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home:diseases:osteoarthritis [01.11.2019] – [Research] sallieqhome:diseases:osteoarthritis [09.14.2022] (current) – external edit 127.0.0.1
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 +Usefulness of broad-range PCR for the diagnosis of osteoarticular infections.(({{pmid>long:18525362}}))
 ===== Evidence of infectious cause ===== ===== Evidence of infectious cause =====
  
 Since studies are now showing that tetracycline can slow down the OA process, this suggests that this process is impacted by bacteria. I suspect that lost cartilage will not be replaced but that eliminating CWD bacteria might halt the degenerative process. Since studies are now showing that tetracycline can slow down the OA process, this suggests that this process is impacted by bacteria. I suspect that lost cartilage will not be replaced but that eliminating CWD bacteria might halt the degenerative process.
  
-<blockquote>The almost universal use of methotrexate and the rapid development of potent biologic agents have eclipsed the potential usage of TETs for RA. Ironically, it is in osteoarthritis, where there has only been one clinical trial which essentially failed, that the best potential exists for use of an MMP-inhibiting TET.   (({{pubmed>long:21723947}}))</blockquote> +<blockquote>The almost universal use of methotrexate and the rapid development of potent biologic agents have eclipsed the potential usage of TETs for RA. Ironically, it is in osteoarthritis, where there has only been one clinical trial which essentially failed, that the best potential exists for use of an MMP-inhibiting TET.   (({{pmid>long:21723947}}))</blockquote>  
  
  
-Sample PubMed cite(({{pubmed>long:18525362}})) 
 ===== Accepted knowledge ===== ===== Accepted knowledge =====
-[[http://www.medicinenet.com/osteoarthritis/article.htm|This osteoarthritis (degenerative arthritis) website]] states:+[[https://www.medicinenet.com/osteoarthritis/article.htm|This osteoarthritis (degenerative arthritis) website]] states:
  
 <blockquote>Research scientists have found that doxycycline, a tetracycline drug, has been shown to slow the progression of cartilage degeneration in the knees of patients with osteoarthritis. This effect seems to be a result of the drug's effect on enzymes that destroy cartilage rather than on their properties as antibiotics. More studies are needed to determine the significance of this interesting work.</blockquote> <blockquote>Research scientists have found that doxycycline, a tetracycline drug, has been shown to slow the progression of cartilage degeneration in the knees of patients with osteoarthritis. This effect seems to be a result of the drug's effect on enzymes that destroy cartilage rather than on their properties as antibiotics. More studies are needed to determine the significance of this interesting work.</blockquote>
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 ===== Management ===== ===== Management =====
  
-Is aquatic exercise more effective than land-based exercise for knee osteoarthritis?  (({{pubmed>long:30593178}})) +Is aquatic exercise more effective than land-based exercise for knee osteoarthritis?  (({{pmid>long:30593178}})) 
  
 ===== Research ===== ===== Research =====
  
-Why does hyaline cartilage fail to repair?    (({{pubmed>long:30605736}})) +Why does hyaline cartilage fail to repair?    (({{pmid>long:30605736}})) 
  
-a comprehensive review on recent literature describing signal pathways in the hypertrophy of MSCs-derived in vitro differentiated chondrocytes and chondrocytes, with an emphasis on the crosstalk between these pathways.  (({{pubmed>long:26287176}})) +a comprehensive review on recent literature describing signal pathways in the hypertrophy of MSCs-derived in vitro differentiated chondrocytes and chondrocytes, with an emphasis on the crosstalk between these pathways.  (({{pmid>long:26287176}})) 
      
-Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression. Cytokines also blunt chondrocyte compensatory synthesis pathways required to restore the integrity of the degraded extrecellular matrix (ECM). Moreover, in OA synovium, a relative deficit in the production of natural antagonists of the IL-1 receptor (IL-1Ra) has been demonstrated, and could possibly be related to an excess production of nitric oxide in OA tissues.   (({{pubmed>long:12082286}})) +Cytokines such as IL-1 and TNF-alpha produced by activated synoviocytes, mononuclear cells or by articular cartilage itself significantly up-regulate metalloproteinases (MMP) gene expression. Cytokines also blunt chondrocyte compensatory synthesis pathways required to restore the integrity of the degraded extrecellular matrix (ECM). Moreover, in OA synovium, a relative deficit in the production of natural antagonists of the IL-1 receptor (IL-1Ra) has been demonstrated, and could possibly be related to an excess production of nitric oxide in OA tissues.   (({{pmid>long:12082286}})) 
  
-Altogether, our data show that tetracyclines have no inhibitory potential on any proteoglycanolytic activities within mild or moderately affected human OA cartilage at therapeutic achievable plasma levels.    (({{pubmed>long:20069635}})) +Altogether, our data show that tetracyclines have no inhibitory potential on any proteoglycanolytic activities within mild or moderately affected human OA cartilage at therapeutic achievable plasma levels.    (({{pmid>long:20069635}})) 
  
-Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.  <blockquote>We detected CP in the plasma of healthy subjects and surprisingly found that CP was increased in both patients with eOA and eRA whereas anti-CCP antibodies were predominantly present in eRA. A 4-class diagnostic algorithm combining plasma/serum CP, anti-CCP antibody and hydroxyproline applied to a cohort gave specific and sensitive detection and discrimination of eOA, eRA, other non-RA inflammatory joint diseases and good skeletal health.(({{pubmed>long:25788417}}))</blockquote>+Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.  <blockquote>We detected CP in the plasma of healthy subjects and surprisingly found that CP was increased in both patients with eOA and eRA whereas anti-CCP antibodies were predominantly present in eRA. A 4-class diagnostic algorithm combining plasma/serum CP, anti-CCP antibody and hydroxyproline applied to a cohort gave specific and sensitive detection and discrimination of eOA, eRA, other non-RA inflammatory joint diseases and good skeletal health.(({{pmid>long:25788417}}))</blockquote>
  
 After adjusting for all the covariates, the relative odds (95% confidence interval) of developing definite knee OA per increment of 1 SD (20.7 ng/mL) in winter season 25(OH)D was 1.57 (1.10-2.27), whereas for summer season sera the corresponding rate was 0.53 (0.28-1.00). After adjusting for all the covariates, the relative odds (95% confidence interval) of developing definite knee OA per increment of 1 SD (20.7 ng/mL) in winter season 25(OH)D was 1.57 (1.10-2.27), whereas for summer season sera the corresponding rate was 0.53 (0.28-1.00).
-CONCLUSION: The results do not support the hypothesis that a low level of serum 25(OH)D contributes to the development of OA. (({{pubmed>long:22043944}})) +CONCLUSION: The results do not support the hypothesis that a low level of serum 25(OH)D contributes to the development of OA. (({{pmid>long:22043944}})) 
          
 {{tag>disease }} {{tag>disease }}
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
 +Somewhere I think I have seen the idea that microbes multipy with ease in damged tissu... if only i knew where (sigh) --- //Sallie Q 02.17.2019//
 +
 +
 +//broken link//
 broken promise ?? broken promise ??
 The Promise of a Tetracycline Antibiotic for Treating Osteoarthritis The Promise of a Tetracycline Antibiotic for Treating Osteoarthritis
-[[http://www.soundmedicine.iu.edu/segment.php4?seg=104|An Antibiotic to Slow Osteoarthritis]]+[[https://www.soundmedicine.iu.edu/segment.php4?seg=104|An Antibiotic to Slow Osteoarthritis]]
  
 <DiseaseHierarchy> <DiseaseHierarchy>
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   * legacy content   * legacy content
-  * http://www.marshallprotocol.com/view_topic.php?id=3220&forum_id=37&jump_to=45630#p45630 s249+  * https://www.marshallprotocol.com/view_topic.php?id=3220&forum_id=37&jump_to=45630#p45630 s249 
  
 +https://www.webmd.com/osteoarthritis/news/20101108/vitamin-d-fails-osteoarthritis-test?ecd=wnl_art_111910
  
-http://www.webmd.com/osteoarthritis/news/20101108/vitamin-d-fails-osteoarthritis-test?ecd=wnl_art_111910 
  
 +===== References =====</nodisp>
  
-===== References ===== 
home/diseases/osteoarthritis.1547172169.txt.gz · Last modified: 01.11.2019 by sallieq
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