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--- home:diseases:hypercalcemia [02.18.2019] – [Introduction] sallieq
+++ home:diseases:hypercalcemia [07.27.2019] – [Infants] sallieq
@@ Line 17: / Line 17: @@
 Although parathyroidectomy is the only curative treatment for PHPT, this is indicated in a minority of cases.
 </blockquote>
+Hyperuricaemia was associated with an unfavourable cardiovascular risk profile in HF patients. Treatment with low doses of allopurinol did not improve the prognosis of HF patients.  (({{pubmed>long:    31119751}}))
 A Quick Reference on Hypercalcemia.  (({{pubmed>long:28012787}}))
@@ Line 23: / Line 25: @@
 Cancer-Related Hypercalcemia.  (({{pubmed>long:27170690}}))
 <blockquote>The most common causes include humoral hypercalcemia of malignancy mediated by parathyroid hormone-related peptide, osteolytic cytokine production, and excess 1,25-dihydroxy vitamin D production.</blockquote>
+The active form of vitamin D3 , calcitriol, is a potent antiproliferative compound. However, when effective antitumor doses of calcitriol are used, hypercalcemic effects are observed, thus blocking its therapeutic application. (({{pubmed>long:    31025400}}))
+==== Infants ====
+Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.  (({{pubmed>long:26681795}}))
+<blockquote> CYP2R1 has been identified as the most important 25-hydroxylase, and a critical role for CYP24A1 in humans was noted in studies showing that inactivating mutations in CYP24A1 are a probable cause of idiopathic infantile hypercalcemia.
+</blockquote>
 ==== Fungal infection ====

home/diseases/hypercalcemia.txt · Last modified: 09.14.2022 by 127.0.0.1