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home:diseases:ms [01.28.2019] – [Recent Research] sallieqhome:diseases:ms [02.07.2019] – [Of further interest] sallieq
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 (({{pubmed>long:19359987}})) (({{pubmed>long:19359987}}))
  
-[[https://www.marshallprotocol.com/view_topic.php?id=14494&forum_id=39&highlight=+Antibiotic+use+increases+the+risk+of+Multiple+Sclerosis|Antibiotic Use]]+ In a collaborative GWAS involving 9772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the Class I region. Immunologically relevant genes are significantly over-represented amongst those mapping close to the identified loci and particularly implicate T helper cell differentiation in the pathogenesis of multiple sclerosis.  (({{pubmed>long:21833088}}))
  
-<blockquote> +Antibiotic Use (({{pubmed>long:21920946}})) 
- +
-From: edj2001 +
-Date: 2011-12-30 20:49:17 +
-Reply: http://www.marshallprotocol.com/reply.php?topic_id=14494+
  
  
 +<blockquote>
 Add vitamin D to Scotland's food – experts, Dosing whole population would help cut levels of multiple sclerosis, say scientists  Sarah      Boseley, health editor guardian.co.uk, Friday       23 December 2011      15.30 EST Article      history   The following is a letter from Professor Stewart Fleming, University  of Dundee to the Guardian in regard to above article: Add vitamin D to Scotland's food – experts, Dosing whole population would help cut levels of multiple sclerosis, say scientists  Sarah      Boseley, health editor guardian.co.uk, Friday       23 December 2011      15.30 EST Article      history   The following is a letter from Professor Stewart Fleming, University  of Dundee to the Guardian in regard to above article:
  
  
 {{http://www.guardian.co.uk/science/2011/dec/28/vitamin-d-ms-medical-research?newsfeed=true|bureaucratic blight on medical research}} {{http://www.guardian.co.uk/science/2011/dec/28/vitamin-d-ms-medical-research?newsfeed=true|bureaucratic blight on medical research}}
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 Your report  (24 December) on the proposal that there should be artificial supplementation of Scotland's food by vitamin D to reduce the frequency of multiple sclerosis did not address the two main questions of whole-population interventions. Is it effective? Is it safe? Your report  (24 December) on the proposal that there should be artificial supplementation of Scotland's food by vitamin D to reduce the frequency of multiple sclerosis did not address the two main questions of whole-population interventions. Is it effective? Is it safe?
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 Current evidence strongly supports a role for low levels of vitamin D in the development of MS, as your article says. However, other factors are also involved. There are no population-based clinical trials supporting the effectiveness of artificial dietary supplementation by vitamin D in lowering the frequency of MS. Current evidence strongly supports a role for low levels of vitamin D in the development of MS, as your article says. However, other factors are also involved. There are no population-based clinical trials supporting the effectiveness of artificial dietary supplementation by vitamin D in lowering the frequency of MS.
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 How common are these conditions? In Scotland hyperparathyroidism alone affects 6 per 1,000 of the population – it is several times more frequent than MS. So while we need to examine this issue carefully, mass medication with no published evidence of benefit, and with the risk that more people could be harmed than are likely to benefit, would be irresponsible.” How common are these conditions? In Scotland hyperparathyroidism alone affects 6 per 1,000 of the population – it is several times more frequent than MS. So while we need to examine this issue carefully, mass medication with no published evidence of benefit, and with the risk that more people could be harmed than are likely to benefit, would be irresponsible.”
  
- +//Professor  Stewart Fleming, University of Dundee//
-Professor  Stewart Fleming +
- +
-University of Dundee+
 </blockquote> </blockquote>
  
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 </blockquote> </blockquote>
  
-{{https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531/|Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis}} 
  
  
-==== Myelin sheath ====+[{{home:diseases:multiple_sclerosis_incidence_world_map.jpg|MS is rare in China. 
 +Low prevalence in Russia, although it varies by ethnic region.}}] **map from msrc.co.uk** 
 + 
 + 
 + 
 + 
 + 
 + 
 +===== Myelin sheath =====
  
  
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     •    Calcium influx from the extracellular space drives axon degeneration     •    Calcium influx from the extracellular space drives axon degeneration
     •    Nanoscale ruptures allow entry of calcium across the axonal plasma membrane     •    Nanoscale ruptures allow entry of calcium across the axonal plasma membrane
 +    
 ===== Member experience ===== ===== Member experience =====
  
home/diseases/ms.txt · Last modified: 09.14.2022 by 127.0.0.1
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