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--- home:othertreatments:boneagents [10.24.2010] – external 127.0.0.1
+++ home:othertreatments:boneagents [09.14.2022] (current) – external edit 127.0.0.1
@@ Line 3: / Line 3: @@
-<relatedarticle> [[home:diseases|Osteoporosis and osteopenia]] </article>
+<relatedarticle> [[home:diseases:osteoporosis_osteopenia|Osteoporosis and osteopenia]] </article>
 A variety of medications including the bisphosphonates have been touted to conserve or increase bone mass. These drugs have a number of side effects and are known or suspected to interfere with proper immune function.
@@ Line 10: / Line 10: @@
 Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digesting of bone by osteoclasts.
-The bisphosphonate has a variety of side effects:(({{pubmed>long:19371818}}))
+The bisphosphonate has a variety of side effects:(({{pmid>long:19371818}}))
-  * chronic musculoskeletal pain(({{pubmed>long:17627083}}))
+  * chronic musculoskeletal pain(({{pmid>long:17627083}}))
-  * atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pubmed>long:8114238}}))
+  * atrial fibrillation – Numerous studies have shown that the frequency of atrial fibrillation increases with increasing age in both men and women. Data from the Framingham Heart Study showed a greater biennial incidence of AF with increasing age, with the odds ratio rising by a factor of 2.2 for every additional 10 years of age.(({{pmid>long:8114238}}))
-  * calcium deposition in the soft tissues(({{pubmed>long: 14523647}}))
+  * calcium deposition in the soft tissues(({{pmid>long: 14523647}}))
   * osteonecrosis of the jaw, i.e. bone death
   * reduced organ function, e.g. renal dysfunction or failure
@@ Line 37: / Line 37: @@
   * **calcitonin (Miacalcin nasal spray)** – A synthetic hormone with unknown effects on the immune system
-  * **raloxifene  (Evista)** – An oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention ofosteoporosis in postmenopausal women. In a 2006 study published in //New England Journal of Medicine//, raloxifene produced significantly more strokes and blood clots than the placebo.(({{pubmed>long: 16837676}}))
+  * **raloxifene  (Evista)** – An oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention ofosteoporosis in postmenopausal women. In a 2006 study published in //New England Journal of Medicine//, raloxifene produced significantly more strokes and blood clots than the placebo.(({{pmid>long: 16837676}}))
   * **teriparatide (Forteo)** – A hormonal injection of parathyroid hormone, a hormone secreted by the parathyroid gland that regulates calcium in the body. Parathyroid hormone controls many other hormones, and may cause deposition of calcium into soft tissues.
 {{tag>non-MP_therapies}}
+<nodisp>
 ===== Notes and comments =====
-EDIT
-===== References =====
+FDA Alert - Oral Bisphosphonates: Ongoing Safety Review - https://bit.ly/9EfpXY
+===== References ===== </nodisp>

home/othertreatments/boneagents.txt · Last modified: 09.14.2022 by 127.0.0.1