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home:diseases:cfs [06.12.2019] – [Recent research] sallieqhome:diseases:cfs [07.06.2019] – [Evidence of infectious cause] sallieq
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 The absence of clear laboratory markers affects not only how CFS is diagnosed, but whether or not it is viewed as fundamentally psychological illness, and how it is treated. The absence of clear laboratory markers affects not only how CFS is diagnosed, but whether or not it is viewed as fundamentally psychological illness, and how it is treated.
  
-==== Recent research ====+==== Research ==== 
 + 
 +There is considerable evidence that mitochondrial dysfunction is present in some CFS patients. (({{pubmed>long:19436827}}))
  
 This work contributes key elements to the development of ME/CFS diagnostics, a crucial step required for discovering a therapy for any disease of unknown origin.   (({{pubmed>long:30563204}}))   This work contributes key elements to the development of ME/CFS diagnostics, a crucial step required for discovering a therapy for any disease of unknown origin.   (({{pubmed>long:30563204}}))  
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 Altered composition of the gut microbiome    (({{pubmed>long:27338587}}))   Altered composition of the gut microbiome    (({{pubmed>long:27338587}}))  
  
-. A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain.(({{pubmed>long:29497420}}))+A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain.(({{pubmed>long:29497420}}))
  
  
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 Patients with CFS showed abnormalities in 20 metabolic pathways. (({{pubmed>long:    27573827}})) Patients with CFS showed abnormalities in 20 metabolic pathways. (({{pubmed>long:    27573827}}))
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 =====Symptoms===== =====Symptoms=====
  
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-Today scientific evidence provides a growing link between infectious agents and Chronic Fatigue Syndrome.+Today scientific evidence may provide a link between infectious agents and Chronic Fatigue Syndrome. 
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 +In October 2009, we reported the first direct isolation of infectious xenotropic murine leukemia virus-related virus (XMRV). In that study, we used a combination of biological amplification and molecular enhancement techniques to detect XMRV in more than 75% of 101 patients with chronic fatigue syndrome (CFS).(({{pubmed>long:21178474}})) 
 + 
 +[[http://sacfs.asn.au/download/XMRV%20-%20Supporting%20Online%20Material.pdf|Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome]]
  
 ===== Impairment of immune function ===== ===== Impairment of immune function =====
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 <mainarticle> [[home:patients:mp_duration|Length of the Marshall Protocol]]</article> <mainarticle> [[home:patients:mp_duration|Length of the Marshall Protocol]]</article>
  
-The length of time it takes an MP patient to return to a given level of functionality seems to vary somewhat by disease. Diseases like CFS and Lyme may take longer. This may be because patients with these diseases tend to be sicker than most.+The length of time it takes an MP patient to return to a given level of functionality seems to vary somewhat by disease. Diseases like CFS and Lyme are likely to take longer. This may be because patients with these diseases tend to be sicker than most.
  
  
home/diseases/cfs.txt · Last modified: 09.14.2022 by 127.0.0.1
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