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+ | Wikipedia says | ||
+ | The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.[2] | ||
+ | and | ||
+ | Anti-metabolites masquerade as a purine (azathioprine, | ||
+ | |||
+ | Antimetabolite | ||
+ | Also found in: Dictionary, Thesaurus, Medical, Encyclopedia. | ||
+ | Related to Antimetabolite: | ||
+ | The drug methotrexate (right) is an antimetabolite that interferes with the metabolism of folic acid (left). | ||
+ | |||
+ | An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism.[1] Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.[2] | ||
+ | |||
+ | Function | ||
+ | Cancer treatment | ||
+ | |||
+ | Antimetabolites can be used in cancer treatment, | ||
+ | |||
+ | Anti-metabolites masquerade as a purine (azathioprine, | ||
+ | |||
+ | They also affect RNA synthesis. However, because thymidine is used in DNA but not in RNA (where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. | ||
+ | |||
+ | Antimetabolites may also be antibiotics, | ||
+ | Types | ||
+ | |||
+ | Main categories of these drugs include: | ||
+ | |||
+ | base analogs (altered nucleobases): | ||
+ | purine analogues | ||
+ | pyrimidine analogues | ||
+ | nucleoside analogues: | ||
+ | nucleosides with altered nucleobases | ||
+ | nucleosides with altered sugar component (e.g. Cytarabine, ...) | ||
+ | nucleotide analogues | ||
+ | antifolates | ||
{{tag> | {{tag> |
home/othertreatments/antimetabolites.txt · Last modified: 09.14.2022 by 127.0.0.1
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