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home:physicians:vitamin_d_leaflet [06.26.2018] – [The body controls activity of the VDR through regulation of the Vitamin D Metabolites] sallieqhome:physicians:vitamin_d_leaflet [09.14.2022] (current) – external edit 127.0.0.1
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-====== Testing Your Vitamin D Metabolites ======+====== Testing Vitamin D Metabolites ======
  
 ===== Inflammatory Markers Of Chronic Disease  ===== ===== Inflammatory Markers Of Chronic Disease  =====
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 disease, prevention of harmful supplementation, bone  disease, prevention of harmful supplementation, bone 
 density and calcification risk. density and calcification risk.
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 +see also Clinical Utility of Measurement of Vitamin D-Binding Protein and Calculation of Bioavailable Vitamin D in Assessment of Vitamin D Status  (({{pmid>long:27834063}})) 
  
 ==== Metabolism and Immunostimulation ==== ==== Metabolism and Immunostimulation ====
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 Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary defense of the intra-phagocytic innate immune system.   Only in homo sapiens is the VDR responsible for expression of the Cathelicidin antimicrobial peptide, the primary defense of the intra-phagocytic innate immune system.  
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 ==== Humans Are Not Tall Mice Without Tails! ==== ==== Humans Are Not Tall Mice Without Tails! ====
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 Importantly, the innate immune functions of the VDR are unique to Homo sapiens. In Homo sapiens, and only in Homo sapiens, there is one nuclear receptor, the VDR, which expresses genes for TLR2, as well as the cathelicidin and beta-defensin anti-microbial peptides, all of these are essential to the intracellular innate immune defences.   Importantly, the innate immune functions of the VDR are unique to Homo sapiens. In Homo sapiens, and only in Homo sapiens, there is one nuclear receptor, the VDR, which expresses genes for TLR2, as well as the cathelicidin and beta-defensin anti-microbial peptides, all of these are essential to the intracellular innate immune defences.  
  
-You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, which is the primary anti-microbial producing peptides that protect the phagocytes themselves. And TLR2, the primary toll-like receptor which detects pathogens inside the macrophages, there is no such homology in mice.  //9// +You cannot study the vitamin D receptor in mice, how it relates to the immune system, and expect it to translate to Homo sapiens. Whereas in man the VDR transcribes cathelicidin, which is the primary anti-microbial producing peptides that protect the phagocytes themselves and TLR2, the primary toll-like receptor which detects pathogens inside the macrophages, there is no such homology in mice.  //9// 
  
 In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens.  In mice, there are other receptors, and other genes that do that. Even the higher primates do not emulate the cathelicidin innate immunity of Homo sapiens. 
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 References: References:
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 1. Marshall TG: Vitamin D discovery outpaces FDA decision making.  1. Marshall TG: Vitamin D discovery outpaces FDA decision making. 
 BioEssays. 2008 Feb;30(2):173-82 Online ISSN: 1521-1878 Print ISSN: 0265-9247  Preprint of FullText available from URL  BioEssays. 2008 Feb;30(2):173-82 Online ISSN: 1521-1878 Print ISSN: 0265-9247  Preprint of FullText available from URL 
-http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf +https://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf 
  
 2. Proal AD, Albert PJ, Marshall TG: Dysregulation of the Vitamin D Nuclear  2. Proal AD, Albert PJ, Marshall TG: Dysregulation of the Vitamin D Nuclear 
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 3. Albert PJ, Proal AD, Marshall TG: Vitamin D: the alternative hypothesis.  3. Albert PJ, Proal AD, Marshall TG: Vitamin D: the alternative hypothesis. 
 Autoimmunity Reviews. 2009 Jul;8(8):677-81.Preprint available from  Autoimmunity Reviews. 2009 Jul;8(8):677-81.Preprint available from 
-http://AutoimmunityResearch.org/transcripts/AR-Albert-VitD.pdf+https://AutoimmunityResearch.org/transcripts/AR-Albert-VitD.pdf
  
 4. Proal AD, Albert PJ, Marshall TG: Autoimmune disease in the era of the  4. Proal AD, Albert PJ, Marshall TG: Autoimmune disease in the era of the 
 Metagenome. Autoimmunity Reviews. 2009 Jul;8(8):639-44.  Metagenome. Autoimmunity Reviews. 2009 Jul;8(8):639-44. 
-http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf+https://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf
  
 5. Proal AD, Albert PJ, Marshall TG: Infection, Autoimmunity, and Vitamin  5. Proal AD, Albert PJ, Marshall TG: Infection, Autoimmunity, and Vitamin 
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 Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent.  A case series of 64 patient-reported outcomes subsequent to use of a silver-threaded cap designed to protect the brain and brain stem from microwave Electrosmog resulted in 90% reporting "definite" or "strong" changes in their disease symptoms.  This is much higher than the 3-5% rate reported for electromagnetic hypersensitivity in a healthy population and suggests that effective control of environmental Electrosmog immunomodulation may soon become necessary for successful therapy of autoimmune disease.  Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent.  A case series of 64 patient-reported outcomes subsequent to use of a silver-threaded cap designed to protect the brain and brain stem from microwave Electrosmog resulted in 90% reporting "definite" or "strong" changes in their disease symptoms.  This is much higher than the 3-5% rate reported for electromagnetic hypersensitivity in a healthy population and suggests that effective control of environmental Electrosmog immunomodulation may soon become necessary for successful therapy of autoimmune disease. 
-     Trevor  G. Marshall :  Trudy Rumann Heil :  PMID 27412293+Trevor  G. Marshall :  Trudy Rumann Heil :  PMID 27412293 
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 +==== in this section ==== 
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 +{{tag>resources_for_physicians}} 
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 +==== Notes and comments ==== 
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home/physicians/vitamin_d_leaflet.1530051840.txt.gz · Last modified: 06.26.2018 by sallieq
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