Home

Telmisartan

Nuclear receptors and ligands

Nuclear receptorsIntracellular receptor proteins that bind to hydrophobic signal molecules (such as steroid and thyroid hormones) or intracellular metabolites and are thus activated to bind to specific DNA sequences which affect transcription. are a class of proteins found within the interior of cells that are responsible for sensing the presence of hormones and certain other molecules. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA.

Some of the molecules (or ligands) which bind the nuclear receptorIntracellular receptor proteins that bind to hydrophobic signal molecules (such as steroid and thyroid hormones) or intracellular metabolites and are thus activated to bind to specific DNA sequences which affects transcription. activate (agonize) it and some inactivate (antagonize) it.

It is commonly accepted that most ligands, approximately 95% to 98%, inactivate the nuclear receptors. Since the nuclear receptors play a significant role in the immune response, this factor alone may explain why so many drugs and substances found in food and drink are immunosuppressive.

Transcription of antimicrobial peptides

One of the VDRThe Vitamin D Receptor. A nuclear receptor located throughout the body that plays a key role in the innate immune response.'s key functions is the transcription of naturally produced broad-spectrum antibacterials which target pathogens.1) 2)

Telmisartan

Telmisartan, an ARBA drug which is an angiotensin receptor blocker. One of the ARBs is olmesartan (Benicar). Not all ARBs activate the Vitamin D Receptor., is an extreme immunosuppressant by means of being a strongly active antagonist of VDRs

My in-silico work showed Telmisartan totally shuts off the VDR and is therefore highly immunosuppressive.

Trevor Marshall, PhD (personal communication to research team)

Due to differences in molecular structure, each ARB is shown to have significantly different properties when interacting with the nuclear receptors in the immune cells. For example: where Telmisartan will quickly and completely suppress immune function, frequent dosing of olmesartan medoxomil (which is an agonist of VDRs) over a prolonged period allows recovery of immune function via activation of the vitamin D receptorA nuclear receptor located throughout the body that plays a key role in the innate immune response..

Particular care

Patients seeking to keep the health regained by following the Marshall ProtocolA curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis., must take care, even when apparently recovered, or having achieved resolution of many or most of their troublesome symptoms, to diligently avoid challenge to their longterm status, by continuing to avoid immuno-suppressants, and by asking the support team for information if any doctor recommends an alternative regime. Many standard treatment for auto-immune symptoms are based solely on suppressing the immune response. That is to say, the patient will shortly feel and look much better, but long term health again becomes compromised as bacteria, viruses and fungi use whatever means available to re-invade.

References

Notes and comments

1)
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression.
Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera-Mendoza L, Lin R, Hanrahan JW, Mader S, White JH
J Immunol173p2909-12(2004 Sep 1)
home/othertreatments/telmisartan.txt · Last modified: 09.16.2017 by sallieq
© 2015, Autoimmunity Research Foundation. All Rights Reserved.