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home:pathogenesis:vitamind:mechanisms [10.27.2018] – [Related publications and presentations] sallieq | home:pathogenesis:vitamind:mechanisms [01.25.2019] – [Effects of VDR blockage on the PXR, a receptor which converts pre-vitamin D into 25-D] sallieq | ||
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This mechanism works well when 1,25-D is within normal ranges. But when 1,25-D becomes extremely high, as in the case of chronic diseases, 25-D is downregulated to abnormally low levels, leading some observers to erroneously conclude that vitamin D deficiency causes disease. | This mechanism works well when 1,25-D is within normal ranges. But when 1,25-D becomes extremely high, as in the case of chronic diseases, 25-D is downregulated to abnormally low levels, leading some observers to erroneously conclude that vitamin D deficiency causes disease. | ||
+ | ===== Recent research ===== | ||
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+ | We evaluated whether the ability of M. leprae to induce type I IFN blocks the intrinsic activation of the vitamin D pathway, representing an escape mechanism by which the bacterium evades the host response. | ||
===== Related publications and presentations ===== | ===== Related publications and presentations ===== | ||