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--- home:diseases:obesity [02.08.2019] – [Research] sallieq
+++ home:diseases:obesity [02.19.2019] – [Learn More] sallieq
@@ Line 126: / Line 126: @@
 Fecal microbiota composition in children may predict overweight.(({{pubmed>long:18326589}}))
+===== Research =====
+Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance.  (({{pubmed>long:23707515}}))
+Adenosine is an endogenous metabolite that is released from all tissues and cells including liver, pancreas, muscle and fat, particularly under stress, intense exercise, or during cell damage.  (({{pubmed>long:23460239}}))
+Here, we report that adenosine level in the cerebrospinal fluid, and hypothalamic expression of A1R, are increased in the diet-induced obesity (DIO) mouse. We find that mice with overexpression of A1R in the neurons of paraventricular nucleus (PVN) of the hypothalamus are hyperphagic, have glucose intolerance and high body weight. Central or peripheral administration of caffeine reduces the body weight of DIO mice by the suppression of appetite and increasing of energy expenditure. We also show that caffeine excites oxytocin expressing neurons, and blockade of the action of oxytocin significantly attenuates the effect of caffeine on energy balance.  (({{pubmed>long:28654087}}))
+Higher zonulin levels are associated with higher waist circumference, diastolic blood pressure, fasting glucose, and increased risk of metabolic diseases  (({{pubmed>long:28282855}}))
+'Western'-style diets, high in fat/sugar, low in fibre, decrease beneficial Firmicutes that metabolise dietary plant-derived polysaccharides to SCFAs and increase mucosa-associated Proteobacteria (including enteric pathogens).   (({{pubmed>long:26011307}}))
+This was of particular interest to us because other research has shown that having more Bacteroidetes may be beneficial because the higher that proportion is, the individual tends to be leaner. With higher Firmicutes, that individual tends to be more obese," Holscher said. "We don't know if there is any causality for weight loss, but studies have shown that having a higher fiber diet is protective against obesity.  (({{pubmed>long:    25414978}}))   (({{pubmed>long:25527750}}))
 ===== Learn More =====
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 [[http://www.foodsmatter.com/es/health_risks/articles/goldsworthy-biological-effects-04-12.pdf|biological effects]]
-{{tag>diseases arrange}}
+{{tag>diseases }}
 ===== Notes and comments =====

home/diseases/obesity.txt · Last modified: 09.14.2022 by 127.0.0.1