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home:othertreatments:pain_medication [09.01.2019] – [Opioids] sallieqhome:othertreatments:pain_medication [09.14.2022] (current) – external edit 127.0.0.1
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   * **hydrocodone-acetaminophen (Lortab, Norco, Percocet, Vicodin, Xodol)** - Generally reported OK   * **hydrocodone-acetaminophen (Lortab, Norco, Percocet, Vicodin, Xodol)** - Generally reported OK
   * **ibuprofen (Motrin, Advil)** – of Motrin and Advil, Advil is preferred: Motrin has two times the additives a Motrin – 18 versus 9 – and the additives are some very difficult substances for the body to break down; //see NSAIDs//   * **ibuprofen (Motrin, Advil)** – of Motrin and Advil, Advil is preferred: Motrin has two times the additives a Motrin – 18 versus 9 – and the additives are some very difficult substances for the body to break down; //see NSAIDs//
-  * **ketamine** – An anesthetic drug commonly used in Lyme disease and chronic fatigue syndrome. Reports suggested that Ketamine doesn't work very well at palliation, and it loses efficacy quickly as the months go by. Also, Ketamine may damage bladder function.(({{pubmed>long:21684556}})) +  * **ketamine** – An anesthetic drug commonly used in Lyme disease and chronic fatigue syndrome. Reports suggested that Ketamine doesn't work very well at palliation, and it loses efficacy quickly as the months go by. Also, Ketamine may damage bladder function.(({{pmid>long:21684556}})) 
-  * **morphine** – avoid if possible - shown to be immunosuppressive in a study(({{pubmed>long:9208156}})) +  * **morphine** – avoid if possible - shown to be immunosuppressive in a study(({{pmid>long:9208156}})) 
-  * **naltrexone** – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone would certainly appear to affect the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.+  * **naltrexone** – an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. Naltrexone appears to negatively impact the ability of the MP to return the human immune system to full function again. Lymphocytes express opioid receptors, probably for a good reason. Even though that reason is not fully understood, it is not a good idea to block those opioid receptors (with naltrexone) if one expects to be able to return your immune system to normal.
  
  
-Ultra-low dose naltrexone enhances cannabinoid-induced antinociception.  (({{pubmed>long:16286810}}))+Ultra-low dose naltrexone enhances cannabinoid-induced antinociception.  (({{pmid>long:16286810}}))
  
 Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone. Surprisingly, the analgesic effects of opioids are enhanced by ultra-low doses (nanomolar to picomolar) of the opioid antagonist, naltrexone.
  
-<blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[http://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773|thread on CureMyTh1.org]] where these issues were briefly discussed.+<blockquote>Low dose naltrexone (LDN) is palliative. It doesn't help the innate immune system in any significant way. If it were helping the immune system to kill the microbiota then your immunopathology would increase, not decrease. However, I have looked into whether it is likely to stop healing, and it does not seem to interfere with the known actions of Olmesartan on the VDR. So it seems a "safe" palliative. There was a [[https://www.curemyth1.org/view_topic.php?id=3589&forum_id=2&jump_to=31773|thread on CureMyTh1.org]] where these issues were briefly discussed.
  
 LDN is special because it is a very low dose drug, and it must therefore be targeted tightly towards whatever it affects. Science is still not completely sure what LDN does, which is why there is this myth about it helping the immune system. However, it doesn't seem to get in the way of olmesartan, especially at low doses.  LDN is special because it is a very low dose drug, and it must therefore be targeted tightly towards whatever it affects. Science is still not completely sure what LDN does, which is why there is this myth about it helping the immune system. However, it doesn't seem to get in the way of olmesartan, especially at low doses. 
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 ==== Opioids ==== ==== Opioids ====
  
-Temporary use of opioids are the preferred method of dealing with extreme pain in the MP cohort. +Temporary use of opioids are the preferred method of dealing with **extreme** pain in the MP cohort. 
  
 An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. Opioids work to relieve pain in two ways. First, they attach to opioid receptors, which are specific proteins on the surface of cells in the brain, spinal cord and gastrointestinal tract. These drugs interfere and stop the transmission of pain messages to the brain. Second, they work in the brain to alter the sensation of pain. These drugs do not take the pain away, but they do reduce and alter the patient’s perception of the pain. An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. Opioids work to relieve pain in two ways. First, they attach to opioid receptors, which are specific proteins on the surface of cells in the brain, spinal cord and gastrointestinal tract. These drugs interfere and stop the transmission of pain messages to the brain. Second, they work in the brain to alter the sensation of pain. These drugs do not take the pain away, but they do reduce and alter the patient’s perception of the pain.
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 //**Trevor Marshall, PhD**// </blockquote> //**Trevor Marshall, PhD**// </blockquote>
  
-Opioids do suppress the immune system,(({{pubmed>long:8947928}})) so it is important not to use them more than necessary. Patients should work with their physician to find an appropriate dose.+Opioids do suppress the immune system,(({{pmid>long:8947928}})) so it is important not to use them more than necessary. Patients should work with their physician to find an appropriate dose.
 ==== NSAIDs ==== ==== NSAIDs ====
  
 Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are commonly used for mild to moderate pain. The most commonly used members of this group are over the counter drugs: aspirin, ibuprofen, and naproxen. Taken regularly, NSAIDs can lead to stomach upset and prolonged bleeding. NSAIDs should only be taken with a physician's say so. NSAIDs can inhibit the excretion of sodium and lithium as well as interfere with other medications.
  
-NSAIDS and COX-2 inhibitors can inhibit antibody production in human cells, thus lowering host defense.(({{pubmed>long:19345936}})) NSAIDs can also increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used.  A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.(({{pubmed>long:20031832}}))+NSAIDS and COX-2 inhibitors can inhibit antibody production in human cells, thus lowering host defense.(({{pmid>long:19345936}})) NSAIDs can also increase the risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer they are used.  A recent study indicated that Naproxen may pose less risk to the circulatory system than the others.(({{pmid>long:20031832}}))
    
  
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 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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-[[http://www.diagnosisms.com/2011/04/29/what-is-the-ms-hug/|Excellent article re: "the MS Hug"]]+[[https://www.diagnosisms.com/2011/04/29/what-is-the-ms-hug/|Excellent article re: "the MS Hug"]]
  
-More than 20 studies, including a large analysis of data on more than 200,000 children, have produced results that link acetaminophen use to an increased risk of asthma. http://nyti.ms/u9ZxHZ+More than 20 studies, including a large analysis of data on more than 200,000 children, have produced results that link acetaminophen use to an increased risk of asthma. https://nyti.ms/u9ZxHZ
  
  
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 Common pain relief medications may influence cancer growth: Common pain relief medications may influence cancer growth:
-http://news.uchicago.edu/news.php?asset_id=1780+https://news.uchicago.edu/news.php?asset_id=1780
  
 <blockquote>NSAIDs actually inhibit immune tolerance/suppression. Prostanoids are highly immuno-suppressive, in particular PGE2, which is also associated with pain perception, fever and tissue healing. NSAIDs inhibit the cyclo-oxygenases and in this manner limit the conversion of arachidonic acid into PGE2. Thus, NSAIDs can alleviate pain and fever but can also lead to further joint destruction, for example. <blockquote>NSAIDs actually inhibit immune tolerance/suppression. Prostanoids are highly immuno-suppressive, in particular PGE2, which is also associated with pain perception, fever and tissue healing. NSAIDs inhibit the cyclo-oxygenases and in this manner limit the conversion of arachidonic acid into PGE2. Thus, NSAIDs can alleviate pain and fever but can also lead to further joint destruction, for example.
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 Hope you feel better soon....:) Hope you feel better soon....:)
  
-I also found a post here: http://www.marshallprotocol.com/view_topic.php?id=12488&forum_id=35&highlight=robaxin+I also found a post here: https://www.marshallprotocol.com/view_topic.php?id=12488&forum_id=35&highlight=robaxin
  
 When searching methocarbamol and muscle relaxant I found many posts about MP'ers taking a muscle relaxant. I don't recall finding any info on the MPKB site. It would be helpful to have info about muscle relaxants added to the MPKB site if not already there. When searching methocarbamol and muscle relaxant I found many posts about MP'ers taking a muscle relaxant. I don't recall finding any info on the MPKB site. It would be helpful to have info about muscle relaxants added to the MPKB site if not already there.
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-===== References =====+===== References =====</nodisp> 
home/othertreatments/pain_medication.1567374513.txt.gz · Last modified: 09.01.2019 by sallieq
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