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home:othertreatments:quercetin [02.22.2019] – [Using quercetin in conjunction with the Marshall Protocol] sallieqhome:othertreatments:quercetin [09.14.2022] (current) – external edit 127.0.0.1
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-Quercetin is a kinase inhibitor and it binds to many, if not all, of the kinases. The most important action of quercetin is the ability to inhibit I-kappaB kinase, the dimer protein which migrates to the phagocyte nucleus. When the I-kappaB kinase is inhibited, production of Nuclear Factor-kappa B (NF-kB) is downregulated.(({{pubmed>long:17184768}})) I-kappa B and NF-kB are at the heart of the Th1 inflammatory reaction. +Quercetin is a kinase inhibitor and it binds to many, if not all, of the kinases. The most important action of quercetin is the ability to inhibit I-kappaB kinase, the dimer protein which migrates to the phagocyte nucleus. When the I-kappaB kinase is inhibited, production of Nuclear Factor-kappa B (NF-kB) is downregulated.(({{pmid>long:17184768}})) I-kappa B and NF-kB are at the heart of the Th1 inflammatory reaction. 
  
 Note that olmesartan also acts on NF-kB, but by a different pathway. Quercetin is therefore synergistic with the NF-kappaB-calming actions of olmesartan. It is this synergistic action combined with the anti-inflammatory effects of olmesartan which can reduce some immunopathology, especially fatigue, muscle pain and mind-fog. Note that olmesartan also acts on NF-kB, but by a different pathway. Quercetin is therefore synergistic with the NF-kappaB-calming actions of olmesartan. It is this synergistic action combined with the anti-inflammatory effects of olmesartan which can reduce some immunopathology, especially fatigue, muscle pain and mind-fog.
 +
 + Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane.  (({{pmid>long:25050823}})) 
 +
  
 ===== Using quercetin in conjunction with the Marshall Protocol ===== ===== Using quercetin in conjunction with the Marshall Protocol =====
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 [{{:home:othertreatments:merchandizer-68003.jpg|**Quercetin can offer some reduction in symptom severity to patients on the Marshall Protocol.**}}] [{{:home:othertreatments:merchandizer-68003.jpg|**Quercetin can offer some reduction in symptom severity to patients on the Marshall Protocol.**}}]
  
-Quercetin, not caffeine, is a major neuroprotective component in coffee.   (({{pubmed>long:27479153}}))+Quercetin, not caffeine, is a major neuroprotective component in coffee.   (({{pmid>long:27479153}}))
  
  
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 These medications include: These medications include:
  
-  * **fluoroquinolone antibiotics** – Based on laboratory study, quercetin may bind to the DNA gyrase site on bacteria and competitively inhibit quinolone antibiotics.(({{pubmed>long:8718602}}))+  * **fluoroquinolone antibiotics** – Based on laboratory study, quercetin may bind to the DNA gyrase site on bacteria and competitively inhibit quinolone antibiotics.(({{pmid>long:8718602}}))
   * **warfarin (Coumadin)** – Patients need to seek professional advice if they are using warfarin //prior// to taking quercetin.     * **warfarin (Coumadin)** – Patients need to seek professional advice if they are using warfarin //prior// to taking quercetin.  
  
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 //**Trevor Marshall, PhD**// </blockquote> //**Trevor Marshall, PhD**// </blockquote>
  
-Quercetin, not caffeine, is a major neuroprotective component in coffee.  (({{pubmed>long:27479153}}))+Quercetin, not caffeine, is a major neuroprotective component in coffee.  (({{pmid>long:27479153}}))
  
  
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 +The Loranthus genus has been demonstrated to be used in the treatment of wide range of diseases e.g. diabetes, inflammations and cancers. (({{pmid>long:31297028}}))
 ===== Buying quercetin ===== ===== Buying quercetin =====
  
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 Ask regarding the method of shipping. Patients have had trouble with shipments sent by courier which incurred an unavoidable very high extra charge. Ask regarding the method of shipping. Patients have had trouble with shipments sent by courier which incurred an unavoidable very high extra charge.
  
-  * [[http://www.purecaps.net/at/|Pure Encapsulations]] – European distributor for pure encapsulations  +  * [[https://www.purecaps.net/at/|Pure Encapsulations]] – European distributor for pure encapsulations  
-  * [[http://www.freedavitamins.com/|Freeda Vitamins]] - U.S. based, ships abroad+  * [[https://www.freedavitamins.com/|Freeda Vitamins]] - U.S. based, ships abroad
  
  
  
 {{tag>supplements }} {{tag>supplements }}
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
  
   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=127970#p127970+    * https://www.marshallprotocol.com/view_topic.php?id=10371&forum_id=2&jump_to=127970#p127970
     *      * 
  
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 At 11:58 AM 9/8/2010, you wrote: At 11:58 AM 9/8/2010, you wrote:
 Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims
-http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf101580j+https://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf101580j
  
  
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 PMID: 21228504 [PubMed - in process] PMID: 21228504 [PubMed - in process]
 </blockquote> </blockquote>
-===== References =====+===== References =====</nodisp> 
home/othertreatments/quercetin.1550870823.txt.gz · Last modified: 02.22.2019 by sallieq
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