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home:diseases:cancer [06.12.2019]
sallieq [Recent research]
home:diseases:cancer [08.03.2019] (current)
sallieq [Evidence of infectious cause]
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 ======Cancer====== ======Cancer======
  
-According to a 2006 estimate, 18% of the global cancer burden is attributable to infectious agents, but almost every indication is that this figure is far too conservative.(({{pubmed>​long:​20930075}})) Researchers confined by the logic of Koch's postulates have looked for a single microbe causing a single disease. Evidence ​is accumulating, however, that it is communities of microbes that are responsible for cancer. According to the Marshall Pathogenesis,​ chronic microbes persist, in large part, by dysregulating the Vitamin D Receptor (VDR), a key nuclear receptor with a well-characterized role in both the innate immune response and metastasis suppression. Indeed one of the hallmarks of cancer is a disruption in the vitamin D endocrine system including high 1,25-D and slowed activity of the receptor. As they progressively multiply through a process known as successive infection, microbes elicit an inflammatory response, a response which has been shown to increase over time the risk of metastasis. ​+According to a 2006 estimate, 18% of the global cancer burden is attributable to infectious agents, but almost every indication is that this figure is far too conservative.(({{pubmed>​long:​20930075}})) Researchers confined by the logic of Koch's postulates have looked for a single microbe causing a single disease. Evidence ​suggests, however, that it is communities of microbes that are responsible for cancer. According to the Marshall Pathogenesis,​ chronic microbes persist, in large part, by dysregulating the Vitamin D Receptor (VDR), a key nuclear receptor with a well-characterized role in both the innate immune response and metastasis suppression. Indeed one of the hallmarks of cancer is a disruption in the vitamin D endocrine system including high 1,25-D and slowed activity of the receptor. As they progressively multiply through a process known as successive infection, microbes elicit an inflammatory response, a response which has been shown to increase over time the risk of metastasis. ​
  
 Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure. Several patients have worked with their doctors to treat their cancer with the Marshall Protocol. However, the MP appears to be most effective as a preventative measure.
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 =====Evidence of infectious cause===== =====Evidence of infectious cause=====
  
-According to D.L. Mager, “An overwhelming body of evidence has determined that relationships among certain bacteria and cancers exist.”(({{pubmed>​long:​14594792}})) ​ The growing number of examples of microbes associated with cancers include:+According to D.L. Mager, “An overwhelming body of evidence has determined that relationships among certain bacteria and cancers exist.”(({{pubmed>​long:​14594792}}))  ​ 
 + 
 +[[https://​bmccancer.biomedcentral.com/​track/​pdf/​10.1186/​s12885-017-3234-4|Infections and cancer: the “fifty shades of immunity” hypothesis]] ​  
 + 
 +The growing number of examples of microbes associated with cancers include:
  
   * **breast cancer** – Underscoring how cancer is a systemic disease, a 2006 study found that the gut bacteria //​Helicobacter hepaticus// induces mammary adenocarcinoma in mice.(({{pubmed>​long:​16885333}}))   * **breast cancer** – Underscoring how cancer is a systemic disease, a 2006 study found that the gut bacteria //​Helicobacter hepaticus// induces mammary adenocarcinoma in mice.(({{pubmed>​long:​16885333}}))
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 +===== Microbial involvement =====
  
  
-===== Single species vs. communities of microbes ​=====+==== Single species vs. communities of microbes ====
  
 Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}})) Alicia H. Chang and Julie Parsonnet of Stanford University writes that a transmissible cause of cancer was suspected as early as the 16th century. It was not until the late 20th century definitively identified a bacterial cause of at least some types of cancer to most researchers'​ satisfaction.(({{pubmed>​long:​20930075}})) Identifying the full range of microbes which cause cancer, however, has been more challenging. To date, there have been a handful of cases that fulfill Koch's postulates (e.g., //H. pylori// and gastric cancer) where a single microbe is known to cause a single type of cancer. Consistent with Koch, researchers have tended to work in this vein, for example, looking at the 500+ species that inhabit the colon in the hopes of pinpointing the one and only bacterial species responsible for colorectal cancer.(({{pubmed>​long:​20930075}}))
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-===== Slow-growing microbes elicit inflammation ​=====+==== Slow-growing microbes elicit inflammation ====
  
 <​blockquote>​In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //​Helicobacter pylori// (gastric adenocarcinoma) and //​Salmonella enterica serovar Typhimurium//​ or //​Paratyphi//​ (biliary cancer). <​blockquote>​In almost all examples of bacterial inflammation and human cancer, the implicated bacteria reside in the host for many years and create an environment of persistent inflammation. Specific bacteria that have been shown to cause chronic inflammation and an increased risk of cancer include //​Helicobacter pylori// (gastric adenocarcinoma) and //​Salmonella enterica serovar Typhimurium//​ or //​Paratyphi//​ (biliary cancer).
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-===== Inflammation induces cancer ​=====+==== Inflammation induces cancer ====
  
 According to Chang,​(({{pubmed>​long:​20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow'​s discoveries,​ the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation,​ innate immunity and cancer is widely accepted.(({{pubmed>​long:​21088404}})) ​ According to Chang,​(({{pubmed>​long:​20930075}})) Virchow first described the irritation hypothesis of carcinogenesis in the 19th century concluding that chronic irritation stimulated the cancer cells to grow. The inflammatory process is characterized by damage caused by the host's immune response to the infection rather than by the infecting organism itself. Over 100 years since Virchow'​s discoveries,​ the “chronic irritation hypothesis” remains a widely supported mechanism for carcinogenesis by infectious agents. Today the relationship between inflammation,​ innate immunity and cancer is widely accepted.(({{pubmed>​long:​21088404}})) ​
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-===== Microbial interaction and disease ​=====+==== Microbial interaction and disease ====
  
 According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​ According to some sporadic reports, cancer regresses following spontaneous bacterial infection.(({{pubmed>​long:​15663328}})) Competition between an ever-changing mix of microbes, and the variable attention the immune system pays to any one component of that mix, may explain the waxing and waning of different cancerous states. ​
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-===== Metastatic communities parallel biofilm ​=====+==== Metastatic communities parallel biofilm ====
  
 Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm. Some have suggested provocatively that communities of metastatic cancerous cells closely resemble communities of microbes known as biofilm.
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- +==== Tobacco ====
-====Tobacco====+
 {{section>:​home:​special:​smoking#​smoking_tobacco&​noheader&​firstseconly}} {{section>:​home:​special:​smoking#​smoking_tobacco&​noheader&​firstseconly}}
 +
 +
 +==== Stress derived from interaction of particular personalities ====
 +
 +in particular [[https://​duckduckgo.com/?​q=energy+vampires&​t=ffnt&​atb=v117-1&​ia=about|the empathic personality and the '​energy vampire'​]]
 +
 +from https://​mpkb.org/​home/​social/​talking#​dealing_with_antagonism
 +
 +<​blockquote>​Sadly,​ some people in your life may not want you to get well. For example, sometimes a partner or close friend can not tolerate change. Consciously or unconsciously they may undermine your efforts. It will be up to you to quietly persist, knowing that your recovery can only lead to a better outcome for both of you.
 +
 +In an extreme case, there may be someone who is literally toxic, even socio-pathic. “Learn to value yourself, Learn to say No!” and if necessary, Remove yourself from the influence of any such person.</​blockquote> ​
  
  
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 //**Gene**, MarshallProtocol.com//</​blockquote> ​ //**Gene**, MarshallProtocol.com//</​blockquote> ​
-==== Vitamin D====+==== Vitamins ==== 
 + 
 +=== Vitamin D === 
 <​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​ <​mainarticle>​ [[home:​pathogenesis:​vitamind:​cancer|Vitamin D and cancer]] </​article>​
  
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 ===== Recent research ===== ===== Recent research =====
 +
 +Senescent cells contribute to both age-related degeneration and hyperplastic pathologies,​ including cancer. (({{pubmed>​long:​31138644}}))
 +
  
 Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. ​ (({{pubmed>​long:​30104241}})) ​ Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. ​ (({{pubmed>​long:​30104241}})) ​
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 Vitamin D and immune cells stimulate bone marrow disease (({{pubmed>​long:​30718230}})) ​ Vitamin D and immune cells stimulate bone marrow disease (({{pubmed>​long:​30718230}})) ​
 +
 + a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. ​ (({{pubmed>​long:​29444771}}))
 +
 +In this large prospective study, (101 257 participants aged 18 and over, mean age 42.2, SD 14.4; median follow-up time 5.1 years) ​ the consumption of sugary drinks was positively associated with the risk of overall cancer and breast cancer. 100% fruit juices were also positively associated with the risk of overall cancer. These results need replication in other large scale prospective studies. They suggest that sugary drinks, which are widely consumed in Western countries, might represent a modifiable risk factor for cancer prevention. [[https://​www.bmj.com/​content/​366/​bmj.l2408|BMJ 2019;​366:​l2408]]
 +
 +
  
 =====Read more===== =====Read more=====
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   * [[http://​www.youtube.com/​watch?​v=s-uCeh7BGBY|Inflammation,​ metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens. ​   * [[http://​www.youtube.com/​watch?​v=s-uCeh7BGBY|Inflammation,​ metabolism, aging and cancer: Dangerous Liaisons]] – Distinguished Prof. Michael Karin 2010 Harvey Prize Laureate delivered this lecture at the Technion Rappaport Faculty of Medicine on March 14, 2011. Prof. Karin received the Harvey prize in recognition of his pioneering research that has led to the deciphering of the molecular mechanisms by which mammalian cells respond to inflammatory cytokines, environmental stress and various pathogens. ​
   * [[http://​www.oatext.com/​pdf/​ICST-4-231.pdf|2017 review of RAS system observations suggesting cancer stem cells may be a novel therapeutic target]]   * [[http://​www.oatext.com/​pdf/​ICST-4-231.pdf|2017 review of RAS system observations suggesting cancer stem cells may be a novel therapeutic target]]
 +  * [[http://​cancerres.aacrjournals.org/​content/​79/​13_Supplement/​5282.short|2019 focusing on how senescence occurs in epithelial cells, the cells that line the surfaces of the organs and structures in the body and the type of cells in which most cancers arise]] ​
 +
 +  *  Bicarbonate of soda may even contribute to cancer prevention.(({{pubmed>​long:​28083722}}))
   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.   * [[http://​www.reuters.com/​article/​2012/​01/​07/​us-argentina-fernandez-idUSTRE8060CB20120107|Argentina'​s Fernandez sent home, never had cancer]] – Argentine President Cristina Fernandez never had cancer despite being diagnosed with the disease last month and having her thyroid gland removed.
   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]   * [[https://​en.wikipedia.org/​wiki/​List_of_unproven_and_disproven_cancer_treatments|Wiki list of unproven & disproven treatments]]
home/diseases/cancer.1560306638.txt.gz · Last modified: 06.12.2019 by sallieq
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