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home:physicians:concerns [02.09.2019] – [Concerns about lack of clinical evidence] sallieqhome:physicians:concerns [07.13.2019] – [Concerns about immunopathology] sallieq
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 ====== Physicians' concerns about the Marshall Protocol ====== ====== Physicians' concerns about the Marshall Protocol ======
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 +<relatedarticle> [[home:starting:physician:reluctant#specific_research|Section  to print off - Independant research into Olmesartan with PMIDs for doctor.]] </article>
  
 Over the years, physicians have voiced various concerns about the Marshall Protocol, concerns ranging from the safety of higher doses of olmesartan (Benicar) to concerns about long-term antibiotic use. The Autoimmunity Research Foundation has assembled articles, well-grounded in scientific research, which address these concerns. Physicians who choose to use and administer the MP do so on the basis of the [[home:physicians:concerns#concerns_about_lack_of_clinical_evidence|available evidence]]. Over the years, physicians have voiced various concerns about the Marshall Protocol, concerns ranging from the safety of higher doses of olmesartan (Benicar) to concerns about long-term antibiotic use. The Autoimmunity Research Foundation has assembled articles, well-grounded in scientific research, which address these concerns. Physicians who choose to use and administer the MP do so on the basis of the [[home:physicians:concerns#concerns_about_lack_of_clinical_evidence|available evidence]].
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 ===== Concerns about lack of clinical evidence ===== ===== Concerns about lack of clinical evidence =====
  
-  - **"There are no well-controlled studies to support the use of the Marshall Protocol for a given indication."** This statement is accurate. As of 2012, patients and physicians who choose to use and administer the MP do so based on the following evidence:+  - **"There are no well-controlled studies to support the use of the Marshall Protocol for a given indication."** This statement is accurate. In 2012, patients and physicians who chose to use and administer the MP did so based on the following evidence:
     * a [[home:publications:proal_molecular_2011|2011 case series of MP patients]] appearing in the (Nature Publishing Group) journal //Clinical & molecular immunology//     * a [[home:publications:proal_molecular_2011|2011 case series of MP patients]] appearing in the (Nature Publishing Group) journal //Clinical & molecular immunology//
     * a [[home:publications:mp2008_survey|2008 retrospective survey]] of 100 MP patients with autoimmune diagnoses     * a [[home:publications:mp2008_survey|2008 retrospective survey]] of 100 MP patients with autoimmune diagnoses
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 For some physicians, the above evidence is not sufficiently compelling to warrant automatically starting a patient on the MP without further consideration. Here are some other factors which may play a role in the clinical judgment: For some physicians, the above evidence is not sufficiently compelling to warrant automatically starting a patient on the MP without further consideration. Here are some other factors which may play a role in the clinical judgment:
-  * evidence for the efficacy of MP versus other available treatment options(({{pubmed>long:19050187}})) +  * alternative hypotheses and evidence of research (({{pubmed>long:    15246025}})), (({{pubmed>long:16403216}})), (({{pubmed>long:23370376}})), (({{pubmed>long:18200565}}))  
-  * more recent material on patient response, see below update+  * evidence for the efficacy of MP versus other available treatment in 2013 data on patient response, see section below 
   * patients' expressed preferences and values(({{pubmed>long:19050187}}))   * patients' expressed preferences and values(({{pubmed>long:19050187}}))
   * additional benefits of Olmesartan [[https://mpkb.org/home/protocol/olmesartan#other_benefits_of_olmesartan_in_patients_-_recent_studies|other researched benefits]]   * additional benefits of Olmesartan [[https://mpkb.org/home/protocol/olmesartan#other_benefits_of_olmesartan_in_patients_-_recent_studies|other researched benefits]]
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-===== Numerical improvements update =====+==== Recorded results assessed 2013  ====
  
 <blockquote>//DJ posted// :- During the summer of 2013 I looked at 2,000 records of people using the Marshall Protocol.</blockquote>  <blockquote>//DJ posted// :- During the summer of 2013 I looked at 2,000 records of people using the Marshall Protocol.</blockquote> 
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   - **"A temporary increase in symptoms or laboratory values means the treatment is not working."** – \\ Immunopathology is an increase in one's present symptoms of Th1 inflammation or a return of previous Th1 inflammatory symptoms, that is caused by cytokines and endotoxins being released from dying bacteria. In some cases there may be a temporary experience of symptoms attributable to a previously unexperienced condition. Immunopathology is a necessary part of recovery. The amount of immunopathology a patient experiences on the Marshall Protocol (MP) is correlated with disease severity. Patients who are less sick will have comparatively less strong immunopathology. [[home:protocol:immunopathology|Read more →]]   - **"A temporary increase in symptoms or laboratory values means the treatment is not working."** – \\ Immunopathology is an increase in one's present symptoms of Th1 inflammation or a return of previous Th1 inflammatory symptoms, that is caused by cytokines and endotoxins being released from dying bacteria. In some cases there may be a temporary experience of symptoms attributable to a previously unexperienced condition. Immunopathology is a necessary part of recovery. The amount of immunopathology a patient experiences on the Marshall Protocol (MP) is correlated with disease severity. Patients who are less sick will have comparatively less strong immunopathology. [[home:protocol:immunopathology|Read more →]]
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 +see also [[home:protocol:olmesartan:safety|https://mpkb.org/home/protocol/olmesartan/safety#recent_research|research into enteropathy]] 
  
 ===== Concerns about antibiotics=====  ===== Concerns about antibiotics===== 
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 ==== Read also ==== ==== Read also ====
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 +[[http://electromagnetichealth.org/wp-content/uploads/2012/04/EMF-Guideline.pdf|Guideline of the Austrian Medical Association for the diagnosis and treatment of EMF-related health problems and illnesses (EMF syndrome) ]]
  
 **Evaluation of the Effect of Radiofrequency Radiation Emitted From Wi-Fi Router and Mobile Phone Simulator on the Antibacterial Susceptibility of Pathogenic Bacteria Listeria monocytogenes and Escherichia coli.**\\ Altogether, the findings of this study showed that exposure to Wi-Fi and RF simulator radiation can significantly alter the inhibition zone diameters and growth rate for L monocytogenes and E coli. These findings may have implications for the management of serious infectious diseases.  (({{pubmed>long:28203122}})) **Evaluation of the Effect of Radiofrequency Radiation Emitted From Wi-Fi Router and Mobile Phone Simulator on the Antibacterial Susceptibility of Pathogenic Bacteria Listeria monocytogenes and Escherichia coli.**\\ Altogether, the findings of this study showed that exposure to Wi-Fi and RF simulator radiation can significantly alter the inhibition zone diameters and growth rate for L monocytogenes and E coli. These findings may have implications for the management of serious infectious diseases.  (({{pubmed>long:28203122}}))
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-{{tag>resources_for_physicians}}+{{tag>resources_for_physicians research}} 
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 +[[home:starting:physician:reluctant#Specific_research|Section  to print off - Independent research into Olmesartan with PMIDs for doctor.]]
 ===== Notes and comments ===== ===== Notes and comments =====
  
home/physicians/concerns.txt · Last modified: 09.14.2022 by 127.0.0.1
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