You are here: Welcome to the MPKB » Welcome to the MPKB » Science behind Pathogenesis » Science behind vitamin D » Diseases associated with low levels of 25-D
Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revision		Previous revision
Next revisionBoth sides next revision
home:pathogenesis:vitamind:low25d [09.16.2016] – [Anomalies] sallieqhome:pathogenesis:vitamind:low25d [10.27.2018] – [Anomalies] sallieq
Line 76: Line 76:
  
   * **mortality in the Danish population** – A 2012 study of 247,574 subjects found that both lower and higher levels of 25-D were associated with an increased likelihood of mortality (right).(({{pubmed>long:22573406}}))   * **mortality in the Danish population** – A 2012 study of 247,574 subjects found that both lower and higher levels of 25-D were associated with an increased likelihood of mortality (right).(({{pubmed>long:22573406}}))
-  * **U-shaped relationship between vitamin D levels @ long-term outcome.** – In a 5 year follow-up of survivors of acute myocardial infarction patients with vitamin D<10ng/mL and >30ng/mL had higher mortality rate than those with intermediate values. (({{pubmed>long:27589046}}))+  * **U-shaped relationship between vitamin D levels and long-term outcome.** – In a 5 year follow-up of survivors of acute myocardial infarction patients with vitamin D<10ng/mL and >30ng/mL had higher mortality rate than those with intermediate values. (({{pubmed>long:27589046}}))
   * **risk of breast cancer** – In a 2011 study of nurses who were predominantly premenopausal, circulating 25-D levels were not significantly associated with breast cancer risk.   * **risk of breast cancer** – In a 2011 study of nurses who were predominantly premenopausal, circulating 25-D levels were not significantly associated with breast cancer risk.
   * **risk of prostate cancer** – In a 2008 nested case-control study appearing in //Journal of the National Cancer Institute//, Ahn //et al.// found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.(({{pubmed>long:18505967}}))    * **risk of prostate cancer** – In a 2008 nested case-control study appearing in //Journal of the National Cancer Institute//, Ahn //et al.// found that patients with the lowest levels of 25-D also had the lowest risk of prostate cancer.(({{pubmed>long:18505967}})) 
Line 86: Line 86:
   * **atherosclerosis in African Americans** – Vitamin D is widely used to treat patients with osteoporosis and/or low vitamin D levels based on a medically accepted normal range. This "normal" range is typically applied to all race groups, although it was established predominantly in whites. It is thought that as low vitamin D levels rise to the normal range with supplementation, protection from bone and heart disease (atherosclerosis) may increase, as well. Blacks generally have lower vitamin D levels than whites, partly because their darker skin pigmentation limits the amount of the vitamin produced by sunlight. "Despite" these lower vitamin D levels and dietary calcium ingestion, blacks naturally experience lower rates of osteoporosis and have far less calcium in their arteries. Studies further reveal that black patients with diabetes have half the rate of heart attack as whites, when provided equal access to health care. A 2010 study (explained [[http://www.sciencedaily.com/releases/2010/03/100315091259.htm|here]]) determined the relationship between circulating vitamin D levels and arterial calcium in 340 black men and women with type 2 diabetes.(({{pubmed>long:20061416}})) The team concluded that higher circulating levels of 25-D in blacks were associated with higher levels of calcified atherosclerotic plaque.    * **atherosclerosis in African Americans** – Vitamin D is widely used to treat patients with osteoporosis and/or low vitamin D levels based on a medically accepted normal range. This "normal" range is typically applied to all race groups, although it was established predominantly in whites. It is thought that as low vitamin D levels rise to the normal range with supplementation, protection from bone and heart disease (atherosclerosis) may increase, as well. Blacks generally have lower vitamin D levels than whites, partly because their darker skin pigmentation limits the amount of the vitamin produced by sunlight. "Despite" these lower vitamin D levels and dietary calcium ingestion, blacks naturally experience lower rates of osteoporosis and have far less calcium in their arteries. Studies further reveal that black patients with diabetes have half the rate of heart attack as whites, when provided equal access to health care. A 2010 study (explained [[http://www.sciencedaily.com/releases/2010/03/100315091259.htm|here]]) determined the relationship between circulating vitamin D levels and arterial calcium in 340 black men and women with type 2 diabetes.(({{pubmed>long:20061416}})) The team concluded that higher circulating levels of 25-D in blacks were associated with higher levels of calcified atherosclerotic plaque. 
  
 +
 +{{tag>pathogenesis Science_behind_vitamin_D}}
  
 ===== Notes and comments ===== ===== Notes and comments =====
home/pathogenesis/vitamind/low25d.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.