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home:diseases:ibd [03.13.2019]
sallieq [Research]
home:diseases:ibd [03.24.2019] (current)
sallieq [Antibiotics]
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 [[http://​www.newswise.com/​articles/​view/​515982|Targeted Antibiotics Lead to Long-lasting Improvement in IBS Symptoms]] ​ [[http://​www.newswise.com/​articles/​view/​515982|Targeted Antibiotics Lead to Long-lasting Improvement in IBS Symptoms]] ​
 +
 +It is apparently very rare for a patient to actually be allergic to Olmesartan (see Research below). An alternative approach where there is present a confirmed mycobacterial infection was recorded here [[http://​www.mattioli1885journals.com/​index.php/​sarcoidosis/​article/​view/​6769/​4736|MAP Abx]] .
  
  
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 "It is increasingly apparent that bacteria are playing a role in healthy development,​ and need to be properly managed by the mucosal immune system to avoid inflammatory diseases"​ Gewirtz explained. (({{pubmed>​long:​22863420}})) </​blockquote>​ "It is increasingly apparent that bacteria are playing a role in healthy development,​ and need to be properly managed by the mucosal immune system to avoid inflammatory diseases"​ Gewirtz explained. (({{pubmed>​long:​22863420}})) </​blockquote>​
- 
-===== Research ===== 
- 
-Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely. ​ (({{pubmed>​long:​25023670}})) 
- 
-In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. ​  ​(({{pubmed>​long:​25947920}})) 
- 
-Development,​ validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium. ​ (({{pubmed>​long:​25557335}})) ​ 
- 
-<​blockquote>​ It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies. ​ 
- 
- 
-Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa. ​ 
- 
- Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly,​ the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation,​ contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment.</​blockquote>​ 
- 
- 
-'​Western'​-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens). ​  ​(({{pubmed>​long:​26011307}})) ​ 
- 
-[[https://​www.sciencemag.org/​news/​2018/​11/​do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]] 
-  ​ 
  
 =====  Patient interviews ​ ===== =====  Patient interviews ​ =====
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 Interviews of patients with other diseases are [[home:​patients:​patient_interviews|also available]]. Interviews of patients with other diseases are [[home:​patients:​patient_interviews|also available]].
 +
  
 {{tag>​disease }} {{tag>​disease }}
 +
 +===== Research =====
 +
 +Findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely. ​ (({{pubmed>​long:​25023670}}))
 +
 +In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity. ​  ​(({{pubmed>​long:​25947920}}))
 +
 +Development,​ validation and implementation of an in vitro model for the study of metabolic and immune function in normal and inflamed human colonic epithelium. ​ (({{pubmed>​long:​25557335}})) ​
 +
 +<​blockquote>​ It is now known that epithelial cells have the capacity to secrete and respond to a range of immunological mediators and this suggests that these cells play a prominent role in the pathogenesis of IBD. Current knowledge about the intestinal epithelium has mainly been obtained using models based on animal cells, transformed human intestinal cell lines and isolated cells from resected colonic bowel segments. Species difference, malignant origin and confounders related to surgery, obviously make these cell models however less applicable for patophysiological studies. ​
 +
 +Using a functional peptide cleavage assay it was shown that epithelial cells secreted proteolytic active enzymes and that the functional MMP activity was increased in inflamed IBD mucosa. ​
 +
 + Our results revealed that colonic epithelial cells express TLR9, a key pattern recognition receptor. Interestingly,​ the differentiated epithelial cells, which have been exposed to the luminal bacterial flora in vivo, were unresponsive to TLR9 ligand stimulation,​ contrasting findings in the epithelial cell line HT-29 that is cultured continuously in bacteria free environment.
 +</​blockquote>​
 +
 +'​Western'​-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens). ​  ​(({{pubmed>​long:​26011307}})) ​
 +
 +Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease. ​ [[https://​jmm.microbiologyresearch.org/​content/​journal/​jmm/​10.1099/​jmm.0.017541-0#​tab2|microbiology research]]
 +
 +Butyric acid in functional constipation ​  ​(({{pubmed>​long:​24868272}}))
 +
 +Butyric acid in irritable bowel syndrome ​ (({{pubmed>​long:​24868283}}))
 +  ​
 +[[https://​www.sciencemag.org/​news/​2018/​11/​do-gut-bacteria-make-second-home-our-brains|Roberts doesn’t know how these gut bacteria could have gotten into the brain. They may have crossed from blood vessels, traveling up nerves from the gut, or even come in through the nose]]
 +
 +[[https://​www.karger.com/​Article/​FullText/​477386|Resistant Starch Regulates Gut Microbiota: Structure, ​
 +Biochemistry and Cell Signalling]]
 +
 +[{{:​home:​diseases:​file:​table_1_yang_et_al.gif|**Table 1  Yang et al **}}]
 +
  
  
home/diseases/ibd.1552512459.txt.gz · Last modified: 03.13.2019 by sallieq
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