Differences

This shows you the differences between two versions of the page.

--- home:othertreatments:chemotherapy [11.13.2011] – [Rituximab] paulalbert
+++ home:othertreatments:chemotherapy [12.10.2011] – paulalbert
@@ Line 27: / Line 27: @@
 ===== Methotrexate =====
-Methotrexate (MTX) is an antibiotic, which interferes with bacteria's ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol antibiotic, Bactrim DS:
+<mainarticle> [[home:othertreatments:antibacterials:methotrexate|Methotrexate]] </article>
-<blockquote>MTX is an anti-folate – actually it is an anti-dihydrofolate reductase (anti-DHFR) – which inhibits one stage in the formation of DNA. Thus any bacteria dwelling within a body which has MTX in the bloodstream will find it more difficult to replicate, and hopefully the bacteria will gradually die off. Bactrim (Sulfa/trimeth) not only blocks DHFR (with trimethoprim) but also blocks P-ABA with Sulfonamide. Here is a diagram showing the Folate biochemistry in more detail. As you know, Bactrim is not a terribly effective antibiotic against intracellular pathogens, at least acting on its own. Neither is MTX especially effective acting on its own.
+Methotrexate (MTX) is an antibiotic, which interferes with bacteria's ability to synthesize folate. It is used to treat diseases with rapid cell growth such as cancer and some autoimmune diseases. A superior alternative to MTX is the Marshall Protocol antibiotic, Bactrim DS.
-The interesting thing is that Folic Acid supplements are often given to ease the "side effects" of MTX. Folic Acid directly reduces the antibiotic action of both Trimethoprim and MTX. Sure, this may reduce pain from the immunopathology, but wouldn't it be more sensible to just lower the dose of MTX and reduce the risk of liver damage.
-//**Trevor Marshall, PhD**// </blockquote>
-==== Discontinuing methotrexate ====
-The antibiotic action of MTX is likely to increase the immunopathology associated with olmesartan (Benicar) therapy, which is why patients should discontinue MTX before starting the Marshall Protocol.
-It is not harmful to the body to discontinue MTX abruptly. This is in contrast to Prednisone, where abruptly stopping can cause a number of serious problems. Some doctors think there is a risk of rebound inflammation from stopping methotrexate abruptly. Taking a few weeks to wean from MTX, while probably not necessary, is the cautious approach to avoid the symptoms of rebound inflammation.
 ===== Rituximab =====
-In 2011, a Norwegian study published in //PLoS One// studied the effect of Rituximab – a monoclonal antibody otherwise used in cancers and anti-rejection treatment for organ transplants – on patients with CFS. In the 25-week study period, fatigue improved significantly in 10 out of 15 patients versus 2 out of 15 controls.(({{pubmed>long:22039471}})) This positive result may be due to the fact that Rituximab is a strong immunosuppressant. It may be telling to see a follow up of the patients who received the drug ten or even fifteen years from now.
+In 2011, a Norwegian study published in //PLoS One// studied the effect of Rituximab – a monoclonal antibody otherwise used in cancers and anti-rejection treatment for organ transplants – on patients with chronic fatigue syndrome. In the 25-week study period, fatigue improved significantly in 10 out of 15 patients versus 2 out of 15 controls.(({{pubmed>long:22039471}})) This positive result may be due to the fact that Rituximab is a strong immunosuppressant. It may be telling to see a follow up of the patients who received the drug ten or even fifteen years from now.
 =====  Patient interviews  =====

home/othertreatments/chemotherapy.txt · Last modified: 09.14.2022 by 127.0.0.1