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home:diseases:depression [12.17.2018] – [Evidence of infectious cause] sallieqhome:diseases:depression [08.03.2019] – [Recent research] sallieq
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 +[[http://www.jneuropsychiatry.org/peer-review/depression-and-inflammation-disentangling-a-clear-yet-complex-and-multifaceted-link.html|depression and inflammation seem closely connected. Specifically that patients with inflammatory diseases are more likely to have MDD,  a large number of people with major depression show inflammatory biomarkers, and patients treated with cytokines are at increased risk of developing depression. Also inflammatory mediators have been found to alter glutamate and monoamine neurotransmission, glucocorticoid receptor resistance and hippocampal neurogenesis. Also, inflammation is able to alter brain signalling patterns, to affect cognition.]]
  
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 +The 'cytokine hypothesis of depression' implies that proinflammatory cytokines, acting as neuromodulators, represent the key factor in the (central) mediation of the behavioural, neuroendocrine and neurochemical features of depressive disorders. This view is supported by various findings. Several medical illnesses, which are characterised by chronic inflammatory responses, e.g. rheumatoid arthritis, have been reported to be accompanied by depression. (({{pubmed>long:    15694227}}))
  
  
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 <blockquote>- I also suffered from childhood depression, which continued to plague me much of my life - to an extent I only realized when I felt it lift upon starting the Marshall Protocol. My brain seems to work so much better and my life long biologic depression has lifted. //P.Bear, RN//</blockquote>  <blockquote>- I also suffered from childhood depression, which continued to plague me much of my life - to an extent I only realized when I felt it lift upon starting the Marshall Protocol. My brain seems to work so much better and my life long biologic depression has lifted. //P.Bear, RN//</blockquote> 
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 +<blockquote>I used to say my son got the mania while I got the depression. I only started the MP in the hope that he would be able to do so also. (//hospital staff discouraged him from doing so//)
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 + On MP my depression resolved long before CFS was reduced, but the most interesting experience was an actual day of manic symptoms I never had before... quite obviously the intensification of symptoms to be expected in the early years on the protocol.   //Sallie// </blockquote>
  
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home/diseases/depression.txt · Last modified: 09.14.2022 by 127.0.0.1
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