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home:othertreatments:antioxidants [07.03.2011] – [Interference with apoptosis] paulalbert | home:othertreatments:antioxidants [09.14.2022] (current) – external edit 127.0.0.1 | ||
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Evidence supporting the efficacy of antioxidants against disease is limited. | Evidence supporting the efficacy of antioxidants against disease is limited. | ||
- | Supplementation with antioxidants beyond the [[http:// | + | Supplementation with antioxidants beyond the [[https:// |
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==== Interference with apoptosis ==== | ==== Interference with apoptosis ==== | ||
- | Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Reactive oxygen species (ROS) are chemically-reactive molecules containing oxygen, which act to neutralize antioxidants, | + | Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Reactive oxygen species (ROS) are chemically-reactive molecules containing oxygen, which act to neutralize antioxidants, |
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Since the early 1990s scientists have been putting antioxidants through their paces, using double-blind randomised controlled trials - the gold standard for medical intervention studies. Time and again, however, the supplements failed to pass the test. True, they knock the wind out of free radicals in a test tube. But once inside the human body, they seem strangely powerless. Not only are they bad at preventing oxidative damage, they can even make things worse. At worst, antioxidants may even have the opposite effect, promoting the very problems they are supposed to stamp out. | Since the early 1990s scientists have been putting antioxidants through their paces, using double-blind randomised controlled trials - the gold standard for medical intervention studies. Time and again, however, the supplements failed to pass the test. True, they knock the wind out of free radicals in a test tube. But once inside the human body, they seem strangely powerless. Not only are they bad at preventing oxidative damage, they can even make things worse. At worst, antioxidants may even have the opposite effect, promoting the very problems they are supposed to stamp out. | ||
- | //**Lisa Melton**, [[http:// | + | //**Lisa Melton**, [[https:// |
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< | < | ||
- | In 1992 researchers at the US National Cancer Institute set about testing beta carotene. They recruited more than 18,000 people at high risk of developing lung cancer, either because they smoked or had been exposed to asbestos, and gave around half of them beta carotene supplements.(({{pubmed> | + | In 1992 researchers at the US National Cancer Institute set about testing beta carotene. They recruited more than 18,000 people at high risk of developing lung cancer, either because they smoked or had been exposed to asbestos, and gave around half of them beta carotene supplements.(({{pmid> |
- | //**Lisa Melton**, [[http:// | + | //**Lisa Melton**, [[https:// |
==== Vitamin E ==== | ==== Vitamin E ==== | ||
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It's a similar story with the world' | It's a similar story with the world' | ||
- | //**Lisa Melton**, [[http:// | + | //**Lisa Melton**, [[https:// |
====Vitamin C ==== | ====Vitamin C ==== | ||
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Vitamin C is another disappointment. " | Vitamin C is another disappointment. " | ||
- | //**Lisa Melton**, [[http:// | + | //**Lisa Melton**, [[https:// |
- | Researchers at Memorial Sloan-Kettering Cancer Center studied the effects of vitamin C on cancer cells.(({{pubmed> | + | Researchers at Memorial Sloan-Kettering Cancer Center studied the effects of vitamin C on cancer cells.(({{pmid> |
Dr. Heaney and his colleagues tested five different chemotherapy drugs on cancer cells in the laboratory. Some of the cells were first treated with vitamin C. In each case and in dose-dependent fashion, chemotherapy did not work as well if cells had been exposed to vitamin C. The chemotherapy agents killed 30 to 70 percent fewer cancer cells when the cells were treated with the vitamin. | Dr. Heaney and his colleagues tested five different chemotherapy drugs on cancer cells in the laboratory. Some of the cells were first treated with vitamin C. In each case and in dose-dependent fashion, chemotherapy did not work as well if cells had been exposed to vitamin C. The chemotherapy agents killed 30 to 70 percent fewer cancer cells when the cells were treated with the vitamin. | ||
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==== Selenium ==== | ==== Selenium ==== | ||
- | A food frequency questionaire administered to 7,182 women in Northern Italy found that increased dietary selenium intake was associated with an increased risk of type 2 diabetes.(({{pubmed> | + | A food frequency questionaire administered to 7,182 women in Northern Italy found that increased dietary selenium intake was associated with an increased risk of type 2 diabetes.(({{pmid> |
==== Other compounds ==== | ==== Other compounds ==== | ||
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===== Read more ===== | ===== Read more ===== | ||
- | * [[http:// | + | * [[https:// |
{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | EDIT | + | |
"It may well be that the only one benefiting from supplements is the one making the profits." | "It may well be that the only one benefiting from supplements is the one making the profits." | ||
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* Legacy content | * Legacy content | ||
- | * http:// | + | * https:// |
* | * | ||
* This whole article is awkward reading. Can some of the block quotes be worked into text blocks or the sources be made more evident? | * This whole article is awkward reading. Can some of the block quotes be worked into text blocks or the sources be made more evident? | ||
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Another important mechanism involved in the host response to infection is oxidative stress, which plays a major role in the systemic inflammatory response in bacterial(16178750) and viral infections.(15944946)(Olteanu, | Another important mechanism involved in the host response to infection is oxidative stress, which plays a major role in the systemic inflammatory response in bacterial(16178750) and viral infections.(15944946)(Olteanu, | ||
- | ===== References ===== | + | ===== References =====</ |