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home:physicians [12.18.2018] – [Resources for physicians] sallieqhome:physicians [12.18.2018] – [Resources for physicians] sallieq
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 diagnosis is not as important as the clinical assessment by an interested health care provider, the results of a [[home:starting:therapeutic_probe|therapeutic probe]], and outcome of the [[home:tests:vitdinterpretation|vitamin D metabolites blood test]].(({{pubmed>long:19758177}}))  diagnosis is not as important as the clinical assessment by an interested health care provider, the results of a [[home:starting:therapeutic_probe|therapeutic probe]], and outcome of the [[home:tests:vitdinterpretation|vitamin D metabolites blood test]].(({{pubmed>long:19758177}})) 
  
-According to the Marshall Pathogenesis, chronic inflammatory disease is characterized by dysregulation of the nuclear receptor pathways which control the innate immune response. For example, the Vitamin D nuclear receptor (VDR) expresses many of the body's antimicrobial peptides (along with TLR2). In addition to down-regulation of expression of the VDR itself by many common bacteria and viruses, antagonistic microbial metabolites incrementally block ligands from activating it. Ingested vitamin D slows activity of the receptor in this same manner, preventing the body from killing the pathogens at the heart of the disease state.  That is why avoidance of ingested vitamin D (in food and supplements) is essential for the innate immune system to function correctly while patients are on the MP.(({{pubmed>long:19393200}})) ((Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. [[home:publications:waterhouse_new_research_2006|High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor — Implications of dysregulated vitamin D for diagnosis and treatment of Chronic Disease]]. In //Vitamin D: New Research//. +According to the Marshall Pathogenesis, chronic inflammatory disease is characterized by dysregulation of the nuclear receptor pathways which control the innate immune response. For example, the Vitamin D nuclear receptor (VDR) expresses many of the body's antimicrobial peptides (along with TLR2). In addition to down-regulation of expression of the VDR itself by many common bacteria and viruses, antagonistic microbial metabolites incrementally block ligands from activating it. Ingested vitamin D slows activity of the receptor in this same manner, preventing the body from killing the pathogens at the heart of the disease state.  That is why avoidance of ingested vitamin D (in food and supplements) is essential for the innate immune system to recover while patients are on the MP.(({{pubmed>long:19393200}})) ((Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G. [[home:publications:waterhouse_new_research_2006|High levels of active 1,25-dihydroxyvitamin D despite low levels of the 25-hydroxyvitamin D precursor — Implications of dysregulated vitamin D for diagnosis and treatment of Chronic Disease]]. In //Vitamin D: New Research//. 
 Volume 1. Edited by: Stoltz VD. New York: Nova Science Publishers; 2006. ISBN: 1-60021-000-7.))   Volume 1. Edited by: Stoltz VD. New York: Nova Science Publishers; 2006. ISBN: 1-60021-000-7.))  
  
home/physicians.txt · Last modified: 09.14.2022 by 127.0.0.1
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