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home:diseases:hashimotos [01.01.2019] – [Hashimoto's disease] sallieqhome:diseases:hashimotos [09.14.2022] (current) – external edit 127.0.0.1
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-Hashimoto's disease is characterized by chronic inflammation of the thyroid gland, often leading to a less than sufficient production of the hormones T3 and T4. In some cases hormone replacement therapy may alleviate the majority of symptoms, at least for a while, while in other cases euthyroid patients suffer from a variety of symptoms; lethargy and fatigue being prominent symptoms.(({{pubmed>long:21186954}}))+Hashimoto's disease is characterized by chronic inflammation of the thyroid gland, often leading to a less than sufficient production of the hormones T3 and T4. In some cases hormone replacement therapy may alleviate the majority of symptoms, at least for a while, while in other cases euthyroid patients suffer from a variety of symptoms; lethargy and fatigue being prominent symptoms.(({{pmid>long:21186954}}))
  
-<blockquote>Women with Hashimotos thyroiditis suffer from a high symptom load. Hypothyroidism is only a contributing factor to the development of associated conditions.(({{pubmed>long:21186954}}))</blockquote>+<blockquote>Women with Hashimotos thyroiditis suffer from a high symptom load. Hypothyroidism is only a contributing factor to the development of associated conditions.(({{pmid>long:21186954}}))</blockquote>
  
-An infectious etiology has long been suspected in different thyroid diseases, including Hashimoto's thyroiditis. As with many other inflammatory diseases most reasearchers appear to be searching for one specific culprit, something which seems ulikely in light of the many findings of links to many different viruses and bacteria in thyroid disease. Further, in the light of last few years' progress in metagenomics, a multimicrobial, successive type infection appears more likely to drive the disease process.(({{pubmed>long:23370376}}))  +An infectious etiology has long been suspected in different thyroid diseases, including Hashimoto's thyroiditis. As with many other inflammatory diseases most reasearchers appear to be searching for one specific culprit, something which seems unlikely in light of the many findings of links to many different viruses and bacteria in thyroid disease. Further, in the light of the last few years' progress in metagenomics, a multimicrobial, successive type infection appears more likely to drive the disease process.(({{pmid>long:23370376}}))  
  
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
-There are many links to infection in Hashimoto's disease, both sereological(({{pubmed>long:3754083}}))(({{pubmed>long:19356903}}))(({{pubmed>long:11318812}}))  and DNA based.(({{pubmed>long:23055929}}))(({{pubmed>long:24008857}}))(({{pubmed>long:18788945}}))+There are many links to infection in Hashimoto's disease, both sereological(({{pmid>long:3754083}}))(({{pmid>long:19356903}}))(({{pmid>long:11318812}}))  and DNA based.(({{pmid>long:23055929}}))(({{pmid>long:24008857}}))(({{pmid>long:18788945}}))
  
-Also, inflammatory thyroid disease has also been shown to occur as part of the immmunopathology resulting from treatment of HIV infection.(({{pubmed>long:22784301}})) In line with the Marshall Pathogenesis of inflammatory disease, this is most readily explained by an enhanced function of the immune system upon initiating antiviral therapy, revealing subclinical thyroid disease and multimicrobial infection of the thyroid gland.  +Also, inflammatory thyroid disease has also been shown to occur as part of the immmunopathology resulting from treatment of HIV infection.(({{pmid>long:22784301}})) In line with the Marshall Pathogenesis of inflammatory disease, this is most readily explained by an enhanced function of the immune system upon initiating antiviral therapy, revealing subclinical thyroid disease and multimicrobial infection of the thyroid gland.  
-==== Other evidence ====+==== Research ====
  
-Patients suffering from Hashimoto's disease have lower levels of vitamin 25-D, and disease severity correlates with vitamin D levels.(({{pubmed>long:23337162}})) In line with the Marshall Pathogenesis of inflammatory disease, this points to microbes having subverted the function of the vitamin D receptor. +Patients suffering from Hashimoto's disease have lower levels of vitamin 25-D, and disease severity correlates with vitamin D levels.(({{pmid>long:23337162}})) In line with the Marshall Pathogenesis of inflammatory disease, this points to microbes having subverted the function of the vitamin D receptor. 
  
-The ratio of Th1/Th2 cells is higher in Hashimoto's, indicating presence of intracellular infection.(({{pubmed>long:19415997}}))+The ratio of Th1/Th2 cells is higher in Hashimoto's, indicating presence of intracellular infection.(({{pmid>long:19415997}}))
  
 +Selenium and iodine are essential for thyroid hormone synthesis and function.(({{pmid>long:26088475}})) 
  
  
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 Close to our science is this paper showing that the Alpha Thyroid receptor is key to bone structure. Close to our science is this paper showing that the Alpha Thyroid receptor is key to bone structure.
-http://tinyurl.com/mlaea+https://tinyurl.com/mlaea
  
 A simpler summary of what is known is found here A simpler summary of what is known is found here
-http://tinyurl.com/nwpaj+https://tinyurl.com/nwpaj
  
 My molecular genomics shows that 1,25-D directly acts on the alpha-1-Thyroid receptor, with higher affinity even than it has for the VDR. This is clearly an important pathway towards the osteopenia we often see in Th1 disease, especially when folks exhibit hypothyroid symptoms. My molecular genomics shows that 1,25-D directly acts on the alpha-1-Thyroid receptor, with higher affinity even than it has for the VDR. This is clearly an important pathway towards the osteopenia we often see in Th1 disease, especially when folks exhibit hypothyroid symptoms.
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 and the rebuttal: and the rebuttal:
  
-http://www.wilsonsthyroidsyndrome.com/OpinionsOnWTS.htm+https://www.wilsonsthyroidsyndrome.com/OpinionsOnWTS.htm
  
 Please research carefully and discuss this issue which your doctor. Please research carefully and discuss this issue which your doctor.
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 Dr. Marshall has created a diagram summarizing some of the key relationships between the body's hormones and 1,25-D. You can access it at Dr. Marshall has created a diagram summarizing some of the key relationships between the body's hormones and 1,25-D. You can access it at
-http://autoimmunityresearch.org/hormones.pdf+https://autoimmunityresearch.org/hormones.pdf
  
 Related Topics:  Related Topics: 
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-<blockquote>Prevalence of Yersinia plasmid-encoded outer protein (Yop)  class-specific antibodies in patients with Hashimoto's thyroiditis(({{pubmed>long:11318812}}))+<blockquote>Prevalence of Yersinia plasmid-encoded outer protein (Yop)  class-specific antibodies in patients with Hashimoto's thyroiditis(({{pmid>long:11318812}}))
  
 Clin Microbiol Infect. 2001 Mar;7(3):138-43. Clin Microbiol Infect. 2001 Mar;7(3):138-43.
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 PMID: 11318812</blockquote>  PMID: 11318812</blockquote> 
  
-===== References =====+===== References =====</nodisp> 
home/diseases/hashimotos.1546380237.txt.gz · Last modified: 01.01.2019 by sallieq
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