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home:othertreatments:corticosteroids [04.09.2011] – [Notes and comments] paulalberthome:othertreatments:corticosteroids [09.14.2022] (current) – external edit 127.0.0.1
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 ===== Corticosteroids are ineffective ====== ===== Corticosteroids are ineffective ======
  
-There are no studies which show that steroids improve long-term prognosis in the treatment of illness. Van den Bosch and Grutters write(({{pubmed>long:16946094}})), "Remarkably, despite over 50 years of use, there is no proof of long-term (survival) benefit from corticosteroid treatment."+There are no studies which show that steroids improve long-term prognosis in the treatment of illness. Van den Bosch and Grutters write(({{pmid>long:16946094}})), "Remarkably, despite over 50 years of use, there is no proof of long-term (survival) benefit from corticosteroid treatment."
  
-The 2003 NIH ACCESS study(({{pubmed>long:14620163}})), the largest and most ambitious to date, validates that these drugs are ineffective for sarcoidosis patients, even for a time period as short as two years.+The 2003 NIH ACCESS study(({{pmid>long:14620163}})), the largest and most ambitious to date, validates that these drugs are ineffective for sarcoidosis patients, even for a time period as short as two years.
  
 Table 3 in the paper shows how, for the majority of patients, markers of the disease process remained unchanged. Table 3 in the paper shows how, for the majority of patients, markers of the disease process remained unchanged.
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 Latent pathogens grow slowly and accumulate over the course of decades. There is every reason to believe that a longer-term study as well as one looking at dose would further demonstrate how corticosteroids are worse than ineffective – they're dangerous. A more comprehensive paper would also have examined the range of negative side effects associated with coriticosteroid use. Latent pathogens grow slowly and accumulate over the course of decades. There is every reason to believe that a longer-term study as well as one looking at dose would further demonstrate how corticosteroids are worse than ineffective – they're dangerous. A more comprehensive paper would also have examined the range of negative side effects associated with coriticosteroid use.
  
-A systematic review(({{pubmed>long:15846612}})) of studies looking at the efficacy of inhaled and oral corticosteroids for pulmonary sarcoidosis concluded:+A systematic review(({{pmid>long:15846612}})) of studies looking at the efficacy of inhaled and oral corticosteroids for pulmonary sarcoidosis concluded:
  
 <blockquote> <blockquote>
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 ==== Corticosteroids cause relapse ===== ==== Corticosteroids cause relapse =====
  
-According to a comparative study(({{pubmed>long:9118698}})), 74% of patients relapse after trying to ease up their Prednisone dose, a significantly higher percentage of the time, and: +According to a comparative study(({{pmid>long:9118698}})), 74% of patients relapse after trying to ease up their Prednisone dose, a significantly higher percentage of the time, and: 
  
 <blockquote> <blockquote>
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 ===== Side effects of corticosteroid therapy ===== ===== Side effects of corticosteroid therapy =====
  
-Corticosteroid therapy can produce a range of negative side effects in humans. Side effects tend to be dose- and duration-dependent. The table below summarizes some of the more common side effects. A more [[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&term=%22Glucocorticoids%2Fadverse%20effects%22[MAJR]|complete and up-to-date list]] of such studies is available at PubMed.+Corticosteroid therapy can produce a range of negative side effects in humans. Side effects tend to be dose- and duration-dependent. The table below summarizes some of the more common side effects. A more [[https://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&term=%22Glucocorticoids%2Fadverse%20effects%22[MAJR]|complete and up-to-date list]] of such studies is available at PubMed.
  
  
 ^System or function ^ Side effect^ ^System or function ^ Side effect^
-|brain    |loss of brain tissue(({{pubmed>long:15882880}})) loss of cognition(({{pubmed>long:12013026}}))     | +|brain    |loss of brain tissue(({{pmid>long:15882880}})) loss of cognition(({{pmid>long:12013026}}))     | 
-|bone   |avascular necrosis of the bone(({{pubmed>long:11850924}})) (({{pubmed>long:10099819}})) osteoporosis(({{pubmed>long:15732231}})) osteonecrosis(({{pubmed>long:18757967}}))| +|bone   |avascular necrosis of the bone(({{pmid>long:11850924}})) (({{pmid>long:10099819}})) osteoporosis(({{pmid>long:15732231}})) osteonecrosis(({{pmid>long:18757967}}))| 
-|endocrine |suppression of adrenal response(({{pubmed>long:10683005}})) (({{pubmed>long:9623166}})) widespread endocrine dysfunction(({{pubmed>long:2320881}})) Cushing's Syndrome(({{pubmed>long:15850848}})) | +|endocrine |suppression of adrenal response(({{pmid>long:10683005}})) (({{pmid>long:9623166}})) widespread endocrine dysfunction(({{pmid>long:2320881}})) Cushing's Syndrome(({{pmid>long:15850848}})) | 
-|eyes |cataracts(({{pubmed>long:3541262}})) glaucoma(({{pubmed>long:10641955}})) (({{pubmed>long:7701998}})) range of other side effects(({{pubmed>long:11820911}}))    | +|eyes |cataracts(({{pmid>long:3541262}})) glaucoma(({{pmid>long:10641955}})) (({{pmid>long:7701998}})) range of other side effects(({{pmid>long:11820911}}))    | 
-|gastrointestinal |gastrointestinal hemorrhage(({{pubmed>long:8927965}})) | +|gastrointestinal |gastrointestinal hemorrhage(({{pmid>long:8927965}})) | 
-|muscle  |loss of skeletal muscle(({{pubmed>long: 12843161}})) myopathy (muscle weakness)(({{pubmed>long: 6851197}})) (({{pubmed>long: 9551512}})) (({{pubmed>long: 10939120}}))   | +|muscle  |loss of skeletal muscle(({{pmid>long: 12843161}})) myopathy (muscle weakness)(({{pmid>long: 6851197}})) (({{pmid>long: 9551512}})) (({{pmid>long: 10939120}}))   | 
-|psychological |dementia(({{pubmed>long:15677408}})) | +|psychological |dementia(({{pmid>long:15677408}})) | 
-|sexual, female |menstruation disturbance(({{pubmed>long:2815743}}))| +|sexual, female |menstruation disturbance(({{pmid>long:2815743}}))| 
-|sexual, male |decrease testosterone(({{pubmed>long: 3083749}})) (({{pubmed>long: 7983641}})) | +|sexual, male |decrease testosterone(({{pmid>long: 3083749}})) (({{pmid>long: 7983641}})) | 
-|skin  |skin atrophy(({{pubmed>long:11393207}}))  |+|skin  |skin atrophy(({{pmid>long:11393207}}))  |
  
  
 ==== Side effects in children ==== ==== Side effects in children ====
  
-Whether taking injectable or inhaled corticosteroids, children are particularly susceptible to the negative long-term effects of the drugs. The table below summarizes some of the more common side effects in children. A more [[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Glucocorticoids%2Fadverse+effects%22[MAJR]+AND+%22Child%22[MeSH]|complete and up-to-date list]] of such studies is available at PubMed.+Whether taking injectable or inhaled corticosteroids, children are particularly susceptible to the negative long-term effects of the drugs. The table below summarizes some of the more common side effects in children. A more [[https://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=%22Glucocorticoids%2Fadverse+effects%22[MAJR]+AND+%22Child%22[MeSH]|complete and up-to-date list]] of such studies is available at PubMed.
  
 ^System or function ^ Side effect^ ^System or function ^ Side effect^
-|bone   |higher risk of fractures(({{pubmed>long:12733732}})) loss of density(({{pubmed>long:18595975}}))   | +|bone   |higher risk of fractures(({{pmid>long:12733732}})) loss of density(({{pmid>long:18595975}}))   | 
-|dental  |eruption of permanent molars(({{pubmed>long:15470830}}))     | +|dental  |eruption of permanent molars(({{pmid>long:15470830}}))     | 
-|endocrine |suppression of adrenal response(({{pubmed>long:15269067}})(({{pubmed>long:12904139}})) growth suppression(({{pubmed>long:1823076}})) (({{pubmed>long:9709954}})) (({{pubmed>long:11826253}})) Cushing's syndrome(({{pubmed>long:18183788}})) +|endocrine |suppression of adrenal response(({{pmid>long:15269067}})(({{pmid>long:12904139}})) growth suppression(({{pmid>long:1823076}})) (({{pmid>long:9709954}})) (({{pmid>long:11826253}})) Cushing's syndrome(({{pmid>long:18183788}})) 
-|immunological   |allergies(({{pubmed>long:11456363}})) |    +|immunological   |allergies(({{pmid>long:11456363}})) |    
-|psychological   |psychosis(({{pubmed>long:15851433}})) poor attention(({{pubmed>long:14577022}})) | +|psychological   |psychosis(({{pmid>long:15851433}})) poor attention(({{pmid>long:14577022}})) | 
-|skin     |skin death(({{pubmed>long:1806315}}))     | +|skin     |skin death(({{pmid>long:1806315}}))     | 
-|urinary  |kidney stones(({{pubmed>long:8576746}}))  |+|urinary  |kidney stones(({{pmid>long:8576746}}))  |
  
  
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 ==== Images of side effects ==== ==== Images of side effects ====
  
-Courtesy the [[http://vasculitis.med.jhu.edu/treatments/prednisone.html|Johns Hopkins Vasculitis Center]], these images are of corticosteroid users. (Click for a larger image and description.)+Courtesy the [[https://vasculitis.med.jhu.edu/treatments/prednisone.html|Johns Hopkins Vasculitis Center]], these images are of corticosteroid users. (Click for a larger image and description.)
  
 {{gallery>home:othertreatments:sideeffects?showtitle&150x150&3&lightbox&nodirect }} {{gallery>home:othertreatments:sideeffects?showtitle&150x150&3&lightbox&nodirect }}
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 {{tag>non-MP_therapies}} {{tag>non-MP_therapies}}
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
-OVERSEER+
   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum2/12438.html+    * https://www.marshallprotocol.com/forum2/12438.html
  
  
-  * **SARS and mental health problems** –  In a 2009 study, many survivors of the severe acute respiratory syndrome (SARS) pandemic of 2003 suffer from persistent mental health problems and chronic fatigue years later.(({{pubmed>long:20008700}})) Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, with 27.1% meeting the modified 1994 CDC criteria for chronic fatigue syndrome. Also, being a health care worker at the time of SARS infection more than tripled the risk of psychiatric morbidities at follow-up. This may be because corticoteroids were used heavily during the recent SARS outbreak.(({{pubmed>long:16172857}}))+  * **SARS and mental health problems** –  In a 2009 study, many survivors of the severe acute respiratory syndrome (SARS) pandemic of 2003 suffer from persistent mental health problems and chronic fatigue years later.(({{pmid>long:20008700}})) Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, with 27.1% meeting the modified 1994 CDC criteria for chronic fatigue syndrome. Also, being a health care worker at the time of SARS infection more than tripled the risk of psychiatric morbidities at follow-up. This may be because corticoteroids were used heavily during the recent SARS outbreak.(({{pmid>long:16172857}}))
  
  
 <blockquote>Hip necrosis can occur with a single dose of just 30mg of prednisone: <blockquote>Hip necrosis can occur with a single dose of just 30mg of prednisone:
  
-http://www.ncbi.nlm.nih.gov/pubmed/12189457+https://www.ncbi.nlm.nih.gov/pubmed/12189457
  
 ..Trevor.. ..Trevor..
 </blockquote> </blockquote>
-===== References =====+===== References =====</nodisp> 
home/othertreatments/corticosteroids.1302388340.txt.gz · Last modified: 04.09.2011 by paulalbert
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