Antifungal agents

Antifungal agents such as fluconazole (Diflucan) are sometimes prescribed to treat fungal infections, of which Candida is one kind. While some patients have reported feeling better after taking antifungal agents, antifungals interfere with immune function.

The antifungals directly inhibit the enzyme CYP27B1, which is needed for the mitichondria in the macrophages to convert 25-DThe vitamin D metabolite widely (and erroneously) considered best indicator of vitamin D "deficiency." Inactivates the Vitamin D Nuclear Receptor. Produced by hydroxylation of vitamin D3 in the liver. to 1,25-DPrimary biologically active vitamin D hormone. Activates the vitamin D nuclear receptor. Produced by hydroxylation of 25-D. Also known as 1,25-dihydroxycholecalciferol, 1,25-hydroxyvitamin D and calcitirol..¹⁾ With an artificially depressed rate of generating 1,25-D, patients taking antifungals tend to feel better for a period and then relapse worse than before.

By increasing levels of 25-D and therefore inhibiting immunopathologyA temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed., long-term use of antifungal drugs may delay progress on the Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP).

Note that, at least according to one study, patients are a poor judge of whether they have fungal infections.

Patient symptom scores were a poor predictor of yeast infections based on yeast culture results. … Self-reported symptoms are not reliable for diagnosis.

Susan Hoffstetter et al. ²⁾

• afluconazole (Diflucan)
• griseofulvin (Fulvicin)
• itraconazole (Sporonox)
• ketoconazole (Nizoral)
• nimesulide (Aulin, Mesulid, Nimed) - may promote bleeding
• nystatin
• terfinabine (Lamisil)

If candida is suspected, I usually treat prior to starting MP. This is often helpful also as gives a mild herx reaction and can prepare them for MP herx. Occasionally, I have used nystatin with patients on Benicar. These are usually patients who have had high dose antibiotics for Lyme disease in the past. This is very rare though.

Dr G.B.

Ketoconazole cream, sometimes referred to as “K-cream,” is a topical cream or shampoo that may reduce sun flare or light-driven immunopathology. Although ketoconazole cream was once recommended to MP patients, the recommendation that patients routinely use K-cream has been withdrawn. Like the other antifungals, ketoconazole cream may inhibit bacteria die-off, especially in the skin areas where it has the highest concentration.

Patients for whom light sensitivity is a problem should consider zinc oxide as an alternative for preventing moderate symptoms associated with sun exposure that cannot be avoided. For some of the most severely sun sensitive, ketoconazole cream or shampoo seems to work better for preventing or reducing sun flare symptoms, but for others, zinc oxide (not an anti-fungal) seems to work better. Both may have inhibitory effects on the immune response.

Before the MP, I tolerated nystatin but the Diflucan shut down my liver function. I never saw big improvenments in my health with the nystatin, so I don't think the yeast was a major part of the underlying problem with me. Diet changes as you know should go along with any possible course of nystatin. As the immune system kicks in on the MP, the yeast infections seem to be much less frequent or stop altogether.

P.Bear, MarshallProtocol.com

I was at the doc for my annual physical and he suggested a anti-fungal medication. I knew I was “playing with fire” but I was feeling very well- excercising regularly and taking a sauna at least three time per week- without any IP. Well, six weeks into the anti-fungal medication, I was awaken from a sound sleep into a deep, very physical panic attack.

I stopped the medication immediately. That was a few days ago. I have not had any (further) panic attacks but the anxiety and depression have been significant.

bobi August 2017

From: Dr. Greg Blaney Date: 2010-07-04 14:39:15 Reply: http://www.marshallprotocol.com/reply.php?topic_id=13184

If candida is suspected, I usually treat prior to starting MP. This is often helpful also as gives a mild herx reaction and can prepare them for MP herx. Occasionally, I have used nystatin with patients on Benicar. These are usually patients who have had high dose antibiotics for Lyme disease in the past. This is very rare though.

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  • http://www.marshallprotocol.com/view_topic.php?id=3139&forum_id=37&jump_to=34393#p34393 s226

I did a quick pubmed seach and found two useful articles that indicate natamycin’s action may be “to disturb ergosterol-dependent protein functions” and that “natamycin acts via a novel mode of action and blocks fungal growth by binding specifically to ergosterol” rather than acting on the fungi cell membrane.

1. Natamycin Inhibits Vacuole Fusion at the Priming Phase via a Specific Interaction with Ergoste http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876427/

2. Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. http://www.jbc.org/content/283/10/6393.long

While a search in wikapedia states under natamycin saftety that, “Natamycin lacks acute toxicity“ it then goes on to state that “In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.”