Home

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revisionPrevious revision
Next revisionBoth sides next revision
home:pathogenesis:vitamind:mechanisms [10.27.2018] – [Related publications and presentations] sallieqhome:pathogenesis:vitamind:mechanisms [01.25.2019] – [Effects of VDR blockage on the PXR, a receptor which converts pre-vitamin D into 25-D] sallieq
Line 44: Line 44:
 This mechanism works well when 1,25-D is within normal ranges. But when 1,25-D becomes extremely high, as in the case of chronic diseases, 25-D is downregulated to abnormally low levels, leading some observers to erroneously conclude that vitamin D deficiency causes disease. This mechanism works well when 1,25-D is within normal ranges. But when 1,25-D becomes extremely high, as in the case of chronic diseases, 25-D is downregulated to abnormally low levels, leading some observers to erroneously conclude that vitamin D deficiency causes disease.
  
 +===== Recent research =====
 +
 +We evaluated whether the ability of M. leprae to induce type I IFN blocks the intrinsic activation of the vitamin D pathway, representing an escape mechanism by which the bacterium evades the host response.    (({{pubmed>long:000}})) 
 ===== Related publications and presentations ===== ===== Related publications and presentations =====
  
home/pathogenesis/vitamind/mechanisms.txt · Last modified: 09.14.2022 by 127.0.0.1
© 2015, Autoimmunity Research Foundation. All Rights Reserved.