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home:diseases:cystic_fibrosis [02.18.2019] – [Evidence of infectious cause] sallieqhome:diseases:cystic_fibrosis [02.18.2019] – [Evidence of infectious cause] sallieq
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 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
 +Pseudomonal infection in cystic fibrosis: the battle continues.(({{pubmed>long:15482158}}))
 +<blockquote>
 +Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis. Infection usually begins in childhood and is responsible for respiratory failure and death in most patients with cystic fibrosis. The organism triggers an exuberant chronic inflammatory reaction which damages the airways and leads to progressive loss of lung function. 
  
-Expert Rev Anti Infect Ther. 2003 Dec;1(4):609-18.Links +This review provides an overview of pseudomonal infection in cystic fibrosis, including mechanisms by which the bacteria may colonize the cystic fibrosis airway, persistence of pseudomonal infection and the biofilm mode of growth. Available treatments and possible novel approaches to therapy will be discussed.</blockquote>
-Pseudomonal infection in cystic fibrosisthe battle continues.+
  
-Elkin S, Geddes D. 
-Department of Cystic Fibrosis Royal Brompton Hospital London SW3 6NP, UK. sarah.elkin@st-marys.nhs.uk 
-Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis. Infection usually begins in childhood and is responsible for respiratory failure and death in most patients with cystic fibrosis. The organism triggers an exuberant chronic inflammatory reaction which damages the airways and leads to progressive loss of lung function. Over the last decade significant advances have been made in the understanding of the pathophysiology of cystic fibrosis airways disease. These should assist the development of new and better therapies to treat this pathogen. This review provides an overview of pseudomonal infection in cystic fibrosis, including mechanisms by which the bacteria may colonize the cystic fibrosis airway, persistence of pseudomonal infection and the biofilm mode of growth. Available treatments and possible novel approaches to therapy will be discussed. 
-(({{pubmed>long:15482158}})) 
  
-<blockquote>Bacterial colonization of the airways of the infant with cystic fibrosis is usually established early in life, and, once established, is difficult to eradicate and is associated with progressive lung disease.   (({{pubmed>long:1475540}}))</blockquote> +Evolution of airway microbiology in the infant with cystic fibrosis: role of nonpseudomonal and pseudomonal pathogens.(({{pubmed>long:1475540}})) 
 +<blockquote>Bacterial colonization of the airways of the infant with cystic fibrosis is usually established early in life, and, once established, is difficult to eradicate and is associated with progressive lung disease.   
 + 
 + Recent research on risk factors for early Pseudomonas aeruginosa colonization, including the potential role of respiratory viral infections, is discussed. We conclude with a discussion of the role of prophylactic antibiotic therapy. 
 +</blockquote> 
  
 ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa  (({{pubmed>long:    26206672}})) ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa  (({{pubmed>long:    26206672}}))
 +<blockquote>AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa.
 +
 +A ΔalgR strain produced lesser biofilm than did the wild-type strain, which is consistent with a phenotype controlled by c-di-GMP. 
 +</blockquote>
  
  
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 {{tag>diseases no_current_patients incomplete}} {{tag>diseases no_current_patients incomplete}}
  
-<note>Dear MPKB Reader: You have arrived at one of the articles that has not yet completed the development and review process in the knowledge base. Some of the content here may be helpful, but please know that this page is not complete. There are about 400 articles in the KB, and this is one we are still working on. Thanks for your patience.</note> 
  
 ===== Notes and comments ===== ===== Notes and comments =====
home/diseases/cystic_fibrosis.txt · Last modified: 09.14.2022 by 127.0.0.1
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