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home:pathogenesis:familial_aggregation [05.02.2011] – external edit 127.0.0.1home:pathogenesis:familial_aggregation [09.09.2012] – [Family members are more likely to develop different diseases too] paulalbert
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   * **sarcoidosis** – A six-year study of the Th1 disease sarcoidosis, conducted by the National Heart, Lung and Blood Institute at the National Institutes of Health (NIH) in Maryland found that among the 215 study participants who had been diagnosed with sarcoidosis, there were five husband-and-wife couples that both had the disease.  Yet sarcoidosis is such a rare disease that, statistically speaking, there should have been none.  This means the incidence of sarcoidosis in spouses in the study was 1,000 greater than could be expected by chance. The researchers also noted that the risk for sarcoidosis increased nearly five-fold in parents and siblings of people with the disease. (({{pubmed>long:17684288}}))   * **sarcoidosis** – A six-year study of the Th1 disease sarcoidosis, conducted by the National Heart, Lung and Blood Institute at the National Institutes of Health (NIH) in Maryland found that among the 215 study participants who had been diagnosed with sarcoidosis, there were five husband-and-wife couples that both had the disease.  Yet sarcoidosis is such a rare disease that, statistically speaking, there should have been none.  This means the incidence of sarcoidosis in spouses in the study was 1,000 greater than could be expected by chance. The researchers also noted that the risk for sarcoidosis increased nearly five-fold in parents and siblings of people with the disease. (({{pubmed>long:17684288}}))
   * **hypertension** – Researchers at Queens Medical School in England found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects persisted after adjustment for other variables such as diet. (({{pubmed>long:9830183}}))   * **hypertension** – Researchers at Queens Medical School in England found that men whose spouses had hypertension had a two-fold increased risk of hypertension. Similarly, women whose spouses had hypertension also doubled their risk of developing the disease. The risk for both male and female subjects persisted after adjustment for other variables such as diet. (({{pubmed>long:9830183}}))
 +  * **exfoliative glaucoma** – In the middle Norway eye-screening study, the prevalence of XFG in both members of married couples is significantly higher than expected, "thereby suggesting a common environmental (probably infectious) agent, which may be of aetiological significance for the XFG development."(({{pubmed>long:19854735}}))
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 ==== Family members develop the same diseases ==== ==== Family members develop the same diseases ====
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   * **mental disorders** – A 2008 study of parents of children with autism found they were more likely to have been hospitalized for a mental disorder than parents of control subjects. Schizophrenia was more common among case mothers and fathers compared with respective control parents.(({{pubmed>long:18450879}})) In a case study, Beleza-Meirles found that schizophrenia and mental retardation had very high rates of incidence in a particular family.(({{pubmed>long:18254962}})) A similar by Sveinbjörnsdóttir also observed high rates of Parkinson's in an extended family.(({{pubmed>long:11114315}}))   * **mental disorders** – A 2008 study of parents of children with autism found they were more likely to have been hospitalized for a mental disorder than parents of control subjects. Schizophrenia was more common among case mothers and fathers compared with respective control parents.(({{pubmed>long:18450879}})) In a case study, Beleza-Meirles found that schizophrenia and mental retardation had very high rates of incidence in a particular family.(({{pubmed>long:18254962}})) A similar by Sveinbjörnsdóttir also observed high rates of Parkinson's in an extended family.(({{pubmed>long:11114315}}))
   * **autism and eye disorders** – Researchers working at the University of Illinois at Chicago have found a [[http://www.scientificamerican.com/article.cfm?id=autism-relatives-symptoms|striking trend]]: those with autistic relatives are more likely to show disrupted eye movement similar to their afflicted relation.(({{pubmed>long:20679591}}))   * **autism and eye disorders** – Researchers working at the University of Illinois at Chicago have found a [[http://www.scientificamerican.com/article.cfm?id=autism-relatives-symptoms|striking trend]]: those with autistic relatives are more likely to show disrupted eye movement similar to their afflicted relation.(({{pubmed>long:20679591}}))
 +  * **autoimmune disease** – In a study of families who have a member with primary Sjögren's syndrome, 38% had at least one first-degree relative with an autoimmune disease, versus 22% in control families.(({{pubmed>long:17086607}})) The most frequent autoimmune diseases registered among the patients' first-degree relatives were autoimmune thyroid disease, systemic lupus erythematosus, and rheumatoid arthritis.
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 As evidenced by progress reports on the Marshall Protocol site, there are a substantial number of spouses who both suffer from chronic inflammatory diseases. There are also entire families on the MP - with each member using the treatment to eliminate his or her own [[home:pathogenesis:successive_infection#pea_soup|pea-soup]]. As evidenced by progress reports on the Marshall Protocol site, there are a substantial number of spouses who both suffer from chronic inflammatory diseases. There are also entire families on the MP - with each member using the treatment to eliminate his or her own [[home:pathogenesis:successive_infection#pea_soup|pea-soup]].
  
 When one considers how often chronic diseases co-occur within a family unit – heart disease, arthritis, bipolar disorder, breast cancer, inflammatory bowel disease, Alzheimer’s disease – it becomes increasingly plausible that nearly all inflammatory diseases are communicable and that this communicability results in familial aggregation. When one considers how often chronic diseases co-occur within a family unit – heart disease, arthritis, bipolar disorder, breast cancer, inflammatory bowel disease, Alzheimer’s disease – it becomes increasingly plausible that nearly all inflammatory diseases are communicable and that this communicability results in familial aggregation.
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 ===== Non-relations in close proximity develop the same diseases ===== ===== Non-relations in close proximity develop the same diseases =====
  
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 ===== Notes and comments ===== ===== Notes and comments =====
-TECHEDIT+
   * Should the last section here be nixed (it's not really about "familial" aggregation in lieu of what is said at the [[home:alternate:genetic_predisposition|genetic predisposition]] article?  --- //Paul Albert 2008/12/08 11:35//   * Should the last section here be nixed (it's not really about "familial" aggregation in lieu of what is said at the [[home:alternate:genetic_predisposition|genetic predisposition]] article?  --- //Paul Albert 2008/12/08 11:35//
    
home/pathogenesis/familial_aggregation.txt · Last modified: 09.14.2022 by 127.0.0.1
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