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home:diseases:kidney_disease [02.17.2019] – [Calcium-alkali syndrome] sallieqhome:diseases:kidney_disease [09.14.2022] (current) – external edit 127.0.0.1
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 ==== Dialysis ==== ==== Dialysis ====
  
-Dialysis is primarily used to provide an artificial replacement for lost kidney function in people with renal failure. The death rate from cardiovascular disease for dialysis patients is much higher than the general population, regardless of age.(({{pubmed>long:20411052}})) Patients with renal failure are not only exposed to higher volumes of water in their lifetime than the general population, but the barrier between blood and dialysis fluid is generally in the form of a nonselective semipermeable membrane, providing a direct route for any contaminants into the bloodstream. Consequently many of the permitted levels of contaminants in drinking water have the potential to cause problems in dialysis patients.(({{pubmed>long:12953025}})) +Dialysis is primarily used to provide an artificial replacement for lost kidney function in people with renal failure. The death rate from cardiovascular disease for dialysis patients is much higher than the general population, regardless of age.(({{pmid>long:20411052}})) Patients with renal failure are not only exposed to higher volumes of water in their lifetime than the general population, but the barrier between blood and dialysis fluid is generally in the form of a nonselective semipermeable membrane, providing a direct route for any contaminants into the bloodstream. Consequently many of the permitted levels of contaminants in drinking water have the potential to cause problems in dialysis patients.(({{pmid>long:12953025}})) 
  
-It is known that tap water harbors potentially pathogenic micro-organisms that can pose a significant health threat to patients, especially those people with compromised immune systems and haemodialysis.(({{pubmed>long:9950177}}))(({{pubmed>long:16329897}})) For decades, hospital water sources have been known to be reservoirs of nosocomial pathogens, especially organisms of the //Pseudomonas sp.// yet guidelines for preventing such infections do not exist.(({{pubmed>long:12090885}}))(({{pubmed>long:12861087}}))+It is known that tap water harbors potentially pathogenic micro-organisms that can pose a significant health threat to patients, especially those people with compromised immune systems and haemodialysis.(({{pmid>long:9950177}}))(({{pmid>long:16329897}})) For decades, hospital water sources have been known to be reservoirs of nosocomial pathogens, especially organisms of the //Pseudomonas sp.// yet guidelines for preventing such infections do not exist.(({{pmid>long:12090885}}))(({{pmid>long:12861087}}))
  
-Today, specialists in infectious diseases are considering point-of-use filters. They presume that the filters achieve a greater than 99% reduction in total heterotrophic plate count of bacteria in the immediate and postflush samples.(({{pubmed>long:15940113}}))(({{pubmed>long:15940115}})) They conclude that such filtration units would prevent exposure of high-risk patients to waterborne pathogens. However, the results of Silbaq's 2009 study show that viable ultra-microcells pass through 0.2 micron filtration, and can be cultured on agar, as early as 72 hours after collection. The bacteria were identified using 16S ribosomal DNA sequences. The presence of those ultra-small bacteria in water filtrates would remain undetected by the standard and total heterotrophic plate count. +Today, specialists in infectious diseases are considering point-of-use filters. They presume that the filters achieve a greater than 99% reduction in total heterotrophic plate count of bacteria in the immediate and postflush samples.(({{pmid>long:15940113}}))(({{pmid>long:15940115}})) They conclude that such filtration units would prevent exposure of high-risk patients to waterborne pathogens. However, the results of Silbaq's 2009 study show that viable ultra-microcells pass through 0.2 micron filtration, and can be cultured on agar, as early as 72 hours after collection. The bacteria were identified using 16S ribosomal DNA sequences. The presence of those ultra-small bacteria in water filtrates would remain undetected by the standard and total heterotrophic plate count. 
  
-<blockquote>From the results in this study, one might conclude that the filtration strategies may remove most microbes from water, but cannot prevent it. The ability of UMC to pass through the 0.2 m filters and even 0.1 m filters might select for new emerging pathogens from diverse phyla such as //S. maltophilia// and //Pandoraea sp.// which are well recognized as pathogens among cystic fibrosis patients.(({{pubmed>long:15865277}})) +<blockquote>From the results in this study, one might conclude that the filtration strategies may remove most microbes from water, but cannot prevent it. The ability of UMC to pass through the 0.2 m filters and even 0.1 m filters might select for new emerging pathogens from diverse phyla such as //S. maltophilia// and //Pandoraea sp.// which are well recognized as pathogens among cystic fibrosis patients.(({{pmid>long:15865277}})) 
  
-//**F.S. Silbaq**//(({{pubmed>long:19040704}}))+//**F.S. Silbaq**//(({{pmid>long:19040704}}))
 </blockquote> </blockquote>
  
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 ===== Role of Vitamin D Receptor in in chronic kidney disease ===== ===== Role of Vitamin D Receptor in in chronic kidney disease =====
  
-Excess 25(OH)D3 worsens tubulointerstitial injury by modulating macrophage phenotype.   (({{pubmed>long:26176830}})) +Excess 25(OH)D3 worsens tubulointerstitial injury by modulating macrophage phenotype.   (({{pmid>long:26176830}})) 
  
 <blockquote>Continuously evidence indicates that deficiencies in vitamin D receptor activation represents one of key players in adversely affecting cardiovascular health, as well as inducing to secondary hyperparathyroidism in chromic kidney disease patients.... Potentially, selective VDR activators not only reduce serum parathyroid hormone levels minimizing the risk of hypercalcemia and hyperphosphatemia, but also may improve patient health, reducing the risk of cardiovascular disease. <blockquote>Continuously evidence indicates that deficiencies in vitamin D receptor activation represents one of key players in adversely affecting cardiovascular health, as well as inducing to secondary hyperparathyroidism in chromic kidney disease patients.... Potentially, selective VDR activators not only reduce serum parathyroid hormone levels minimizing the risk of hypercalcemia and hyperphosphatemia, but also may improve patient health, reducing the risk of cardiovascular disease.
  
-M. Cozzolino //et al.//(({{pubmed>long:20411052}}))</blockquote>+M. Cozzolino //et al.//(({{pmid>long:20411052}}))</blockquote>
  
  
-<blockquote>Thessaloniki - Greece, June 2010 (({{pubmed>long:20540037}}))+<blockquote>Thessaloniki - Greece, June 2010 (({{pmid>long:20540037}}))
  
 Abstract Abstract
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 <blockquote> <blockquote>
-from Torino - Italy:  Selective vitamin D receptor activation: effect on renal physiopathology. (({{pubmed>long:19941275}}))+from Torino - Italy:  Selective vitamin D receptor activation: effect on renal physiopathology. (({{pmid>long:19941275}}))
  
  
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 <blockquote>Sept. 2010 <blockquote>Sept. 2010
-Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.(({{pubmed>long:20844473}})) +Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease.(({{pmid>long:20844473}})) 
  
  
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-Calcium-alkali syndrome due to vitamin D administration and magnesium oxide administration.(({{pubmed>long:19185403}}))+Calcium-alkali syndrome due to vitamin D administration and magnesium oxide administration.(({{pmid>long:19185403}}))
  
  
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 Intricate mechanisms mediating the calcium-alkali syndrome depend on interplay among intestine, kidney, and bone. New insights regarding its pathogenesis focus on the key role of calcium-sensing receptors and TRPV5 channels in the modulation of renal calcium excretion.  Intricate mechanisms mediating the calcium-alkali syndrome depend on interplay among intestine, kidney, and bone. New insights regarding its pathogenesis focus on the key role of calcium-sensing receptors and TRPV5 channels in the modulation of renal calcium excretion. 
  
-Restoring extracellular blood volume, increasing GFR and calcium excretion, and discontinuing calcium supplementation provide best treatment.   (({{pubmed>long:20413609}}))+Restoring extracellular blood volume, increasing GFR and calcium excretion, and discontinuing calcium supplementation provide best treatment.   (({{pmid>long:20413609}}))
  
  
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
-[[http://www.nature.com/ja/journal/v65/n3/full/ja2011131a.html|Creatinine inhibits bacterial replication]]+[[https://www.nature.com/ja/journal/v65/n3/full/ja2011131a.html|Creatinine inhibits bacterial replication]]
  
  
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 //**Claudia**, MarshallProtocol.com//</blockquote> //**Claudia**, MarshallProtocol.com//</blockquote>
  
 +==== Patient's chart ====
  
 +//with notes re eating meat before a test//
  
  
 +Creatinine, at 130 umole/L, was above normal range from the start. It took a few months to reach around 150 umole/L which seemed to become the basic level for the the next 11 years with peaks above that level being associated with other factors. The two anomalous peaks above 200umole/L were associated with having meat meals too close to the time of the test. The creatine and creatinine content in vertebrate muscle, or creatine supplements, can be absorbed to add to the body's potential to generate serum creatinine (70Effect of a Cooked Meat Meal on Serum Creatinine and Estimated Glomerular Filtration Rate in Diabetes-Related Kidney Disease | Diabetes Care). After the early 200+ peak, from a sample taken after a light chicken lunch, meat was avoided for a day or two before sampling for subsequent tests. 
  
-{{tag>disease kidneys arrange}}+The other exception was the second last one, for which meat was eaten the night before sampling.    Apart from the aberrations arising from meat eating, eGFR values remained in the 30 to 40 range throughout the 11 year period. Thus the MP treatment, while inducing an initial fall in eGFR, has subsequently allowed the kidney function to remain stable. 
  
 +{{:home:tests:kidney_tests..gif?700|}}
  
 +
 +{{tag>disease kidneys }}
 +
 +
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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   * legacy content   * legacy content
-  * http://www.marshallprotocol.com/view_topic.php?id=2487&forum_id=32&jump_to=84509#p84509 f109+  * https://www.marshallprotocol.com/view_topic.php?id=2487&forum_id=32&jump_to=84509#p84509 f109
  
   * Avoid foods high in potassium for people with kidney disease?   * Avoid foods high in potassium for people with kidney disease?
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 <blockquote>From: Jigsaw <blockquote>From: Jigsaw
 Date: 2011-03-10 19:19:56 Date: 2011-03-10 19:19:56
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=1448+Reply: https://www.marshallprotocol.com/reply.php?topic_id=1448
  
  Hi Trevor. I am pleased to see your positive results from the use of sodium bicarbonate. I started using it (840 mg/ day) in August and have had one favourable result with potassium back into the normal range. Not much effect on creatinine.  Hi Trevor. I am pleased to see your positive results from the use of sodium bicarbonate. I started using it (840 mg/ day) in August and have had one favourable result with potassium back into the normal range. Not much effect on creatinine.
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   All values were from blood samples taken in the morning after overnight fasting. Seven days before the the 3/08 readings (urea, 18.3; creatinine, 148; eGFR, 40; potassium 5.5) , I had one set taken in the afternoon after a chicken lunch, where urea was 23.3, creatinine 201 and eGFR 28. Potassium was 5.4.   All values were from blood samples taken in the morning after overnight fasting. Seven days before the the 3/08 readings (urea, 18.3; creatinine, 148; eGFR, 40; potassium 5.5) , I had one set taken in the afternoon after a chicken lunch, where urea was 23.3, creatinine 201 and eGFR 28. Potassium was 5.4.
  
-As I noted in a reply to Inge's thread, my cardiologist/physician and the Path lab said this would have no effect: but http://www.medicine.ox.ac.uk/bandolier/band156/b156-3.html noted that the test was standardised on samples taken in the morning from subjects after an overnight fast and quoting data showing that blood creatinine was raised an average of 25% for samples taken 1-2 hours after a meat meal One might say mine was raised by 53/148 x 100 = 35.5%..+As I noted in a reply to Inge's thread, my cardiologist/physician and the Path lab said this would have no effect: but https://www.medicine.ox.ac.uk/bandolier/band156/b156-3.html noted that the test was standardised on samples taken in the morning from subjects after an overnight fast and quoting data showing that blood creatinine was raised an average of 25% for samples taken 1-2 hours after a meat meal One might say mine was raised by 53/148 x 100 = 35.5%..
  
 I am not sure that the web link will still come up. I think the tests were done on healthy subjects and imagine that the effect would be greater where GFR is less adequate. I am not sure that the web link will still come up. I think the tests were done on healthy subjects and imagine that the effect would be greater where GFR is less adequate.
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 Here is an article giving a glimpse into what it is like to experience true kidney failure: Here is an article giving a glimpse into what it is like to experience true kidney failure:
  
-http://www.vcstar.com/news/2011/jan/02/woman-starts-countys-first-group-for-dialysis-i/+https://www.vcstar.com/news/2011/jan/02/woman-starts-countys-first-group-for-dialysis-i/
  
 and another: and another:
  
-http://thehill.com/blogs/healthwatch/medicare/135463-medicare-agency-creates-quality-standards-for-kidney-disease-treatment+https://thehill.com/blogs/healthwatch/medicare/135463-medicare-agency-creates-quality-standards-for-kidney-disease-treatment
  
 and another from India: and another from India:
  
-http://www.indianexpress.com/news/dialysis-treatment-via-home-hemodialysis/732720/+https://www.indianexpress.com/news/dialysis-treatment-via-home-hemodialysis/732720/
  
 ..Trevor..</blockquote> ..Trevor..</blockquote>
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 </blockquote> </blockquote>
  
-<note>a link to the document http://mpkb.org/home/othertreatments/sodium_bicarbonate would be appropriate somewhere here IMO+<note>a link to the document https://mpkb.org/home/othertreatments/sodium_bicarbonate would be appropriate somewhere here IMO
 //Sallie Q// Jan 2014</note> //Sallie Q// Jan 2014</note>
 made Link  --- //Sallie Q 11.18.2015// made Link  --- //Sallie Q 11.18.2015//
-===== References =====+===== References =====</nodisp> 
home/diseases/kidney_disease.1550445913.txt.gz · Last modified: 02.17.2019 by sallieq
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