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home:patients:grappling_uncertainty [06.06.2019] – [Frequent question] sallieqhome:patients:grappling_uncertainty [09.14.2022] (current) – external edit 127.0.0.1
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 <blockquote>We as scientists are very good at studying what we know. But the unknown is out of reach, and what it may take... is someone who just has what might seem like a crazy idea, but the means to pursue it, and find that there are new links between the human microbiome, and diseases that today we don't really think of as having any underlying microbiological component. <blockquote>We as scientists are very good at studying what we know. But the unknown is out of reach, and what it may take... is someone who just has what might seem like a crazy idea, but the means to pursue it, and find that there are new links between the human microbiome, and diseases that today we don't really think of as having any underlying microbiological component.
  
-//**Claire Fraser-Liggett,** Director of the Institute for Genome Sciences at the University of Maryland, [[http://www.bbc.co.uk/programmes/b011jv8r|BBC Radio 4 program about the Human Microbiome]]//+//**Claire Fraser-Liggett,** Director of the Institute for Genome Sciences at the University of Maryland, [[https://www.bbc.co.uk/programmes/b011jv8r|BBC Radio 4 program about the Human Microbiome]]//
 </blockquote> </blockquote>
  
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 Another common source of questions is recent studies. PubMed has tens of millions of studies. Some of them, many in fact, seem to contradict the conclusions put forth in the Knowledge Base or in the ARF research team's published papers. Often, a critical thinker may be able to apply the evidence and criticisms in the Knowledge Base to a study and make sense of it. Another common source of questions is recent studies. PubMed has tens of millions of studies. Some of them, many in fact, seem to contradict the conclusions put forth in the Knowledge Base or in the ARF research team's published papers. Often, a critical thinker may be able to apply the evidence and criticisms in the Knowledge Base to a study and make sense of it.
    
-An example: one study concluded that vitamin D might lower the incidence of colorectal cancer.(({{pubmed>long:17556697}})) A critical thinker might realize that the study was only for four years and might even be able to find studies over a longer period, which contradicted the original study's findings.(({{pubmed>long:12117397}})) +An example: one study concluded that vitamin D might lower the incidence of colorectal cancer.(({{pmid>long:17556697}})) A critical thinker might realize that the study was only for four years and might even be able to find studies over a longer period, which contradicted the original study's findings. See (({{pmid>long:18065602}})), (({{pmid>long:17991672}})), (({{pmid>long:18326620}})), (({{pmid>long:18326621}})) and select OXFORD//academic//  to read the comments.
  
-Using statistical inferences, John P. A. Ioannidis concluded in the prestigious journal //PLoS Medicine// that half of published research must be wrong.(({{pubmed>long:16060722}})) The arguments of that paper are beyond the scope of this article; but in grappling with a confusing study, it's seriously worth considering how Ioannidis could be right. +Using statistical inferences, John P. A. Ioannidis concluded in the prestigious journal //PLoS Medicine// that half of published research must be wrong.(({{pmid>long:16060722}})) The arguments of that paper are beyond the scope of this article; but in grappling with a confusing study, it's seriously worth considering how Ioannidis could be right. 
  
-Karhausen wrote(({{pubmed>long:11080970}})), "Actually, there is no experience of causation: events do not wear their causal credentials on their faces." Many of the statements a reader sees in the context of a scientific paper is dependent on interpretation. +Karhausen wrote(({{pmid>long:11080970}})), "Actually, there is no experience of causation: events do not wear their causal credentials on their faces." Many of the statements a reader sees in the context of a scientific paper is dependent on interpretation. 
  
 The point of the MP is that [[assessing_literature|several of those key interpretations are wrong]]. The point of the MP is that [[assessing_literature|several of those key interpretations are wrong]].
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 <blockquote>Researchers have estimated that 60-80 percent of microbial infections in the body are caused by bacteria growing as a biofilm – as opposed to planktonic (free-floating) bacteria</blockquote> <blockquote>Researchers have estimated that 60-80 percent of microbial infections in the body are caused by bacteria growing as a biofilm – as opposed to planktonic (free-floating) bacteria</blockquote>
  
-This includes sub-clinical or undiagnosed conditions which were building up unnoticed.  In my case in the second year I had flare-up followed by disappearance of symptoms which I formerly thought to be normal aging. +This includes sub-clinical or undiagnosed conditions which were building up unnoticed.  In my case by the second year I had flare-ups followed by disappearance of symptoms which I formerly thought to be normal aging. 
  
 When MP is maintained for many years, the recovering immune system is dealing with   [[home:pathogenesis:microbiota:biofilm|biofilm]]. When MP is maintained for many years, the recovering immune system is dealing with   [[home:pathogenesis:microbiota:biofilm|biofilm]].
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 As before, it is again impossible to predict how long any bout of IP will last, how it will manifest, whether it will become intolerable.  Often people give up, they decide they would rather feel better now and take the risk of feeling much worse when older. As before, it is again impossible to predict how long any bout of IP will last, how it will manifest, whether it will become intolerable.  Often people give up, they decide they would rather feel better now and take the risk of feeling much worse when older.
  
-Sometimes a person decides the MP "does not work" for them   ....but it is very likely that MP is working 'too well' at the time, with great quantities of cytokines being produced by death of microbes.+Sometimes a person decides the MP "does not work" for them   ....but it is very likely that MP is working 'too well' at the time, with great quantities of cytokines being produced by death of microbes in biofilm.
 Our job as support team includes asking MPeers to 'phone home' with information and experiences which will help others, often ways of ameliorating nasty IP whether physical or pharmaceutical.  There is no easy or short term way, we wish there were. Our job as support team includes asking MPeers to 'phone home' with information and experiences which will help others, often ways of ameliorating nasty IP whether physical or pharmaceutical.  There is no easy or short term way, we wish there were.
  
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 {{tag> resource Resources_for_Physicians research}} {{tag> resource Resources_for_Physicians research}}
  
 +<nodisp>
 ===== Notes and comments ===== ===== Notes and comments =====
  
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 <blockquote> <blockquote>
-[[http://www.the-scientist.com/2010/12/1/32/1/|Evidence: A Seductive but Slippery Concept]]+[[https://www.the-scientist.com/2010/12/1/32/1/|Evidence: A Seductive but Slippery Concept]]
 Medical guidelines based on so-called scientific evidence are not a panacea. Medical guidelines based on so-called scientific evidence are not a panacea.
  
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   * Legacy content   * Legacy content
-    * http://www.marshallprotocol.com/forum32/3163.html#p28099 f274 +    * https://www.marshallprotocol.com/forum32/3163.html#p28099 f274 
-    * http://www.marshallprotocol.com/forum32/8533.html f146 +    * https://www.marshallprotocol.com/forum32/8533.html f146 
-    * http://www.marshallprotocol.com/view_topic.php?id=4142&forum_id=37&jump_to=91203#p91203 s155+    * https://www.marshallprotocol.com/view_topic.php?id=4142&forum_id=37&jump_to=91203#p91203 s155
        
  
-===== References =====+===== References =====</nodisp> 
home/patients/grappling_uncertainty.1559857069.txt.gz · Last modified: 06.06.2019 by sallieq
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