You are here: Welcome to the MPKB » Welcome to the MPKB » Diseases » Depression
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
home:diseases:depression [06.28.2019] – [Recent research] sallieqhome:diseases:depression [09.14.2022] (current) – external edit 127.0.0.1
Line 5: Line 5:
 Looking out for friends and loved ones is an important part of preventing suicide. You can call to speak with a crisis worker on behalf of someone you are concerned about. The crisis workers have access to local resources, and can help you identify ways to get help to your loved ones.  Looking out for friends and loved ones is an important part of preventing suicide. You can call to speak with a crisis worker on behalf of someone you are concerned about. The crisis workers have access to local resources, and can help you identify ways to get help to your loved ones. 
  
-To find out more about the difference you can make in a friend or loved one's life, visit [[http://www.suicidepreventionlifeline.org/GetHelp/WhatIfSomeoneIKnowNeedsHelp.aspx|What If Someone I Know Needs Help]].</note> +To find out more about the difference you can make in a friend or loved one's life, visit [[https://www.suicidepreventionlifeline.org/GetHelp/WhatIfSomeoneIKnowNeedsHelp.aspx|What If Someone I Know Needs Help]].</note> 
  
 ====== Depression ====== ====== Depression ======
Line 13: Line 13:
  
  
-Why are depressed patients inflamed? (({{pubmed>long:28479211}}))    +Why are depressed patients inflamed? (({{pmid>long:28479211}}))    
  
 <blockquote>It is my opinion that early and prominent symptoms of Th1 disease are psychological which have been interpreted as anxiety, depression, insomnia, learning disabilities etc. These symptoms like physical ones are exacerbated during effective treatment of Th1 [diseases]. <blockquote>It is my opinion that early and prominent symptoms of Th1 disease are psychological which have been interpreted as anxiety, depression, insomnia, learning disabilities etc. These symptoms like physical ones are exacerbated during effective treatment of Th1 [diseases].
Line 21: Line 21:
 //**Greg Blaney, MD**// </blockquote> //**Greg Blaney, MD**// </blockquote>
  
-[[http://np-privatepracticeassoc.com/2016/04/depression-and-insomnia/|Depression and Insomnia study (Trudi Heil) with Recovery Charts on Olmesartan]]+[[https://np-privatepracticeassoc.com/2016/04/depression-and-insomnia/|Depression and Insomnia study (Trudi Heil) with Recovery Charts on Olmesartan]]
  
 Some research indicates that parasites can affect levels of neurotransmitters, and hence behaviour. The implication is that this could apply to humans too.((Journal reference: Proceedings of the Royal Society B (DOI: 10.1098/rspb.2008.1597) )) Some research indicates that parasites can affect levels of neurotransmitters, and hence behaviour. The implication is that this could apply to humans too.((Journal reference: Proceedings of the Royal Society B (DOI: 10.1098/rspb.2008.1597) ))
Line 27: Line 27:
 <blockquote>Understanding how parasites and pathogens alter brain function and behaviour may also help us understand the suspected links between some infectious diseases and mental illness in humans. <blockquote>Understanding how parasites and pathogens alter brain function and behaviour may also help us understand the suspected links between some infectious diseases and mental illness in humans.
  
-//**Shelly Adamo**, [[http://www.newscientist.com/article/dn16283-prozac-may-counter-parasite-mind-control.html?DCMP=OTC-rss&nsref=online-news|New Scientist]]// </blockquote>+//**Shelly Adamo**, [[https://www.newscientist.com/article/dn16283-prozac-may-counter-parasite-mind-control.html?DCMP=OTC-rss&nsref=online-news|New Scientist]]// </blockquote>
  
 [[https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.12198|Impact of microbiota on brain function]] [[https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.12198|Impact of microbiota on brain function]]
  
 +2019 There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced [[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222768#pone.0222768.ref012|risk of depression]].(({{pmid>long:88888888}})) 
 ===== Virtues of depression ===== ===== Virtues of depression =====
  
Line 46: Line 46:
 [[https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.12198|Melancholic microbes]] [[https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.12198|Melancholic microbes]]
  
-[[https://www.ncbi.nlm.nih.gov/pubmed/28736331|The gut microbiota plays an important role in modulating small RNAs that influence hippocampal gene expression, a process critical to hippocampal development.]](({{pubmed>long:28736331}}))+[[https://www.ncbi.nlm.nih.gov/pubmed/28736331|The gut microbiota plays an important role in modulating small RNAs that influence hippocampal gene expression, a process critical to hippocampal development.]](({{pmid>long:28736331}}))
  
 [[https://www.sciencedirect.com/topics/immunology-and-microbiology/psychoneuroimmunology|Psychoneuroimmunology is starting to think that the immune system can also affect our psychology]] [[https://www.sciencedirect.com/topics/immunology-and-microbiology/psychoneuroimmunology|Psychoneuroimmunology is starting to think that the immune system can also affect our psychology]]
  
  
-In the research field of psychoneuroimmunology, accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. In this respect, there has been increasing interest in the putative involvement of the immune system in psychiatric disorders. Cytokines and major depression (({{pubmed>long:15694227}})) +In the research field of psychoneuroimmunology, accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. In this respect, there has been increasing interest in the putative involvement of the immune system in psychiatric disorders. Cytokines and major depression (({{pmid>long:15694227}}))  
 + 
 +==== Immune suppression ==== 
 + 
 +Two U.S. government reports from the 1970s to 1980s provide evidence for many neuropsychiatric effects of non-thermal microwave EMFs, based on occupational exposure studies.[[https://www.ncbi.nlm.nih.gov/pubmed/26300312|(EMFs) produce widespread neuropsychiatric effects including depression.]] 
 + 
 +In summary, then, the mechanism of action of microwave EMFs, the role of the VGCCs in the brain, the impact of non-thermal EMFs on the brain, extensive epidemiological studies performed over the past 50 years, and five criteria testing for causality, all collectively show that various non-thermal microwave EMF exposures produce diverse neuropsychiatric effects. 
  
 ===== Immune signaling ===== ===== Immune signaling =====
  
-A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells (({{pubmed>long:16223770}}))  + 
 +A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells (({{pmid>long:16223770}}))  
  
  
 ===== Co-morbidity ===== ===== Co-morbidity =====
  
-Association with R.A. (({{pubmed>long:30366684}})) +Association with R.A. (({{pmid>long:30366684}})) 
  
 ===== Management ===== ===== Management =====
Line 77: Line 85:
 If slowing the immune response is ineffective, you may need to try an antidepressant. Many of the prescription antidepressant medications are compatible with the MP meds if depression is not resolved by reducing immunopathology.  If slowing the immune response is ineffective, you may need to try an antidepressant. Many of the prescription antidepressant medications are compatible with the MP meds if depression is not resolved by reducing immunopathology. 
  
-Preliminary results suggest that chronic depression, in contrast to acute melancholic depression, might be characterized by increased ACTH response to CRH challenge. Short-term treatment with vagus nerve stimulation was associated with normalization of this response. (({{pubmed>long:16005439}}))+Preliminary results suggest that chronic depression, in contrast to acute melancholic depression, might be characterized by increased ACTH response to CRH challenge. Short-term treatment with vagus nerve stimulation was associated with normalization of this response. (({{pmid>long:16005439}}))
  
-Action of SSRIs  (({{pubmed>long:22251606}}))+Action of SSRIs  (({{pmid>long:22251606}}))
  
 <blockquote>High-Dose Vitamin D Does Not Prevent Depression <blockquote>High-Dose Vitamin D Does Not Prevent Depression
Line 128: Line 136:
  
  
-[[http://www.jneuropsychiatry.org/peer-review/depression-and-inflammation-disentangling-a-clear-yet-complex-and-multifaceted-link.html|depression and inflammation seem closely connected. Specifically that patients with inflammatory diseases are more likely to have MDD,  a large number of people with major depression show inflammatory biomarkers, and patients treated with cytokines are at increased risk of developing depression. Also inflammatory mediators have been found to alter glutamate and monoamine neurotransmission, glucocorticoid receptor resistance and hippocampal neurogenesis. Also, inflammation is able to alter brain signalling patterns, to affect cognition.]] +[[https://www.jneuropsychiatry.org/peer-review/depression-and-inflammation-disentangling-a-clear-yet-complex-and-multifaceted-link.html|depression and inflammation seem closely connected. Specifically that patients with inflammatory diseases are more likely to have MDD,  a large number of people with major depression show inflammatory biomarkers, and patients treated with cytokines are at increased risk of developing depression. Also inflammatory mediators have been found to alter glutamate and monoamine neurotransmission, glucocorticoid receptor resistance and hippocampal neurogenesis. Also, inflammation is able to alter brain signalling patterns, to affect cognition.]]
  
  
 +The 'cytokine hypothesis of depression' implies that proinflammatory cytokines, acting as neuromodulators, represent the key factor in the (central) mediation of the behavioural, neuroendocrine and neurochemical features of depressive disorders. This view is supported by various findings. Several medical illnesses, which are characterised by chronic inflammatory responses, e.g. rheumatoid arthritis, have been reported to be accompanied by depression. (({{pmid>long:    15694227}}))
  
  
Line 164: Line 172:
 autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS) autism, ADHD, depression, severe anxiety, chronic fatigue syndrome (CFS)
  
-Read the [[http://bacteriality.com/2008/03/15/interview18/|interview]]+Read the [[https://bacteriality.com/2008/03/15/interview18/|interview]]
  
 <html></div></div></html> <html></div></div></html>
Line 177: Line 185:
 chronic fatigue syndrome (CFS), depression, food sensitivities chronic fatigue syndrome (CFS), depression, food sensitivities
  
-Read the [[http://bacteriality.com/2007/11/10/interview10/|interview]]+Read the [[https://bacteriality.com/2007/11/10/interview10/|interview]]
  
 <html></div></div> <html></div></div>
Line 213: Line 221:
  
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
Line 229: Line 238:
 <blockquote> <blockquote>
 Here is another scholarly article making the connection between depression and inflamation. Here is another scholarly article making the connection between depression and inflamation.
-http://psychcentral.com/news/2009/04/01/chronic-infection-may-spawn-depression/5079.html+https://psychcentral.com/news/2009/04/01/chronic-infection-may-spawn-depression/5079.html
 </blockquote> </blockquote>
  
Line 249: Line 258:
  
 <blockquote>Why do clinical trials exclude depressed people?                               <blockquote>Why do clinical trials exclude depressed people?                              
-http://www.reuters.com/article/2011/03/18/us-trials-idUSTRE72H31320110318+https://www.reuters.com/article/2011/03/18/us-trials-idUSTRE72H31320110318
  
 ..trevor.. ..trevor..
Line 272: Line 281:
 See: See:
 Pro-inflammatory cytokines activate enzymes that consume the precursor to seratonin. Pro-inflammatory cytokines activate enzymes that consume the precursor to seratonin.
-http://www.ncbi.nlm.nih.gov/pubmed/17928982+https://www.ncbi.nlm.nih.gov/pubmed/17928982
        
  
Line 286: Line 295:
  
 It seems that SAM-e may produce homocysteine without supplemental folic acid. Among their other caveats, the newsletter says, "The most important problem: SAM-e is converted into homocysteine in the body. High homocysteine levels appear to raise the risk of heart disease." It seems that SAM-e may produce homocysteine without supplemental folic acid. Among their other caveats, the newsletter says, "The most important problem: SAM-e is converted into homocysteine in the body. High homocysteine levels appear to raise the risk of heart disease."
-http://www.berkeleywellness.com/html/ds/dsSAMe.php +https://www.berkeleywellness.com/html/ds/dsSAMe.php 
  
-High homocysteine levels have also been linked to Alzheimer's. http://www.blackmores.com.au/news/news_detail.asp?art=90+High homocysteine levels have also been linked to Alzheimer's. https://www.blackmores.com.au/news/news_detail.asp?art=90
  
 If your doctor has ordered SAM-e and it is effective for intolerable depression, it's okay to continue it. Monitor your mood carefully and wean from this supplement as your depression resolves. If your doctor has ordered SAM-e and it is effective for intolerable depression, it's okay to continue it. Monitor your mood carefully and wean from this supplement as your depression resolves.
Line 590: Line 599:
 Hi Rich. I think contemplative prayer sounds great; it is similar to other types of meditation, I think. I have done a little of that recently in sessions at a beautiful church -- the beauty of the surroundings helps a lot, though I'd imagine you could set up your own space with a candle, etc. (though I've found that candles hurt my eyes now that I'm on the MP). Hi Rich. I think contemplative prayer sounds great; it is similar to other types of meditation, I think. I have done a little of that recently in sessions at a beautiful church -- the beauty of the surroundings helps a lot, though I'd imagine you could set up your own space with a candle, etc. (though I've found that candles hurt my eyes now that I'm on the MP).
  
-One thing that I find immediately helps with wound up emotional states is something called EFT, or Emotional Freedom Technique. It is essentially a quick tapping routine whilst repeating the negative thought, whatever it is that's bothering you. You tap at acupuncture meridian points which supposedly releases the negative impact of the emotion as you state it. It actually works pretty instantaneously for all sorts of stress situations. Check out http://www.mercola.com/forms/eftcourse.htm to see how it's done. I just do the abbreviated, 7-point tap, only takes a minute.+One thing that I find immediately helps with wound up emotional states is something called EFT, or Emotional Freedom Technique. It is essentially a quick tapping routine whilst repeating the negative thought, whatever it is that's bothering you. You tap at acupuncture meridian points which supposedly releases the negative impact of the emotion as you state it. It actually works pretty instantaneously for all sorts of stress situations. Check out https://www.mercola.com/forms/eftcourse.htm to see how it's done. I just do the abbreviated, 7-point tap, only takes a minute.
  
 Best regards, Best regards,
Line 620: Line 629:
 Whenever I get moody I will stop and think (meditate) about what in this situation can I be grateful for. It rarely doesn't work; but it can be tough depending on my immune response!  Whenever I get moody I will stop and think (meditate) about what in this situation can I be grateful for. It rarely doesn't work; but it can be tough depending on my immune response! 
  
-I also listen to nature sound cds--without music, like these http://www.somersetent.com/store/SearchResult.aspx?CategoryID=20+I also listen to nature sound cds--without music, like these https://www.somersetent.com/store/SearchResult.aspx?CategoryID=20
 from Dan Gibson. I love music, but it can be a real stressor if my immune response is high.   from Dan Gibson. I love music, but it can be a real stressor if my immune response is high.  
  
Line 735: Line 744:
  
 Scientists build on case connecting inflammatory disease and depression Scientists build on case connecting inflammatory disease and depression
-http://www.eurekalert.org/pub_releases/2004-07/uoia-sbo072704.php+https://www.eurekalert.org/pub_releases/2004-07/uoia-sbo072704.php
 and and
-http://www.sciencedaily.com/releases/2004/07/040728084924.htm+https://www.sciencedaily.com/releases/2004/07/040728084924.htm
  
 Dr. Marshall's comment: Dr. Marshall's comment:
Line 1388: Line 1397:
  
 Meg  Meg 
-===== References =====+===== References =====</nodisp> 
home/diseases/depression.1561765559.txt.gz · Last modified: 06.28.2019 by sallieq
© 2015, Autoimmunity Research Foundation. All Rights Reserved.