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home:pathogenesis:vitamind:cancer [01.14.2020] – [Vitamin D and cancer] sallieq | home:pathogenesis:vitamind:cancer [09.14.2022] (current) – external edit 127.0.0.1 | ||
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While some randomized controlled trials have suggested that consuming vitamin D reduces rates of cancer, larger and more carefully controlled studies show no such effect. | While some randomized controlled trials have suggested that consuming vitamin D reduces rates of cancer, larger and more carefully controlled studies show no such effect. | ||
- | Lappe et al published work, conducted over four years, that seemingly showed vitamin D might lower the incidence of colorectal cancer.(({{pubmed> | + | Lappe et al published work, conducted over four years, that seemingly showed vitamin D might lower the incidence of colorectal cancer.(({{pmid> |
Lappe opted to discard the data of subjects who developed cancer during the first year of the study. The rationale was that cancers during the first year would have been present but undiagnosed at entry. Of the 50 people who developed cancer during the four-year study, 13 were removed based on this premise, and only 37 cases of cancer were actually analyzed. But the 13 people who developed cancer during the first year were likely to be the study participants with the highest loads of the Th1 pathogens. They would have been the people to suffer the most from the negative impact of elevated 25-D on the immune system. If data from the 13 participants would have been included in the study, the results would have undoubtedly reflected much less of a “benefit” from vitamin D. Even the researchers admit that “their conclusion was strengthened by both the observational, | Lappe opted to discard the data of subjects who developed cancer during the first year of the study. The rationale was that cancers during the first year would have been present but undiagnosed at entry. Of the 50 people who developed cancer during the four-year study, 13 were removed based on this premise, and only 37 cases of cancer were actually analyzed. But the 13 people who developed cancer during the first year were likely to be the study participants with the highest loads of the Th1 pathogens. They would have been the people to suffer the most from the negative impact of elevated 25-D on the immune system. If data from the 13 participants would have been included in the study, the results would have undoubtedly reflected much less of a “benefit” from vitamin D. Even the researchers admit that “their conclusion was strengthened by both the observational, | ||
- | Another problem with Lappe' | + | Another problem with Lappe' |
- | In a similar study looking at a larger cohort and over a longer period of time, Chlebowski //et al.// found no such effect.(({{pubmed> | + | In a similar study looking at a larger cohort and over a longer period of time, Chlebowski //et al.// found no such effect.(({{pmid> |
< | < | ||
- | //**Jacques Rossouw, MD**,// National Institutes of Health// | + | //**Jacques Rossouw, MD**,// National Institutes of Health// |
- | A second study by the Women’s Health Initiative found no reduction in risk of breast cancer among postmenopausal women supplementing with 1000 mg calcium and 440 IUs of vitamin D.(({{pubmed> | + | A second study by the Women’s Health Initiative found no reduction in risk of breast cancer among postmenopausal women supplementing with 1000 mg calcium and 440 IUs of vitamin D.(({{pmid> |
- | A 2011 systematic review of prospective studies assessing the association of vitamin D intake with the risk of colorectal cancer that vitamin D intake increased risk of colorectal cancer,(({{pubmed> | + | A 2011 systematic review of prospective studies assessing the association of vitamin D intake with the risk of colorectal cancer that vitamin D intake increased risk of colorectal cancer,(({{pmid> |
- | Cohort studies are no more likely to show a long-term positive effect of vitamin D intake, The Iowa Women' | + | Cohort studies are no more likely to show a long-term positive effect of vitamin D intake, The Iowa Women' |
Longitudinal studies (those lasting decades) examining the relationship between long-term intake of vitamin D and incidence of cancer are lacking. Those that have measured incidence of various other diseases, including atopy, allergic rhinitis, and brain lesions, have found that vitamin D intake increases the rate of these diseases. There is no reason to think cancer would be substantially different. | Longitudinal studies (those lasting decades) examining the relationship between long-term intake of vitamin D and incidence of cancer are lacking. Those that have measured incidence of various other diseases, including atopy, allergic rhinitis, and brain lesions, have found that vitamin D intake increases the rate of these diseases. There is no reason to think cancer would be substantially different. | ||
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A number of vitamin D studies point to low levels of the inactive metabolite, 25-D, as playing a causative role in the incidence of cancer. Large, well-controlled studies have not been able to verify this claim. | A number of vitamin D studies point to low levels of the inactive metabolite, 25-D, as playing a causative role in the incidence of cancer. Large, well-controlled studies have not been able to verify this claim. | ||
- | A recent study by the National Cancer Institute - the first study to look at the relationship between measured vitamin D in the blood and subsequent total cancer deaths - failed to show an association between baseline vitamin D status and overall cancer risk in men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older.(({{pubmed> | + | A recent study by the National Cancer Institute - the first study to look at the relationship between measured vitamin D in the blood and subsequent total cancer deaths - failed to show an association between baseline vitamin D status and overall cancer risk in men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older.(({{pmid> |
- | When asked by a correspondent from CBS News if vitamin D can reduce the risk of cancer, [[http:// | + | When asked by a correspondent from CBS News if vitamin D can reduce the risk of cancer, [[https:// |
< | < | ||
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==== Evidence that vitamin D intake increases incidence of cancer ==== | ==== Evidence that vitamin D intake increases incidence of cancer ==== | ||
- | An underreported body of research shows that levels of 25-D sufficiently high enough to suggest heavy supplementation are consistent with //higher// rates of cancer. Stolzenberg-Solomon //et al// tracked a cohort of men over the course of 16 years for pancreatic cancer.(({{pubmed> | + | An underreported body of research shows that levels of 25-D sufficiently high enough to suggest heavy supplementation are consistent with //higher// rates of cancer. Stolzenberg-Solomon //et al// tracked a cohort of men over the course of 16 years for pancreatic cancer.(({{pmid> |
< | < | ||
- | //**Rachael Stolzenberg-Solomon**, | + | //**Rachael Stolzenberg-Solomon**, |
- | Researchers at the Chinese Academy of Medical Sciences in China found a similar association between excessive vitamin D intake and esophageal and gastric cancers in men. Male subjects with levels of 25-D in the range of 48.7 ng/ml (which once again suggests heavy supplementation) were much more likely to develop one of the two forms of cancer.(({{pubmed> | + | Researchers at the Chinese Academy of Medical Sciences in China found a similar association between excessive vitamin D intake and esophageal and gastric cancers in men. Male subjects with levels of 25-D in the range of 48.7 ng/ml (which once again suggests heavy supplementation) were much more likely to develop one of the two forms of cancer.(({{pmid> |
The following research by //Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI// remains unpublished | The following research by //Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI// remains unpublished | ||
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===== Observational studies===== | ===== Observational studies===== | ||
- | One Norway-based study surveyed over 50,000 participants for their intake of dietary vitamin D and then compared those results to their later risk of cutaneous malignant melanoma. The researchers found that female subjects who consumed cod liver oil, which is high in vitamin D, were significantly more likely to later be diagnosed with melanoma.(({{pubmed> | + | One Norway-based study surveyed over 50,000 participants for their intake of dietary vitamin D and then compared those results to their later risk of cutaneous malignant melanoma. The researchers found that female subjects who consumed cod liver oil, which is high in vitamin D, were significantly more likely to later be diagnosed with melanoma.(({{pmid> |
- | A 2010 study showed that multivitamin use may be correlated with increased risk of breast cancer.(({{pubmed> | + | A 2010 study showed that multivitamin use may be correlated with increased risk of breast cancer.(({{pmid> |
+ | ===== Patient reports ===== | ||
+ | < | ||
+ | |||
+ | I first had lumpectomy, followed by complete breast removal and removal of some lymph nodes, because the cancer was beginning to spread into the lymph system. | ||
+ | |||
+ | While on MP, a " | ||
+ | |||
+ | I am glad he took pictures, as the possible cancer continued to change and then disappeared entirely. | ||
+ | |||
+ | Good old MP, when followed as precisely as I was doing at that time. | ||
+ | |||
+ | |||
+ | //Sallie Q// | ||
+ | </ | ||
===== Read more ===== | ===== Read more ===== | ||
- | Clinical Utility of Measurement of Vitamin D-Binding Protein and Calculation of Bioavailable Vitamin D in Assessment of Vitamin D Status | + | Clinical Utility of Measurement of Vitamin D-Binding Protein and Calculation of Bioavailable Vitamin D in Assessment of Vitamin D Status |
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{{tag> | {{tag> | ||
+ | < | ||
===== Notes and comments ===== | ===== Notes and comments ===== | ||
- | broken link [[http:// | + | broken link [[https:// |
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Cancer Res. 2010 Sep 16. [Epub ahead of print] | Cancer Res. 2010 Sep 16. [Epub ahead of print] | ||
- | Serum Vitamin D and Cancer Mortality in the NHANES III Study (1988-2006).(({{pubmed> | + | Serum Vitamin D and Cancer Mortality in the NHANES III Study (1988-2006).(({{pmid> |
Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI. | Freedman DM, Looker AC, Abnet CC, Linet MS, Graubard BI. | ||
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J Natl Med Assoc. 2009 Dec; | J Natl Med Assoc. 2009 Dec; | ||
- | Black-white differences in cancer risk and the vitamin D hypothesis.(({{pubmed> | + | Black-white differences in cancer risk and the vitamin D hypothesis.(({{pmid> |
Frost P. | Frost P. | ||
Comment on: | Comment on: | ||
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- | < | + | < |
Robins AH. | Robins AH. | ||
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CONCLUSION: Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression. | CONCLUSION: Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression. | ||
PMID: 21203822</ | PMID: 21203822</ | ||
- | ===== References ===== | + | ===== References =====</ |