​s12885-017-3234-4|Infections and Cancer]]
  
  
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 Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis. (({{pubmed>​long:​30718230}})) ​ Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis. (({{pubmed>​long:​30718230}})) ​
 +
 +2014  a Cochrane meta-analysis that included 18 randomized clinical trials comparing vitamin D administration versus no intervention in healthy population found no difference regarding cancer incidence. ​ In randomised controlled trials, relative risks for all cause mortality were 0.89 (0.80 to 0.99) for vitamin D3 supplementation and 1.04 (0.97 to 1.11) for vitamin D2 supplementation. The effects observed for vitamin D3 supplementation remained unchanged when grouped by various characteristics. However, for vitamin D2 supplementation,​ increased risks of mortality were observed in studies with lower intervention doses and shorter average intervention periods. ​ (({{pubmed>​long: ​   24690623}}))
  
 ====1,​25-dihydroxyvitamin D ==== ====1,​25-dihydroxyvitamin D ====
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-Women with hereditary ​breast ​cancer predispositions should ​avoid using their smartphones,​ tablets, and laptops at night.   ​(({{pubmed>​long: ​   29456806}}))+Women with hereditary cancer predispositions should ​put their smartphones,​ tablets, and laptops ​into air-plane mode at all times when not in use.   ​(({{pubmed>​long: ​   29456806}}))
  
 Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma. ​  ​(({{pubmed>​long: ​   24193082}})) ​ Glioblastomas and malignant gliomas are the most common primary malignant brain tumors, with an annual incidence of 5.26 per 100,000 population. These tumors are typically associated with a dismal prognosis and poor quality of life. Only radiation exposure and certain genetic syndromes are well-defined risk factors for malignant glioma. ​  ​(({{pubmed>​long: ​   24193082}})) ​
 +
 +This compound has antiproliferative and antimigratory effects in squamous cell carcinoma, glioblastoma,​ and breast cancer cell lines (({{pubmed>​long: ​   31025400}}))
  
 Several researchers have highlighted a possible link between glioma and human cytomegalovirus (HCMV). ​ (({{pubmed>​long:​30888562}})) ​ Several researchers have highlighted a possible link between glioma and human cytomegalovirus (HCMV). ​ (({{pubmed>​long:​30888562}})) ​
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 +===== Microbial involvement =====
  
  
-===== Single species vs. communities of microbes ​=====+==== Single species vs. communities of microbes ====
  
 Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}})) Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}}))
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-===== Slow-growing microbes elicit inflammation ​=====+==== Slow-growing microbes elicit inflammation ====
  
 <​blockquote>​In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //​Helicobacter pylori// (gastric adenocarcinoma) and //​Salmonella enterica serovar Typhimurium//​ or //​Paratyphi//​ (biliary cancer). <​blockquote>​In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //​Helicobacter pylori// (gastric adenocarcinoma) and //​Salmonella enterica serovar Typhimurium//​ or //​Paratyphi//​ (biliary cancer).
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-===== Inflammation induces cancer ​=====+==== Inflammation induces cancer ====
  
 According to Chang,​(({{pubmed>​long:​20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow'​s discoveries,​ the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation,​ innate immunity and cancer is widely accepted.(({{pubmed>​long:​21088404}})) ​ According to Chang,​(({{pubmed>​long:​20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow'​s discoveries,​ the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation,​ innate immunity and cancer is widely accepted.(({{pubmed>​long:​21088404}})) ​
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-===== Microbial interaction and disease ​=====+==== Microbial interaction and disease ====
  
 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​ According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​
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-===== Metastatic communities parallel biofilm ​=====+==== Metastatic communities parallel biofilm ====
  
 Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm. Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm.
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- +==== Tobacco ====
-====Tobacco====+
 {{section>:​home:​special:​smoking#​smoking_tobacco&​noheader&​firstseconly}} {{section>:​home:​special:​smoking#​smoking_tobacco&​noheader&​firstseconly}}
 +
 +
 +==== Stress derived from interaction of particular personalities ====
 +
 +in particular [[https://​duckduckgo.com/?​q=energy+vampires&​t=ffnt&​atb=v117-1&​ia=about|the empathic personality and the '​energy vampire'​]]
 +
 +from https://​mpkb.org/​home/​social/​talking#​dealing_with_antagonism
 +
 +<​blockquote>​Sadly,​ some people in your life may not want you to get well. For example, sometimes a partner or close friend can not tolerate change. Consciously or unconsciously they may undermine your efforts. It will be up to you to quietly persist, knowing that your recovery can only lead to a better outcome for both of you.
 +
 +In an extreme case, there may be someone who is literally toxic, even socio-pathic. “Learn to value yourself, Learn to say No!” and if necessary, Remove yourself from the influence of any such person.</​blockquote> ​
  
  
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 //**Gene**, MarshallProtocol.com//</​blockquote> ​ //**Gene**, MarshallProtocol.com//</​blockquote> ​
-====Vitamin D========+==== Vitamins ​==== 
 + 
 +=== Vitamin D === 
 <​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​ <​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​
  
 {{section>:​home:​pathogenesis:​vitamind:​cancer#​vitamin_D_and_cancer&​noheader&​firstseconly}} {{section>:​home:​pathogenesis:​vitamind:​cancer#​vitamin_D_and_cancer&​noheader&​firstseconly}}
  
 +
 +=== Vitamin E ===
  
  
 +Vitamin E supplementation and the risk of heart failure in women.
 +(({{pubmed>​long: ​   22438520}}))
  
 +Supplementation with vitamin E did not result in any significant improvements in prognostic or functional indexes of heart failure or in the quality of life of patients with advanced heart failure.(({{pubmed>​long: ​   11157316}}))
  
 +Canolol was found to counteract the fibrotic effects of vitamin E + CoQ10 on cardiac fibrosis in the context of a high-fat diet enriched with RSO. This effect occurred through a restoration of cardiac Ag2R-1b mRNA expression and decreased ischemia.(({{pubmed>​long: ​   29456586}}))
  
  
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 ===== Recent research ===== ===== Recent research =====
- 
  
 Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. ​ (({{pubmed>​long:​30104241}})) ​ Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. ​ (({{pubmed>​long:​30104241}})) ​
- 
  
 {{section>:​home:​pathogenesis:​innate_immunity#​recent_research_into_valuable_proteins&​noheader}} {{section>:​home:​pathogenesis:​innate_immunity#​recent_research_into_valuable_proteins&​noheader}}
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 In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required. ​ (({{pubmed>​long:​29105106}})) In this large population-based gastro-oesophageal cancer cohort, we found moderately reduced cancer-specific mortality among ARB users. However, confirmation in further independent epidemiological studies with sufficient staging information is required. ​ (({{pubmed>​long:​29105106}}))
  
-miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. ​ (({{pubmed>​long: ​   28304186}}))+miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. ​ (({{pubmed>​long:​28304186}}))
  
 Therapeutic potentials of SCFA receptors [section 7 in   ​(({{pubmed>​long:​27113407}})) ] Therapeutic potentials of SCFA receptors [section 7 in   ​(({{pubmed>​long:​27113407}})) ]
 Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis,​ central nervous system and cardiovascular health. Recent progress in understanding the role of GPR41, GPR43 and GPR109A in health and disease demonstrate that these receptors do not just regulate inflammation and cancer in intestine, but also influence other gastrointestinal functions, allergies, adipogenesis,​ central nervous system and cardiovascular health.
  
 + ​review current evidence on the role of the human microbiota in four cancer types (colorectal cancer, head and neck cancer, pancreatic cancer, and lung cancer) proposed as affected by both the oral and gut microbiota (({{pubmed>​long:​28822617}}))
 +
 + ​results suggest that the six lactic acid bacteria mixture from kefir has strong effects on natural immunity and tumor cell cytotoxicity(({{pubmed>​long:​29584690}}))
 +
 + Using metabolomics,​ we investigated the metabolic influence that microbial biofilms have on colon tissues and the related occurrence of cancer.(({{pubmed>​long:​25959674}}))
  
  
 Vitamin D and immune cells stimulate bone marrow disease (({{pubmed>​long:​30718230}})) ​ Vitamin D and immune cells stimulate bone marrow disease (({{pubmed>​long:​30718230}})) ​
 +
 + a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. ​ (({{pubmed>​long:​29444771}}))
 +
 +In this large prospective study, (101 257 participants aged 18 and over, mean age 42.2, SD 14.4; median follow-up time 5.1 years) ​ the consumption of sugary drinks was positively associated with the risk of overall cancer and breast cancer. 100% fruit juices were also positively associated with the risk of overall cancer. These results need replication in other large scale prospective studies. They suggest that sugary drinks, which are widely consumed in Western countries, might represent a modifiable risk factor for cancer prevention. [[https://​www.bmj.com/​content/​366/​bmj.l2408|BMJ 2019;​366:​l2408]]
 +
 +
  
 =====Read more===== =====Read more=====
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   * [[http://​www.youtube.com/​watch?​v=s-uCeh7BGBY|Inflammation,​ metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens. ​   * [[http://​www.youtube.com/​watch?​v=s-uCeh7BGBY|Inflammation,​ metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens. ​
   * [[http://​www.oatext.com/​pdf/​ICST-4-231.pdf|2017 review of RAS system observations suggesting cancer stem cells may be a novel therapeutic target]]   * [[http://​www.oatext.com/​pdf/​ICST-4-231.pdf|2017 review of RAS system observations suggesting cancer stem cells may be a novel therapeutic target]]
 +  *  Bicarbonate of soda may even contribute to cancer prevention.(({{pubmed>​long:​28083722}}))
   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
home/diseases/cancer.1554603677.txt.gz · Last modified: 04.07.2019 by sallieq
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