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home:pathogenesis:microbiota:lforms [07.01.2019] – [Future research] sallieqhome:pathogenesis:microbiota:lforms [01.12.2020] – [L-form bacteria] sallieq
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 ====== L-form bacteria ====== ====== L-form bacteria ======
  
-As a part of their natural life cycle, bacteria can transform into a variety of forms. One of those phases is the L-form. L-form bacteria, also known as cell wall deficient bacteria, are a phase of bacteria that are very small and lack cell walls. +As a part of their natural life cycle, bacteria can transform into a variety of forms. One of those phases is the L-form.  
 + 
 +L-form bacteria, also known as cell wall deficient bacteria, are a phase of bacteria that are very small and lack cell walls. 
  
 Though the subject of a great deal of research over the last 100 years and implicated in a variety of diseases, L-forms remain largely misunderstood - or at the very least, underappreciated - by the medical research community. According to the Marshall Pathogenesis, L-forms are part of a metagenomic microbiota responsible for chronic disease.   Though the subject of a great deal of research over the last 100 years and implicated in a variety of diseases, L-forms remain largely misunderstood - or at the very least, underappreciated - by the medical research community. According to the Marshall Pathogenesis, L-forms are part of a metagenomic microbiota responsible for chronic disease.  
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 ===== Culturing and detection ===== ===== Culturing and detection =====
  
-Once bacteria have transformed into the L-form they can no longer be detected by many standard laboratory procedures. Although scientists have known about L-form bacteria for over a century, many of them have not detected them in tissue and blood samples because they are very difficult to culture. +Once bacteria have transformed into the L-form they can no longer be detected by ordinary laboratory procedures. Although scientists have known about L-form bacteria for over a century, many of them have not been detected in tissue and blood samples because they are very difficult to culture. 
  
 Forms of bacteria with cell walls can be easily grown outside the body (grown //[[home:patients:assessing_literature:in_vitro_studies#in_vitro_studies|in vitro]]//). However L-form bacteria have great difficulty surviving in a foreign environment. In order to grow them successfully in the lab, conditions must be similar to those in the human body (grown [[home:patients:assessing_literature:in_vitro_studies#in_vivo_studies|in vivo]]). Consequently they can be cultured on a medium called blood agar at very specific temperatures and at a certain pH. Forms of bacteria with cell walls can be easily grown outside the body (grown //[[home:patients:assessing_literature:in_vitro_studies#in_vitro_studies|in vitro]]//). However L-form bacteria have great difficulty surviving in a foreign environment. In order to grow them successfully in the lab, conditions must be similar to those in the human body (grown [[home:patients:assessing_literature:in_vitro_studies#in_vivo_studies|in vivo]]). Consequently they can be cultured on a medium called blood agar at very specific temperatures and at a certain pH.
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 Several studies have shown that once inside a macrophage, L-form bacteria are able to delay the process of apoptosis, or programmed cell death, allowing them to thrive inside the cell for a period of time even longer than 45 days. Several studies have shown that once inside a macrophage, L-form bacteria are able to delay the process of apoptosis, or programmed cell death, allowing them to thrive inside the cell for a period of time even longer than 45 days.
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 +Life without a wall or division machine in Bacillus subtilis.  (({{pubmed>long:19212404}})) 
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 L-form bacteria cohabitants in human blood: significance for health and diseases. (({{pubmed>long:28715646}})) L-form bacteria cohabitants in human blood: significance for health and diseases. (({{pubmed>long:28715646}}))
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 +Possible role of L-form switching in recurrent urinary tract infection  (({{pubmed>long:31558767}})) 
  
 ==== Future research ==== ==== Future research ====
home/pathogenesis/microbiota/lforms.txt · Last modified: 09.14.2022 by 127.0.0.1
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