This shows you the differences between two versions of the page.
home:diseases:osteoporosis_osteopenia [02.02.2020] – [Patients experiences] sallieq | home:diseases:osteoporosis_osteopenia [09.14.2022] (current) – external edit 127.0.0.1 | ||
---|---|---|---|
Line 38: | Line 38: | ||
* minimizing intake of caffeine | * minimizing intake of caffeine | ||
* refraining from excess alcohol or sodium consumption | * refraining from excess alcohol or sodium consumption | ||
- | * limiting smoking (({{pubmed> | + | * limiting smoking (({{pmid> |
* weaning from drugs, which lead to bone loss including: | * weaning from drugs, which lead to bone loss including: | ||
* [[home: | * [[home: | ||
Line 70: | Line 70: | ||
- | * **high levels of 1,25-D affect osteoclast activity** – When functioning properly, the Vitamin D Receptor contributes to bone health in an underecognized way distinct from other classical calcium regulating hormones.(({{pubmed> | + | * **high levels of 1,25-D affect osteoclast activity** – When functioning properly, the Vitamin D Receptor contributes to bone health in an underecognized way distinct from other classical calcium regulating hormones.(({{pmid> |
- | * **osteoporotic bone has lower levels of expression //of// VDR** – A recent study evaluating expression of (rather than by) the VDR in platelets in osteoporotic bone versus healthy subjects.(({{pubmed> | + | * **osteoporotic bone has lower levels of expression //of// VDR** – A recent study evaluating expression of (rather than by) the VDR in platelets in osteoporotic bone versus healthy subjects.(({{pmid> |
* lower levels of VDR in all patients, | * lower levels of VDR in all patients, | ||
* number of VDRs was positively correlated with bone density, and | * number of VDRs was positively correlated with bone density, and | ||
Line 80: | Line 80: | ||
< | < | ||
- | In addition, if the VDR is blocked, the enzyme CYP24 is not transcribed. Since CYP24 is needed to keep levels of 1,25-D in check, the level of 1,25-D becomes greatly elevated in individuals without the active enzyme. The cytokine release stimulated by Th1 pathogens activates the pathway which causes increased production of CYP27B1, the enzyme that converts 25-D into 1,25-D. As more conversion occurs, the level of 1,25-D in the body rises.(({{pubmed> | + | In addition, if the VDR is blocked, the enzyme CYP24 is not transcribed. Since CYP24 is needed to keep levels of 1,25-D in check, the level of 1,25-D becomes greatly elevated in individuals without the active enzyme. The cytokine release stimulated by Th1 pathogens activates the pathway which causes increased production of CYP27B1, the enzyme that converts 25-D into 1,25-D. As more conversion occurs, the level of 1,25-D in the body rises.(({{pmid> |
--> | --> | ||
</ | </ | ||
Line 86: | Line 86: | ||
===== Other treatments ===== | ===== Other treatments ===== | ||
- | Calcitonin | + | Calcitonin |
< | < | ||
Line 93: | Line 93: | ||
</ | </ | ||
+ | |||
+ | |||
+ | ==== Boron ==== | ||
+ | |||
+ | [[https:// | ||
+ | |||
+ | < | ||
==== Cannabinoids | ==== Cannabinoids | ||
- | An optimal correlation of cannabinoid dose, duration, moment of action, and affinity can lead to an increased bone regeneration capacity | + | An optimal correlation of cannabinoid dose, duration, moment of action, and affinity can lead to an increased bone regeneration capacity |
- | Heavy cannabis use is associated with low bone mineral density, low BMI, high bone turnover, and an increased risk of fracture. (({{pubmed> | + | Heavy cannabis use is associated with low bone mineral density, low BMI, high bone turnover, and an increased risk of fracture. (({{pmid> |
Line 106: | Line 113: | ||
[[https:// | [[https:// | ||
- | Cannabinoids induce incomplete maturation of cultured human leukemia cells. (({{pubmed> | + | Cannabinoids induce incomplete maturation of cultured human leukemia cells. (({{pmid> |
+ | |||
+ | The psychoactive component of marijuana, delta9-tetrahydrocannabinol (THC) suppresses different functions of immunocytes, | ||
+ | |||
+ | the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, | ||
- | The psychoactive component of marijuana, delta9-tetrahydrocannabinol (THC) suppresses different functions of immunocytes, | ||
- | the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, | ||
==== Calcium supplementation ==== | ==== Calcium supplementation ==== | ||
Line 123: | Line 132: | ||
==== TNF-alpha drugs ==== | ==== TNF-alpha drugs ==== | ||
- | Multiple research teams have found that drugs which inhibit production of TNF-alpha lead to a short-term increase in patients’ spine and femoral bone mineral density. (({{pubmed> | + | Multiple research teams have found that drugs which inhibit production of TNF-alpha lead to a short-term increase in patients’ spine and femoral bone mineral density. (({{pmid> |
It should be noted that [[home: | It should be noted that [[home: | ||
Line 130: | Line 139: | ||
==== Vitamin D supplementation ==== | ==== Vitamin D supplementation ==== | ||
- | Some clinicians encourage patients with inadequate bone density to supplement with vitamin D and calcium. (({{pubmed> | + | Some clinicians encourage patients with inadequate bone density to supplement with vitamin D and calcium. (({{pmid> |
- | < | + | < |
- | < | + | < |
" | " | ||
Line 141: | Line 150: | ||
^Author/ | ^Author/ | ||
- | |Steven R. Cummings, MD; Douglas P. Kiel, MD, MPH; Dennis M. Black, PhD, 2016 (({{pubmed> | + | |Steven R. Cummings, MD; Douglas P. Kiel, MD, MPH; Dennis M. Black, PhD, 2016 (({{pmid> |
- | |Karen E. Hansen, MD, MS; R. Erin Johnson, BS; Kaitlin R. Chambers, BS et al., 2015 (({{pubmed> | + | |Karen E. Hansen, MD, MS; R. Erin Johnson, BS; Kaitlin R. Chambers, BS et al., 2015 (({{pmid> |
- | |J Christopher Gallagher, | + | |J Christopher Gallagher, |
- | |Gallagher JC1, Yalamanchili V, Smith LM., 2012(({{pubmed> | + | |Gallagher JC1, Yalamanchili V, Smith LM., 2012(({{pmid> |
- | |Brunner //et al.//, 2008(({{pubmed> | + | |Brunner //et al.//, 2008(({{pmid> |
- | |Tang //et al.//, 2007 (({{pubmed> | + | |Tang //et al.//, 2007 (({{pmid> |
- | |Porthouse //et al.//, 2005(({{pubmed> | + | |Porthouse //et al.//, 2005(({{pmid> |
- | |Sanders KM1, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. 2010(({{pubmed> | + | |Sanders KM1, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. 2010(({{pmid> |
A number of recent studies examining calcium and vitamin D supplementation are compromised by a flaw in methodology: | A number of recent studies examining calcium and vitamin D supplementation are compromised by a flaw in methodology: | ||
- | For example, one study found that calcium supplementation (750 mg) improved bone density over a four-year period, whereas vitamin D supplementation (600 IU) had no effect. In fact, the effect of calcium on bone loss was blunted in subjects with the highest levels of vitamin D, causing the team to point out the danger of over-supplementation of the elderly with vitamin D if they have an adequate calcium intake.(({{pubmed> | + | For example, one study found that calcium supplementation (750 mg) improved bone density over a four-year period, whereas vitamin D supplementation (600 IU) had no effect. In fact, the effect of calcium on bone loss was blunted in subjects with the highest levels of vitamin D, causing the team to point out the danger of over-supplementation of the elderly with vitamin D if they have an adequate calcium intake.(({{pmid> |
In the case of studies showing a neutral effect of vitamin D and calcium supplementation, | In the case of studies showing a neutral effect of vitamin D and calcium supplementation, | ||
Line 162: | Line 171: | ||
< | < | ||
- | // | + | // |
Adams' | Adams' | ||
- | Similarly, researchers at the University of Science and Technology in Norway published a study that measured the forearm bone mineral density of 3,042 Norwegian women, aged 50 to 70 years old. They found that those women who had not taken cod liver oil (a substance that contains high levels of vitamin D) during childhood had higher bone mineral density compared to those who had ingested cod liver oil.(({{pubmed> | + | Similarly, researchers at the University of Science and Technology in Norway published a study that measured the forearm bone mineral density of 3,042 Norwegian women, aged 50 to 70 years old. They found that those women who had not taken cod liver oil (a substance that contains high levels of vitamin D) during childhood had higher bone mineral density compared to those who had ingested cod liver oil.(({{pmid> |
- | Yet another example came in a 2010 double-blind, | + | Yet another example came in a 2010 double-blind, |
=== Molecular evidence against vitamin D supplementation === | === Molecular evidence against vitamin D supplementation === | ||
- | Contrary to most received wisdom, vitamin D does not enhance the absorption of calcium. As Aloia showed there is no relationship whatsoever between 25-D levels and calcium absorption.(({{pubmed> | + | Contrary to most received wisdom, vitamin D does not enhance the absorption of calcium. As Aloia showed there is no relationship whatsoever between 25-D levels and calcium absorption.(({{pmid> |
- | By way of contrast, the Vitamin D Receptor is a receptor that transcribes thousands of genes,(({{pubmed> | + | By way of contrast, the Vitamin D Receptor is a receptor that transcribes thousands of genes,(({{pmid> |
< | < | ||
Line 185: | Line 194: | ||
===== Evidence of infectious cause ===== | ===== Evidence of infectious cause ===== | ||
- | * **certain antibiotics help strengthen bones** – NIH animal studies have shown that minocycline, | + | * **certain antibiotics help strengthen bones** – NIH animal studies have shown that minocycline, |
- | * **connection with disparate diseases** – the NIH connects several Th1 diseases with higher risk of osteoporosis, | + | * **connection with disparate diseases** – the NIH connects several Th1 diseases with higher risk of osteoporosis, |
Line 197: | Line 206: | ||
< | < | ||
- | My (//not on MP//) husband' | + | My husband' |
Line 243: | Line 252: | ||
===== Recent Research ===== | ===== Recent Research ===== | ||
- | //Zhao JG, Zeng XT, Wang J, Liu L. in// Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. (({{pubmed> | + | //Zhao JG, Zeng XT, Wang J, Liu L. in// Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. (({{pmid> |
< | < | ||
Line 253: | Line 262: | ||
- | //Bolland MJ, Grey A and Avenell A. in// Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, | + | //Bolland MJ, Grey A and Avenell A. in// Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, |
Line 266: | Line 275: | ||
< | < | ||
- | This large scale GWAS meta-analysis for fracture identified 15 genetic determinants of fracture, all of which also influenced bone mineral density. Among the clinical risk factors for fracture assessed, only bone mineral density showed a major causal effect on fracture. Genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy sources were not associated with fracture risk. (({{pubmed> | + | This large scale GWAS meta-analysis for fracture identified 15 genetic determinants of fracture, all of which also influenced bone mineral density. Among the clinical risk factors for fracture assessed, only bone mineral density showed a major causal effect on fracture. Genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy sources were not associated with fracture risk. (({{pmid> |
{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
Line 277: | Line 287: | ||
* To do - create new article for secondary hyperparathyroidism. | * To do - create new article for secondary hyperparathyroidism. | ||
- | * To begin with, patients with chronic disease may obtain less of a benefit from calcium supplements since the calcium metabolism of patients suffering from chronic disease is different from that of healthy individuals.(({{pubmed> | + | * To begin with, patients with chronic disease may obtain less of a benefit from calcium supplements since the calcium metabolism of patients suffering from chronic disease is different from that of healthy individuals.(({{pmid> |
* Legacy content | * Legacy content | ||
* f166 | * f166 | ||
Line 291: | Line 301: | ||
* f97 | * f97 | ||
- | http:// | + | https:// |
I removed this. I'm not too sure how this quote was helping. It is unprofessional, | I removed this. I'm not too sure how this quote was helping. It is unprofessional, | ||
Line 308: | Line 318: | ||
All the intricate central processing takes place in the hypothalamus, | All the intricate central processing takes place in the hypothalamus, | ||
- | From: [[http:// | + | From: [[https:// |
</ | </ | ||
Line 325: | Line 335: | ||
< | < | ||
- | http:// | + | https:// |
So why do we continue to ' | So why do we continue to ' | ||
- | | + | |
IMO Vitamin D will turn out to be the biggest, and most costly, mistake that Medicine has ever made. Worse than Thalidomide. Worse than FenFen. It is just a matter of time until the people taking high doses of Vitamin D find that not only is it harming them, but they cannot even wean from this steroid. | IMO Vitamin D will turn out to be the biggest, and most costly, mistake that Medicine has ever made. Worse than Thalidomide. Worse than FenFen. It is just a matter of time until the people taking high doses of Vitamin D find that not only is it harming them, but they cannot even wean from this steroid. | ||
Line 347: | Line 357: | ||
CONCLUSIONS: | CONCLUSIONS: | ||
PMID: 20948558</ | PMID: 20948558</ | ||
- | ===== References ===== | + | ===== References =====</ |