You are here: Welcome to the MPKB » Welcome to the MPKB » Non-MP therapies » Sunshine/light exposure as therapy
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Last revisionBoth sides next revision
home:othertreatments:sunshine [10.26.2018] – [Patients experiences] sallieqhome:othertreatments:sunshine [06.30.2019] – [Sunlight can be immunosuppressive] sallieq
Line 48: Line 48:
  
 Phototherapy suppresses immunity which can lead to the progression of other infections such as human papilloma virus (HPV). A 2010 study used a nested polymerase chain reaction, to analyze skin biopsies taken a from 20 psoriasis patients under phototherapy (UVB) and 20 untreated psoriatic patients. The authors were able to detect viruses in 60% of the treatment but in none of the controls.(({{pubmed>long:20415738}}))  Phototherapy suppresses immunity which can lead to the progression of other infections such as human papilloma virus (HPV). A 2010 study used a nested polymerase chain reaction, to analyze skin biopsies taken a from 20 psoriasis patients under phototherapy (UVB) and 20 untreated psoriatic patients. The authors were able to detect viruses in 60% of the treatment but in none of the controls.(({{pubmed>long:20415738}})) 
 +
 +1,25(OH)2D3 resulted in suppression of proinflammatory cytokine response in vitro
 +First, we carried out LPS and Pam3Cys stimulation on PBMC with the addition of 100 nM 1,25(OH)2D3. After 24 h, IL-6 secretion was reduced by 53% and 29% upon Pam3Cys and LPS stimulation, respectively, in the cells treated with 1,25(OH)2D3 (Fig. 1a). A significant drop in TNF-α production by 17% (Pam3Cys stimulation) and 35% (LPS stimulation) was also observed with 1,25(OH)2D3 at 24 h. Having demonstrated that 1,25(OH)2D3 had the capacity to modulated IL-6 and TNF-α response in vitro, and with the understanding that physiological vitamin D3 levels in the body may vary through the seasons, we validate these observations in vivo in a cohort of healthy volunteers.(({{pubmed>long:21323660}}))
  
 A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pubmed>long:21375518}})) A 2011 study by Damian //et al.// concluded that exposure to sunlight even at suberythemal levels – sunlight which doesn't cause redness – is "profoundly immunosuppressive" in humans and that it is the immune-suppressive effects of sunlight that play a central role in skin carcinogenesis.(({{pubmed>long:21375518}}))
home/othertreatments/sunshine.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.